Abstract:
:Systemic lupus erythematosus (SLE) is an autoimmune disease. Antibodies directed mainly against DNA and/or phospholipids are present in the serum of SLE patients. Therefore phosphorylated polystyrene derivatives acting as DNA-like polymers should be able to interact with the SLE anti-DNA antibodies. Such functional polymers were synthesized and subsequently their interactions with the anti-DNA antibodies studied. Adsorption experiments performed with both anti-DNA antibodies and normal immunoglobulins showed high affinity constants of the phosphorylated polymer for anti-DNA antibodies (4 x 10(9) M-1) whereas for normal IgG the affinity was low (2 x 10(5) M-1). Moreover, the interaction was specific involving the idiotypic moiety of the anti-DNA antibodies and an array of phosphoester groups at the surface of this biomaterial.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Letourneur D,Jozefowicz Mdoi
10.1016/0142-9612(92)90096-7keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
59-63issue
1eissn
0142-9612issn
1878-5905pii
0142-9612(92)90096-7journal_volume
13pub_type
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