Dual-drug delivery system based on hydrogel/micelle composites.

abstract：:A system of nanoparticles of mixed lipid monolayer shell and biodegradable polymer core was developed for targeted delivery of anticancer drugs with Docetaxel as a model drug, which provide targeting versatility with a quantitative control of the targeting effect by adjusting the lipid component ratio of the mixed lip...

journal_title：Biomaterials

authors： Liu Y,Li K,Pan J,Liu B,Feng SS

更新日期：2010-01-01 00:00:00

abstract：:The carboxymethylcellulose-gelatine carrier system was investigated for invertase immobilization. Chromium (III) acetate, chromium (III) sulphate and potassium chromium (III) sulphate were used as cross-linking agents. Effect of carboxymethylcellulose-gelatine ratio and cross-linker concentration on immobilized enzyme...

journal_title：Biomaterials

authors： Emregül E,Sungur S,Akbulut U

更新日期：1996-07-01 00:00:00

abstract：:The differences in morphological behaviour between fibroblasts cultured on smooth and nanogrooved substrata (groove depth: 5-350 nm, width: 20-1000 nm) have been evaluated in vitro. The aim of the study was to clarify to what extent cell guidance occurs on increasingly smaller topographies. Pattern templates were made...

journal_title：Biomaterials

authors： Loesberg WA,te Riet J,van Delft FC,Schön P,Figdor CG,Speller S,van Loon JJ,Walboomers XF,Jansen JA

更新日期：2007-09-01 00:00:00

abstract：:Zwitterionic hydrogels such as those based on polycarboxybetaine (PCB) or polysulfobetaine (PSB) have potential for various biomedical applications, due to their biocompatibility and low biofouling properties. However, the poor mechanical properties of zwitterionic hydrogels developed to date remain a challenge, sever...

journal_title：Biomaterials

authors： Liu Q,Chiu A,Wang L,An D,Li W,Chen EY,Zhang Y,Pardo Y,McDonough SP,Liu L,Liu WF,Chen J,Ma M

更新日期：2020-02-01 00:00:00

abstract：:The torque-tension characteristics of standard, conical and flanged external fixator pins and a cortical screw were compared using a commercially available testing apparatus. The flanged pin and the screw were similar in behaviour, and converted torque into tension more efficiently than conical and standard external f...

journal_title：Biomaterials

authors： Oni OO,Batchelor JS

更新日期：1995-11-01 00:00:00

abstract：:Human platelet lysates (PLs), which contain multiple neurotrophins, have been proposed for treating neurodegenerative disorders, including Parkinson's disease (PD). However, current PLs suspended in plasma have high protein content and contain fibrinogen/fibrin and, following activation, also proteolytic and thromboge...

journal_title：Biomaterials

authors： Chou ML,Wu JW,Gouel F,Jonneaux A,Timmerman K,Renn TY,Laloux C,Chang HM,Lin LT,Devedjian JC,Devos D,Burnouf T

更新日期：2017-10-01 00:00:00

abstract：:The superelastic nature of bones requires matching biomechanical properties from the ideal artificial biomedical implants in order to provide smooth load transfer and foster the growth of new bone tissues. In this work, we determine the biomechanical characteristics of porous NiTi implants and investigate bone ingrowt...

journal_title：Biomaterials

authors： Liu X,Wu S,Yeung KW,Chan YL,Hu T,Xu Z,Liu X,Chung JC,Cheung KM,Chu PK

更新日期：2011-01-01 00:00:00

abstract：:Excessive production of reactive oxygen species (ROS) is a hallmark feature in nanomaterials (NMs) induced cellular toxicity. However, the inter-relationship between NMs induced ROS generation and the cells innate ability to regulate intracellular ROS level in effecting a particular cellular outcome is currently under...

journal_title：Biomaterials

authors： Setyawati MI,Tay CY,Leong DT

更新日期：2013-12-01 00:00:00

abstract：:Umbilical cord mesenchymal stem cells (UCMSCs) have shown great potentials in regenerative medicine for their extensive sources, multilineage differentiation potential, low immunogenicity and self-renewal ability. However, the clinical application of UCMSCs still confronts many challenges including the requirement of ...

journal_title：Biomaterials

authors： Qiao Y,Xu Z,Yu Y,Hou S,Geng J,Xiao T,Liang Y,Dong Q,Mei Y,Wang B,Qiao H,Dai J,Suo G

更新日期：2020-01-01 00:00:00

abstract：:High-throughput screening techniques for cellular response are often unable to account for several factors present in the in vivo environment, many of which have been shown to modulate cellular response to the screened parameter. Culture in three-dimensional biomaterials and active mechanical stimulation are two such ...

journal_title：Biomaterials

authors： Moraes C,Wang G,Sun Y,Simmons CA

更新日期：2010-01-01 00:00:00

abstract：:Permanent male sterilization has been recognized as useful tools for the development of neuter experimental animals and fattening livestock, as well as efficient control of pet overpopulation. Traditional routes such as surgical ways, chemical injections, and anti-fertility vaccines have addressed these crucial proble...

journal_title：Biomaterials

authors： Liu Z,Liu X,Ran X,Ju E,Ren J,Qu X

更新日期：2015-11-01 00:00:00

abstract：:Collagen has been widely used for tissue engineering. Here, we applied bioactive laminin-derived peptides as an additive for collagen, laminin-111, and fibronectin matrices resulting in peptide/collagen, peptide/laminin-111, and peptide/fibronectin matrices. Several syndecan-binding peptides, including AG73 (RKRLQVQLS...

journal_title：Biomaterials

authors： Yamada Y,Katagiri F,Hozumi K,Kikkawa Y,Nomizu M

更新日期：2011-07-01 00:00:00

abstract：:Titanium can form a bone-like apatite layer on its surface in SBF when it is treated in NaOH. When pre-treated titanium is exposed to SBF, the alkali ions are released from the surface into the surrounding fluid. The Na+ ions increase the degree of supersaturation of the soaking solution with respect to apatite by inc...

journal_title：Biomaterials

authors： Jonásová L,Müller FA,Helebrant A,Strnad J,Greil P

更新日期：2002-08-01 00:00:00

abstract：:Angiogenesis is critical in the early stage of reparative processes and tissue regeneration, but the persistence of a vascular network may interfere with later transformation/maturation in naturally avascular tissues such as articular cartilage. Our supposition is that the timed delivery of an anti-angiogenic factor i...

journal_title：Biomaterials

authors： Sun XD,Jeng L,Bolliet C,Olsen BR,Spector M

更新日期：2009-02-01 00:00:00

abstract：:Recent advances in stem cell research and nanotechnology have significantly influenced the landscape of tissue engineering and regenerative medicine. Precise and reproducible control of the fate of stem cells and their lineage specification have, therefore, become more crucial than ever for the success of stem cell-ba...

journal_title：Biomaterials

authors： Kenry,Lee WC,Loh KP,Lim CT

更新日期：2018-02-01 00:00:00

abstract：:Self-assembling peptides and peptide derivatives bearing cell-binding ligands are increasingly being investigated as defined cell culture matrices and as scaffolds for regenerative medicine. In order to systematically refine such scaffolds to elicit specific desired cell behaviors, ligand display should ideally be ach...

journal_title：Biomaterials

authors： Jung JP,Nagaraj AK,Fox EK,Rudra JS,Devgun JM,Collier JH

更新日期：2009-04-01 00:00:00

abstract：:Cell labeling using magnetic nanoparticles is an increasingly used approach in noninvasive behavior tracking, in vitro separation of cancer stem cells (CSCs), and CSC-based research in cancer therapy. However, the impact of magnetic labeling on the biological properties of targeted CSCs, such as self-renewal, prolifer...

journal_title：Biomaterials

authors： Wang X,Wei F,Liu A,Wang L,Wang JC,Ren L,Liu W,Tu Q,Li L,Wang J

更新日期：2012-05-01 00:00:00

abstract：:Polydimethylsiloxanes exhibit hydrophobic behaviour and poor wettability. These features impose some problems with the clinical performance of the material when used for the construction of intraoral and extraoral facial prostheses. Surface active agents were added to modify the surface energy of the polydimethylsilox...

journal_title：Biomaterials

authors： Polyzois GL,Winter RW,Stafford GD

更新日期：1991-01-01 00:00:00

abstract：:Calcium phosphate bioceramics have been applied as bone substitutes for several decades. Aseptic loosening after total joint arthroplasty is a major problem in orthopaedic surgery. Hydroxyapatite particles from materials wear have been reported as the main cause of implant failure. For this reason, an investigation in...

journal_title：Biomaterials

authors： Laquerriere P,Grandjean-Laquerriere A,Jallot E,Balossier G,Frayssinet P,Guenounou M

更新日期：2003-07-01 00:00:00

abstract：:Inorganic phosphate (Pi) is a physiological regulator of osteoblasts and chondrocytes, suggesting that phosphate may contribute to the biological response of these cells to bioactive glasses like Bioglass 45S5, which is composed of 45% SiO2, 24.5% CaO, 24.5% Na2O, and 6% P2O5. We investigated the effect of varying the...

journal_title：Biomaterials

authors： Lossdörfer S,Schwartz Z,Lohmann CH,Greenspan DC,Ranly DM,Boyan BD

更新日期：2004-06-01 00:00:00

abstract：:ROCK activity increases due to ECM rigidity in the tumor microenvironment and promotes a malignant phenotype via actomyosin contractility. Invasive migration is facilitated by actin-rich adhesive protrusions known as invadopodia that degrade the ECM. Invadopodia activity is dependent on matrix rigidity and contractile...

journal_title：Biomaterials

authors： Jerrell RJ,Parekh A

更新日期：2016-04-01 00:00:00

abstract：:To evaluate whether cytokeratin expression in human oral epithelial cells could be influenced by implant materials used in dental surgery, passaged human oral gingival epithelial cells were seeded on commercially pure titanium (CP-Ti) or on Ti6Al4V titanium alloy. Confluence was achieved after about 15 days on both su...

journal_title：Biomaterials

authors： Lagneau C,Farges JC,Exbrayat P,Lissac M

更新日期：1998-06-01 00:00:00

abstract：:Doxorubicin (DOX)-loaded glycyrrhetinic acid (GA)-modified alginate (ALG) nanoparticles (DOX/GA-ALG NPs) were prepared for targeting therapy of liver cancer. This study focused on the biodistribution of DOX/GA-ALG NPs in Kunming mice as well as their antitumor activity against liver tumors in situ and side effects. Th...

journal_title：Biomaterials

authors： Zhang C,Wang W,Liu T,Wu Y,Guo H,Wang P,Tian Q,Wang Y,Yuan Z

更新日期：2012-03-01 00:00:00

abstract：:Chondrogenic differentiation of mesenchymal stem cells (MSCs) is critical for successful cartilage regeneration. Several methods have been developed to attempt to chondrogenic differentiation, because chondrogenic differentiated cells can form stable cartilage and induce expression of a cartilage-specific phenotype. I...

journal_title：Biomaterials

authors： Ham O,Song BW,Lee SY,Choi E,Cha MJ,Lee CY,Park JH,Kim IK,Chang W,Lim S,Lee CH,Kim S,Jang Y,Hwang KC

更新日期：2012-06-01 00:00:00

abstract：:In this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into ...

journal_title：Biomaterials

authors： Laïb S,Fellah BH,Fatimi A,Quillard S,Vinatier C,Gauthier O,Janvier P,Petit M,Bujoli B,Bohic S,Weiss P

更新日期：2009-03-01 00:00:00

abstract：:Cerium oxide nanoparticles (nanoceria) are promising materials for intracellular oxygen free radical scavenging providing a potential therapy for reactive oxygen species (ROS)-mediated inflammatory processes. In this study rhombohedral-shaped nanoceria were synthesized by flame spray pyrolysis with tuneable particle d...

journal_title：Biomaterials

authors： Lord MS,Jung M,Teoh WY,Gunawan C,Vassie JA,Amal R,Whitelock JM

更新日期：2012-11-01 00:00:00

abstract：:This experimental investigation aims at revealing the mechanical behaviour and failure pattern of direct fibre-reinforced resin-bonded dental bridge with various designs. To evaluate the overall effects of some newly developed dental materials, in the experiment, genuine composite dental bridge specimens are prepared ...

journal_title：Biomaterials

authors： Li W,Swain MV,Li Q,Ironside J,Steven GP

更新日期：2004-09-01 00:00:00

abstract：:Modified high shear homogenization and ultrasound techniques were employed to produce solid lipid nanoparticles (SLNs). Model drug mifepristone had been incorporated in SLNs. The mean particle size measured by laser diffractometry (LD) was found to be 106 nm with a narrow particle distribution of polydispersity index,...

journal_title：Biomaterials

authors： Hou D,Xie C,Huang K,Zhu C

更新日期：2003-05-01 00:00:00

abstract：:This study examined the nature of the surface presented by a machinable feldspathic porcelain and by a machinable glass-ceramic for bonding to conventional composite luting agents and measured the bond strengths which may be achieved with various surface treatments. There was no significant difference between the bond...

journal_title：Biomaterials

authors： Jedynakiewicz NM,Martin N

更新日期：2001-04-01 00:00:00

abstract：:Hypoxia, as an inevitable characteristic of solid tumors, has been regarded as a noticeably causative factor to therapeutic resistance and metastatic variants. Exploring novel theranostics to realize the accurate diagnosis of hypoxia and the simultaneous implementation of effective therapy is a promising prospect for ...

journal_title：Biomaterials

authors： Song R,Zhang M,Liu Y,Cui Z,Zhang H,Tang Z,Chen X,Wu H,Yao Z,He M,Bu W

更新日期：2018-08-01 00:00:00