Sustained release of ascorbate-2-phosphate and dexamethasone from porous PLGA scaffolds for bone tissue engineering using mesenchymal stem cells.

abstract：:One of the key challenges for neural tissue engineering is to exploit supporting materials with robust functionalities not only to govern cell-specific behaviors, but also to form functional neural network. The unique electrical and mechanical properties of graphene imply it as a promising candidate for neural interfa...

journal_title：Biomaterials

authors： Tang M,Song Q,Li N,Jiang Z,Huang R,Cheng G

更新日期：2013-09-01 00:00:00

abstract：:Interest in constructing a reliable 3-dimensional (3D) collagen culture platform in microfabricated systems is increasing as researchers strive to investigate reciprocal interaction between extracellular matrix (ECM) and cells under various conditions. However, in comparison to conventional 2-dimensional (2D) cell cul...

journal_title：Biomaterials

authors： Sung KE,Su G,Pehlke C,Trier SM,Eliceiri KW,Keely PJ,Friedl A,Beebe DJ

更新日期：2009-09-01 00:00:00

abstract：:A practical method of photocrosslinking high molecular weight poly(trimethylene carbonate)(PTMC) is presented. Flexible, elastomeric and biodegradable networks could be readily prepared by UV irradiating PTMC films containing pentaerythritol triacrylate (PETA) and a photoinitiator. The network characteristics, mechani...

journal_title：Biomaterials

authors： Bat E,Kothman BH,Higuera GA,van Blitterswijk CA,Feijen J,Grijpma DW

更新日期：2010-11-01 00:00:00

abstract：:There is a broad interest in the development of nanoparticles (NPs) carrying on their surface carbohydrates such as sialic acids. It is known that these carbohydrates influence the biological and physical properties of biopharmaceutical proteins and living cells. Macromolecular compounds containing these carbohydrates...

journal_title：Biomaterials

authors： Bondioli L,Costantino L,Ballestrazzi A,Lucchesi D,Boraschi D,Pellati F,Benvenuti S,Tosi G,Vandelli MA

更新日期：2010-04-01 00:00:00

abstract：:Poly(ω-pentadecalactone-co-p-dioxanone) [poly(PDL-co-DO)] copolyesters are copolymers of an isodimorphic system, which remain semicrystalline over the whole range of compositions. Here, we evaluated enzymatically synthesized poly(PDL-co-DO) copolymers as new materials for biomedical applications. In vivo experiments u...

journal_title：Biomaterials

authors： Liu J,Jiang Z,Zhang S,Liu C,Gross RA,Kyriakides TR,Saltzman WM

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Carboplatin, an antineoplastic agent, binds DNA and enhances radiotherapy (RT) effects. Carboplatin-loaded hydrogel (oxidized hyaluronic acid/adipic acid dihydrazide) enables the sustained drug release and facilitates the synergistic effect with RT. PURPOSE:We investigated the effectiveness and convenience ...

journal_title：Biomaterials

authors： Liang HT,Lai XS,Wei MF,Lu SH,Wen WF,Kuo SH,Chen CM,Tseng WI,Lin FH

更新日期：2018-01-01 00:00:00

abstract：:Interventional closure of intracardiac wall defects using occluder devices has evolved as a highly attractive treatment option. However, incomplete and delayed healing reactions often result in a major risk of residual defects, thromboembolism, or device fractures. Biodegradable living tissue engineered occluder membr...

journal_title：Biomaterials

authors： Weber B,Schoenauer R,Papadopulos F,Modregger P,Peter S,Stampanoni M,Mauri A,Mazza E,Gorelik J,Agarkova I,Frese L,Breymann C,Kretschmar O,Hoerstrup SP

更新日期：2011-12-01 00:00:00

abstract：:Unhealed chronic wounds often deteriorate into multiple infection with several kinds of bacteria and excessive proteolytic wound exudate and remains one of the common healthcare issues. Here, the functional and antimicrobial hydrogel and cryogel biomaterials were prepared from glycol chitosan and a novel biodegradable...

journal_title：Biomaterials

authors： Chen TY,Wen TK,Dai NT,Hsu SH

更新日期：2020-12-16 00:00:00

abstract：:Nordihydroguaiaretic acid (NDGA), an antioxidant with two functional ortho-catechols from the creosote bush, has been shown to increase the mechanical properties of synthetic collagen fibers, producing biologically based, biocompatible fibers with material properties in uniaxial tensile tests to failure that are compa...

journal_title：Biomaterials

authors： Koob TJ,Hernandez DJ

更新日期：2003-03-01 00:00:00

abstract：:Platelet concentrates (PCs) constitute new biological mediators used in osseous reconstructive surgery. In this study, we assessed (i) the effects of various concentrations of calcium and thrombin on the kinetics of platelet-derived growth factor (PDGF-BB), transforming growth factor-beta1(TGF-beta 1), basic fibroblas...

journal_title：Biomaterials

authors： Martineau I,Lacoste E,Gagnon G

更新日期：2004-08-01 00:00:00

abstract：:Employing equilibrium dialysis, the binding abilities of Cu, Al, Co and Cr ions from corroded Cu-Al and Co-Cr dental casting alloys towards human saliva and two of its gel chromatographic fractions were determined. Results indicate that both Cu and Co bind to human saliva i.e. 0.045 and 0.027 mg/mg protein, respective...

journal_title：Biomaterials

authors： Mueller HJ

更新日期：1985-05-01 00:00:00

abstract：:The reaction of calcium ions and organic phosphate ester monomer at varying pHs was examined. Above pH 10, poorly crystallized hydroxyapatite was formed, which had lower crystallinity than that synthesized with inorganic phosphate as a source of P under the same conditions. On the other hand, the results of X-ray diff...

journal_title：Biomaterials

authors： Okazaki M,Hattori M

更新日期：1989-03-01 00:00:00

abstract：:Ectopic expression of heme oxygenase-1 (HO-1) in ischemic tissue protects the tissue from apoptosis and necrosis and promotes angiogenesis. However, apoptosis and necrosis will decrease HO-1 gene transfection efficacy. We hypothesized that fibroblast growth factor-2 (FGF2) would attenuate ischemic damage during the in...

journal_title：Biomaterials

authors： Bhang SH,Kim JH,Yang HS,La WG,Lee TJ,Sun AY,Kim GH,Lee M,Kim BS

更新日期：2009-10-01 00:00:00

abstract：:The emergence of combinatorial chemistries and the increased discovery of natural compounds have led to the production of expansive libraries of drug candidates and vast numbers of compounds with potentially interesting biological activities. Despite broad interest in high throughput screening (HTS) across varied fiel...

journal_title：Biomaterials

authors： Wu J,Wheeldon I,Guo Y,Lu T,Du Y,Wang B,He J,Hu Y,Khademhosseini A

更新日期：2011-01-01 00:00:00

abstract：:Low molecular weight polyurethanes with sites for metal complexation were synthesized. The -SO(2) and the -COOH groups were incorporated into the polyurethane chain by the reactions of tri-functional monomers, 4,4'-bis(hydroxyphenyl)sulfone and 4,4'-bis(hydroxyphenyl) valeric acid with hexa-methylene di-isocyanate (HM...

journal_title：Biomaterials

authors： Acharya V,Prabha CR,Narayanamurthy C

更新日期：2004-08-01 00:00:00

abstract：:Biodegradable polyurethanes are typically prepared from polyester polyols, aliphatic diisocyanates and chain extenders. We have developed a degradable chain extender (DCE) based on dl-lactic acid and ethylene glycol to accelerate hard segment degradation. Three series of polyurethane elastomers were synthesised to inv...

journal_title：Biomaterials

authors： Tatai L,Moore TG,Adhikari R,Malherbe F,Jayasekara R,Griffiths I,Gunatillake PA

更新日期：2007-12-01 00:00:00

abstract：:The limited intrinsic repair capacity of articular cartilage has stimulated continuing efforts to develop tissue engineered analogues. Matrices composed of type II collagen and chondroitin sulfate (CS), the major constituents of hyaline cartilage, may create an appropriate environment for the generation of cartilage-l...

journal_title：Biomaterials

authors： Pieper JS,van der Kraan PM,Hafmans T,Kamp J,Buma P,van Susante JL,van den Berg WB,Veerkamp JH,van Kuppevelt TH

更新日期：2002-08-01 00:00:00

abstract：:Impurity centers associated with silicon have been observed in the phase mixture of silicon substituted apatite (Si-Ap) and silicon stabilized tricalcium phosphate (Si-TCP) using electron spin resonance (ESR). Two unique centers occur upon addition of SiO2 to the calcium phosphate system: an orthorhombic center with g...

journal_title：Biomaterials

authors： Pietak AM,Reid JW,Sayer M

更新日期：2005-06-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) play an important role in regulating osteoblastic differentiation and bone formation. But the diffuse of BMPs into muscle tissues around bone injury sites often leads to heterotopic ossification, which has been regarded as one of major side-effects of BMP implementation in bone defec...

journal_title：Biomaterials

authors： Zhang J,Zhao Y,Hou X,Chen B,Xiao Z,Han J,Shi C,Liu J,Miao Q,Dai J

更新日期：2014-11-01 00:00:00

abstract：:Microencapsulation of dopamine-secreting cells in biocompatible, semi-permeable polymer membranes has been proposed as an alternative strategy for dopamine replacement for Parkinson's disease. In order to assess the viability of this proposal, dopamine-secreting PC12 cells were immunoisolated via microencapsulation in...

journal_title：Biomaterials

authors： Campioni EG,Nobrega JN,Sefton MV

更新日期：1998-04-01 00:00:00

abstract：:We compared the osteogenic response in porous alumni (Al) and hydroxyapatite coated porous alumni ceramic (HA/Al) by grafting rat bone marrow cells with these implants subcutaneously in the back of syngeneic rats. The ceramics did not show any bone formation without marrow, but did when combined with marrow cells. The...

journal_title：Biomaterials

authors： Takaoka T,Okumura M,Ohgushi H,Inoue K,Takakura Y,Tamai S

更新日期：1996-08-01 00:00:00

abstract：:Cancer cell metabolism is quite different from normal cells. Targeting cancer metabolism and untuning the tumor metabolic machine has emerged as a promising strategy for cancer therapy. We have developed a multi-functional Re-dca conjugate (Re-dca 2) by conjugating the metabolic modulator dichloroacetate (DCA) to mito...

journal_title：Biomaterials

authors： Yang J,Cao Q,Zhang H,Hao L,Zhou D,Gan Z,Li Z,Tong YX,Ji LN,Mao ZW

更新日期：2018-09-01 00:00:00

abstract：:We have developed a crosslinked hyaluronic acid (HA) film with DNA incorporated within its structure and have characterized this system for its efficacy in sustained transferring of a vector encoding mouse hyaluronan synthase 2 (Has2). Analysis of the DNA release kinetics indicated that the HA films degraded when trea...

journal_title：Biomaterials

authors： Kim AP,Yellen P,Yun YH,Azeloglu E,Chen W

更新日期：2005-05-01 00:00:00

abstract：:The study was to produce a novel hybrid poly-(lactic-co-glycolic acid) (PLGA)-gelatin/chondroitin/hyaluronate (PLGA-GCH) scaffold and evaluate its potentials in cartilage repair. The porous PLGA-GCH scaffold was developed to mimic the natural extra cellular matrix of cartilage. The differentiated mesenchymal stem cell...

journal_title：Biomaterials

authors： Fan H,Hu Y,Zhang C,Li X,Lv R,Qin L,Zhu R

更新日期：2006-09-01 00:00:00

abstract：:3D printing is known as a cost-effective technique that shows huge potential in fabrication of graft substitutes for bone tissue regeneration. However, the tradeoff between 3D printability, mechanical strength and bioactivity of the printed materials (i.e., inks) remains a challenge. In this work, we present a novel p...

journal_title：Biomaterials

authors： Yang Y,Zhang Q,Xu T,Zhang H,Zhang M,Lu L,Hao Y,Fuh JH,Zhao X

更新日期：2020-12-01 00:00:00

abstract：:We have used a new synthetic injectable composite constituted of hydroxyapatite/tricalcium phosphate (HA/TCP) particles in suspension in a self-hardening Si-hydroxypropylmethylcellulose (HPMC) hydrogel. The aim of this study was to evaluate in vivo the biocompatibility and the new bone formation efficacy of this scaff...

journal_title：Biomaterials

authors： Trojani C,Boukhechba F,Scimeca JC,Vandenbos F,Michiels JF,Daculsi G,Boileau P,Weiss P,Carle GF,Rochet N

更新日期：2006-06-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are the vital, life-long source of all blood cell types. They are found in stem cell niches, specific anatomic locations that offer all the factors and signals necessary for the maintenance of the stem cell potential of HSCs. Much attention has been paid to the biochemical composition o...

journal_title：Biomaterials

authors： Altrock E,Muth CA,Klein G,Spatz JP,Lee-Thedieck C

更新日期：2012-04-01 00:00:00

abstract：:Combined and targeted therapy have been extensively employed to achieve more effective elimination of tumor tissues. In this study, biocompatible multifunctional lipid-coated calcium phosphate nanoparticles (LCP NPs) were designed and constructed as an efficient targeted delivery system for combined gene/photothermal ...

journal_title：Biomaterials

authors： Tang J,Li B,Howard CB,Mahler SM,Thurecht KJ,Wu Y,Huang L,Xu ZP

更新日期：2019-09-01 00:00:00

abstract：:The in vivo cellular microenvironment is regulated by a complex interplay of soluble factors and signaling molecules secreted by cells and it plays a critical role in the growth and development of normal and diseased tissues. In vitro systems that can recapitulate the microenvironment at the cellular level are needed ...

journal_title：Biomaterials

authors： Chandrasekaran S,Giang UB,King MR,DeLouise LA

更新日期：2011-10-01 00:00:00

abstract：:A series of hydrogels composed of varying fractions of dodecyl methacrylate (DM) and 2,3-dihydroxypropyl methacrylate (GM) were prepared using ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent. The study found that for a series of gels with the same monomer ratio, bulk hydration could be controlled by ...

journal_title：Biomaterials

authors： Haigh R,Rimmer S,Fullwood NJ

更新日期：2000-04-01 00:00:00