Abstract:
PURPOSE:The purpose of this preliminary and descriptive study was to evaluate a biodegradable drug delivery system in combination with an innovative ceramic implant. METHODS:The delivery of gentamicin of standardized samples was measured in the laboratory using ultra-high-performance liquid chromatography. Biocompatibility and biodegradation of the materials was investigated in an animal experiment in sheep up to 14 months. As carrier ε-caprolactone, 1:1 mixed with gentamicin, intruded into micro-chambered β-tricalcium-phosphate beads (MCB®) was studied. RESULTS AND DISCUSSION:Gentamicin was released in calculable concentrations during the first 30 days. The release from ε-caprolactone was higher than that from polymethylmethacrylate and more predictable. The caprolactone carrier was reabsorbed by osteoclasts.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Draenert ME,Hickel R,Draenert Ydoi
10.1159/000354986subject
Has Abstractpub_date
2013-01-01 00:00:00pages
239-46issue
4eissn
0009-3157issn
1421-9794pii
000354986journal_volume
59pub_type
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