Urinary pharmacokinetics and bactericidal activity of finafloxacin (200 and 800 mg) in healthy volunteers receiving a single oral dose.


BACKGROUND:Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection. METHODS:Urinary concentrations and urinary bactericidal titers (UBT) of finafloxacin 200- and 800-mg single doses in 6 healthy volunteers were measured up to 48 h. UBT were determined for a reference strain and 9 selected clinical uropathogens at the pH of native, acidified (pH 5.5) and alkalinized (pH 8.0) urine. RESULTS:The mean maximum urine concentrations for 200 and 800 mg finafloxacin were 69.3 mg/l (0-2 h) and 150 mg/l (4-8 h). Median UBT were between 0 and 1:>2,048 and were in general agreement with minimal inhibitory concentrations of strains and urinary pH values. UBT in alkaline urine were significantly lower than those in native or acidic urine, except for Enterococcus faecalis. CONCLUSIONS:Finafloxacin exhibited significant bactericidal activity against susceptible uropathogens. The urinary bactericidal activity of finafloxacin was enhanced in acidic urine and significantly lower in alkaline urine.






Wagenlehner FM,Wagenlehner CM,Blenk B,Blenk H,Schubert S,Dalhoff A,Naber KG




Has Abstract


2011-01-01 00:00:00














  • Interpretation criteria for sensitivity testing of ceftriaxone in agar diffusion test according to the DIN 58940 method.

    abstract::On the basis of a regression analysis of the correlation between minimal inhibitory concentration (MIC) and inhibitory zone diameter, interpretative criteria are established for the agar diffusion test with ceftriaxone disks (30 micrograms) in DST agar according to the DIN method. The correlation is good (r = -0.9242)...


    pub_type: 杂志文章


    authors: Grimm H

    更新日期:1984-01-01 00:00:00

  • In vitro and in vivo antibacterial activities of AM-1155 in the fields of obstetrics and gynecology.

    abstract::AM-1155 is a new 8-methoxyquinolonecarboxylic acid with a broad spectrum of antibacterial activity. It inhibited more than 90% of clinical isolates of Streptococcus agalactiae, Escherichia coli, Peptostreptococcus magnus, Bacteroides fragilis and Prevotella bivia at the concentration of 3.13 mg/l. The antibacterial ac...


    pub_type: 杂志文章


    authors: Mikamo H,Kawazoe K,Sato Y,Hayasaki Y,Izumi K,Tamaya T

    更新日期:1998-07-01 00:00:00

  • Antiandrogen and antineoplastic effects of a novel drug, CPC10997.

    abstract::CPC10997 was found to be effective in vitro as an antiandrogen without effects on either the estrogen or the progesterone receptors in carcinomas of the breast, ovary and prostate as well as in malignant melanomas. Using the clonogenic assay of Salmon et al. [Cancer Treat. Rep. 65: 1-12, 1981], CPC10997 was found to b...


    pub_type: 杂志文章


    authors: Ford LC,Kasha W,Chang NH,DeLange RJ

    更新日期:1985-01-01 00:00:00

  • Virus inhibitory effect of combination of 9-(S)-(2,3-dihydroxypropyl) adenine and 6-azauridine.

    abstract::Combination of 9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] and 6-azauridine (AzUrd) is highly active in the selective inhibition of vaccinia virus in chick embryo cell culture. Synergic effect of this combination of compounds was not encountered in HeLa cell culture. Of the 17 analogues related to DHPA studied in th...


    pub_type: 杂志文章


    authors: Rada B,Holý A

    更新日期:1980-01-01 00:00:00

  • Antiproliferative properties of toremifene on AIDS-related Kaposi's sarcoma cells.

    abstract:BACKGROUND:Kaposi's sarcoma (KS) is the most common neoplastic apoptosis manifestation of acquired immunodeficiency syndrome. Toremifene is known to upregulate transforming growth factor beta-1 (TGF-beta1), which is a growth-inhibitory factor for KS. We investigated the in vitro effect of toremifene on KS cells. METHO...


    pub_type: 杂志文章


    authors: Hong A,Leigh BR

    更新日期:2002-12-01 00:00:00

  • Effectiveness of antiinfectives.

    abstract:BACKGROUND:Helicobacter pylori is one of the most common infections of mankind, with persistent colonization causing significant morbidity and mortality. TREATMENT:First-line therapy, consisting of 7-day treatment with a proton pump inhibitor or ranitidine bismuth citrate, amoxicillin and clarithromycin, with second-l...


    pub_type: 杂志文章,评审


    authors: McLoughlin R,O'Morain C

    更新日期:2005-08-01 00:00:00

  • Response to interferon-alpha in chronic hepatitis B patients with and without precore mutant strain and effects on HBsAg titers.

    abstract:BACKGROUND:Chronic hepatitis B (CHB) affects 400 million people worldwide and is a major cause of morbidity and mortality. It is known that HBV DNA sequences were detected after the clearance of serum hepatitis B surface antigen (HBsAg) often in serum, liver and peripheral blood mononuclear cells. The objectives of our...


    pub_type: 杂志文章


    authors: Akhan SC,Yulugkural Z,Vahaboglu H

    更新日期:2007-01-01 00:00:00

  • Silver sulfadiazine: lack of mutagenic activity.

    abstract::Silver sulfadiazine was found to be devoid of mutagenic potential in a sensitive mutagenicity assay using Salmonella typhimurium. In view of the close relationship between mutagenicity in this system and carcinogenicity in animals, these findings suggest that silver sulfadiazine is apparently also devoid of carcinogen...


    pub_type: 杂志文章


    authors: McCoy EC,Rosenkranz HS

    更新日期:1978-01-01 00:00:00

  • Outer membrane proteins and elastase of Pseudomonas aeruginosa after the postantibiotic effect induced by amikacin.

    abstract::Postantibiotic effects were induced in three Pseudomonas aeruginosa strains after short-term treatment (30 min) with amikacin at suprainhibitory concentrations in the range of 0.6-1.2 h (2 x MIC) and of 3.0-4.4 h (4 x MIC). Significant suppression of P. aeruginosa elastase activity was found after treatment with amika...


    pub_type: 杂志文章


    authors: Hostacká A,Karelová E

    更新日期:1997-03-01 00:00:00

  • Candida glabrata, Candida krusei, non-albicans Candida spp., and other fungal organisms in a sixty-bed national cancer center in 1989-1993: no association with the use of fluconazole.

    abstract::During the 5-year period 1989-1993, the incidence of Candida krusei, and other non-albicans Candida spp., was analyzed in a 60-bed cancer department. The frequency of C. krusei, before fluconazole was introduced into therapeutic protocols in 1990, was 16.5%, and after introduction of fluconazole into prophylaxis in ac...


    pub_type: 杂志文章


    authors: Kunová A,Trupl J,Spánik S,Drgona L,Sufliarsky J,Lacka J,Studená V,Hlavácová E,Studená M,Kukucková E

    更新日期:1995-01-01 00:00:00

  • In vitro activity and post-antibiotic effect of quinupristin/dalfopristin (Synercid).

    abstract::The in vitro activities of quinupristin/dalfopristin (Synercid), ampicillin, erythromycin, clarithromycin, vancomycin, teicoplanin, ciprofloxacin and tetracycline were examined and compared against 526 gram-positive bacteria. The minimal inhibitory concentrations (MICs) for quinupristin/dalfopristin against Staphyloco...


    pub_type: 杂志文章


    authors: Ling TK,Fung KS,Cheng AF

    更新日期:2001-07-01 00:00:00

  • Bactericidal effect of levofloxacin on strains with equal susceptibility in an in vitro urinary bladder model.

    abstract::The in vitro bactericidal effects of therapeutic concentrations of levofloxacin (LVFX) on clinical isolates of Pseudomonas aeruginosa and Enterococcus faecalis were assessed. Starting from 10(7) CFU/ml, the bacterial count was determined serially during the exposure to LVFX present at concentrations automatically simu...


    pub_type: 杂志文章


    authors: Takahashi S,Sano M,Nishimura M,Matsukawa M,Mikami M,Hirose T,Tsukamoto T

    更新日期:1998-09-01 00:00:00

  • Antibacterial effects of niridazole. I. Effect on infection of mice with Salmonella typhimurium.

    abstract::Niridazole was shown to be an effective chemotherapeutic agent for mice infected intravenously with a niridazole-sensitive strain of Salmonella typhimurium. Death rates as well as bacterial counts per spleen were reduced, even in compromised animals. Histologic examination of spleens proved the reduction of inflammato...


    pub_type: 杂志文章


    authors: Hof H,Müller KM,Heine WD

    更新日期:1982-01-01 00:00:00

  • Tapering and discontinuation of glucocorticoid prophylaxis during prolonged weekly to biweekly paclitaxel administration.

    abstract:BACKGROUND:Taxanes cause hypersensitivity reactions, averted by premedication with H1 blockers and high glucocorticoid (GC) doses. Prolonged weekly taxane administration may lead to GC toxicity. PURPOSE:To determine whether patients not hypersensitive to initial paclitaxel (PTX) infusion after high-dose GC premedicati...


    pub_type: 杂志文章


    authors: Braverman AS,Rao S,Salvatti ME,Adamson B,McManus M,Pierre S

    更新日期:2005-05-01 00:00:00

  • Tissue distribution of cefotetan in patients with Crohn's disease.

    abstract::Concentrations of cefotetan in the intestinal wall of patients with Crohn's disease were investigated with the method of tissue homogenates with the aim to evaluate the effects of inflammation on tissue distribution. Twenty-four patients who underwent surgery were treated with a 2-gram single dose of cefotetan intrave...


    pub_type: 杂志文章


    authors: Mazzei T,Tonelli F,Anastasi A,Ficari F,Novelli A,Periti P

    更新日期:1991-01-01 00:00:00

  • Biochemical and pharmacological effects of mitoxantrone and acetyl-L-carnitine in mice with a solid form of Ehrlich tumour.

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    pub_type: 杂志文章


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  • Antibiotic susceptibility of clinical isolates of Streptococcus pneumoniae.

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    pub_type: 杂志文章


    authors: Traub WH,Leonhard B

    更新日期:1996-07-01 00:00:00

  • Preventive effects of trimethoprim/sulphamethoxazole on experimental staphylococcic pyelonephritis in rats.

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    pub_type: 杂志文章


    authors: Obek A,Anğ O,Iplikçi A,Güvener Z,Eroğlu L,Güngör M,Yurtkuran M

    更新日期:1975-01-01 00:00:00

  • Hepatic arterial infusion of gemcitabine plus oxaliplatin as second-line treatment for locally advanced intrahepatic cholangiocarcinoma: preliminary experience.

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    pub_type: 杂志文章


    authors: Ghiringhelli F,Lorgis V,Vincent J,Ladoire S,Guiu B

    更新日期:2013-01-01 00:00:00

  • In vitro susceptibility of Salmonella to ciprofloxacin and pefloxacin compared with three other antibiotics.

    abstract::The in vitro susceptibilities of 703 clinical isolates of Salmonella to ciprofloxacin (CIP) and pefloxacin (PEF) were compared with those to trimethoprim-sulfamethoxazole (TMP-SMZ), chloramphenicol (CO) and ampicillin (AP). All isolates were susceptible to CIP, while PEF inhibited 90.7% of the strains. In contrast, re...


    pub_type: 杂志文章


    authors: Campos LC,dos Reis EM,Ribeiro Dias JC

    更新日期:1990-01-01 00:00:00

  • Studies on the antitumour effects of N-137.

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    pub_type: 杂志文章


    authors: Rees RC,Potter CW,Clegg A,Hall JM

    更新日期:1982-01-01 00:00:00

  • Bendamustine and Rituximab: Complete Response in a 62-Year-Old Female with an Aggressive Lymphoma and an Ejection Fraction of 20.

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    pub_type: 杂志文章,评审


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  • Renal sparing by amphotericin B colloidal dispersion: clinical experience in 572 patients.

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    pub_type: 杂志文章,评审


    authors: Gurwith M,Mamelok R,Pietrelli L,Du Mond C

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  • In vitro and in vivo studies of the action of rifampicin, clofazimine and B1912 on Mycobacterium marinum.

    abstract::Rifampicin (RMP) and two riminophenazine compounds (B663 and B1912) suppressed the growth of Mycobacterium marinum in vitro and in a mouse footpad infection. At appropriate concentrations and dietary dosage, all three drugs showed bactericidal activity in vitro and in vivo. On the basis of minimum inhibitory concentra...


    pub_type: 杂志文章


    authors: Banerjee DK,Holmes IB

    更新日期:1976-01-01 00:00:00

  • Adenosylmethionine decarboxylase inhibitors--lack of activity against cytopathic effects of HIV.

    abstract::Many bis(amidinohydrazones) are potent inhibitors of adenosylmethionine decarboxylase (AdoMetDC), a key enzyme of polyamine biosynthesis, and some of them are also known to be powerful antiviral agents. Therefore, seven bis(amidinohydrazones), including the two most potent inhibitors of eukaryotic AdoMetDC so far repo...


    pub_type: 杂志文章


    authors: Elo H

    更新日期:1990-01-01 00:00:00

  • Antibacterial activity of ticarcillin, tobramycin and gentamicin alone and in combination against Pseudomonas aeruginosa in vitro.

    abstract::Using the biophotometer with ticarcillin no persistent bactericidal effect was found against Pseudomonas aeruginosa NCTC 10490. After addition of 1.2 microgram/ml gentamicin an increase of multiplication of bacteria was observed, but not after 1.2 microgram/ml tobramycin. With 6.2 microgram/ml tobramycin bactericidal ...


    pub_type: 杂志文章


    authors: Ullmann U

    更新日期:1977-01-01 00:00:00

  • Cefodizime modulates in vitro tumor necrosis factor-alpha, interleukin-6 and interleukin-8 release from human peripheral monocytes.

    abstract::Among third-generation cephalosporins, cefodizime (CFDZ) has shown to modulate many functions of the host defense system against infections. The aim of the present study was to assess the in vitro CFDZ-dependent modulation of interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha) and IL-8 release from lipopolysac...


    pub_type: 杂志文章


    authors: Meloni F,Ballabio P,Bianchi L,Grassi FA,Gialdroni Grassi GG

    更新日期:1995-07-01 00:00:00

  • Fungemia in patients with hematologic malignancies: therapeutic effects of concomitant administration of fluconazole and granulocyte-colony-stimulating factor.

    abstract::Serum (beta 1-->3)-D-glucan was elevated in 34 of 126 patients (27%) with hematologic malignancy who were clinically suspected of having a deep-seated mycosis. Although 11 patients (8.8%) were thought to have fungemia, fungi were isolated from blood culture in only 4. These results suggest that measurement of serum be...


    pub_type: 杂志文章


    authors: Niitsu N,Umeda M

    更新日期:1996-05-01 00:00:00

  • In vitro and in vivo antiplasmodial activity of Momordica balsamina alone or in a traditional mixture.

    abstract:BACKGROUND:Because of the dramatic situation of malaria in Africa, there is an urgent need to find new and cheap drugs, such as herbal medicines. Here we report the study of the in vitro and in vivo antimalarial activity of Momordica balsamina alone or in a traditional mixture used in Niger. METHODS:Extracts were obta...


    pub_type: 杂志文章


    authors: Benoit-Vical F,Grellier P,Abdoulaye A,Moussa I,Ousmane A,Berry A,Ikhiri K,Poupat C

    更新日期:2006-01-01 00:00:00

  • Effect of in vitro acyclovir treatment on selected functions of blood-derived macrophages.

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    pub_type: 杂志文章


    authors: Stenseth AM,Rollag H,Degré M

    更新日期:1993-05-01 00:00:00