In vitro activity of A-56619 and A-56620 against multi-resistant and routine clinical isolates.

abstract：BACKGROUND/AIMS:A single-institution phase I trial to determine the feasibility of using filgrastim or pegfilgrastim to increase the dose intensity of biweekly docetaxel and gemcitabine. METHODS:Patients with metastatic solid tumors received gemcitabine 3,000 mg/m(2) and increasing doses of docetaxel (55 mg/m(2) in 10...

journal_title：Chemotherapy

authors： Dragnev KH,Hardin SB,Pipas JM,Davis TH,Rigas JR

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Dosage recommendations for antibiotics in patients receiving continuous veno-venous hemofiltration (CVVH) should be based on pharmacodynamic requirements. For meropenem, this would be achieving appropriate time above the minimum inhibitory concentration (T > MIC). We employed Monte Carlo simulation to calcul...

journal_title：Chemotherapy

authors： Kuti JL,Nicolau DP

更新日期：2005-07-01 00:00:00

abstract：:One patient of sepsis by P. aeruginosa after the implanting of a ventriculoatrial valve following extirpation of an expansive intracranial process is studied. During the evolution of the septic process there appeared as associated nephrotic syndrome with histologic lesions corresponding to an acute exudative glomerula...

journal_title：Chemotherapy

authors： Rodriguéz-Gironés M,Genovés A

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Viscum album (VA) Qu FrF preparation consists of an aqueous extract of Viscum album, the European mistletoe. It has cytotoxic and immunomodulatory properties that support its usefulness in cancer therapy. However, only little information is available on the interaction between mistletoe lectin (ML) and the h...

journal_title：Chemotherapy

authors： Duong Van Huyen JP,Sooryanarayana,Delignat S,Bloch MF,Kazatchkine MD,Kaveri SV

更新日期：2001-09-01 00:00:00

abstract：:Ofloxacin, like other 4-quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial DNA synthesis, rather than cell wall or protein synthesis. The 4-quinolones are also unusual because even for serious infections they can be given orally. Most unusually transferable...

journal_title：Chemotherapy

authors： Smith JT

更新日期：1991-01-01 00:00:00

abstract：:The influence of normal human serum on bactericidal activity of ceftizoxime sodium (CZX) was studied in vitro against Escherichia coli and Staphylococcus aureus. Subminimal inhibitory concentrations of CZX inhibited the growth of bacteria. Normal human serum as a source of complement and low doses of CZX, such as 1/20...

journal_title：Chemotherapy

authors： Watanabe K,Kin R,Murakami M,Kondo M

更新日期：1986-01-01 00:00:00

abstract：:The introduction of highly active antiretroviral therapy (HAART) has significantly modified the course of human immunodeficiency virus (HIV) disease, with longer survival and improved quality of life of HIV-infected subjects. However, HAART regimens, especially those including protease inhibitors, have been shown to c...

journal_title：Chemotherapy

authors： Barbaro G,Barbarini G

更新日期：2006-01-01 00:00:00

abstract：:The choice of antimicrobial therapy for the treatment of bacteremia is often empirical and based on the knowledge of susceptibility profiles of the most common bacteria. We analyzed blood culture isolates from a teaching hospital for 13 years prospectively. This study examined the susceptibility profiles of 6,616 gram...

journal_title：Chemotherapy

authors： Ling TK,Liu EY,Cheng AF

更新日期：2001-01-01 00:00:00

abstract：:This study was performed in female B6C3F1 mice to confirm previously observed effects of selected cephalosporin antibiotics on nonspecific immunity, and to determine possible effects on specific acquired immunity and host resistance. Mice were treated intravenously with DQ-2556, ceftizoxime or ceftezole at 800 mg/kg/d...

journal_title：Chemotherapy

authors： Furuhama K,Benson RW,Knowles BJ,Roberts DW

更新日期：1993-07-01 00:00:00

abstract：:The in vitro activities of the newer agents Deptomycin, Difloxacin, A-56620 and Ciprofloxacin were compared with those of vancomycin, rifampin and gentamicin against methicillin-susceptible and -resistant Staphylococcus aureus and coagulase-negative staphylococci. All isolates were susceptible to vancomycin, rifampin,...

journal_title：Chemotherapy

authors： Chandrasekar PH,Sluchak JA

更新日期：1989-01-01 00:00:00

abstract：:The activities of amphotericin B, miconazole, fluconazole, and itraconazole against Trichosporon beigelii were assessed in a mouse model of disseminated infection. Cyclophosphamide plus prednisolone-immunosuppressed ICR mice, intravenously challenged with a lethal inoculum of (6 x 10(6) CFU/ mouse), were assigned to r...

journal_title：Chemotherapy

authors： Kamberi P,Atsuro H,Takayoshi T,Masaru N

更新日期：1998-01-01 00:00:00

abstract：:The pharmacokinetic disposition of 5-fluorocytosine (5-FC) was studied in 7 patients with acute renal failure undergoing continuous hemofiltration (CH). CH was performed with a high-flux membrane and the average filtration rate (FR) was 16.3 ml/min. Following an intravenous loading dose of 2,500 mg, 5-FC concentration...

journal_title：Chemotherapy

authors： Ittel TH,Legler UF,Polak A,Glöckner WM,Sieberth HG

更新日期：1987-01-01 00:00:00

abstract：:We tested 42 strains of amikacin-resistant gram-negative bacilli with amikacin in combination with six beta-lactam antibiotics using the checkerboard and time-kill curve techniques. Synergism was demonstrated with time-killing curve in 43-68% of the strains tested. Ceftazidime plus amikacin was the most active combina...

journal_title：Chemotherapy

authors： Alvarez S,Jones M,Holtsclaw-Berk S,Berk SL

更新日期：1988-01-01 00:00:00

abstract：:Rifampicin (RMP) and two riminophenazine compounds (B663 and B1912) suppressed the growth of Mycobacterium marinum in vitro and in a mouse footpad infection. At appropriate concentrations and dietary dosage, all three drugs showed bactericidal activity in vitro and in vivo. On the basis of minimum inhibitory concentra...

journal_title：Chemotherapy

authors： Banerjee DK,Holmes IB

更新日期：1976-01-01 00:00:00

abstract：:The in vitro activity of cefetamet against Escherichia coli, Klebsiella pneumoniae and Serratia marcescens strains expressing an SHV-5-type beta-lactamase was evaluated. Most of the examined strains were susceptible to the antibiotic. Cefetamet was found to be considerably more active than ceftazidime and aztreonam. I...

journal_title：Chemotherapy

authors： Tzouvelekis LS,Prinarakis EE,Gazouli M,Miriagou V,Tzelepi E,Legakis NJ

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection. METHODS:Urinary concentrations and urinary bactericidal titers (UBT) of finafloxacin 200- and 800-mg single doses in 6 healthy volunteers were measured up to 48 h. UBT were determined for a referenc...

journal_title：Chemotherapy

authors： Wagenlehner FM,Wagenlehner CM,Blenk B,Blenk H,Schubert S,Dalhoff A,Naber KG

更新日期：2011-01-01 00:00:00

abstract：:Mezlocillin was used alone and in combination with cloxacillin in the treatment of chronic experimental osteomyelitis due to Morganella morganii. This combination showed in vitro synergy as measured by the checkerboard technique. A marked inoculum affect was demonstrated in vitro with mezlocillin and the infecting str...

journal_title：Chemotherapy

authors： Norden CW,Shaffer M

更新日期：1984-01-01 00:00:00

abstract：:Aztreonam is the first monobactam antibiotic to be used clinically. It is highly resistant to beta-lactamases, and although its activity spectrum is similar to that of the aminoglycoside antibiotics, it has no effect on gram-positive bacteria. The current study was undertaken to determine the efficacy of aztreonam in ...

journal_title：Chemotherapy

authors： Schönwald S,Schoss-Vidensek Z,Car V,Krznar B

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:It was the aim of our study to evaluate the in vitro activities of tetracycline (TET), erythromycin (ERY) and levofloxacin (LVX) alone and in dual combinations against ureaplasmas. METHODS:The minimum inhibitory concentrations (MICs) of 51 ureaplasmal strains were determined by microdilution assay. RESULTS:TE...

journal_title：Chemotherapy

authors： Luo DQ,Liu JY,Yang W,Zhang B,Yu MJ,Wu YM

更新日期：2011-01-01 00:00:00

abstract：:The effects of cis-[Pt(NH3)2Cl2] on the spontaneous cell-mediated cytotoxicity of human lymphoblast cell lines mediated by normal human peripheral blood lymphocytes was investigated. Direct addition of cis-[Pt(NH3)2Cl2], but not its tumor inactive trans isomer, to the in vitro spontaneous cytotoxicity assay resulted i...

journal_title：Chemotherapy

authors： Mally MB,Taylor RC,Callewaert DM

更新日期：1980-01-01 00:00:00

abstract：:Despite extensive research efforts, effective therapies for refractive cancers have not yet been established, and development of successful treatment strategies remains the most important task in the field of oncology. We recently showed that AVE8062 (formerly AC7700), a derivative of combretastatin A-4, achieved irre...

journal_title：Chemotherapy

authors： Hori K

更新日期：2005-10-01 00:00:00

abstract：:We report here the antibacterial activity of the new penem antibiotic Men 10700 against a total of 740 gram-positive and gram-negative clinical isolates, in comparison to imipenem, meropenem, cefotaxime, ceftriaxone, ciprofloxacin and gentamicin. Men 10700 has shown a wide spectrum of antibacterial activity, with a po...

journal_title：Chemotherapy

authors： Varotto F,Parravidini E,De Luca M,Casini A,Fraschini F

更新日期：1999-11-01 00:00:00

abstract：:Fosfomycin, an antibiotic discovered in Spain, has a unique chemical structure and pharmacologic features that are promising for clinical therapy. It is only partially absorbed orally, with relatively low blood levels. Intramuscularly, however, absorption is complete with peak blood levels 3-5 times as high as orally,...

journal_title：Chemotherapy

authors： Kirby WM

更新日期：1977-01-01 00:00:00

abstract：:A technique for inducing pneumococcal meningitis in mice and a description of the histopathologic changes that accompany this experimentally produced disease are provided in the present report. This infection of mice was investigated to determine whether it could serve as a suitable model for detecting agents that hav...

journal_title：Chemotherapy

authors： Tsai YH,Williams EB,Hirth RS,Price KE

更新日期：1975-01-01 00:00:00

abstract：:Gametocytocidal activity of artemisinin (qinghaosu) has been demonstrated against simian malaria parasite Plasmodium cynomolgi B. Colony-bred Anopheles stephensi were allowed to feed on gametocyte-carrying rhesus monkeys and the mosquito infectivity rate and oocyst count of the infected mosquito gut were recorded on d...

journal_title：Chemotherapy

authors： Dutta GP,Bajpai R,Vishwakarma RA

更新日期：1989-01-01 00:00:00

abstract：:A simple combined agar-strip test (CAST), involving filter paper strips charged with 20 micrograms of ampicillin or 40 micrograms of gentamicin, accurately detected high-level gentamicin resistance among 43 of 146 isolates of Enterococcus faecalis and additive activity of ampicillin plus gentamicin against 101 of 103 ...

journal_title：Chemotherapy

authors： Traub WH,Leonhard B

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Mutant prevention concentration (MPC) is a new parameter that may be of aid in determining the risk of resistant mutants being selected. METHODS:The MPCs of 224 Mycobacterium tuberculosis clinical isolates were estimated by plating more than 10(10) cells on drug-containing agar and determining the concentra...

journal_title：Chemotherapy

authors： Rodríguez JC,Cebrián L,Ruiz M,López M,Royo G

更新日期：2005-05-01 00:00:00

abstract：:BMY-28142 was compared in vitro with ceftazidime, cefotaxime and cefoperazone and was found to be more active against Pseudomonas aeruginosa and Staphylococcus aureus. Essentially no effect of increasing inoculum size 100-fold was seen-on MICs with BMY-28142 or ceftazidime; some effect was noted with cefotaxime and ce...

journal_title：Chemotherapy

authors： Norden CW,Neiderriter K

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:We evaluated the effectiveness of docetaxel or erlotinib in second-line treatment of non-small cell lung cancer (NSCLC) and focused on the impact of predictive factors on the outcome of therapy. METHODS:204 patients with progressive disease after platinum-based therapy were enrolled: 102 received an infusio...

journal_title：Chemotherapy

authors： Krawczyk P,Kowalski DM,Wojas-Krawczyk K,Mlak R,Jaśkiewicz P,Kucharczyk T,Winiarczyk K,Krzakowski M,Milanowski J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:To define the maximum tolerated dose (MTD) tolerability and efficacy of intra-arterial chemotherapy with irinotecan in patients with liver metastases of colorectal carcinoma (CRC). METHODS:Superselective intra-arterial irinotecan was applied on days 1, 14, 28 and 42. The initial dose was 140 mg/m² with esca...

journal_title：Chemotherapy

authors： Eichler K,Dufas T,Hammerstingl R,Gruber-Rouh T,Vogl TJ,Zangos S

更新日期：2013-01-01 00:00:00