Abstract:
BACKGROUND:Transplant-related mortality (TRM) significantly decreases the long-term survival of patients with hematopoietic diseases who undergo hematopoietic stem cell transplantation (HSCT). METHODS:We retrospectively evaluated the risk factors for TRM of 58 consecutive patients with hematopoietic disease who underwent allogeneic myeloablative HSCT between April 1994 and June 2002. RESULTS:Thirty-one patients died after HSCT, 16 of whom were diagnosed as TRM. The actuarial incidence of TRM was 57.6 % in patients who received conditioning chemotherapies including high-dose busulfan and 19.4 % in those who did not (p = 0.008). Multivariate Cox model analysis revealed that disease status, graft versus host disease (GVHD) grades III-IV and the use of high-dose busulfan were significant and independent risk factors for TRM. CONCLUSION:These results suggest that high-dose busulfan as a conditioning therapy for allogeneic HSCT should be used cautiously, especially in patients with advanced disease.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Nakamae H,Yamane T,Aoyama Y,Yamamura R,Ohta K,Hino Mdoi
10.1159/000080691subject
Has Abstractpub_date
2004-10-01 00:00:00pages
178-83issue
4eissn
0009-3157issn
1421-9794pii
80691journal_volume
50pub_type
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