Drug Resistance to EGFR Inhibitors in Lung Cancer.

abstract：:Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects. Somatostatin acts throug...

journal_title：Chemotherapy

authors： Bousquet C,Puente E,Buscail L,Vaysse N,Susini C

更新日期：2001-01-01 00:00:00

abstract：:The antimicrobial resistance patterns of respiratory pathogens isolated during an 8-year period (1990-1997) in an Italian hospital from patients with bronchopulmonary infections were investigated. A global variation in the resistance of Staphylococcus aureus to all relevant antibiotics was observed during the years 19...

journal_title：Chemotherapy

authors： Dos Santos C,Capelo A,Cimbro M,Ferrara A

更新日期：2000-05-01 00:00:00

abstract：:A method is described which may be used to compare the relative activity of beta-lactam antibiotics against gram-negative bacilli. The method offers several important advantages over conventional methods of evaluation of the antibacterial activity of beta-lactam agents: the bacterial inoculum is simply and accurately ...

journal_title：Chemotherapy

authors： Greenwood D

更新日期：1977-01-01 00:00:00

abstract：:The in vitro bactericidal effects of therapeutic concentrations of levofloxacin (LVFX) on clinical isolates of Pseudomonas aeruginosa and Enterococcus faecalis were assessed. Starting from 10(7) CFU/ml, the bacterial count was determined serially during the exposure to LVFX present at concentrations automatically simu...

journal_title：Chemotherapy

authors： Takahashi S,Sano M,Nishimura M,Matsukawa M,Mikami M,Hirose T,Tsukamoto T

更新日期：1998-09-01 00:00:00

abstract：:The effect of acyclovir (ACV) treatment on selected functions of human blood-derived macrophages was examined. ACV was not cytotoxic when applied in a wide range of concentrations. Only minor effects on macrophage functions were observed when cells were treated with therapeutic concentrations of ACV:phagocytosis and t...

journal_title：Chemotherapy

authors： Stenseth AM,Rollag H,Degré M

更新日期：1993-05-01 00:00:00

abstract：:Mezlocillin was used alone and in combination with cloxacillin in the treatment of chronic experimental osteomyelitis due to Morganella morganii. This combination showed in vitro synergy as measured by the checkerboard technique. A marked inoculum affect was demonstrated in vitro with mezlocillin and the infecting str...

journal_title：Chemotherapy

authors： Norden CW,Shaffer M

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Nevirapine (NVP) is a nonnucleoside reverse transcriptase inhibitor used in HIV patients and recently evaluated as a differentiating and antiproliferative agent in human malignancies. However, while NVP is a safe treatment in immunocompromised patients, NVP-containing regimens have been associated with sever...

journal_title：Chemotherapy

authors： Landriscina M,Fabiano A,Lombardi V,Santodirocco M,Piscazzi A,Fersini A,De Vis K,Barone C,Cignarelli M

更新日期：2008-01-01 00:00:00

abstract：:Ten years of controlled clinical trials supported single-dose therapy efficacy and safety in uncomplicated lower urinary tract infections (UTI). Both local and systematic factors contribute to the high UTI prevalence seen in elderly people. A controlled open randomized study was undertaken to evaluate the clinical eff...

journal_title：Chemotherapy

authors： Ferraro G,Ambrosi G,Bucci L,Palmieri R,Palmieri G

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:In an ongoing project to evaluate essential oils as modulators of antibiotic resistance, the essential oil from Origanum vulgare L. (OVEO), as well as its individual constituents carvacrol (CAR) and thymol (THY), were investigated using Staphylococcus aureus strains possessing efflux mechanisms of resistance...

journal_title：Chemotherapy

authors： Cirino IC,Menezes-Silva SM,Silva HT,de Souza EL,Siqueira-Júnior JP

更新日期：2014-01-01 00:00:00

abstract：:The effect of tinidazole on several ciliates (Stylonychia muscorum, Stylonychia mytilus, Tetrahymena pyriformis, Vorticella companula) has been studied. There is a very pronounced difference in sensitivity against this drug between the free-living ciliates here investigated and certain parasitic protozoa. A high resis...

journal_title：Chemotherapy

authors： Alonso P

更新日期：1979-01-01 00:00:00

abstract：:The antitumour properties of the drug N-137 were assessed in vivo in two murine T lymphoma models and two naturally metastatic hamster fibrosarcomas of Herpesvirus hominis aetiology. N-137 therapy caused a significant delay in the subcutaneous growth rate of both lymphomas (EL4 and TLX9) and in many cases completely p...

journal_title：Chemotherapy

authors： Rees RC,Potter CW,Clegg A,Hall JM

更新日期：1982-01-01 00:00:00

abstract：:A simple combined agar-strip test (CAST), involving filter paper strips charged with 20 micrograms of ampicillin or 40 micrograms of gentamicin, accurately detected high-level gentamicin resistance among 43 of 146 isolates of Enterococcus faecalis and additive activity of ampicillin plus gentamicin against 101 of 103 ...

journal_title：Chemotherapy

authors： Traub WH,Leonhard B

更新日期：1993-03-01 00:00:00

abstract：:In a randomized study 87 patients received perioperative antibiotic prophylaxis with 2 x 2 g ceftriaxone (Rocephin) at the beginning of the operation and in the following morning. Seventy-two patients received no antibiotic prophylaxis. In patients receiving the prophylaxis, a lower incidence of infections was observe...

journal_title：Chemotherapy

authors： Winkler D,Rehn H,Freckmann N,Nowak G,Herrmann HD

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:In this study (part of the global TEST program), the in vitro activity of tigecycline, a member of a new class of antimicrobial agents, the glycylcyclines, against clinical isolates collected in Italy was evaluated. METHODS:A total of 200 clinical isolates were collected and identified in our institution du...

journal_title：Chemotherapy

authors： Roveta S,Marchese A,Debbia EA

更新日期：2008-01-01 00:00:00

abstract：:Patients with a mycologically confirmed vaginal mycosis were treated either with one 100-mg vaginal ovule of clotrimazole each for 6 days, or with one 200-mg vaginal ovule of clotrimazole each for 3 days, or with one 500-mg vaginal ovule of clotrimazole for 1 day, the ovule having been supplied in a novel, acid formul...

journal_title：Chemotherapy

authors： Mendling W,Plempel M

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:It was the aim of this study to report clinical characteristics and treatment of thyroid tuberculosis (TT). METHODS:During 16 years, 2,426 patients have been operated on the thyroid in the surgical department 'A' in Ibn Sina Hospital, Rabat, Morocco. Anatomopathological results of the removed thyroid were an...

journal_title：Chemotherapy

authors： El Malki HO,Mohsine R,Benkhraba K,Amahzoune M,Benkabbou A,El Absi M,Ifrine L,Belkouchi A,Balafrej S

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Mutant prevention concentration (MPC) is a new parameter that may be of aid in determining the risk of resistant mutants being selected. METHODS:The MPCs of 224 Mycobacterium tuberculosis clinical isolates were estimated by plating more than 10(10) cells on drug-containing agar and determining the concentra...

journal_title：Chemotherapy

authors： Rodríguez JC,Cebrián L,Ruiz M,López M,Royo G

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Patients with cancer are particularly susceptible to drug interactions (DIs), but the extent of the problem has received limited attention. We aimed to evaluate the frequency of interactions with anticancer agents in a group of cancer patients. METHODS:The study was performed in a Belgian teaching hospital....

journal_title：Chemotherapy

authors： Mouzon A,Kerger J,D'Hondt L,Spinewine A

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Combination antimicrobial therapy is often necessary to eradicate infections caused by gram-negative bacteria. METHODS:To evaluate the potential benefit of aztreonam and fluoroquinolone combination therapy, the activity of aztreonam in combination with ciprofloxacin, gatifloxacin, levofloxacin and moxifloxa...

journal_title：Chemotherapy

authors： Critchley IA,Sahm DF,Kelly LJ,Karlowsky JA

更新日期：2003-05-01 00:00:00

abstract：:Niridazole was shown to be an effective chemotherapeutic agent for mice infected intravenously with a niridazole-sensitive strain of Salmonella typhimurium. Death rates as well as bacterial counts per spleen were reduced, even in compromised animals. Histologic examination of spleens proved the reduction of inflammato...

journal_title：Chemotherapy

authors： Hof H,Müller KM,Heine WD

更新日期：1982-01-01 00:00:00

abstract：:The pharmacokinetics of ceftriaxone (CRO) after subcutaneous and intravenous administration was studied in 10 healthy volunteers (5 males, 5 females, age 22-43 years, body weight 64.3 +/- 9.5 kg). Each of them received 2.0 g CRO i.v., and then 0.5 g i.v. and 0.5 g CRO s.c. in a randomized cross-over design. Subcutaneo...

journal_title：Chemotherapy

authors： Borner K,Lode H,Hampel B,Pfeuffer M,Koeppe P

更新日期：1985-01-01 00:00:00

abstract：:100 febrile patients with chemotherapy-induced neutropenia (less than 0.5 x 10(9)/l) were empirically treated by ceftriaxone (2 g daily in adults, 50 mg/kg daily in children, as a once daily injection) and amikacin (15-20 mg/kg daily). The mean age was 41 years (range 8-72). 51 patients had acute leukemia, 29 non-Hodg...

journal_title：Chemotherapy

authors： Blanc C,Pollet JP,Bauters F

更新日期：1991-01-01 00:00:00

abstract：:Several agar media (Mueller-Hinton agar, MHA; diagnostic sensitivity test agar, DSTA; Schaedler agar, SchA; Todd-Hewitt agar with added yeast extract, THYA; Wilkins-Chalgren agar, WCA) were compared using the Bauer-Kirby agar disk diffusion test against six nonfastidious quality control strains: Staphylococcus aureus ...

journal_title：Chemotherapy

authors： Traub WH,Leonhard B

更新日期：1994-01-01 00:00:00

abstract：:The influence of normal human serum on bactericidal activity of ceftizoxime sodium (CZX) was studied in vitro against Escherichia coli and Staphylococcus aureus. Subminimal inhibitory concentrations of CZX inhibited the growth of bacteria. Normal human serum as a source of complement and low doses of CZX, such as 1/20...

journal_title：Chemotherapy

authors： Watanabe K,Kin R,Murakami M,Kondo M

更新日期：1986-01-01 00:00:00

abstract：:We studied penicillin-binding protein (PBP) profiles of two Pseudomonas aeruginosa strains stably derepressed for constitutive, type Id beta-lactamase overproduction. Substantial levels of beta-lactamase were found to be strongly associated with isolated inner membranes of these two strains, as well as from a plasmid-...

journal_title：Chemotherapy

authors： Parr TR Jr,Chan L,Bayer AS

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:5-Fluorouracil (5-FU) is a widely used drug in head and neck squamous cell carcinoma (HNSCC). Thymidylate synthase (TS), which is the target enzyme of 5-FU, has been demonstrated to be a key regulatory enzyme. In this study, we examined whether TS expression is correlated with chemosensitivity to 5-FU, cell ...

journal_title：Chemotherapy

authors： Yasumatsu R,Nakashima T,Uryu H,Ayada T,Wakasaki T,Kogo R,Masuda M,Fukushima M,Komune S

更新日期：2009-01-01 00:00:00

abstract：:Malignant external otitis is a serious infection most frequently caused by Pseudomonas aeruginosa. Because of its antipseudomonal activity and good tissue penetration, ciprofloxacin is an antibiotic which should, in theory, be effective in the treatment of this type of infection. Publications on the use of ciprofloxac...

journal_title：Chemotherapy

authors： Gehanno P

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The efficacy of fluconazole (FLU), amphotericin B (AMB) and caspofungin (CAS) was tested against three Candida orthopsilosis, three C. metapsilosis and two C. parapsilosis sensu stricto isolates in neutropenic mice. METHODS:Mice were immunosuppressed by 200 mg/kg cyclophosphamide. Five-day intraperitoneal t...

journal_title：Chemotherapy

authors： Szilágyi J,Földi R,Gesztelyi R,Bayegan S,Kardos G,Juhász B,Majoros L

更新日期：2012-01-01 00:00:00

abstract：:During the 5-year period 1989-1993, the incidence of Candida krusei, and other non-albicans Candida spp., was analyzed in a 60-bed cancer department. The frequency of C. krusei, before fluconazole was introduced into therapeutic protocols in 1990, was 16.5%, and after introduction of fluconazole into prophylaxis in ac...

journal_title：Chemotherapy

authors： Kunová A,Trupl J,Spánik S,Drgona L,Sufliarsky J,Lacka J,Studená V,Hlavácová E,Studená M,Kukucková E

更新日期：1995-01-01 00:00:00

abstract：:The binding of five structurally diverse beta-lactam antibiotics to penicillin-binding proteins (PBPs) of two clinical isolates of Streptococcus pneumoniae resistant to penicillin G was compared with that of a susceptible strain. A common feature of the PBP patterns of the resistant strains was the absence of PBP 1a d...

journal_title：Chemotherapy

authors： Ikeda F,Yokota Y,Ikemoto A,Teratani N,Shimomura K,Kanno H

更新日期：1995-05-01 00:00:00