Abstract:
:This work demonstrated the development of multifunctional silica nanotubes (SNT) by functionalization of their inner void and outer surface with magnetic-fluorescence nanocomposites and cationic polymers, respectively. The successful construction of BPEI-SNT was established by electron energy loss spectroscopy in conjugation with standard analytical tools. The mean fluorescence intensity in a FACS assay, a luciferase gene expression assay and a confocal fluorescence study demonstrated the efficacy of BPEI-SNT as a gene delivery vector. Endocytotic uptake was also demonstrated by the colocalization of LysoTracker Red(®) and green fluorescent quantum dots. Moreover, enhanced magnetic resonance imaging revealed the potential of the BPEI-SNT nanocomposite to act as a dual-modality nano-device.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Namgung R,Zhang Y,Fang QL,Singha K,Lee HJ,Kwon IK,Jeong YY,Park IK,Son SJ,Kim WJdoi
10.1016/j.biomaterials.2010.12.018subject
Has Abstractpub_date
2011-04-01 00:00:00pages
3042-52issue
11eissn
0142-9612issn
1878-5905pii
S0142-9612(10)01578-4journal_volume
32pub_type
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