Abstract:
:Sixteen adult beagles (10-12 kg) were used to evaluate combinations of 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZQ, aziridinylbenzoquinone), 1,3-bis-2-chloroethyl-1-nitrosourea (BCNU, carmustine), and cis-dichlorodiammineplatinum(II) (CDDP, cisplatin) administered by intravenous or intracarotid infusion. Moderate to severe systemic toxicities resulted from all drug infusions, but no histopathologic changes were found in the central nervous system (CNS) of any of the dogs. Results indicated that the toxicities were not dependent on the route of administration or the recipient's gender, and they were reversible in most cases with intravenous supportive therapy. Cisplatin seemed to have an additive effect when administered in combination with AZQ and/or BCNU.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Wright KC,Stephens LC,Wallace S,Savaraj N,Feun LGdoi
10.1159/000238532subject
Has Abstractpub_date
1987-01-01 00:00:00pages
437-44issue
6eissn
0009-3157issn
1421-9794journal_volume
33pub_type
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