Enzyme delivery using the 30Kc19 protein and human serum albumin nanoparticles.

abstract：:We hypothesized that reduced stem stiffness of orthopaedic implants contributes to a high risk of loosening, since interface stresses and relative motions may exceed a tolerable range. To study this hypothesis, three types of load-bearing implant with different stiffnesses were inserted into the tibia of the goat. His...

journal_title：Biomaterials

authors： Buma P,van Loon PJ,Versleyen H,Weinans H,Slooff TJ,de Groot K,Huiskes R

更新日期：1997-09-01 00:00:00

abstract：:Artemisinin (ART) is an iron-dependent anti-cancer drug. However, simultaneous delivery of hydrophobic ART and Fe(2+) ions into cancer cells remains a major challenge. Herein, we reported Fe3O4@C/Ag@mSiO2 (FCA@mSiO2) multifunctional nanocarriers which can load ART as high as 484 mg/g. Moreover, FCA@mSiO2 nanoparticles...

journal_title：Biomaterials

authors： Chen J,Guo Z,Wang HB,Zhou JJ,Zhang WJ,Chen QW

更新日期：2014-08-01 00:00:00

abstract：:Breast cancer is associated with high mortality due to tumor metastasis. The anti-metastasis efficacy of photochemotherapy is strictly limited by poor targeting capability with respect to circulating tumor cells (CTCs) in blood and lymph. Herein, we decorate the platelet membrane (PM) on a surface of nanoparticles (NP...

journal_title：Biomaterials

authors： Ye H,Wang K,Wang M,Liu R,Song H,Li N,Lu Q,Zhang W,Du Y,Yang W,Zhong L,Wang Y,Yu B,Wang H,Kan Q,Zhang H,Wang Y,He Z,Sun J

更新日期：2019-06-01 00:00:00

abstract：:The rate of change of pH of aqueous lactic acid at pH 4.2-4.5 (i.e. a little below that of active caries in vivo) in contact with disks of various commercial glass-ionomer cements has been determined in two configurations. In the first of them, a thin film set-up, 20 microl of solution was spread across the surface of...

journal_title：Biomaterials

authors： Nicholson JW,Aggarwal A,Czarnecka B,Limanowska-Shaw H

更新日期：2000-10-01 00:00:00

abstract：:A amphiphilic block copolymer composed of conventional monomethoxy (polyethylene glycol)-poly (d,l-lactide-co-glycolide)-poly (l-lysine) (mPEG-PLGA-b-PLL) was synthesized. The chemical structure of this copolymer and its precursors was confirmed by Fourier Transform Infrared Spectroscopy (FTIR), (1)H Nuclear Magnetic ...

journal_title：Biomaterials

authors： Liu P,Yu H,Sun Y,Zhu M,Duan Y

更新日期：2012-06-01 00:00:00

abstract：:Surface biofouling poses an increasing problem in industrial and health care applications, driving research for surface coatings to prevent anti-microbial colonization and characterization of the efficacy of the same. The diversity and increasing sophistication of such coatings, which postulate different types of anti...

journal_title：Biomaterials

authors： Xie X,Möller J,Konradi R,Kisielow M,Franco-Obregón A,Nyfeler E,Mühlebach A,Chabria M,Textor M,Lu Z,Reimhult E

更新日期：2011-07-01 00:00:00

abstract：:FT-IR analysis was performed for the hydroxyapatite (HAp)/collagen (COL) nanocomposite cross-linked by glutaraldehyde (GA). The amide bands I, II and III from COL matrix, and phosphate and carbonate bands from HAp were identified. The amide B band arising from C-H stretching mode showed a sensitive conformation by the...

journal_title：Biomaterials

authors： Chang MC,Tanaka J

更新日期：2002-12-01 00:00:00

abstract：:We describe here for the first time an efficient high yield production method for clinical grade recombinant human Oncofetal Antigen/immature laminin receptor protein (OFA/iLRP). We also demonstrate significant antitumor activity for this protein when administered in liposomal delivery form in a murine model of syngen...

journal_title：Biomaterials

authors： Barsoum AL,Liu B,Rohrer JW,Coggin JH Jr,Tucker JA,Pannell LK,Schwarzenberger PO

更新日期：2009-06-01 00:00:00

abstract：:The bioactivity of plasma-sprayed hydroxyapatite (HA)/Ti-6Al-4V composite coatings was studied by soaking the coatings in simulated body fluid (SBF) for up to 8 weeks. This investigation was aimed at elucidating the biological behaviour of plasma-sprayed HA/Ti-6Al-4V composite coatings by analyzing the changes in chem...

journal_title：Biomaterials

authors： Gu YW,Khor KA,Cheang P

更新日期：2003-04-01 00:00:00

abstract：:A glass of nominal composition (wt%) 17.25 MgO-52.75 3CaO.P2O5-30 SiO2 and a glass-ceramic obtained from it showed surface modifications when immersed in an acellular medium having a composition similar to that of human blood plasma. A (Ca, P)-rich layer, with an approximate Ca/P atomic ratio of 1.7, identified as hyd...

journal_title：Biomaterials

authors： Oliveira JM,Correia RN,Fernandes MH

更新日期：1995-07-01 00:00:00

abstract：:Nano-scale modification of a segmented polyurethane (SPU) with cross-linked 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer was performed to obtain a biocompatible elastomer. To control the domain size and the depth of the modified layer, various compositions of monomers, including MPC, 2-ethylhexyl methacrylat...

journal_title：Biomaterials

authors： Morimoto N,Watanabe A,Iwasaki Y,Akiyoshi K,Ishihara K

更新日期：2004-10-01 00:00:00

abstract：:PVA-AA, an esterification product of poly(vinyl alcohol) and acryloyl chloride, was synthesized and tested for its dentine bonding ability as an additive to 2-hydroxyethyl methacrylate (HEMA). The dentine bonding strength increased significantly by increasing the concentration of PVA-AA in HEMA. The dentine tensile bo...

journal_title：Biomaterials

authors： Gung YW,Kuo SM,Wang YJ

更新日期：1997-02-01 00:00:00

abstract：:The objective of this study was to develop radiopaque iodinated emulsions for use as CT blood pool contrast agents. Three hydrophobic iodinated oils were synthesized based on the 2,3,5-triiodobenzoate moiety and formulated into emulsions using either phospholipids or amphiphilic polymers, i.e. Pluronic F68 and poly(bu...

journal_title：Biomaterials

authors： de Vries A,Custers E,Lub J,van den Bosch S,Nicolay K,Grüll H

更新日期：2010-09-01 00:00:00

abstract：:Current advances in stem cell biology have brought much hope for therapy of neuro-degenerative diseases. However, neural stem cells (NSCs) are rare adult stem cells, and the use of non-NSCs requires efficient and high-yielding lineage-specific differentiation prior to transplantation for efficacy. We report on the eff...

journal_title：Biomaterials

authors： Wang CH,Wu CC,Hsu SH,Liou JY,Li YW,Wu KK,Lai YK,Yen BL

更新日期：2013-04-01 00:00:00

abstract：:Metal sensitivity (MS) reactions to implant metals represent a rare but well-documented complication following total joint arthroplasty (TJA). Although 20-25% of post-TJA patients develop MS, only a few highly susceptible patients (< 1%) exhibit symptoms. Whether surgeons should perform screening for MS is currently a...

journal_title：Biomaterials

authors： Niki Y,Matsumoto H,Otani T,Yatabe T,Kondo M,Yoshimine F,Toyama Y

更新日期：2005-03-01 00:00:00

abstract：:Osteoblasts proliferate slowly on the surface of calcium phosphate apatite which is widely used as a substrate biomaterial in bone regeneration. Owing to poor adhesion signaling in the cells grown on the calcium phosphate surface, inadequate growth factor signaling is generated to trigger cell cycle progression. The p...

journal_title：Biomaterials

authors： Yang S,Tian YS,Lee YJ,Yu FH,Kim HM

更新日期：2011-04-01 00:00:00

abstract：:Hydroxyapatite ceramics with zirconia dispersion from fine powders synthesized hydrothermally were post-sintered at 1000-1300 degrees C under 200 MPa of argon for 1 h without capsules, after normal sintering in air at 1200 degrees C for 3 h. Densification was most significant with post-sintering at 1200 degrees C. Fra...

journal_title：Biomaterials

authors： Ioku K,Yoshimura M,Somiya S

更新日期：1990-01-01 00:00:00

abstract：:This study was undertaken to investigate the relative importance of a hydroxyapatite (HA) coating and the macrotexture of titanium implants to the quality of bony ingrowth and fixation. Various types of titanium cylinders were implanted into the cancellous bone of the intercondylar region of the distal femur of the do...

journal_title：Biomaterials

authors： Hayashi K,Mashima T,Uenoyama K

更新日期：1999-01-01 00:00:00

abstract：:An increased demand for soft-tissue substitutes has impelled the development of an in vitro adipose tissue. Ideally, such a tissue should contain a vascular network that can deliver blood throughout the construct following its engraftment. This study describes the in vitro fabrication of a pre-vascularized adipose tis...

journal_title：Biomaterials

authors： Sorrell JM,Baber MA,Traktuev DO,March KL,Caplan AI

更新日期：2011-12-01 00:00:00

abstract：:The metabolic disposition and elimination process of the anhydride co-polymer poly[1,3-bis(p-carboxy-phenoxypropane):sebacic acid] 20:80 [P(CPP:Sa)20:80] implanted in the rat brain was studied. Two polymers were prepared, one with [14C]SA and unlabelled CPP, and the other co-polymer with [14C]CPP and unlabelled SA. Wi...

journal_title：Biomaterials

authors： Domb AJ,Rock M,Schwartz J,Perkin C,Yipchuk G,Broxup B,Villemure JG

更新日期：1994-07-01 00:00:00

abstract：:We demonstrate the ability of immobilized vascular endothelial growth factor (VEGF) to capture endothelial cells (EC) with high specificity under fluid flow. To this end, we engineered a surface consisting of heparin bound to poly-l-lysine to permit immobilization of VEGF through the C-terminal heparin-binding domain....

journal_title：Biomaterials

authors： Smith RJ Jr,Koobatian MT,Shahini A,Swartz DD,Andreadis ST

更新日期：2015-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the loss of neurogenesis and excessive induction of apoptosis. The induction of neurogenesis and inhibition of apoptosis may be a promising therapeutic approach to combating the disease. Celecoxib (CB), a cyclooxygenase-2 specific inhibitor, could offer neuroprotection. Spe...

journal_title：Biomaterials

authors： Guo JW,Guan PP,Ding WY,Wang SL,Huang XS,Wang ZY,Wang P

更新日期：2017-11-01 00:00:00

abstract：:In the present study, we tested the hypothesis that electroporation-mediated transfer of Runx2, Osterix, or both genes enhances the in vitro and in vivo osteogenesis from adipose stem cells (ASCs). ASCs were transfected with Runx2, Osterix, or both genes using electroporation, and further cultured in monolayer or in P...

journal_title：Biomaterials

authors： Lee JS,Lee JM,Im GI

更新日期：2011-01-01 00:00:00

abstract：:A series of coumarin fluorophores (1-3), each bearing a double bond conjugated quinoline unit that can undergo a Michael-type reaction with thiol-containing compounds, is reported. These systems, designed to provide so-called turn-on changes in fluorescence response when exposed to thiols, act as fluorescent chemical ...

journal_title：Biomaterials

authors： Jung HS,Han JH,Pradhan T,Kim S,Lee SW,Sessler JL,Kim TW,Kang C,Kim JS

更新日期：2012-01-01 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is the major cause of lower back pain, while the currently available treatments are symptomatic rather than curative. Tissue engineering is a powerful therapeutic strategy that can restore the normal biomechanical motion of the human spine. The ability of a biphasic elastic scaff...

journal_title：Biomaterials

authors： Wan Y,Feng G,Shen FH,Laurencin CT,Li X

更新日期：2008-02-01 00:00:00

abstract：:The magnetic resonance (MR) functionalities of pullulan-conjugated gadolinium diethylene triamine pentaacetate (Gd-DTPA-Pullulan) as a new hepatocyte-specific contrast agent were evaluated. Pullulan, which specifically accumulates on hepatocytes via asialoglycoprotein receptors, was chemically linked with Gd-DTPA. Gd-...

journal_title：Biomaterials

authors： Yim H,Yang SG,Jeon YS,Park IS,Kim M,Lee DH,Bae YH,Na K

更新日期：2011-08-01 00:00:00

abstract：:Carbon nanotubes have shown great potential in various areas of biomedicine. Herein, we synthesize a series of amphiphilic polymers by anchoring polyethylene glycol (PEG) of different lengths at various densities on poly(maleic anhydride-alt-1-octadecene) (PMHC(18)). The blood circulation and biodistribution of those ...

journal_title：Biomaterials

authors： Liu X,Tao H,Yang K,Zhang S,Lee ST,Liu Z

更新日期：2011-01-01 00:00:00

abstract：:We show here, that the proapoptotic peptide, KLAKLAKKLAKLAK (KLA), which by itself does not penetrate cell membranes, can do so when fused to a protein transduction domain derived from NH(2)-terminus of translationally controlled tumor protein (TCTP-PTD, MIIYRDLISH). Once inside the cell, the conjugated KLA exerts its...

journal_title：Biomaterials

authors： Kim HY,Kim S,Youn H,Chung JK,Shin DH,Lee K

更新日期：2011-08-01 00:00:00

abstract：:Topographical features on the nanometer scale are known to influence cellular behavior. The response of specific cell types to various types of surface structures is currently still being investigated. Alumina ceramics play an important role as biomaterials, e.g., in medical and dental applications. In this study, we ...

journal_title：Biomaterials

authors： Wittenbrink I,Hausmann A,Schickle K,Lauria I,Davtalab R,Foss M,Keller A,Fischer H

更新日期：2015-09-01 00:00:00

abstract：:Directed embryonic stem (ES) cell differentiation is a potentially powerful approach for generating a renewable source of cells for regenerative medicine. Typical in vitro ES cell differentiation protocols involve the formation of ES cell aggregate intermediates called embryoid bodies (EBs). Recently, we demonstrated ...

journal_title：Biomaterials

authors： Moeller HC,Mian MK,Shrivastava S,Chung BG,Khademhosseini A

更新日期：2008-02-01 00:00:00