Urinary pharmacokinetics and bactericidal activity of finafloxacin (200 and 800 mg) in healthy volunteers receiving a single oral dose.

Abstract:

BACKGROUND:Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection. METHODS:Urinary concentrations and urinary bactericidal titers (UBT) of finafloxacin 200- and 800-mg single doses in 6 healthy volunteers were measured up to 48 h. UBT were determined for a reference strain and 9 selected clinical uropathogens at the pH of native, acidified (pH 5.5) and alkalinized (pH 8.0) urine. RESULTS:The mean maximum urine concentrations for 200 and 800 mg finafloxacin were 69.3 mg/l (0-2 h) and 150 mg/l (4-8 h). Median UBT were between 0 and 1:>2,048 and were in general agreement with minimal inhibitory concentrations of strains and urinary pH values. UBT in alkaline urine were significantly lower than those in native or acidic urine, except for Enterococcus faecalis. CONCLUSIONS:Finafloxacin exhibited significant bactericidal activity against susceptible uropathogens. The urinary bactericidal activity of finafloxacin was enhanced in acidic urine and significantly lower in alkaline urine.

journal_name

Chemotherapy

journal_title

Chemotherapy

authors

Wagenlehner FM,Wagenlehner CM,Blenk B,Blenk H,Schubert S,Dalhoff A,Naber KG

doi

10.1159/000321028

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

97-107

issue

2

eissn

0009-3157

issn

1421-9794

pii

000321028

journal_volume

57

pub_type

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