Preparation and in vitro evaluation of porous silica gels.

Abstract:

:Porous silica gels with high surface areas were prepared from tetraethylothosilicate and polyacrylic acid (PAA) of high molecular weight in acidic media by a sol-gel method. PAA content and ageing temperatures were varied in order to obtain different microstructures. Samples were sintered at temperatures up to 400 degrees C, and subjected to in vitro evaluation by soaking them in acellular inorganic solutions at 37 degrees C and pH 7.3. Surface precipitation of carbonate-apatite on some of the gels was observed by FTIR spectroscopy, scanning electron microscopy and EPMA. Silica dissolution and re-precipitation phenomena were also observed. The relationship between both phenomena during the in vitro test is discussed mainly in terms of structural and microstructural features of the gel.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Gallardo J,Galliano PG,Porto López JM

doi

10.1016/s0142-9612(02)00190-4

keywords:

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

4277-84

issue

21

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(02)00190-4

journal_volume

23

pub_type

杂志文章
  • The promotion of angiogenesis by growth factors integrated with ECM proteins through coiled-coil structures.

    abstract::An appropriate method to bind extracellular matrix (ECM) proteins and growth factors using advanced protein engineering techniques has the potential to enhance cell proliferation and differentiation for tissue regeneration and repair. In this study we developed a method to co-immobilize non-covalently an ECM protein t...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2013.01.067

    authors: Assal Y,Mie M,Kobatake E

    更新日期:2013-04-01 00:00:00

  • Rat embryonic liver cell expansion and differentiation on NH3 plasma-grafted PEEK-WC-PU membranes.

    abstract::Biomaterials can potentially influence stem and progenitor cell proliferation and differentiation in both a positive and a negative way. Herein, we report on the expansion and differentiation of rat embryonic (E17) liver (RLC-18) cells on new bioactive membrane made of PEEK-WC-PU, whose surface was grafted with nitrog...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2009.08.024

    authors: Pavlica S,Piscioneri A,Peinemann F,Keller M,Milosevic J,Staeudte A,Heilmann A,Schulz-Siegmund M,Laera S,Favia P,De Bartolo L,Bader A

    更新日期:2009-11-01 00:00:00

  • Erythrocyte membrane-encapsulated celecoxib improves the cognitive decline of Alzheimer's disease by concurrently inducing neurogenesis and reducing apoptosis in APP/PS1 transgenic mice.

    abstract::Alzheimer's disease (AD) is characterized by the loss of neurogenesis and excessive induction of apoptosis. The induction of neurogenesis and inhibition of apoptosis may be a promising therapeutic approach to combating the disease. Celecoxib (CB), a cyclooxygenase-2 specific inhibitor, could offer neuroprotection. Spe...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2017.07.023

    authors: Guo JW,Guan PP,Ding WY,Wang SL,Huang XS,Wang ZY,Wang P

    更新日期:2017-11-01 00:00:00

  • Engineering advanced neural tissue constructs to mitigate acute cerebral inflammation after brain transplantation in rats.

    abstract::Stroke, traumatic brain injuries, and other similar conditions often lead to significant loss of functional brain tissue and associated disruption of neuronal signaling. A common strategy for replacing lost neurons is the injection of dissociated neural stem cells or differentiated neurons. However, this method is unl...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2018.11.031

    authors: Liaudanskaya V,Jgamadze D,Berk AN,Bischoff DJ,Gu BJ,Hawks-Mayer H,Whalen MJ,Chen HI,Kaplan DL

    更新日期:2019-02-01 00:00:00

  • Near-infrared fluorescence heptamethine carbocyanine dyes mediate imaging and targeted drug delivery for human brain tumor.

    abstract::Brain tumors and brain metastases are among the deadliest malignancies of all human cancers, largely due to the cellular blood-brain and blood-tumor barriers that limit the delivery of imaging and therapeutic agents from the systemic circulation to tumors. Thus, improved strategies for brain tumor visualization and ta...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2015.07.028

    authors: Wu JB,Shi C,Chu GC,Xu Q,Zhang Y,Li Q,Yu JS,Zhau HE,Chung LW

    更新日期:2015-10-01 00:00:00

  • Adhesion and spreading of cultured endothelial cells on modified and unmodified poly (ethylene terephthalate): a morphological study.

    abstract::The in vitro adhesion and spreading of human endothelial cells (HEC) on hydrophobic poly(ethylene terephthalate) (PETP) and moderately wettable tissue culture poly(ethylene terephthalate) (TCPETP) were studied with light microscopy and electron microscopy. Numbers of HEC adhering on TCPETP were always higher than thos...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(89)90058-6

    authors: van Wachem PB,Schakenraad JM,Feijen J,Beugeling T,van Aken WG,Blaauw EH,Nieuwenhuis P,Molenaar I

    更新日期:1989-10-01 00:00:00

  • The role of mechanical tension on lipid raft dependent PDGF-induced TRPC6 activation.

    abstract::Canonical transient receptor potential channel 6 (TRPC6) can play an important role in governing how cells perceive the surrounding material environment and regulate Ca(2+) signaling. We have designed a TRPC6 reporter based on fluorescence resonance energy transfer (FRET) to visualize the TRPC6-mediated calcium entry ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2013.12.030

    authors: Lei L,Lu S,Wang Y,Kim T,Mehta D,Wang Y

    更新日期:2014-03-01 00:00:00

  • In vivo mineralization and osteogenesis of nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with poly(L-lactide).

    abstract::Nanocomposite of hydroxyapatite (HAP) surface-grafted with poly(l-lactide) (PLLA) (g-HAP) shows a wide application for bone fixation materials due to its improved interface compatibility, mechanical property and biocompatibility in our previous study. In this paper, a 3-D porous scaffold of g-HAP/poly(lactide-co-glyco...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2008.08.041

    authors: Zhang P,Hong Z,Yu T,Chen X,Jing X

    更新日期:2009-01-01 00:00:00

  • Effects of compatibility of deproteinized antler cancellous bone with various bioactive factors on their osteogenic potential.

    abstract::Combinations of calcium phosphate scaffolds and bioactive factors are promising niche-mimetic solutions for repairing large-sized bone defects. However, the importance of compatibility between scaffolds and bioactive factors on their osteogenic outcomes has been largely ignored. This study aimed to investigate the com...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2013.08.024

    authors: Zhang X,Xu M,Song L,Wei Y,Lin Y,Liu W,Heng BC,Peng H,Wang Y,Deng X

    更新日期:2013-12-01 00:00:00

  • Some properties of keratin biomaterials: kerateines.

    abstract::Keratins are a family of structural proteins that can be isolated from a variety of tissues. "Soft" keratins are cytoskeletal elements found in epithelial tissues while protective tissues such as nails, hooves, and hair are composed of "hard" keratins. Hard keratins have been the subject of biomaterials investigations...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2009.09.076

    authors: Hill P,Brantley H,Van Dyke M

    更新日期:2010-02-01 00:00:00

  • Electroporation-mediated transfer of Runx2 and Osterix genes to enhance osteogenesis of adipose stem cells.

    abstract::In the present study, we tested the hypothesis that electroporation-mediated transfer of Runx2, Osterix, or both genes enhances the in vitro and in vivo osteogenesis from adipose stem cells (ASCs). ASCs were transfected with Runx2, Osterix, or both genes using electroporation, and further cultured in monolayer or in P...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2010.09.042

    authors: Lee JS,Lee JM,Im GI

    更新日期:2011-01-01 00:00:00

  • Structure-biocompatibility relationship of dendritic polyglycerol derivatives.

    abstract::Nanocarriers possess advanced physicochemical properties that improve bioavailability, enhance cellular dynamics, and control targetability in drug delivery. In particular, dendritic polyglycerol is a promising new biocompatible scaffold for drug delivery. The present explores the structure-biocompatibility relationsh...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2010.02.001

    authors: Khandare J,Mohr A,Calderón M,Welker P,Licha K,Haag R

    更新日期:2010-05-01 00:00:00

  • 3D porous chitosan-alginate scaffold stiffness promotes differential responses in prostate cancer cell lines.

    abstract::Prostate cancer (PCa) is a leading cause of death for men worldwide. Most PCa patients die from metastasis and bone is the most common metastatic site. Three dimensional (3D) porous chitosan-alginate (CA) scaffolds were developed for bone tissue engineering and demonstrated for culture of cancer cells and enrichment o...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2019.119311

    authors: Xu K,Ganapathy K,Andl T,Wang Z,Copland JA,Chakrabarti R,Florczyk SJ

    更新日期:2019-10-01 00:00:00

  • Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens.

    abstract::Therapeutic options to treat primary glioblastoma (GBM) tumors are scarce. GBM tumors with epidermal growth factor receptor (EGFR) mutations, in particular a constitutively active EGFRvIII mutant, have extremely poor clinical outcomes. GBM tumors with concurrent EGFR amplification and active phosphatase and tensin hom...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2019.119371

    authors: Pedron S,Wolter GL,Chen JE,Laken SE,Sarkaria JN,Harley BAC

    更新日期:2019-10-01 00:00:00

  • Cartilage repair in transplanted scaffold-free chondrocyte sheets using a minipig model.

    abstract::Lacking a blood supply and having a low cellular density, articular cartilage has a minimal ability for self-repair. Therefore, wide-ranging cartilage damage rarely resolves spontaneously. Cartilage damage is typically treated by chondrocyte transplantation, mosaicplasty or microfracture. Recent advances in tissue eng...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2012.01.056

    authors: Ebihara G,Sato M,Yamato M,Mitani G,Kutsuna T,Nagai T,Ito S,Ukai T,Kobayashi M,Kokubo M,Okano T,Mochida J

    更新日期:2012-05-01 00:00:00

  • Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain.

    abstract::The blood-brain barrier (BBB) prevents entry of neurotoxic substances but also that of drugs into the brain. Here, the paracellular barrier is formed by tight junctions (TJs) with claudin-5 (Cldn5) being the main sealing constituent. Transient BBB opening by targeting Cldn5 could improve paracellular drug delivery. Th...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2018.01.028

    authors: Neuhaus W,Piontek A,Protze J,Eichner M,Mahringer A,Subileau EA,Lee IM,Schulzke JD,Krause G,Piontek J

    更新日期:2018-04-01 00:00:00

  • Corrosion behavior of titanium nitride coated Ni-Ti shape memory surgical alloy.

    abstract::Nickel-titanium (NiTi, nitinol) shape memory alloy was nitrided using an original powder immersion reaction assisted coating (PIRAC) method in order to modify its surface properties. PIRAC nitriding method is based on annealing the samples in the atmosphere of highly reactive nitrogen supplied by decomposition of unst...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(00)00368-9

    authors: Starosvetsky D,Gotman I

    更新日期:2001-07-01 00:00:00

  • Tailoring lactide/caprolactone co-oligomers as tissue adhesives.

    abstract::This article introduces novel biocompatible tissue adhesives that do not involve any chemical or biochemical reactions, during their application in vivo. The use of these new adhesives is based exclusively on their temperature-dependent rheological properties. Since biocompatibility and biodegradability are additional...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2004.01.040

    authors: Cohn D,Lando G

    更新日期:2004-12-01 00:00:00

  • Micropatterned polymer substrates control alignment of proliferating Schwann cells to direct neuronal regeneration.

    abstract::Microcontact printed polymeric substrates were evaluated for their ability to control Schwann cell attachment and direct proliferation, as Schwann cell guidance is a crucial factor in directing peripheral nerve regeneration. Elastomeric stamps of poly(dimethylsiloxane) were "inked" with laminin, a permissive protein f...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2004.04.046

    authors: Schmalenberg KE,Uhrich KE

    更新日期:2005-04-01 00:00:00

  • Long-term maintenance of human hepatocytes in oxygen-permeable membrane bioreactor.

    abstract::An oxygen-permeable membrane bioreactor utilizing human hepatocytes has been tested in this study. In the bioreactor, human hepatocytes were cultured between flat-sheet gas-permeable polymeric membranes, which ensure the diffusion of O(2) and CO(2) providing a support for cell anchorage and growth and permit the onlin...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2006.05.015

    authors: De Bartolo L,Salerno S,Morelli S,Giorno L,Rende M,Memoli B,Procino A,Andreucci VE,Bader A,Drioli E

    更新日期:2006-09-01 00:00:00

  • Diaminododecane-based cationic bolaamphiphile as a non-viral gene delivery carrier.

    abstract::The advancement in gene therapy relies upon the discovery of safe and efficient delivery agents and methods. In this study, we report the design and synthesis of a cationic bolaamphiphile as a non-viral gene delivery agent. The bolaamphiphile is composed of 1,12-diaminododecane as the central hydrophobic unit linked t...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2012.02.067

    authors: Khan M,Ang CY,Wiradharma N,Yong LK,Liu S,Liu L,Gao S,Yang YY

    更新日期:2012-06-01 00:00:00

  • Microspheres of hydroxyapatite/reconstituted collagen as supports for osteoblast cell growth.

    abstract::Microspheres comprised of particulate hydroxyapatites dispersed in fibrous collagen matrices were prepared. The procedure involved the droplet formation of hydroxyapatite/collagen mixture emulsified in olive oil, followed by the reconstitution of collagen in the presence of hydroxyapatite particles at 37 degrees C. Va...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(99)00095-2

    authors: Hsu FY,Chueh SC,Wang YJ

    更新日期:1999-10-01 00:00:00

  • A biomimetic nanovector-mediated targeted cholesterol-conjugated siRNA delivery for tumor gene therapy.

    abstract::RNA interference holds tremendous potential as a therapeutic approach of malignant tumors. However, safe and efficient nanovectors are extremely lack for systemic delivery of small interfering RNA (siRNA). The study aimed to develop a biomimetic nanovector, reconstituted high density lipoprotein (rHDL), mediating targ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2012.08.057

    authors: Ding Y,Wang W,Feng M,Wang Y,Zhou J,Ding X,Zhou X,Liu C,Wang R,Zhang Q

    更新日期:2012-12-01 00:00:00

  • Variations in tooth surface temperature in the oral cavity during fluid intake.

    abstract::Measurements were made of the extremes in temperature which occur at different sites in the oral cavity during fluid intake. The results indicate that temperatures noted at the tooth surface, within the mouth, during fluid intake were less than the temperatures of the fluid imbibed. Variations in temperature were note...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(87)90016-0

    authors: Longman CM,Pearson GJ

    更新日期:1987-09-01 00:00:00

  • Differential and synergistic effects of mechanical stimulation and growth factor presentation on vascular wall function.

    abstract::We investigated the hypothesis that immobilizing TGF-β1 within fibrin hydrogels may act in synergy with cyclic mechanical stimulation to enhance the properties of vascular grafts. To this end, we engineered a fusion TGF-β1 protein that can covalently anchor to fibrin during polymerization upon the action of factor XII...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2013.05.073

    authors: Liang MS,Koobatian M,Lei P,Swartz DD,Andreadis ST

    更新日期:2013-10-01 00:00:00

  • Mechanical and thermal properties of novel polymerized NDGA-gelatin hydrogels.

    abstract::Nordihydroguaiaretic acid (NDGA), an antioxidant with two functional ortho-catechols from the creosote bush, has been shown to increase the mechanical properties of synthetic collagen fibers, producing biologically based, biocompatible fibers with material properties in uniaxial tensile tests to failure that are compa...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(02)00465-9

    authors: Koob TJ,Hernandez DJ

    更新日期:2003-03-01 00:00:00

  • Viral-mimicking protein nanoparticle vaccine for eliciting anti-tumor responses.

    abstract::The immune system is a powerful resource for the eradication of cancer, but to overcome the low immunogenicity of tumor cells, a sufficiently strong CD8(+) T cell-mediated adaptive immune response is required. Nanoparticulate biomaterials represent a potentially effective delivery system for cancer vaccines, as they c...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2016.01.056

    authors: Molino NM,Neek M,Tucker JA,Nelson EL,Wang SW

    更新日期:2016-04-01 00:00:00

  • Multifunctional rare-earth self-assembled nanosystem for tri-modal upconversion luminescence /fluorescence /positron emission tomography imaging.

    abstract::Rare-earth upconversion nanoparticles (UCNP) which can absorb low-energy photons and emit high energy photons have attracted great interest not only because of their unique application in upconversion luminescence imaging, but also because they can be used as ideal building blocks for multimodal bioimaging probes. Imp...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2011.07.053

    authors: Liu Q,Chen M,Sun Y,Chen G,Yang T,Gao Y,Zhang X,Li F

    更新日期:2011-11-01 00:00:00

  • A dual-modal PET/near infrared fluorescent nanotag for long-term immune cell tracking.

    abstract::Adoptive cell transfer of targeted chimeric antigen receptor (CAR) T cells has emerged as a highly promising cancer therapy. The pharmacodynamic action or CAR T cells is closely related to their pharmacokinetic profile; because of this as well as the risk of non-specific action, it is important to monitor their biodis...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120630

    authors: Harmsen S,Medine EI,Moroz M,Nurili F,Lobo J,Dong Y,Turkekul M,Pillarsetty NVK,Ting R,Ponomarev V,Akin O,Aras O

    更新日期:2020-12-23 00:00:00

  • Tuning photothermal properties of gold nanodendrites for in vivo cancer therapy within a wide near infrared range by simply controlling their degree of branching.

    abstract::Although dendritic nanoparticles have been prepared by many different methods, control over their degree of branching (DB) is still impossible, preventing us from understanding the effect of the DB on the properties of the nanodendrites as cancer therapeutics. Herein, we developed a novel seed-mediated method to prepa...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2016.06.033

    authors: Qiu P,Yang M,Qu X,Huai Y,Zhu Y,Mao C

    更新日期:2016-10-01 00:00:00