Effects of rokitamycin on phagocytosis and release of oxidant radicals of human polymorphonuclear leukocytes.

abstract：:The cellular/extracellular (C/E) concentration ratio of teicoplanin in polymorphonuclear leukocytes (PMNs) increased rapidly with time (C/E 60 +/- 13 at 20 min). The C/E ratio was time- and concentration-dependent. At 20 min and an initial concentration of 75 +/- 16 micrograms/ml the cellular drug concentration was 4,...

journal_title：Chemotherapy

authors： Maderazo EG,Breaux SP,Woronick CL,Quintiliani R,Nightingale CH

更新日期：1988-01-01 00:00:00

abstract：:Serum (beta 1-->3)-D-glucan was elevated in 34 of 126 patients (27%) with hematologic malignancy who were clinically suspected of having a deep-seated mycosis. Although 11 patients (8.8%) were thought to have fungemia, fungi were isolated from blood culture in only 4. These results suggest that measurement of serum be...

journal_title：Chemotherapy

authors： Niitsu N,Umeda M

更新日期：1996-05-01 00:00:00

abstract：AIMS:This study aimed to evaluate the different abilities of various Phellinus igniarius strains inhibiting quorum sensing (QS), to search for novel QS inhibitors from them and to analyze their inhibitory activity, with a view to their possible use in controlling infections. METHODS:The bioactive metabolites produced ...

journal_title：Chemotherapy

authors： Zhu H,Liu W,Wang SX,Tian BZ,Zhang SS

更新日期：2012-01-01 00:00:00

abstract：:The concentrations of clarithromycin after a single oral dose of 500 mg were determined in serum and saliva of ten healthy adult volunteers. After 2 h, the levels were 4.04 +/- 1.14 (SD) mg/l in serum and 2.72 +/- 0.87 mg/l in saliva. After 7 h these values were 1.98 +/- 0.65 and 1.21 +/- 0.34 mg/l, respectively, and ...

journal_title：Chemotherapy

authors： Wüst J,Hardegger U

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection. METHODS:Urinary concentrations and urinary bactericidal titers (UBT) of finafloxacin 200- and 800-mg single doses in 6 healthy volunteers were measured up to 48 h. UBT were determined for a referenc...

journal_title：Chemotherapy

authors： Wagenlehner FM,Wagenlehner CM,Blenk B,Blenk H,Schubert S,Dalhoff A,Naber KG

更新日期：2011-01-01 00:00:00

abstract：:Ninety-three representative, recent clinical isolates of Streptococcus pneumoniae were examined for susceptibility to 9 antimicrobial drugs utilizing Mueller-Hinton agar (MHA) enriched with sheep blood and a hypercapnic atmosphere of incubation. One isolate was resistant to penicillin G (minimum inhibitory concentrati...

journal_title：Chemotherapy

authors： Traub WH,Leonhard B

更新日期：1996-07-01 00:00:00

abstract：:Mezlocillin was used alone and in combination with cloxacillin in the treatment of chronic experimental osteomyelitis due to Morganella morganii. This combination showed in vitro synergy as measured by the checkerboard technique. A marked inoculum affect was demonstrated in vitro with mezlocillin and the infecting str...

journal_title：Chemotherapy

authors： Norden CW,Shaffer M

更新日期：1984-01-01 00:00:00

abstract：:We tested 42 strains of amikacin-resistant gram-negative bacilli with amikacin in combination with six beta-lactam antibiotics using the checkerboard and time-kill curve techniques. Synergism was demonstrated with time-killing curve in 43-68% of the strains tested. Ceftazidime plus amikacin was the most active combina...

journal_title：Chemotherapy

authors： Alvarez S,Jones M,Holtsclaw-Berk S,Berk SL

更新日期：1988-01-01 00:00:00

abstract：:We studied penicillin-binding protein (PBP) profiles of two Pseudomonas aeruginosa strains stably derepressed for constitutive, type Id beta-lactamase overproduction. Substantial levels of beta-lactamase were found to be strongly associated with isolated inner membranes of these two strains, as well as from a plasmid-...

journal_title：Chemotherapy

authors： Parr TR Jr,Chan L,Bayer AS

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Pneumolysin is an important virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities released during growth and autolysis. At concentrations above the minimal inhibitory concentration, the protein-synthesis-inhibiting antibiotics erythromycin, clindamycin and rifampicin inhib...

journal_title：Chemotherapy

authors： Spreer A,von Ruden C,Mitchell TJ,Eiffert H,Nau R

更新日期：2007-01-01 00:00:00

abstract：:One patient of sepsis by P. aeruginosa after the implanting of a ventriculoatrial valve following extirpation of an expansive intracranial process is studied. During the evolution of the septic process there appeared as associated nephrotic syndrome with histologic lesions corresponding to an acute exudative glomerula...

journal_title：Chemotherapy

authors： Rodriguéz-Gironés M,Genovés A

更新日期：1977-01-01 00:00:00

abstract：:The aminoglycoside antibiotics are polycationic at physiological pH and hence do not enter most cells. Indeed, when intact mast cells were incubated with gentamicin or tobramycin, extremely low concentrations of the two drugs could be measured. In contrast, when a controlled, specific degranulation of mast cells was i...

journal_title：Chemotherapy

authors： Decorti G,Candussio L,Klugmann FB,Baldini L

更新日期：1997-01-01 00:00:00

abstract：:The in vitro activity of sparfloxacin, a new fluoroquinolone, was compared with ciprofloxacin and ofloxacin against 166 consecutive isolates from the upper respiratory tract of outpatients. The strains were fully susceptible to three quinolones. The antibacterial activity of sparfloxacin was comparable or better than ...

journal_title：Chemotherapy

authors： Malmborg AS,Ahlén S

更新日期：1993-01-01 00:00:00

abstract：:Eight thiadiazine 1,1-dioxide derivatives were evaluated for antitrichomonal and antitrypanosomal activities. In vivo tests were performed on a murine model for trichomoniasis standardized in our laboratory. The capacity of compounds to clear visceral lesions in experimentally infected animals as well as their effects...

journal_title：Chemotherapy

authors： Atienza J,Martínez Díaz RA,Gómez Barrio A,Escario JA,Herrero A,Ochoa C,Rodríguez J

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The efficacy of fluconazole (FLU), amphotericin B (AMB) and caspofungin (CAS) was tested against three Candida orthopsilosis, three C. metapsilosis and two C. parapsilosis sensu stricto isolates in neutropenic mice. METHODS:Mice were immunosuppressed by 200 mg/kg cyclophosphamide. Five-day intraperitoneal t...

journal_title：Chemotherapy

authors： Szilágyi J,Földi R,Gesztelyi R,Bayegan S,Kardos G,Juhász B,Majoros L

更新日期：2012-01-01 00:00:00

abstract：:Thirteen quinolone antibacterial agents were investigated as to their ability to inhibit Micrococcus luteus DNA gyrase and cell growth, and compared to those of novobiocin and coumermycin. Among the quinolones tested, the most active were found to be CI-934 and ciprofloxacin, which inhibited gyrase full supercoiling a...

journal_title：Chemotherapy

authors： Fu KP,Grace ME,McCloud SJ,Gregory FJ,Hung PP

更新日期：1986-01-01 00:00:00

abstract：:The treatment of diffuse large B-cell lymphoma in the presence of cardiac comorbidities can be challenging considering that the standard treatment regimen used for this aggressive subtype of non-Hodgkin lymphoma (NHL) consists of a combination of rituximab, cyclophosphamide, doxorubicin hydrochloride, Oncovin (vincris...

journal_title：Chemotherapy

authors： Alrifai T,Grant Szymanski K,Venugopal P,Mahon B,Okwuosa T,Karmali R

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:There are only limited data on tissue kinetics of ertapenem in colorectal tissue more than 3 h after administration of the drug. The purpose of this study was to assess the pharmacokinetics (PK) of ertapenem in colorectal tissue via population PK modeling. PATIENTS AND METHODS:Patients ≥18 years requiring s...

journal_title：Chemotherapy

authors： Wittau M,Scheele J,Bulitta JB,Mayer B,Kaever V,Burhenne H,Henne-Bruns D,Isenmann R,Brockschmidt C

更新日期：2011-01-01 00:00:00

abstract：:A semi-automated microdilution test was adapted for the in vitro testing of potential antitrichomonal agents. Washed cell suspensions of the pathogenic protozoan Trichomonas vaginalis were incubated in microtitration plates for 4 h at 37 degrees C in the presence radiolabelled adenine and serial dilutions of the test ...

journal_title：Chemotherapy

authors： Meingassner JG,Heyworth PG,Havelec L

更新日期：1985-01-01 00:00:00

abstract：:Body lice (Pediculus humanus corporis L) and ticks (Ornithodoros moubata) that had been infected with Rickettsia prowazekii received varying doses of erythromycin. The anti-rickettsial activity of this drug was evaluated with regard to the determination of the numbers of surviving microorganism (LID100) and the in viv...

journal_title：Chemotherapy

authors： Becla E

更新日期：1976-01-01 00:00:00

abstract：:Fleroxacin, a new long-acting quinolone, induces rapid killing and bacterial filamentation as do other quinolones. Ten strains of Escherichia coli were exposed comparatively to fleroxacin and ampicillin in order to determine the effect of sub- and supra-inhibitory concentrations of each of these two compounds on turbi...

journal_title：Chemotherapy

authors： Yourassowsky E,Van der Linden MP,Crokaert F

更新日期：1989-01-01 00:00:00

abstract：:Our previous studies demonstrated the efficacy of cationic liposome-encapsulated doxycycline (CaL-DOX) on the course of infection with Chlamydia trachomatis in vitro and in vivo. In this investigation, the pharmacokinetics of CaL-DOX are reported. Female mice inoculated intravaginally with 4.84 x 10(5) inclusion-formi...

journal_title：Chemotherapy

authors： Selliah S,Ravaoarinoro M

更新日期：2004-04-01 00:00:00

abstract：:The effect of acyclovir (ACV) treatment on selected functions of human blood-derived macrophages was examined. ACV was not cytotoxic when applied in a wide range of concentrations. Only minor effects on macrophage functions were observed when cells were treated with therapeutic concentrations of ACV:phagocytosis and t...

journal_title：Chemotherapy

authors： Stenseth AM,Rollag H,Degré M

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Bloodstream infections are a significant cause of neonatal morbidity and death. An increase in the incidence of early neonatal sepsis due to Escherichia coli has been reported. The objective was to evaluate the antimicrobial resistance of E. coli strains causing early-onset neonatal sepsis (EONS) and late-on...

journal_title：Chemotherapy

authors： Guiral E,Bosch J,Vila J,Soto SM

更新日期：2012-01-01 00:00:00

abstract：:The frustration and disappointment in managing advanced cancers of the nose and paranasal sinuses are well known. We report a case of a successful treatment of such a tumour in a 37-year-old soldier, using a combination of therapy including surgery, chemotherapy and radiation. Each mode of treatment is discussed. ...

journal_title：Chemotherapy

authors： Chandrasekaran S,Baba AA,Othman N,Jayakumar CR

更新日期：1994-09-01 00:00:00

abstract：:The comparative in vitro activity of amikacin, cefamandole, cefoperazone, cefotaxime, cefoxitin, cephalothin, chloramphenicol, moxalactam, piperacillin, ticarcillin and tobramycin against 170 community blood culture isolates of gram-negative bacilli was investigated using the quantitative plate dilution method. Result...

journal_title：Chemotherapy

authors： Gordon RC,Tack KJ,Haddy RI,Fechner L,Wofford R

更新日期：1984-01-01 00:00:00

abstract：:There is evidence that a variety of anticancer drugs exert their cytotoxic activity by a free-radical-mediated mechanism. These drugs include anthracyclines such as adriamycin, daunorubicin, 4-epi-adriblastin as well as bleomycin, procarbazine, vincristin, cyclophosphamide, etoposide and mitomycin C. The aim of this s...

journal_title：Chemotherapy

authors： Look MP,Musch E

更新日期：1994-01-01 00:00:00

abstract：:Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects. Somatostatin acts throug...

journal_title：Chemotherapy

authors： Bousquet C,Puente E,Buscail L,Vaysse N,Susini C

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Urinary tract infections (UTIs) are a significant health problem and Escherichia coli has been exported to be the primary pathogen in approximately 80% of cases. E. coli express structures called adhesins, fimbriae or pili that help them bind to specific tissue receptors. One such adhesin is Dr, which binds ...

journal_title：Chemotherapy

authors： Kachroo BB

更新日期：2001-03-01 00:00:00

abstract：:Addition of phenylbutazone (2 mg/ml) to 55 vol% of fresh defibrinated human blood permitted leukocytic ingestion of Serratia marcescens bacteria, but blocked phagocytic killing activity. The group A (phage tail) bacteriocin bA+ 16 served to kill extraphagocytic test bacteria. Five bacterial DNA gyrase inhibitors (cipr...

journal_title：Chemotherapy

authors： Traub WH

更新日期：1984-01-01 00:00:00