Physical properties of artificial extracellular matrix protein films prepared by isocyanate crosslinking.

abstract：:Bioencapsulation involves the envelopment of tissues or biological active substances in semipermeable membranes. Bioencapsulation has been shown to be efficacious in mimicking the cell's natural environment and thereby improves the efficiency of production of different metabolites and therapeutic agents. The field of ...

journal_title：Biomaterials

authors： de Vos P,Bucko M,Gemeiner P,Navrátil M,Svitel J,Faas M,Strand BL,Skjak-Braek G,Morch YA,Vikartovská A,Lacík I,Kolláriková G,Orive G,Poncelet D,Pedraz JL,Ansorge-Schumacher MB

更新日期：2009-05-01 00:00:00

abstract：:Embryonic stem cells (ESCs) are promising cell sources for cell-based therapy. It has been established that the formation of ESC aggregates promotes their differentiation into the derivatives of all three germ layers. ESC aggregates are generally prepared via the formation of suspended spherical aggregates called embr...

journal_title：Biomaterials

authors： Sasaki D,Shimizu T,Masuda S,Kobayashi J,Itoga K,Tsuda Y,Yamashita JK,Yamato M,Okano T

更新日期：2009-09-01 00:00:00

abstract：:We present a dual-drug delivery system (DDDS) of hydrogel/polypeptide micelle composites in this work. The DDDS was constructed from aspirin (Asp) dispersed poly(vinyl alcohol) (PVA) or Chitosan (CS)/PVA hydrogel and doxorubicin (DOX) loaded poly(L-glutamic acid)-b-poly(propylene oxide)-b-poly(L-glutamic acid) (GPG) m...

journal_title：Biomaterials

authors： Wei L,Cai C,Lin J,Chen T

更新日期：2009-05-01 00:00:00

abstract：:Unlike silkworm and spider silks assembled from very large and repetitive fibrous proteins, the bee and ant silks were recently demonstrated to consist of four small and non-repetitive coiled-coil proteins. The design principle for this silk family remains largely unknown and so far no structural study is available on...

journal_title：Biomaterials

authors： Shi J,Lua S,Du N,Liu X,Song J

更新日期：2008-06-01 00:00:00

abstract：:Poly(ω-pentadecalactone-co-p-dioxanone) [poly(PDL-co-DO)] copolyesters are copolymers of an isodimorphic system, which remain semicrystalline over the whole range of compositions. Here, we evaluated enzymatically synthesized poly(PDL-co-DO) copolymers as new materials for biomedical applications. In vivo experiments u...

journal_title：Biomaterials

authors： Liu J,Jiang Z,Zhang S,Liu C,Gross RA,Kyriakides TR,Saltzman WM

更新日期：2011-09-01 00:00:00

abstract：:One of the potential factors that may affect the results of mesenchymal stem cell (MSC)-based therapy is the age of donors and recipients. However, there have been no controlled studies to investigate the influence of skeletal maturity on the MSC-based repair of cartilage. The purpose of this study was to compare the ...

journal_title：Biomaterials

authors： Shimomura K,Ando W,Tateishi K,Nansai R,Fujie H,Hart DA,Kohda H,Kita K,Kanamoto T,Mae T,Nakata K,Shino K,Yoshikawa H,Nakamura N

更新日期：2010-11-01 00:00:00

abstract：:Polyurethane microspheres having diameters in the range 150-1500 microns were prepared by condensation polymerization of toluene diisocyanate (TDI) with poly(tetramethylene glycol) (PTMG) of average mol wt 990 in an aqueous dispersion medium containing dioctyl sulphosuccinate (DOS) as the suspension stabilizer and 1,4...

journal_title：Biomaterials

authors： Thanoo BC,Sunny MC,Jayakrishnan A

更新日期：1991-07-01 00:00:00

abstract：:Bone defects caused by fractures or cancer-mediated destruction are debilitating. Chitosan is commonly used in scaffold matrices for bone healing, but rarely as a free drug. We demonstrate that free chitosan promotes osteoblast proliferation and osteogenesis in mesenchymal stem cells, increases osteopontin and collage...

journal_title：Biomaterials

authors： Tan ML,Shao P,Friedhuber AM,van Moorst M,Elahy M,Indumathy S,Dunstan DE,Wei Y,Dass CR

更新日期：2014-09-01 00:00:00

abstract：:We have developed a method to modify cross-linked hyaluronic acid with peptides containing the Arg-Gly-Asp sequence. The material created by this process is a three-dimensional porous matrix capable of supporting integrin receptor-mediated cell attachment. Peptide density can be controlled by varying the reaction cond...

journal_title：Biomaterials

authors： Glass JR,Dickerson KT,Stecker K,Polarek JW

更新日期：1996-06-01 00:00:00

abstract：:Dextran hydrogels were formed in situ by enzymatic crosslinking of dextran-tyramine conjugates and their mechanical, swelling and degradation properties were evaluated. Two types of dextran-tyramine conjugates (M(n,dextran)=14k, M(w)/M(n)=1.45), i.e. dextran-tyramine linked by a urethane bond (denoted as Dex-TA) or by...

journal_title：Biomaterials

authors： Jin R,Hiemstra C,Zhong Z,Feijen J

更新日期：2007-06-01 00:00:00

abstract：:Implant stability is not only a function of strength but also depends on the fixation established with surrounding tissues [Robertson DM, Pierre L, Chahal R. Preliminary observations of bone ingrowth into porous materials. J Biomed Mater Res 1976;10:335-44]. In the past, such stability was primarily achieved using scr...

journal_title：Biomaterials

authors： Ryan G,Pandit A,Apatsidis DP

更新日期：2006-05-01 00:00:00

abstract：:In the present work, we designed and synthesized a novel mono-guanidine heterolipid (MGH) and confirmed its structure by NMR and ESI-MS. The MGH was used as cationic lipid in developing etoposide loaded cationic self-microemulsifying drug delivery system (ECS) intended to be delivered by intratumoral route. The ECS ex...

journal_title：Biomaterials

authors： Shete H,Sable S,Tidke P,Selkar N,Pawar Y,Chakraborty A,De A,Vanage G,Patravale V

更新日期：2015-07-01 00:00:00

abstract：:There is a need for new therapeutic strategies to treat bone defects caused by trauma, disease or tissue loss. Injectable systems for cell transplantation have the advantage of allowing the use of minimally invasive surgical procedures, and thus for less discomfort to patients. In the present study, it is hypothesized...

journal_title：Biomaterials

authors： Evangelista MB,Hsiong SX,Fernandes R,Sampaio P,Kong HJ,Barrias CC,Salema R,Barbosa MA,Mooney DJ,Granja PL

更新日期：2007-09-01 00:00:00

abstract：:The iron-containing fluoridated hydroxyapatites Fe-FeFAp and FeF-FeAp were synthesized heterogeneously in the presence of ferrous ions at 80 degrees C and pH 7.4 in two different types of solution, i.e. fluoride-free solution during the initial half of the experimental period and fluoride-containing solution during th...

journal_title：Biomaterials

authors： Okazaki M,Takahashi J

更新日期：1997-01-01 00:00:00

abstract：:Umbilical cord mesenchymal stem cells (UCMSCs) have shown great potentials in regenerative medicine for their extensive sources, multilineage differentiation potential, low immunogenicity and self-renewal ability. However, the clinical application of UCMSCs still confronts many challenges including the requirement of ...

journal_title：Biomaterials

authors： Qiao Y,Xu Z,Yu Y,Hou S,Geng J,Xiao T,Liang Y,Dong Q,Mei Y,Wang B,Qiao H,Dai J,Suo G

更新日期：2020-01-01 00:00:00

abstract：:A rapid and simple in vitro method is described which measures the extent of unrecoiled solids compression when a complex biopolymer is subjected to a centrifugal force. This method, termed the compaction assay, was used to assess the response of purulent cystic fibrosis (CF) sputum samples to the addition of recombin...

journal_title：Biomaterials

authors： Daugherty AL,Patapoff TW,Clark RC,Sinicropi DV,Mrsny RJ

更新日期：1995-05-01 00:00:00

abstract：:Hydrophobically derivatized hyperbranched polyglycerol (HPG)-polyethylene glycol (PEG) polymers bearing stearoyl chains (HPG-C18-PEG) were originally developed as human serum albumin substitutes and further as a unimolecular drug delivery system. In view of these in vivo applications and the potential for membrane int...

journal_title：Biomaterials

authors： Liu Z,Janzen J,Brooks DE

更新日期：2010-04-01 00:00:00

abstract：:Tumor-homing cytotoxic stem cell (SC) therapy is a promising new approach for treating the incurable brain cancer glioblastoma (GBM). However, problems of retaining cytotoxic SCs within the post-surgical GBM resection cavity are likely to significantly limit the clinical utility of this strategy. Here, we describe a n...

journal_title：Biomaterials

authors： Bagó JR,Pegna GJ,Okolie O,Hingtgen SD

更新日期：2016-04-01 00:00:00

abstract：:The cytocompatibility of amphiphilic, thermoresponsive and chemically crosslinkable macromers was examined in vitro. Macromers synthesized from pentaerythritol diacrylate monostearate, N-isopropylacrylamide, acrylamide and hydroxyethyl acrylate in different molar ratios and with varying molecular weights and lower cri...

journal_title：Biomaterials

authors： Klouda L,Hacker MC,Kretlow JD,Mikos AG

更新日期：2009-09-01 00:00:00

abstract：:Samples of linear (additionally crosslinked) p(HEMA) with different amounts of fibrillar collagen were implanted into the popliteal region of rats. After 3 month, the implanted materials were harvested and examined by SEM. The implants underwent marked structural or morphological changes. While the fibrillar collagen ...

journal_title：Biomaterials

authors： Stol M,Cífková I,Tyrácková V,Adam M

更新日期：1991-07-01 00:00:00

abstract：:Multi-layered poly(glycerol-sebacate) (PGS) scaffolds with controlled pore microarchitectures were fabricated, combined with heart cells, and cultured with perfusion to engineer contractile cardiac muscle constructs. First, one-layered (1L) scaffolds with accordion-like honeycomb shaped pores and elastomeric mechanica...

journal_title：Biomaterials

authors： Park H,Larson BL,Guillemette MD,Jain SR,Hua C,Engelmayr GC Jr,Freed LE

更新日期：2011-03-01 00:00:00

abstract：:Tissue engineering of clinical-relevant large tissue constructs remains a big challenge due to the mass transfer limit. A modular approach via the assembling of modular tissues thus eliminating the mass transfer limit holds great promise for fabricating centimeter-sized constructs. In the present study, we investigate...

journal_title：Biomaterials

authors： Chen M,Wang X,Ye Z,Zhang Y,Zhou Y,Tan WS

更新日期：2011-10-01 00:00:00

abstract：:This article is a review of recent developments of polymer-related stents mainly employed in the coronary arteries, including polymer-coated stents, biostable stents and biodegradable stents. Polymer paving is covered as well. The problems with the stents currently investigated and the development of new stents are di...

journal_title：Biomaterials

authors： Peng T,Gibula P,Yao KD,Goosen MF

更新日期：1996-04-01 00:00:00

abstract：:Tubular vessels for tissue engineering are typically fabricated using a molding, dipping, or electrospinning technique. While these techniques provide some control over inner and outer diameters of the tube, they lack the ability to align the polymers or fibers of interest throughout the tube. This is an important asp...

journal_title：Biomaterials

authors： Lovett ML,Cannizzaro CM,Vunjak-Novakovic G,Kaplan DL

更新日期：2008-12-01 00:00:00

abstract：:The surface of soft contact lenses made of crosslinked poly(2-hydroxyethyl methacrylate). pHEMA, has been investigated with atomic force microscopy in contact mode. The friction force and adhesive force measurements were able to differentiate the non-crosslinked pHEMA chains from the surface of the crosslinked pHEMA n...

journal_title：Biomaterials

authors： Kim SH,Marmo C,Somorjai GA

更新日期：2001-12-01 00:00:00

abstract：:Recently, engineering the surface of nanotherapeutics with biologics to provide them with superior biocompatibility and targeting towards pathological tissues has gained significant popularity. Although the functionalization of drug delivery vectors with cellular materials has been shown to provide synthetic particles...

journal_title：Biomaterials

authors： Evangelopoulos M,Parodi A,Martinez JO,Yazdi IK,Cevenini A,van de Ven AL,Quattrocchi N,Boada C,Taghipour N,Corbo C,Brown BS,Scaria S,Liu X,Ferrari M,Tasciotti E

更新日期：2016-03-01 00:00:00

abstract：:The therapeutic potential of hyperbranched polymers targeted to prostate cancer and loaded with doxorubicin was investigated. Polyethylene glycol hyperbranched polymers were synthesised via RAFT polymerisation to feature glutamate urea targeting ligands for PSMA on the periphery. The chemotherapeutic, doxorubicin, was...

journal_title：Biomaterials

authors： Pearce AK,Simpson JD,Fletcher NL,Houston ZH,Fuchs AV,Russell PJ,Whittaker AK,Thurecht KJ

更新日期：2017-10-01 00:00:00

abstract：:Medical implants used in oral and orthopaedic surgery are mainly produced from titanium. Their biological behaviour, e.g. osseointegration, essentially depends on both the chemical composition and the morphology of the surface. Modifications achieved by excimer laser irradiation of titanium samples were investigated i...

journal_title：Biomaterials

authors： Bereznai M,Pelsöczi I,Tóth Z,Turzó K,Radnai M,Bor Z,Fazekas A

更新日期：2003-10-01 00:00:00

abstract：:A biocompatible hydrogel of poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) which includes the cell-adhesive region of fibronectin Arg-Gly-Asp was synthesized and its structure, rheological and dielectric properties were characterized. The ability of a PHPMA-RGD hydrogel to promote tissue regeneration and support axon...

journal_title：Biomaterials

authors： Woerly S,Pinet E,de Robertis L,Van Diep D,Bousmina M

更新日期：2001-05-01 00:00:00

abstract：:Protein delivery allows a clinical effect to be directly realized without genetic modification of the host cells. We have developed a cationic bolaamphiphile as a non-viral vector for protein delivery application. The relatively low toxicity and efficient protein delivery by the cationic bolaamphiphile prompted us to ...

journal_title：Biomaterials

authors： Khan M,Narayanan K,Lu H,Choo Y,Du C,Wiradharma N,Yang YY,Wan AC

更新日期：2013-07-01 00:00:00