Abstract:
:Mezlocillin was used alone and in combination with cloxacillin in the treatment of chronic experimental osteomyelitis due to Morganella morganii. This combination showed in vitro synergy as measured by the checkerboard technique. A marked inoculum affect was demonstrated in vitro with mezlocillin and the infecting strain of M. morganii. In therapeutic trials, mezlocillin administered for 28 days was totally ineffective. The combination of mezlocillin and cloxacillin (at 800 and 400 mg/kg, respectively, 4 times a day) given for 28 days was significantly better than either no therapy or therapy with mezlocillin alone. However, even after 4 weeks of combined therapy with mezlocillin and cloxacillin M. morganii was recovered from the bones of 55% of the treated rabbits.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Norden CW,Shaffer Mdoi
10.1159/000238267subject
Has Abstractpub_date
1984-01-01 00:00:00pages
188-93issue
3eissn
0009-3157issn
1421-9794journal_volume
30pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract::The antimicrobial resistance patterns of respiratory pathogens isolated during an 8-year period (1990-1997) in an Italian hospital from patients with bronchopulmonary infections were investigated. A global variation in the resistance of Staphylococcus aureus to all relevant antibiotics was observed during the years 19...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007273
更新日期:2000-05-01 00:00:00
abstract::Combination of 9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] and 6-azauridine (AzUrd) is highly active in the selective inhibition of vaccinia virus in chick embryo cell culture. Synergic effect of this combination of compounds was not encountered in HeLa cell culture. Of the 17 analogues related to DHPA studied in th...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237903
更新日期:1980-01-01 00:00:00
abstract::A semi-automated microdilution test was adapted for the in vitro testing of potential antitrichomonal agents. Washed cell suspensions of the pathogenic protozoan Trichomonas vaginalis were incubated in microtitration plates for 4 h at 37 degrees C in the presence radiolabelled adenine and serial dilutions of the test ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238327
更新日期:1985-01-01 00:00:00
abstract::Fosfomycin, an antibiotic discovered in Spain, has a unique chemical structure and pharmacologic features that are promising for clinical therapy. It is only partially absorbed orally, with relatively low blood levels. Intramuscularly, however, absorption is complete with peak blood levels 3-5 times as high as orally,...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222040
更新日期:1977-01-01 00:00:00
abstract::The 2,3-dihydroxy-6-bromo-pyrazino-[2,3-beta]-pyrazine is a substance selected during the antiviral screening of pyrazino-pyrazine derivatives. The compound shows antiviral activity in vitro against measles, NDV, some influenza viruses and against herpes simplex and zoster, infectious canine hepatitis and vaccinia vir...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221862
更新日期:1975-01-01 00:00:00
abstract::Cephalosporins do not reach active therapeutical concentrations in the prostatic tissue in patients suffering from chronic bacterial prostatitis. Cefoperazone is an exception. Its efficacy in the treatment of chronic bacterial prostatitis in 20 patients was studied and the concentrations, obtained after intramuscular ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238704
更新日期:1989-01-01 00:00:00
abstract::A unique process has been developed to convert bituminous coal by controlled wet oxidation followed by base treatment to a water-soluble humate called oxihumate. Oxihumate inhibited HIV-1 infection of MT-2 cells with an IC(50) of 12.5 microg/ml. Treatment of free and cell-attached HIV with oxihumate irreversibly reduc...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000064919
更新日期:2002-07-01 00:00:00
abstract::Eight thiadiazine 1,1-dioxide derivatives were evaluated for antitrichomonal and antitrypanosomal activities. In vivo tests were performed on a murine model for trichomoniasis standardized in our laboratory. The capacity of compounds to clear visceral lesions in experimentally infected animals as well as their effects...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239040
更新日期:1992-01-01 00:00:00
abstract::The in vitro bactericidal effects of therapeutic concentrations of levofloxacin (LVFX) on clinical isolates of Pseudomonas aeruginosa and Enterococcus faecalis were assessed. Starting from 10(7) CFU/ml, the bacterial count was determined serially during the exposure to LVFX present at concentrations automatically simu...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007133
更新日期:1998-09-01 00:00:00
abstract::The effect of deficiency of vitamin A and its supplementation on growth of murine sarcoma 180 was evaluated. The efficacy of cyclophosphamide under depleted and supplemented condition of the vitamin was also scrutinized. Supplemental vitamin A helped to check progression of tumour growth and also increased the effecti...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238497
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Urinary tract infections (UTIs) are a significant health problem and Escherichia coli has been exported to be the primary pathogen in approximately 80% of cases. E. coli express structures called adhesins, fimbriae or pili that help them bind to specific tissue receptors. One such adhesin is Dr, which binds ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048507
更新日期:2001-03-01 00:00:00
abstract::Itraconazole has emerged as an important new oral agent in the treatment of systemic fungal infections. This paper summarizes the data available on its use in aspergillosis, cryptococcosis and histoplasmosis, compiled in the United States with particular attention to the immunocompromised host. Data have been accrued ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239048
更新日期:1992-01-01 00:00:00
abstract::Twenty Pseudomonas maltophilia isolates were examined for susceptibility to beta-lactam antibiotics, including carbapenems, and for beta-lactamase production. All the isolates were resistant to imipenem (MICs 64-512 mg/l) and to a lesser extent, to meropenem (MICs 16-256 mg/l). None of the isolates produced significan...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238757
更新日期:1990-01-01 00:00:00
abstract::There is evidence that a variety of anticancer drugs exert their cytotoxic activity by a free-radical-mediated mechanism. These drugs include anthracyclines such as adriamycin, daunorubicin, 4-epi-adriblastin as well as bleomycin, procarbazine, vincristin, cyclophosphamide, etoposide and mitomycin C. The aim of this s...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239163
更新日期:1994-01-01 00:00:00
abstract::We studied penicillin-binding protein (PBP) profiles of two Pseudomonas aeruginosa strains stably derepressed for constitutive, type Id beta-lactamase overproduction. Substantial levels of beta-lactamase were found to be strongly associated with isolated inner membranes of these two strains, as well as from a plasmid-...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238612
更新日期:1988-01-01 00:00:00
abstract::A technique for inducing pneumococcal meningitis in mice and a description of the histopathologic changes that accompany this experimentally produced disease are provided in the present report. This infection of mice was investigated to determine whether it could serve as a suitable model for detecting agents that hav...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221879
更新日期:1975-01-01 00:00:00
abstract::A group of cis-ethylenediammine platinum (II) complexes were synthesized and their activity against Sarcoma-180 ascites tumour cells in mouse was tested. One of the compounds, Pt(HOCH2CH2NHCH2CH2NH2)Cl2, showed significant antitumour activity having little toxicity to the host. Like the parent compound, cis-DDP, it bi...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238314
更新日期:1985-01-01 00:00:00
abstract::Body lice (Pediculus humanus corporis L) and ticks (Ornithodoros moubata) that had been infected with Rickettsia prowazekii received varying doses of erythromycin. The anti-rickettsial activity of this drug was evaluated with regard to the determination of the numbers of surviving microorganism (LID100) and the in viv...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221910
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Viscum album (VA) Qu FrF preparation consists of an aqueous extract of Viscum album, the European mistletoe. It has cytotoxic and immunomodulatory properties that support its usefulness in cancer therapy. However, only little information is available on the interaction between mistletoe lectin (ML) and the h...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048545
更新日期:2001-09-01 00:00:00
abstract::A new semisynthetic ureidopenicillin (Bay K 4999) demonstrates favorably in vitro antibacterial efficacy against human-pathogenic gram-negative rods in comparison to mezlocillin and azlocillin. A comparative paramcokinetic study was done with 10 test subjects after 30 min intravenous infusion of 4.0 g of Bay K and mez...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237887
更新日期:1980-01-01 00:00:00
abstract::20 patients with serious infections were treated with cefazolin and tobramycin for 9--64 days. Minimal inhibitory concentration (MIC) values and minimal bactericidal concentration (MBC) values were determined for each of the 112 clinical bacterial isolates. The median cefazolin MIC/MBC was 1.56/12.5 micrograms/ml, and...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237931
更新日期:1980-01-01 00:00:00
abstract::The intracellular activity of flurithromycin, erythromycin, roxithromycin and miocamycin against susceptible clinical isolates of Staphylococcus aureus, phagocytosed by human monocytes, was investigated. Intracellular bioactivity was studied in a 24-hour assay, using experimental conditions which allowed the intracell...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238973
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:The aim of this clinical study was to evaluate the efficacy of combination chemotherapy of oxaliplatin, leucovorin and continuous-infusion 5-fluorouracil (5-FU) for advanced gastric cancer. METHODS:Patients with previously untreated gastric cancer with measurable disease received oxaliplatin (100 mg/m(2), d...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000219434
更新日期:2009-01-01 00:00:00
abstract::The pharmacokinetic disposition of 5-fluorocytosine (5-FC) was studied in 7 patients with acute renal failure undergoing continuous hemofiltration (CH). CH was performed with a high-flux membrane and the average filtration rate (FR) was 16.3 ml/min. Following an intravenous loading dose of 2,500 mg, 5-FC concentration...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238478
更新日期:1987-01-01 00:00:00
abstract::Crl:CD1(ICR) BR mice were fed chow containing Candida albicans or regular chow. Both groups were subsequently given either antibiotics or normal saline. Stool cultures were performed before, at the end of treatment and 1 week after treatment, to determine the effect on the stool yeast concentration. Candida-colonized ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007151
更新日期:1998-11-01 00:00:00
abstract::One hundred symptomatic women with clinical bacterial vaginosis (BV) were enrolled in this study. The bacteriological epidemiology of BV and efficacy of oral or vaginal administration of antimicrobial agents for treatment of BV were investigated. The epidemiology of BV was investigated before antimicrobial therapy. Fi...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239425
更新日期:1996-01-01 00:00:00
abstract::Neutropenia induced by intensive chemotherapy and allogeneic bone marrow transplantation are increasingly commonly complicated by fungal infections; thus prophylaxis may be justified. The authors surveyed the literature and culled their experience - few randomized trials have been done and definitions have often been ...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000239052
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the value of tumor markers in monitoring chemotherapy response and predicting prognosis in patients with advanced non-small cell lung cancer (NSCLC). METHODS:We studied carcinoembryonic antigen (CEA), CYFRA21-1 and neuron-specific enolase (NSE) of 111 untreated patients wi...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000317580
更新日期:2010-01-01 00:00:00
abstract::Pharmacokinetic studies were conducted with norfloxacin administered by the oral and subcutaneous routes to mice and rats, and by the oral route to rhesus monkeys. The compound was moderately well absorbed following oral dosing in these animal species. Serum levels in monkeys ranged from 1.0 to 2.35 micrograms/ml afte...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238283
更新日期:1984-01-01 00:00:00
abstract::A-56619 and A-56620 are two new quinolone compounds that are currently being studied. They were found to be active against multi-resistant and routine isolates of Staphylococcus aureus, enterobacteria, aminoglycoside-sensitive and resistant strains of Pseudomonas aeruginosa. Most of the enterobacteria were inhibited b...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238573
更新日期:1988-01-01 00:00:00