Urinary pharmacokinetics and bactericidal activity of finafloxacin (200 and 800 mg) in healthy volunteers receiving a single oral dose.

abstract：:A semi-automated microdilution test was adapted for the in vitro testing of potential antitrichomonal agents. Washed cell suspensions of the pathogenic protozoan Trichomonas vaginalis were incubated in microtitration plates for 4 h at 37 degrees C in the presence radiolabelled adenine and serial dilutions of the test ...

journal_title：Chemotherapy

authors： Meingassner JG,Heyworth PG,Havelec L

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Development of novel strategies to kill cancer by sparing normal cells is of utmost importance. Apart from their known antimicrobial activity, only limited information has been recorded regarding the antitumor potential of biocompatible silver oxide nanoparticles (AgONPs). There is a need to evaluate the ant...

journal_title：Chemotherapy

authors： Banerjee K,Das S,Choudhury P,Ghosh S,Baral R,Choudhuri SK

更新日期：2017-01-01 00:00:00

abstract：:The in vitro activities of quinupristin/dalfopristin (Synercid), ampicillin, erythromycin, clarithromycin, vancomycin, teicoplanin, ciprofloxacin and tetracycline were examined and compared against 526 gram-positive bacteria. The minimal inhibitory concentrations (MICs) for quinupristin/dalfopristin against Staphyloco...

journal_title：Chemotherapy

authors： Ling TK,Fung KS,Cheng AF

更新日期：2001-07-01 00:00:00

abstract：:Combination of 9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] and 6-azauridine (AzUrd) is highly active in the selective inhibition of vaccinia virus in chick embryo cell culture. Synergic effect of this combination of compounds was not encountered in HeLa cell culture. Of the 17 analogues related to DHPA studied in th...

journal_title：Chemotherapy

authors： Rada B,Holý A

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Because of the dramatic situation of malaria in Africa, there is an urgent need to find new and cheap drugs, such as herbal medicines. Here we report the study of the in vitro and in vivo antimalarial activity of Momordica balsamina alone or in a traditional mixture used in Niger. METHODS:Extracts were obta...

journal_title：Chemotherapy

authors： Benoit-Vical F,Grellier P,Abdoulaye A,Moussa I,Ousmane A,Berry A,Ikhiri K,Poupat C

更新日期：2006-01-01 00:00:00

abstract：:Ten years of controlled clinical trials supported single-dose therapy efficacy and safety in uncomplicated lower urinary tract infections (UTI). Both local and systematic factors contribute to the high UTI prevalence seen in elderly people. A controlled open randomized study was undertaken to evaluate the clinical eff...

journal_title：Chemotherapy

authors： Ferraro G,Ambrosi G,Bucci L,Palmieri R,Palmieri G

更新日期：1990-01-01 00:00:00

abstract：:The success of perioperative prophylaxis in gallbladder surgery was examined in two prospective randomized studies with a total of 326 patients. Postoperative wound-healing impairments did not occur in any of the patients receiving a single preoperative application of an antibiotic with a high biliary elimination rate...

journal_title：Chemotherapy

authors： Harnoss BM,Hirner A,Dibbelt H,Häring R,Rodloff R,Lode H

更新日期：1987-01-01 00:00:00

abstract：:Viscum album (VA) preparations consist of aqueous extracts of V. album, the European mistletoe. VA extracts contain mistletoe lectins, which are members of the ribosome-inactivating protein type II family. VA preparations have cytotoxic and immunomodulatory properties. Cytotoxicity induced by VA extracts may differ gr...

journal_title：Chemotherapy

authors： Duong Van Huyen JP,Delignat S,Kazatchkine MD,Kaveri SV

更新日期：2003-12-01 00:00:00

abstract：:A technique for inducing pneumococcal meningitis in mice and a description of the histopathologic changes that accompany this experimentally produced disease are provided in the present report. This infection of mice was investigated to determine whether it could serve as a suitable model for detecting agents that hav...

journal_title：Chemotherapy

authors： Tsai YH,Williams EB,Hirth RS,Price KE

更新日期：1975-01-01 00:00:00

abstract：:The microbiological properties of cephapirin, a new semisynthetis cephalosporin, have been studied. This antibiotic, if compared with ampicillin, shows a greater activity against gram positive bacteria, a lack of sensitivity to staphlococcal beta-lactamase, and a lower sensitivity to those produced by gram-negative ba...

journal_title：Chemotherapy

authors： Renzini G,Ravagnan G,Oliva B

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Recently, multiple-line chemotherapy has become popular for non-small cell lung cancer (NSCLC). The survival time of patients is influenced by patient characteristics and subsequent treatments. METHODS:The usefulness of paclitaxel plus S1 (PTX+S1) was evaluated in 46 pretreated NSCLC patients. Time from the...

journal_title：Chemotherapy

authors： Aono N,Ito Y,Nishino K,Uchida J,Kumagai T,Akazawa Y,Okuyama T,Yoshinami T,Imamura F

更新日期：2012-01-01 00:00:00

abstract：:Without treatment all mice died after receiving 10(3) Klebsiella pneumoniae by intraperitoneal injection. Nevertheless, it was possible to delay treatment for 12 h and still observe a therapeutic response from im gentamicin (5 mg/kg). This gave initial serum concentrations comparable to clinical levels, which fell rap...

journal_title：Chemotherapy

authors： Queiroz ML,Bathirunathan N,Mawer GE

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:It was the aim of our study to evaluate the in vitro activities of tetracycline (TET), erythromycin (ERY) and levofloxacin (LVX) alone and in dual combinations against ureaplasmas. METHODS:The minimum inhibitory concentrations (MICs) of 51 ureaplasmal strains were determined by microdilution assay. RESULTS:TE...

journal_title：Chemotherapy

authors： Luo DQ,Liu JY,Yang W,Zhang B,Yu MJ,Wu YM

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Transplant-related mortality (TRM) significantly decreases the long-term survival of patients with hematopoietic diseases who undergo hematopoietic stem cell transplantation (HSCT). METHODS:We retrospectively evaluated the risk factors for TRM of 58 consecutive patients with hematopoietic disease who underw...

journal_title：Chemotherapy

authors： Nakamae H,Yamane T,Aoyama Y,Yamamura R,Ohta K,Hino M

更新日期：2004-10-01 00:00:00

abstract：:Among third-generation cephalosporins, cefodizime (CFDZ) has shown to modulate many functions of the host defense system against infections. The aim of the present study was to assess the in vitro CFDZ-dependent modulation of interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha) and IL-8 release from lipopolysac...

journal_title：Chemotherapy

authors： Meloni F,Ballabio P,Bianchi L,Grassi FA,Gialdroni Grassi GG

更新日期：1995-07-01 00:00:00

abstract：:A group of cis-ethylenediammine platinum (II) complexes were synthesized and their activity against Sarcoma-180 ascites tumour cells in mouse was tested. One of the compounds, Pt(HOCH2CH2NHCH2CH2NH2)Cl2, showed significant antitumour activity having little toxicity to the host. Like the parent compound, cis-DDP, it bi...

journal_title：Chemotherapy

authors： Chakraborty BK,Biswas N,Choudhury K,Neogy RK,Das Sarma B

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Ginkgolic acids (GAs), extracted from the seed coat of Ginkgo biloba L. Our previous study has shown that GA monomer could inhibit the growth of Hep-2 significantly and induce the fragmentation of the chromosomal DNA. To further assess the antitumor potential and turn it into a candidate new antitumor drug, ...

journal_title：Chemotherapy

authors： Zhou C,Li X,Du W,Feng Y,Kong X,Li Y,Xiao L,Zhang P

更新日期：2010-01-01 00:00:00

abstract：:Eight thiadiazine 1,1-dioxide derivatives were evaluated for antitrichomonal and antitrypanosomal activities. In vivo tests were performed on a murine model for trichomoniasis standardized in our laboratory. The capacity of compounds to clear visceral lesions in experimentally infected animals as well as their effects...

journal_title：Chemotherapy

authors： Atienza J,Martínez Díaz RA,Gómez Barrio A,Escario JA,Herrero A,Ochoa C,Rodríguez J

更新日期：1992-01-01 00:00:00

abstract：:An in vitro infection model was created using a suspension of macrophages, polymorphonuclear leukocytes, lymphocytes, fibroblasts, and human serum to which pathogen and antibiotic were added. Separate intracellular and extracellular antibiotic concentrations and activity against Staphylococcus aureus and Legionella pn...

journal_title：Chemotherapy

authors： Scaglione F,Demartini G,Dugnani S,Fraschini F

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Kaposi's sarcoma (KS) is the most common neoplastic apoptosis manifestation of acquired immunodeficiency syndrome. Toremifene is known to upregulate transforming growth factor beta-1 (TGF-beta1), which is a growth-inhibitory factor for KS. We investigated the in vitro effect of toremifene on KS cells. METHO...

journal_title：Chemotherapy

authors： Hong A,Leigh BR

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:This study assessed the population pharmacokinetics and metabolic conversion of a novel histone deacetylase (HDAC) inhibitor, SD-2007, into its active metabolite, apicidin, in rats. METHODS:SD-2007 was given to rats by intravenous injection (4 mg/kg) and oral administration (40 mg/kg). Serum concentrations ...

journal_title：Chemotherapy

authors： Shin BS,Bulitta JB,Hong DK,Kim HY,Kim MK,Choi Y,Lee JB,Hwang SW,Lee MH,Yoo SD

更新日期：2011-01-01 00:00:00

abstract：:The in vitro activities of the newer agents Deptomycin, Difloxacin, A-56620 and Ciprofloxacin were compared with those of vancomycin, rifampin and gentamicin against methicillin-susceptible and -resistant Staphylococcus aureus and coagulase-negative staphylococci. All isolates were susceptible to vancomycin, rifampin,...

journal_title：Chemotherapy

authors： Chandrasekar PH,Sluchak JA

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Viscum album (VA) Qu FrF preparation consists of an aqueous extract of Viscum album, the European mistletoe. It has cytotoxic and immunomodulatory properties that support its usefulness in cancer therapy. However, only little information is available on the interaction between mistletoe lectin (ML) and the h...

journal_title：Chemotherapy

authors： Duong Van Huyen JP,Sooryanarayana,Delignat S,Bloch MF,Kazatchkine MD,Kaveri SV

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVES:To identify parameters/factors that may contribute to the differential sensitivity to etoposide in two clones isolated from the human ovarian carcinoma SKOV-3 cell line, which does not express p53 and is resistant to platinum-based regimens. METHODS:Differential sensitivity of the cells to etoposide was mon...

journal_title：Chemotherapy

authors： Balan KV,Sitaras NM,Dimas K,Han Z,Wyche JH,Pantazis P

更新日期：2006-01-01 00:00:00

abstract：:Addition of phenylbutazone (2 mg/ml) to 55 vol% of fresh defibrinated human blood permitted leukocytic ingestion of Serratia marcescens bacteria, but blocked phagocytic killing activity. The group A (phage tail) bacteriocin bA+ 16 served to kill extraphagocytic test bacteria. Five bacterial DNA gyrase inhibitors (cipr...

journal_title：Chemotherapy

authors： Traub WH

更新日期：1984-01-01 00:00:00

abstract：:Malignant tumors are known to exhibit high rates of glycolytic activity leading to high production of lactic acid. Hence, neoplastic cells have elevated activity of enzymes responsible for glycolysis. Echitamine chloride, an indole alkaloid extracted from the bark of Alstonia scholaris, has been reported to have a hig...

journal_title：Chemotherapy

authors： Saraswathi V,Ramamoorthy N,Subramaniam S,Mathuram V,Gunasekaran P,Govindasamy S

更新日期：1998-05-01 00:00:00

abstract：:Phase contrast microscopy, killing curves and turbidimetric growth curves were used in a comparative study of the antibacterial effects of imipenem and meropenem on Haemophilus influenzae. The minimal inhibitory concentrations (MICs) and their ranges of meropenem and imipenem using five beta-lactamase-producing strain...

journal_title：Chemotherapy

authors： Yourassowsky E,Van der Linden MP,Crokaert F

更新日期：1991-01-01 00:00:00

abstract：:Body lice (Pediculus humanus corporis L) and ticks (Ornithodoros moubata) that had been infected with Rickettsia prowazekii received varying doses of erythromycin. The anti-rickettsial activity of this drug was evaluated with regard to the determination of the numbers of surviving microorganism (LID100) and the in viv...

journal_title：Chemotherapy

authors： Becla E

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Recurrent tumor growth of colorectal carcinoma at the peritoneal site remains an unsolved problem. The aim of this study was to investigate whether the substance taxol (paclitaxel) can alter intraperitoneal tumor spread using different modes of drug application. METHODS:Intraperitoneal tumor growth was indu...

journal_title：Chemotherapy

authors： Hribaschek A,Meyer F,Schneider-Stock R,Pross M,Ridwelski K,Lippert H

更新日期：2007-01-01 00:00:00

abstract：:In a randomized study 87 patients received perioperative antibiotic prophylaxis with 2 x 2 g ceftriaxone (Rocephin) at the beginning of the operation and in the following morning. Seventy-two patients received no antibiotic prophylaxis. In patients receiving the prophylaxis, a lower incidence of infections was observe...

journal_title：Chemotherapy

authors： Winkler D,Rehn H,Freckmann N,Nowak G,Herrmann HD

更新日期：1989-01-01 00:00:00