Rare-earth-incorporated polymeric vector for enhanced gene delivery.

abstract：:The aim of this study was to identify and quantify potential regional and directional variations in the quasistatic uniaxial mechanical properties of the passive urinary bladder wall. Overall, the lower body and trigone regions demonstrated the highest degree of directional anisotropy, whereas the ventral region demon...

journal_title：Biomaterials

authors： Korossis S,Bolland F,Southgate J,Ingham E,Fisher J

更新日期：2009-01-01 00:00:00

abstract：:Linear alkyl chains containing 2, 10 and 18 carbon atoms were grafted to 10% of the urethane nitrogens in a polyether-polyurethane. The polyurethane was synthesized from methylene bis(p-phenyl isocyanate), 1,4-butanediol, and polytetramethylene oxide of 1000 molecular weight in a molar ratio of 3/2/1. Fourier transfor...

journal_title：Biomaterials

authors： Pitt WG,Grasel TG,Cooper SL

更新日期：1988-01-01 00:00:00

abstract：:The interactions between alginate and polycations have been studied by using different labelling techniques. Binding of poly-L-lysine (PLL) to alginate in the gel state is mainly governed by the amount of dissociable negative charges on the bead surface. PLL was found to bind more rapidly to gel beads made from algina...

journal_title：Biomaterials

authors： Thu B,Bruheim P,Espevik T,Smidsrød O,Soon-Shiong P,Skjåk-Braek G

更新日期：1996-05-01 00:00:00

abstract：:Micro/nanotopographical modification of biomaterials constitutes a promising approach to direct stem cell osteogenic differentiation to promote osseointegration. In this work, titania nanotubes (NTs) 25 and 80 nm in size with the acid-etched Ti topography (AcidTi) and hierarchical hybrid micropitted/nanotubular topogr...

journal_title：Biomaterials

authors： Zhao L,Liu L,Wu Z,Zhang Y,Chu PK

更新日期：2012-03-01 00:00:00

abstract：:A rapid and simple in vitro method is described which measures the extent of unrecoiled solids compression when a complex biopolymer is subjected to a centrifugal force. This method, termed the compaction assay, was used to assess the response of purulent cystic fibrosis (CF) sputum samples to the addition of recombin...

journal_title：Biomaterials

authors： Daugherty AL,Patapoff TW,Clark RC,Sinicropi DV,Mrsny RJ

更新日期：1995-05-01 00:00:00

abstract：:The water-soluble, low toxic and less biodegradable chitosan derivative N-succinyl-chitosan (Suc-chitosan) was investigated for body distribution and urinary excretion on a long-time scale (24-72 h after i.v. injection) using a fluorescein-labeling technique. Fluorescein isothiocyanate (FITC)-labeled Suc-chitosan (Suc...

journal_title：Biomaterials

authors： Kato Y,Onishi H,Machida Y

更新日期：2000-08-01 00:00:00

abstract：:Fibronectin (Fn) forms a fibrillar network that controls cell behavior in both physiological and diseased conditions including cancer. Indeed, breast cancer-associated stromal cells not only increase the quantity of deposited Fn but also modify its conformation. However, (i) the interplay between mechanical and confor...

journal_title：Biomaterials

authors： Wang K,Andresen Eguiluz RC,Wu F,Seo BR,Fischbach C,Gourdon D

更新日期：2015-06-01 00:00:00

abstract：:Polyacrylamide hydrogels have been used extensively to study cell responses to the mechanical and biochemical properties of extracellular matrix substrates. A key step in fabricating these substrates is the conjugation of cell adhesion proteins to the polyacrylamide surfaces, which typically involves nonspecifically a...

journal_title：Biomaterials

authors： Lee JP,Kassianidou E,MacDonald JI,Francis MB,Kumar S

更新日期：2016-09-01 00:00:00

abstract：:Conventional cancer chemotherapy often fails as most anti-cancer drugs are not effective against drug-resistant cancer stem cells. These surviving cancer stem cells lead to relapse and metastasis. In this study, an anti-diabetic drug, phenformin, capable of eliminating cancer stem cells was loaded into micelles via se...

journal_title：Biomaterials

authors： Krishnamurthy S,Ng VW,Gao S,Tan MH,Yang YY

更新日期：2014-11-01 00:00:00

abstract：:Chitosans with various degrees of deacetylation were synthesized by acetylation with acetic anhydride. These chitosans were evaluated for efficacy of nanoparticle formation, DNA binding efficiency, morphology, and in vitro and in vivo gene transfection efficiency. DNA binding efficacy was reduced as degree of deacetyl...

journal_title：Biomaterials

authors： Kiang T,Wen J,Lim HW,Leong KW

更新日期：2004-10-01 00:00:00

abstract：:The ability of different calcium phosphate to activate the complement system is studied by crossed immunoelectrophoresis demonstrating conversion of C3 to C3b. Complement consumption is determined by a haemolytic assay CH50. Hydroxyapatite powders after sintering induce a significant conversion of C3 and reduction of ...

journal_title：Biomaterials

authors： Klein CP,de Groot K,van Kamp G

更新日期：1983-07-01 00:00:00

abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuroendocrine factor that activates both the receptor VPAC1 and VPAC2. Although PACAP possesses insulinotropic activity, its therapeutic application is limited by the extremely short acting half-life and the stimulatory effects on glucagon production via...

journal_title：Biomaterials

authors： Ma Y,Fang S,Zhao S,Wang X,Wang D,Ma M,Luo T,Hong A

更新日期：2015-05-01 00:00:00

abstract：:In-stent restenosis is one of the most serious modes of failure of cardiovascular stent implant. Although drug-eluting stents have been proven to reduce in-stent restenosis, the nonspecific inhibitory effects of anti-proliferative drugs, such as rapamycin, result in delayed re-endothelialization and fatal late stent t...

journal_title：Biomaterials

authors： Zhang H,Ren KF,Chang H,Wang JL,Ji J

更新日期：2017-02-01 00:00:00

abstract：:In this work, five self-assembled monolayers (SAMs) and three polymeric brushes with very low fibrinogen adsorption were prepared. The five SAMs are oligo(ethylene glycol) (OEG), phosphorylcholine (PC), oligo(phosphorylcholine) (OPC), and two mixed positively and negatively charged SAMs of SO(3)(-)/N(+)(CH(3))(3) (SA/...

journal_title：Biomaterials

authors： Zhang Z,Zhang M,Chen S,Horbett TA,Ratner BD,Jiang S

更新日期：2008-11-01 00:00:00

abstract：:Self-assembly is a prominent phenomenon observed in nature. Inspired by this thermodynamically favorable approach, several natural and synthetic materials have been investigated to develop functional systems for various biomedical applications, including drug delivery. Furthermore, layered self-assembled systems provi...

journal_title：Biomaterials

authors： Sarode A,Annapragada A,Guo J,Mitragotri S

更新日期：2020-02-29 00:00:00

abstract：:A new system of single piece electrodes was applied to in vivo and in vitro measurements of anodic polarization of several alloys used in orthopaedic implants. The tested surface was scrutinized with a stereomicroscope after each experiment. This confirmed pit formation and excluded the possibility of other sudden inc...

journal_title：Biomaterials

authors： Nakayama Y,Yamamuro T,Kotoura Y,Oka M

更新日期：1989-08-01 00:00:00

abstract：:Tissue engineering of the cornea could overcome shortages of donor corneas for transplantation and improve quality. Our aim was to grow an endothelial layer on a substratum suitable for transplant. Silkworm (Bombyx mori) fibroin was prepared as 5 μm thick transparent membranes. The B4G12 cell line was used to assess a...

journal_title：Biomaterials

authors： Madden PW,Lai JN,George KA,Giovenco T,Harkin DG,Chirila TV

更新日期：2011-06-01 00:00:00

abstract：:Poly(vinyl alcohol)-heparin hydrogels with varying water content were synthesized for use as sensor catheter membranes. Films were cast from aqueous mixtures of poly(vinyl alcohol) (PVA), a photosensitive cross-linker p-diazonium diphenyl amine polymer (PA), glutaraldehyde (GA) and heparin. After drying, the films wer...

journal_title：Biomaterials

authors： Brinkman E,van der Does L,Bantjes A

更新日期：1991-01-01 00:00:00

abstract：:The differentiation of odontoblasts is initiated by the organization of differentiating ameloblasts during tooth formation. However, the exact roles of ameloblast-derived factors in odontoblast differentiation have not yet been characterized. We investigated the effects of preameloblast-conditioned medium (PA-CM) on t...

journal_title：Biomaterials

authors： Lee JH,Lee DS,Choung HW,Shon WJ,Seo BM,Lee EH,Cho JY,Park JC

更新日期：2011-12-01 00:00:00

abstract：:Immune checkpoint blocking (ICB) antibodies have shown great success in the clinic, but their low response rate in patients with immunosuppressive cold tumors remains a huge challenge. Inspired by the capability of immunogenic cell death (ICD) to convert tumors from cold to hot, we developed a corn-like Au/Ag nanorod ...

journal_title：Biomaterials

authors： Jin L,Shen S,Huang Y,Li D,Yang X

更新日期：2021-01-01 00:00:00

abstract：:Thermosensitive hydrogels based on poly(γ-ethyl-L-glutamate)-poly(ethylene glycol)-poly(γ-ethyl-L-glutamate) triblock copolymers (PELG-PEG-PELG) were prepared for localized and sustained delivery of anticancer drugs. The polypeptide-based hydrogels showed much lower critical gelation concentration than the traditional...

journal_title：Biomaterials

authors： Cheng Y,He C,Ding J,Xiao C,Zhuang X,Chen X

更新日期：2013-12-01 00:00:00

abstract：:Vasculopathy due to ischemia in damaged tissues is a major cause of morbidity and mortality. To treat these conditions, endothelial progenitor cells (EPCs) from various sources, such as umbilical cord or peripheral blood, have been the focus of the regenerative medicine field due to their proliferative and vasculogeni...

journal_title：Biomaterials

authors： Kim J,Jeon YJ,Kim HE,Shin JM,Chung HM,Chae JI

更新日期：2013-02-01 00:00:00

abstract：:FT-IR analysis was performed for the hydroxyapatite (HAp)/collagen (COL) nanocomposite cross-linked by glutaraldehyde (GA). The amide bands I, II and III from COL matrix, and phosphate and carbonate bands from HAp were identified. The amide B band arising from C-H stretching mode showed a sensitive conformation by the...

journal_title：Biomaterials

authors： Chang MC,Tanaka J

更新日期：2002-12-01 00:00:00

abstract：:Duchenne Muscular Dystrophy (DMD) is a fatal genetic disorder currently having no cure. Here we report that culture substrates patterned with nanogrooves and functionalized with Matrigel (or laminin) present an engineered cell microenvironment to allow myotubes derived from non-diseased, less-affected DMD, and severel...

journal_title：Biomaterials

authors： Xu B,Magli A,Anugrah Y,Koester SJ,Perlingeiro RCR,Shen W

更新日期：2018-11-01 00:00:00

abstract：:A three layer (trilayer) polymeric micelle system based on the self-association of the triblock polymer poly(ethylene glycol)-b-poly{N-[N-(2-aminoethyl)-2-aminoethyl] aspartamide}-b-poly(ε-caprolactone) (PEG-b-PAsp(DET)-b-PCL) has been synthesized and investigated for combination delivery of rapamycin (RAP) and siRNA ...

journal_title：Biomaterials

authors： Zeng S,Xiong MP

更新日期：2013-09-01 00:00:00

abstract：:Hydrogels based on ethoxytriethyleneglycol monomethacrylate/methyl methacrylate copolymers were prepared by free radical polymerization at 70 degrees C in bulk with 2,2'-azobisisobutyronitrile as initiator. The swelling behaviour of the hydrogels was studied by immersion of the films in water and in buffered solutions...

journal_title：Biomaterials

authors： Vázquez B,Gurruchaga M,Goñi I,San Román J

更新日期：1997-04-01 00:00:00

abstract：:A major obstacle in the survival and efficacy of tissue engineered transplants is inadequate oxygenation, whereby unsupportive oxygen tensions result in significant cellular dysfunction and death within the implant. In a previous report, we developed an innovative oxygen generating biomaterial, termed OxySite, to prov...

journal_title：Biomaterials

authors： Coronel MM,Geusz R,Stabler CL

更新日期：2017-06-01 00:00:00

abstract：:A collagen prosthesis was developed as a dural substitute. It is composed of a Dallop matrix-polyester knitted net with radiation cross-linked collagen on both sides. Collagen was derived from enzyme-treated bovine Achilles tendons. Improved hydrophilic properties of the polyester base ensuring stronger adhesion to co...

journal_title：Biomaterials

authors： Pietrucha K

更新日期：1991-04-01 00:00:00

abstract：:The main challenge for neural progenitor cell (NPC)-mediated repair of spinal cord injury (SCI) is lack of favorable environment to direct its differentiation towards neurons rather than glial cells. The myelin associated inhibitors have been demonstrated to promote NPC differentiation into glial lineage. Herein, to i...

journal_title：Biomaterials

authors： Li X,Xiao Z,Han J,Chen L,Xiao H,Ma F,Hou X,Li X,Sun J,Ding W,Zhao Y,Chen B,Dai J

更新日期：2013-07-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) are generally induced to differentiate by forming spherical structures termed embryoid bodies (EBs) in the presence of soluble growth factors. hEBs are generated by suspending small clumps of hESC colonies; however, the resulting hEBs are heterogeneous because this method lacks the a...

journal_title：Biomaterials

authors： Moon SH,Ju J,Park SJ,Bae D,Chung HM,Lee SH

更新日期：2014-07-01 00:00:00