Abstract:
BACKGROUND:Bloodstream infections are a significant cause of neonatal morbidity and death. An increase in the incidence of early neonatal sepsis due to Escherichia coli has been reported. The objective was to evaluate the antimicrobial resistance of E. coli strains causing early-onset neonatal sepsis (EONS) and late-onset neonatal sepsis (LONS) and their evolution. METHODS:E. coli strains from EONS and hospital-acquired LONS collected at the Hospital Clinic of Barcelona were included in the study. RESULTS:No statistically significant differences in resistance profiles were found between strains causing EONS and LONS. An increase in the resistance to all the antimicrobial agents studied was observed for the period 2000-2008 in comparison with the 1985-1999 period, with the increase in resistance to gentamicin, piperacillin and tobramycin being statistically significant. Two strains carried the bla(CTX-M) genes (bla(CTX-M-14) and bla(CTX-M-15)). CONCLUSION:The increase in ampicillin and gentamicin resistance makes a change in the treatment of neonates necessary.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Guiral E,Bosch J,Vila J,Soto SMdoi
10.1159/000337062subject
Has Abstractpub_date
2012-01-01 00:00:00pages
123-8issue
2eissn
0009-3157issn
1421-9794pii
000337062journal_volume
58pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract::A multicenter study aimed at assessing the in vitro activity of sulbactam/ampicillin against a wide range of bacterial pathogens was performed using 2,209 clinical strains, all recently collected from inpatients in seven Italian centers and preliminarily screened as being ampicillin-resistant and beta-lactamase produc...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000238760
更新日期:1990-01-01 00:00:00
abstract::The pharmacokinetic disposition of 5-fluorocytosine (5-FC) was studied in 7 patients with acute renal failure undergoing continuous hemofiltration (CH). CH was performed with a high-flux membrane and the average filtration rate (FR) was 16.3 ml/min. Following an intravenous loading dose of 2,500 mg, 5-FC concentration...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238478
更新日期:1987-01-01 00:00:00
abstract::Niridazole was shown to be an effective chemotherapeutic agent for mice infected intravenously with a niridazole-sensitive strain of Salmonella typhimurium. Death rates as well as bacterial counts per spleen were reduced, even in compromised animals. Histologic examination of spleens proved the reduction of inflammato...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238069
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:The purpose of this preliminary and descriptive study was to evaluate a biodegradable drug delivery system in combination with an innovative ceramic implant. METHODS:The delivery of gentamicin of standardized samples was measured in the laboratory using ultra-high-performance liquid chromatography. Biocompatib...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000354986
更新日期:2013-01-01 00:00:00
abstract::20 patients with serious infections were treated with cefazolin and tobramycin for 9--64 days. Minimal inhibitory concentration (MIC) values and minimal bactericidal concentration (MBC) values were determined for each of the 112 clinical bacterial isolates. The median cefazolin MIC/MBC was 1.56/12.5 micrograms/ml, and...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237931
更新日期:1980-01-01 00:00:00
abstract::The introduction of highly active antiretroviral therapy (HAART) has significantly modified the course of human immunodeficiency virus (HIV) disease, with longer survival and improved quality of life of HIV-infected subjects. However, HAART regimens, especially those including protease inhibitors, have been shown to c...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000093034
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Kaposi's sarcoma (KS) is the most common neoplastic apoptosis manifestation of acquired immunodeficiency syndrome. Toremifene is known to upregulate transforming growth factor beta-1 (TGF-beta1), which is a growth-inhibitory factor for KS. We investigated the in vitro effect of toremifene on KS cells. METHO...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000066765
更新日期:2002-12-01 00:00:00
abstract::Five healthy informed male volunteers received oral doses of 820 mg sulfadiazine (SDZ) plus 180 mg trimethoprim (TMP) (co-trimazine) every 24 h. Concentrations in serum, peripheral lymph from the leg and urine were determined after the first dose, and on the 4th day to reflect approximate steady-state conditions. TMP ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238418
更新日期:1986-01-01 00:00:00
abstract::Aztreonam is the first monobactam antibiotic to be used clinically. It is highly resistant to beta-lactamases, and although its activity spectrum is similar to that of the aminoglycoside antibiotics, it has no effect on gram-positive bacteria. The current study was undertaken to determine the efficacy of aztreonam in ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238720
更新日期:1989-01-01 00:00:00
abstract::Reference is made to the results obtained in 24 children, from 11 months to 12 years, affected with acute pneumopathies and treated with fosfomycin with a dosage of 200 mg/kg/day. In all cases a clinical, radiological, biological and bacteriological study was carried out. At the same time, levels of fosfomycin in plas...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222069
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:5-Fluorouracil (5-FU) is a widely used drug in head and neck squamous cell carcinoma (HNSCC). Thymidylate synthase (TS), which is the target enzyme of 5-FU, has been demonstrated to be a key regulatory enzyme. In this study, we examined whether TS expression is correlated with chemosensitivity to 5-FU, cell ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000175465
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:It was the aim of this study to report clinical characteristics and treatment of thyroid tuberculosis (TT). METHODS:During 16 years, 2,426 patients have been operated on the thyroid in the surgical department 'A' in Ibn Sina Hospital, Rabat, Morocco. Anatomopathological results of the removed thyroid were an...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000090244
更新日期:2006-01-01 00:00:00
abstract::The microbiological properties of cephapirin, a new semisynthetis cephalosporin, have been studied. This antibiotic, if compared with ampicillin, shows a greater activity against gram positive bacteria, a lack of sensitivity to staphlococcal beta-lactamase, and a lower sensitivity to those produced by gram-negative ba...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221871
更新日期:1975-01-01 00:00:00
abstract::The antitumour properties of the drug N-137 were assessed in vivo in two murine T lymphoma models and two naturally metastatic hamster fibrosarcomas of Herpesvirus hominis aetiology. N-137 therapy caused a significant delay in the subcutaneous growth rate of both lymphomas (EL4 and TLX9) and in many cases completely p...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238091
更新日期:1982-01-01 00:00:00
abstract::The in vitro bactericidal effects of therapeutic concentrations of levofloxacin (LVFX) on clinical isolates of Pseudomonas aeruginosa and Enterococcus faecalis were assessed. Starting from 10(7) CFU/ml, the bacterial count was determined serially during the exposure to LVFX present at concentrations automatically simu...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007133
更新日期:1998-09-01 00:00:00
abstract::The treatment of diffuse large B-cell lymphoma in the presence of cardiac comorbidities can be challenging considering that the standard treatment regimen used for this aggressive subtype of non-Hodgkin lymphoma (NHL) consists of a combination of rituximab, cyclophosphamide, doxorubicin hydrochloride, Oncovin (vincris...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000452756
更新日期:2017-01-01 00:00:00
abstract::Sixteen adult beagles (10-12 kg) were used to evaluate combinations of 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZQ, aziridinylbenzoquinone), 1,3-bis-2-chloroethyl-1-nitrosourea (BCNU, carmustine), and cis-dichlorodiammineplatinum(II) (CDDP, cisplatin) administered by intravenous or intracarotid infu...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238532
更新日期:1987-01-01 00:00:00
abstract::Eight thiadiazine 1,1-dioxide derivatives were evaluated for antitrichomonal and antitrypanosomal activities. In vivo tests were performed on a murine model for trichomoniasis standardized in our laboratory. The capacity of compounds to clear visceral lesions in experimentally infected animals as well as their effects...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239040
更新日期:1992-01-01 00:00:00
abstract::The in vitro activity of ceftazidime has been compared with those of cephalothin, cefuroxime, and netilmicin against a variety of gram-positive and gram-negative bacteria in order to register sensitivity patterns in the western part of Norway. An agar dilution method was used for minimal inhibitory concentration (MIC)...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238256
更新日期:1984-01-01 00:00:00
abstract::Among third-generation cephalosporins, cefodizime (CFDZ) has shown to modulate many functions of the host defense system against infections. The aim of the present study was to assess the in vitro CFDZ-dependent modulation of interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha) and IL-8 release from lipopolysac...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239358
更新日期:1995-07-01 00:00:00
abstract::Therapeutic effectiveness of 5-fluorocytosine (5-FC), amphotericin B (Am B) and both in combined administration were retrospectively assessed and compared with one another in 28 patients with cryptococcal meningitis. Combined administration was significantly superior to Am B alone and to 5-FC alone, and these agents w...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章
doi:10.1159/000237811
更新日期:1978-01-01 00:00:00
abstract::We have tested the effectiveness of several antibiotic regimens, using a rat model of Escherichia coli experimental pyelonephritis that mimics the conditions of severe renal infections in man because the infection is acquired by the ascending route. We found that ceftriaxone, when given for 5 days to rats with severe ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238130
更新日期:1982-01-01 00:00:00
abstract::Ciprofloxacin (CIP) and metabolite concentrations in lung tissue, parietal pleura and bronchial tissue were assessed in 43 adult patients who underwent lung surgery. A single oral dose of CIP was given for prophylaxis of bacterial infections. Two to 6 h prior to tissues sampling, 23 patients received 250 mg and 20 sub...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238860
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:In this study (part of the global TEST program), the in vitro activity of tigecycline, a member of a new class of antimicrobial agents, the glycylcyclines, against clinical isolates collected in Italy was evaluated. METHODS:A total of 200 clinical isolates were collected and identified in our institution du...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000112415
更新日期:2008-01-01 00:00:00
abstract::Cephalosporins do not reach active therapeutical concentrations in the prostatic tissue in patients suffering from chronic bacterial prostatitis. Cefoperazone is an exception. Its efficacy in the treatment of chronic bacterial prostatitis in 20 patients was studied and the concentrations, obtained after intramuscular ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238704
更新日期:1989-01-01 00:00:00
abstract::Cefepime is active against bacteria producing chromosomally and plasmid-mediated extended broad-spectrum β-lactamase enzymes. The aim of this study was to evaluate risk factors for acquisition of cefepime resistance in Escherichia coli strains among hospitalized patients in a university hospital in Sanandaj, Iran. The...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000323623
更新日期:2011-01-01 00:00:00
abstract::An agar dilution technique was used to determine the MIC of pristinamycin for 124 clinical isolates of methicillin-resistant Staphylococcus aureus. All were inhibited by less than or equal to 0.5 mg/1, quite similar to the sensitivity of a number of methicillin-sensitive strains. MICs obtained using a microdilution me...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238200
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Brucellosis is one of the important health problems for both humans and animals in Turkey since agriculture and stock raising appears to be the most important means of subsistence. Investigations on the pathogenesis of brucellosis reveal that the etiologic agent can survive in phagocytic cells, and cell-medi...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000084020
更新日期:2005-03-01 00:00:00
abstract::We tested 42 strains of amikacin-resistant gram-negative bacilli with amikacin in combination with six beta-lactam antibiotics using the checkerboard and time-kill curve techniques. Synergism was demonstrated with time-killing curve in 43-68% of the strains tested. Ceftazidime plus amikacin was the most active combina...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238556
更新日期:1988-01-01 00:00:00
abstract::A total of 30 hospitalized patients with upper and lower urinary tract infections were treated with cefotaxime (HR-756) by intramuscular or intravenous route. All patients had a monomicrobial infection, and the major part of bacterial isolates were gram-negative bacilli (83%) while gram-positive cocci accounted only f...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238061
更新日期:1982-01-01 00:00:00