解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
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放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
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热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Adherence to imatinib therapy has been significantly associated with disease progression and direct medical costs in gastrointestinal stromal tumor (GIST) patients. However, adherence to oral anticancer drugs is frequently hindered by the influence of various factors. The aim of this study was to evaluate th...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000505177
更新日期:2019-01-01 00:00:00
abstract::Cardiovascular (CV) adverse events are considered common complications of ponatinib treatment. Recently, it has been demonstrated that ponatinib dose reductions in definite settings can obtain optimal responses and lower ponatinib-related CV events. In this study, we describe the management of 5 patients with chronic ...
journal_title:Chemotherapy
pub_type:
doi:10.1159/000504664
更新日期:2019-01-01 00:00:00
abstract::Prolonged intermittent renal replacement therapy (PIRRT) is an increasingly adopted method of renal replacement in critically ill patients. Like continuous renal replacement therapy, PIRRT can alter the pharmacokinetics (PK) of many drugs. In this setting, dosing data for antibiotics like benzylpenicillin are lacking....
journal_title:Chemotherapy
pub_type:
doi:10.1159/000499375
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The combination of transarterial chemoembolization (TACE) and apatinib has been used in the treatment of intermediate or advanced hepatocellular carcinoma (HCC). However, its effectiveness and safety are also argued. METHODS:Eligible studies were collected from a computer search of literatures published fro...
journal_title:Chemotherapy
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000502510
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:T790M is a major cause of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance, but the clinical significance of T790M disappearance is unknown. CASE REPORT:We report 3 cases of pulmonary adenocarcinoma which did not respond to EGFR-TKI retreatment even with T790M disappearance...
journal_title:Chemotherapy
pub_type:
doi:10.1159/000491937
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The glomerular filtration rate (GFR) is essential for calculating the dose and the monitoring of carboplatin. Although GFR measurement (mGFR) by external markers is ideal, in most cases these are not employed; the most used method is GFR estimation (eGFR) by formulae, hence the need to identify the formula w...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000488538
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIM:A phase 3 trial of S-1, leucovorin (LV), and oxaliplatin for treating gastric cancer is now underway. However, the antitumor efficacy of the combination has not yet been examined in an in vivo preclinical study. This study examined the antitumor efficacy of combination therapy consisting of S-1, LV, and ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000486029
更新日期:2018-01-01 00:00:00
abstract::While the majority of patients can be treated safely with fluoropyrimidine, some experience severe fluoropyrimidine-associated toxicity. The frequency and severity of these adverse events vary from patient to patient and are partially explained by genetic polymorphism into the dihydropyrimidine dehydrogenase (DPYD) ge...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000477333
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Development of novel strategies to kill cancer by sparing normal cells is of utmost importance. Apart from their known antimicrobial activity, only limited information has been recorded regarding the antitumor potential of biocompatible silver oxide nanoparticles (AgONPs). There is a need to evaluate the ant...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000453446
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:This phase II study was conducted to evaluate the efficacy and safety of the chemotherapy combination of gemcitabine and vinorelbine in taxane-pretreated Japanese metastatic breast cancer patients. METHODS:In this multicenter, phase II, single-arm study, patients with recurrent or metastatic HER2-negative b...
journal_title:Chemotherapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000475879
更新日期:2017-01-01 00:00:00
abstract::Aggressive non-Hodgkin lymphoma is associated with poor long-term survival after relapse or resistance to chemotherapy. We report a case of aggressive non-Hodgkin lymphoma refractory to first-line R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) and second-line R-DHAP (rituximab, dexameth...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000458147
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To compare incidences of hypersensitivity reaction (HSR) between original and generic taxanes including paclitaxel and docetaxel. METHODS:We conducted a prospective study enrolling all patients receiving taxanes at King Chulalongkorn Memorial Hospital. Taxanes were infused accordingly to the step-wise rate esc...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000450748
更新日期:2017-01-01 00:00:00
abstract::The treatment of diffuse large B-cell lymphoma in the presence of cardiac comorbidities can be challenging considering that the standard treatment regimen used for this aggressive subtype of non-Hodgkin lymphoma (NHL) consists of a combination of rituximab, cyclophosphamide, doxorubicin hydrochloride, Oncovin (vincris...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000452756
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Species-level identification of nontuberculous mycobacteria (NTM) is important in making decisions about the necessity and choice of antimicrobial treatment. The reason is predictable clinical significance and the susceptibility profile of specific NTM species. Matrix-assisted laser desorption/ionizatio...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000442517
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Mitochondria have emerged as a major target for anticancer therapy because of their critical role in cancer cell survival. Our preliminary works have suggested that dihydroergotamine tartrate (DHE), an antimigraine agent, may have effects on mitochondria. METHODS:We examined the effect of DHE on the surviva...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000445044
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The discovery of mutations in epidermal growth factor receptor (EGFR) has dramatically changed the treatment of patients with non-small-cell lung cancer (NSCLC), the leading cause of cancer deaths worldwide. EGFR-targeted therapies show considerable promise, but drug resistance has become a substantial issue...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000443368
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Adjuvant platinum-based chemotherapy improves survival in women with early-stage epithelial ovarian cancer (EOC). Yet, there is a wide variety in clinical practice. METHODS:All patients diagnosed with FIGO I and IIa EOC (2006-2010) in the south of the Netherlands were analyzed. The percentage of patients th...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000445024
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:In an ongoing project to evaluate essential oils as modulators of antibiotic resistance, the essential oil from Origanum vulgare L. (OVEO), as well as its individual constituents carvacrol (CAR) and thymol (THY), were investigated using Staphylococcus aureus strains possessing efflux mechanisms of resistance...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000381175
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the efficacy and tolerability of hepatic arterial infusion (HAI) of gemcitabine plus oxaliplatin as second-line treatment for unresectable locally advanced intrahepatic cholangiocarcinoma. PATIENTS AND METHODS:We retrospectively analyzed the outcome of 12 consecutive pa...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000362223
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Gram-negative bacilli are the most common bacteria causing nosocomial bloodstream infections (NBSIs) in Latin American countries. METHODS:The antibiotic resistance profiles of Gram-negative bacilli isolated from blood cultures in pediatric patients with NBSIs over a 3-year period in a tertiary care pediatri...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000362085
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:To define the maximum tolerated dose (MTD) tolerability and efficacy of intra-arterial chemotherapy with irinotecan in patients with liver metastases of colorectal carcinoma (CRC). METHODS:Superselective intra-arterial irinotecan was applied on days 1, 14, 28 and 42. The initial dose was 140 mg/m² with esca...
journal_title:Chemotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1159/000348579
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The brain is a frequent site of metastases in small-cell lung cancer. Symptoms of cerebral involvement are headache, disorientation, nausea/vomiting and seizures. CASE:A man with small-cell lung cancer developed a human herpesvirus 6 (HHV-6) meningoencephalitis with neurological symptoms that simulated brai...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000360616
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:There is no standard consensus on a strategy in the second-line setting for gemcitabine-refractory advanced pancreatic cancer. This study evaluated the activity and tolerability of oxaliplatin, irinotecan, 5-fluorouracil and leucovorin (FOLFIRINOX) as a second-line therapy in advanced pancreatic adenoca...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000356158
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:The purpose of this preliminary and descriptive study was to evaluate a biodegradable drug delivery system in combination with an innovative ceramic implant. METHODS:The delivery of gentamicin of standardized samples was measured in the laboratory using ultra-high-performance liquid chromatography. Biocompatib...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000354986
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the feasibility and compliance of adjuvant chemotherapy of S-1 plus carboplatin for patients with completely resected non-small cell lung cancer (NSCLC) of pathological stage IB-IIIB. METHODS:S-1 was given orally at a dose of 80 mg/m²/day for 2 weeks, followed by a ...
journal_title:Chemotherapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000351101
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Patients with cancer are particularly susceptible to drug interactions (DIs), but the extent of the problem has received limited attention. We aimed to evaluate the frequency of interactions with anticancer agents in a group of cancer patients. METHODS:The study was performed in a Belgian teaching hospital....
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000351133
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Recently, multiple-line chemotherapy has become popular for non-small cell lung cancer (NSCLC). The survival time of patients is influenced by patient characteristics and subsequent treatments. METHODS:The usefulness of paclitaxel plus S1 (PTX+S1) was evaluated in 46 pretreated NSCLC patients. Time from the...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000345624
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The efficacy of fluconazole (FLU), amphotericin B (AMB) and caspofungin (CAS) was tested against three Candida orthopsilosis, three C. metapsilosis and two C. parapsilosis sensu stricto isolates in neutropenic mice. METHODS:Mice were immunosuppressed by 200 mg/kg cyclophosphamide. Five-day intraperitoneal t...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000337088
更新日期:2012-01-01 00:00:00
abstract:AIMS:This study aimed to evaluate the different abilities of various Phellinus igniarius strains inhibiting quorum sensing (QS), to search for novel QS inhibitors from them and to analyze their inhibitory activity, with a view to their possible use in controlling infections. METHODS:The bioactive metabolites produced ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000338383
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:We evaluated the effectiveness of docetaxel or erlotinib in second-line treatment of non-small cell lung cancer (NSCLC) and focused on the impact of predictive factors on the outcome of therapy. METHODS:204 patients with progressive disease after platinum-based therapy were enrolled: 102 received an infusio...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000336143
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Bloodstream infections are a significant cause of neonatal morbidity and death. An increase in the incidence of early neonatal sepsis due to Escherichia coli has been reported. The objective was to evaluate the antimicrobial resistance of E. coli strains causing early-onset neonatal sepsis (EONS) and late-on...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000337062
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:There are only limited data on tissue kinetics of ertapenem in colorectal tissue more than 3 h after administration of the drug. The purpose of this study was to assess the pharmacokinetics (PK) of ertapenem in colorectal tissue via population PK modeling. PATIENTS AND METHODS:Patients ≥18 years requiring s...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000333377
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The rise in the rates of antibiotic resistance among Pseudomonas aeruginosa strains from cystic fibrosis (CF) patients is concerning and underscores the need for the development of novel compounds. Among them CSA-13, a cationic steroid molecule, mimics the activity of naturally occurring antimicrobial peptid...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000335588
更新日期:2011-01-01 00:00:00
abstract::Cefepime is active against bacteria producing chromosomally and plasmid-mediated extended broad-spectrum β-lactamase enzymes. The aim of this study was to evaluate risk factors for acquisition of cefepime resistance in Escherichia coli strains among hospitalized patients in a university hospital in Sanandaj, Iran. The...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000323623
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:This study assessed the population pharmacokinetics and metabolic conversion of a novel histone deacetylase (HDAC) inhibitor, SD-2007, into its active metabolite, apicidin, in rats. METHODS:SD-2007 was given to rats by intravenous injection (4 mg/kg) and oral administration (40 mg/kg). Serum concentrations ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000328027
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection. METHODS:Urinary concentrations and urinary bactericidal titers (UBT) of finafloxacin 200- and 800-mg single doses in 6 healthy volunteers were measured up to 48 h. UBT were determined for a referenc...
journal_title:Chemotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1159/000321028
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Our objectives were to assess the pharmacokinetic interaction and body fluid penetration of ciprofloxacin and levofloxacin. METHODS:This study was a single-dose open randomized three-way crossover in 15 healthy volunteers receiving 500 mg oral levofloxacin, 500 mg oral ciprofloxacin, or 250 mg levofloxacin ...
journal_title:Chemotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1159/000329520
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Dysfunction of the carnitine system in non-tumour tissue following anticancer therapy has been reported. In this setting, supplementation with carnitine derivatives might increase the general metabolic activity of normal cells so that they might better withstand the adverse effects of chemotherapy aimed at t...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000321296
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:It was the aim of our study to evaluate the in vitro activities of tetracycline (TET), erythromycin (ERY) and levofloxacin (LVX) alone and in dual combinations against ureaplasmas. METHODS:The minimum inhibitory concentrations (MICs) of 51 ureaplasmal strains were determined by microdilution assay. RESULTS:TE...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000323629
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The prognosis of patients with advanced gastric cancer (AGC) remains poor, and no single chemotherapy regimen is recognized as a global standard. A phase II trial was conducted to determine the efficacy and tolerability of capecitabine and oxaliplatin (XELOX) given every 3 weeks in combination in patients wi...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000305256
更新日期:2010-01-01 00:00:00