Abstract:
:Eight thiadiazine 1,1-dioxide derivatives were evaluated for antitrichomonal and antitrypanosomal activities. In vivo tests were performed on a murine model for trichomoniasis standardized in our laboratory. The capacity of compounds to clear visceral lesions in experimentally infected animals as well as their effects on the mortality time of mice were used as criteria for activity. One of the thiadiazines (compound 7b) showed an efficacy similar to that obtained with the reference drug metronidazole, although higher doses were required. Its toxicity on cell proliferation in tissue culture was moderate. In vitro assays on amastigote forms of Trypanosoma cruzi were carried out using cultures of Vero cells infected with metacyclic trypomastigotes. For one compound (1) trypanocidal activity resembled that of nifurtimox as assessed by microscopic counts of infected and uninfected cells. Unfortunately, this compound showed a high degree of cytotoxicity on Vero cell cultures.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Atienza J,Martínez Díaz RA,Gómez Barrio A,Escario JA,Herrero A,Ochoa C,Rodríguez Jdoi
10.1159/000239040subject
Has Abstractpub_date
1992-01-01 00:00:00pages
441-6issue
6eissn
0009-3157issn
1421-9794journal_volume
38pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract::In children undergoing anticancer chemotherapy, a granulocytopenic febrile episode is a life-threatening condition. Prompt initiation of empirical broad-spectrum antibiotics is essential to limit morbidity and mortality. To evaluate the cost-effectiveness of combination antibiotics consisting of a third generation cep...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239590
更新日期:1997-09-01 00:00:00
abstract::Prolonged intermittent renal replacement therapy (PIRRT) is an increasingly adopted method of renal replacement in critically ill patients. Like continuous renal replacement therapy, PIRRT can alter the pharmacokinetics (PK) of many drugs. In this setting, dosing data for antibiotics like benzylpenicillin are lacking....
journal_title:Chemotherapy
pub_type:
doi:10.1159/000499375
更新日期:2019-01-01 00:00:00
abstract::The effect of three nucleoside analogs, including 2-methyl-2'-deoxyadenosine (MDA), 5-amino-2'-deoxyuridine (ADU) and 2',3'-dideoxycytidine (DDC) on colony formation from unfractionated human bone marrow obtained from volunteers expressing parameters typical for normal cells (NBM) and from patients with the diagnosis ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238844
更新日期:1991-01-01 00:00:00
abstract::During the 5-year period 1989-1993, the incidence of Candida krusei, and other non-albicans Candida spp., was analyzed in a 60-bed cancer department. The frequency of C. krusei, before fluconazole was introduced into therapeutic protocols in 1990, was 16.5%, and after introduction of fluconazole into prophylaxis in ac...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239322
更新日期:1995-01-01 00:00:00
abstract::The antitumour properties of the drug N-137 were assessed in vivo in two murine T lymphoma models and two naturally metastatic hamster fibrosarcomas of Herpesvirus hominis aetiology. N-137 therapy caused a significant delay in the subcutaneous growth rate of both lymphomas (EL4 and TLX9) and in many cases completely p...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238091
更新日期:1982-01-01 00:00:00
abstract::Multiple hyperthermia was found to exert an additive antitumor effect when combined with the in vivo production of tumor necrosis factor alpha (TNF-alpha) in mice bearing Ehrlich ascites tumor (EAT). TNF-alpha was produced in EAT-bearing mice by priming the animals with zymosan and subsequently challenging with lipopo...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239370
更新日期:1995-09-01 00:00:00
abstract::Several agar media (Mueller-Hinton agar, MHA; diagnostic sensitivity test agar, DSTA; Schaedler agar, SchA; Todd-Hewitt agar with added yeast extract, THYA; Wilkins-Chalgren agar, WCA) were compared using the Bauer-Kirby agar disk diffusion test against six nonfastidious quality control strains: Staphylococcus aureus ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239296
更新日期:1994-01-01 00:00:00
abstract::BMY-28142 was compared in vitro with ceftazidime, cefotaxime and cefoperazone and was found to be more active against Pseudomonas aeruginosa and Staphylococcus aureus. Essentially no effect of increasing inoculum size 100-fold was seen-on MICs with BMY-28142 or ceftazidime; some effect was noted with cefotaxime and ce...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238470
更新日期:1987-01-01 00:00:00
abstract::Phase contrast microscopy, killing curves and turbidimetric growth curves were used in a comparative study of the antibacterial effects of imipenem and meropenem on Haemophilus influenzae. The minimal inhibitory concentrations (MICs) and their ranges of meropenem and imipenem using five beta-lactamase-producing strain...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238830
更新日期:1991-01-01 00:00:00
abstract::The 2,3-dihydroxy-6-bromo-pyrazino-[2,3-beta]-pyrazine is a substance selected during the antiviral screening of pyrazino-pyrazine derivatives. The compound shows antiviral activity in vitro against measles, NDV, some influenza viruses and against herpes simplex and zoster, infectious canine hepatitis and vaccinia vir...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221862
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVES:To identify parameters/factors that may contribute to the differential sensitivity to etoposide in two clones isolated from the human ovarian carcinoma SKOV-3 cell line, which does not express p53 and is resistant to platinum-based regimens. METHODS:Differential sensitivity of the cells to etoposide was mon...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000093009
更新日期:2006-01-01 00:00:00
abstract::Two gonococcal strains with differing susceptibility to cefotiam and ceftizoxime, as expressed by the minimum inhibitory concentration (MIC), are exposed to continuously changing concentrations of these antibiotics as they are found in plasma and skin cantharidal blister fluid (CBF) after a single intramuscular applic...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238423
更新日期:1986-01-01 00:00:00
abstract::Viscum album (VA) preparations consist of aqueous extracts of V. album, the European mistletoe. VA extracts contain mistletoe lectins, which are members of the ribosome-inactivating protein type II family. VA preparations have cytotoxic and immunomodulatory properties. Cytotoxicity induced by VA extracts may differ gr...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000074530
更新日期:2003-12-01 00:00:00
abstract::The comparative in vitro activity of amikacin, cefamandole, cefoperazone, cefotaxime, cefoxitin, cephalothin, chloramphenicol, moxalactam, piperacillin, ticarcillin and tobramycin against 170 community blood culture isolates of gram-negative bacilli was investigated using the quantitative plate dilution method. Result...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238243
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Patients with cancer are particularly susceptible to drug interactions (DIs), but the extent of the problem has received limited attention. We aimed to evaluate the frequency of interactions with anticancer agents in a group of cancer patients. METHODS:The study was performed in a Belgian teaching hospital....
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000351133
更新日期:2013-01-01 00:00:00
abstract::Thirteen quinolone antibacterial agents were investigated as to their ability to inhibit Micrococcus luteus DNA gyrase and cell growth, and compared to those of novobiocin and coumermycin. Among the quinolones tested, the most active were found to be CI-934 and ciprofloxacin, which inhibited gyrase full supercoiling a...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238458
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Fungal infections are common and life threatening among immunosupressive patients. Rare side effects may occur related to the use of voriconazole, which is the drug of choice in invasive aspergillosis. PATIENTS AND METHODS:Neuropathy was determined through clinical and electromyographic findings during the ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000140466
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection. METHODS:Urinary concentrations and urinary bactericidal titers (UBT) of finafloxacin 200- and 800-mg single doses in 6 healthy volunteers were measured up to 48 h. UBT were determined for a referenc...
journal_title:Chemotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1159/000321028
更新日期:2011-01-01 00:00:00
abstract::The potency of fosfomycin (60 micrograms/ml) to induce bacterial L-forms and protoplasts was studied on two strains of Staphylococcus aureus. On osmotically appropriate agar, L-colonies could be grown and repeatedly transferred to fresh media. The L-forms were sensitive to tetracycline and resistant to penicillin. Pro...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238242
更新日期:1984-01-01 00:00:00
abstract::17,244 pathogens isolated from clinical specimens of 24 hospitals in the Moers area (North-Rhine Westphalia, FRG) were tested in regard to their susceptibility to Augmentin (amoxicillin and clavulanic acid). For this purpose, minimal inhibitory concentrations were determined by use of microbroth dilution technique. 80...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238588
更新日期:1988-01-01 00:00:00
abstract::Twenty Pseudomonas maltophilia isolates were examined for susceptibility to beta-lactam antibiotics, including carbapenems, and for beta-lactamase production. All the isolates were resistant to imipenem (MICs 64-512 mg/l) and to a lesser extent, to meropenem (MICs 16-256 mg/l). None of the isolates produced significan...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238757
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:In an ongoing project to evaluate essential oils as modulators of antibiotic resistance, the essential oil from Origanum vulgare L. (OVEO), as well as its individual constituents carvacrol (CAR) and thymol (THY), were investigated using Staphylococcus aureus strains possessing efflux mechanisms of resistance...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000381175
更新日期:2014-01-01 00:00:00
abstract::Local chemotherapy is an option in bone metastasis treatment. On the other hand, evaluation of side effects on bone is a difficult issue in drug development and biomaterials research. Most animal models to date are inappropriate or not feasible. Rabbits are an alternative to other bigger mammals and have an appropriat...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000153315
更新日期:2008-01-01 00:00:00
abstract::A unique process has been developed to convert bituminous coal by controlled wet oxidation followed by base treatment to a water-soluble humate called oxihumate. Oxihumate inhibited HIV-1 infection of MT-2 cells with an IC(50) of 12.5 microg/ml. Treatment of free and cell-attached HIV with oxihumate irreversibly reduc...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000064919
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:The discovery of mutations in epidermal growth factor receptor (EGFR) has dramatically changed the treatment of patients with non-small-cell lung cancer (NSCLC), the leading cause of cancer deaths worldwide. EGFR-targeted therapies show considerable promise, but drug resistance has become a substantial issue...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000443368
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Species-level identification of nontuberculous mycobacteria (NTM) is important in making decisions about the necessity and choice of antimicrobial treatment. The reason is predictable clinical significance and the susceptibility profile of specific NTM species. Matrix-assisted laser desorption/ionizatio...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000442517
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Chronic hepatitis B (CHB) affects 400 million people worldwide and is a major cause of morbidity and mortality. It is known that HBV DNA sequences were detected after the clearance of serum hepatitis B surface antigen (HBsAg) often in serum, liver and peripheral blood mononuclear cells. The objectives of our...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000109770
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIMS:There is no standard consensus on a strategy in the second-line setting for gemcitabine-refractory advanced pancreatic cancer. This study evaluated the activity and tolerability of oxaliplatin, irinotecan, 5-fluorouracil and leucovorin (FOLFIRINOX) as a second-line therapy in advanced pancreatic adenoca...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000356158
更新日期:2013-01-01 00:00:00
abstract::A total of 1,442 patients with symptoms of chronic prostatitis were examined over a 4-year period at the Outpatient Department for Urogenital Infections, University Hospital for Infectious Diseases Dr. Fran Mihaljević, Zagreb, Croatia. The inclusion criteria for chronic prostatitis caused by Ureaplasma urealyticum wer...
journal_title:Chemotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1159/000090234
更新日期:2006-01-01 00:00:00
abstract::While the majority of patients can be treated safely with fluoropyrimidine, some experience severe fluoropyrimidine-associated toxicity. The frequency and severity of these adverse events vary from patient to patient and are partially explained by genetic polymorphism into the dihydropyrimidine dehydrogenase (DPYD) ge...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000477333
更新日期:2017-01-01 00:00:00