Abstract:
:Artemisinin (ART) is an iron-dependent anti-cancer drug. However, simultaneous delivery of hydrophobic ART and Fe(2+) ions into cancer cells remains a major challenge. Herein, we reported Fe3O4@C/Ag@mSiO2 (FCA@mSiO2) multifunctional nanocarriers which can load ART as high as 484 mg/g. Moreover, FCA@mSiO2 nanoparticles demonstrated pH-responsive Fe(2+) release, the concentration of Fe(2+) ions can reach 2.765 nmol/L in HeLa cells cultured with FCA@mSiO2 nanoparticles. The antitumor efficacy of ART-loaded FCA@mSiO2 nanoparticles measured by MTT assay was significantly enhanced compared with free ART. It was suggested that the ART-loaded FCA@mSiO2 nanoparticles are internalized by HeLa cells and located at the acidic compartments of endosomes and lysosomes, releasing Fe(2+) ions to non-enzymatically convert ART to toxic products for killing cancer cells. This result provides a way for using promising natural drugs in anti-cancer therapeutics.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Chen J,Guo Z,Wang HB,Zhou JJ,Zhang WJ,Chen QWdoi
10.1016/j.biomaterials.2014.04.028subject
Has Abstractpub_date
2014-08-01 00:00:00pages
6498-507issue
24eissn
0142-9612issn
1878-5905pii
S0142-9612(14)00415-3journal_volume
35pub_type
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