Serum and tissue tinidazole concentrations after intravenous infusion.

abstract：:During the 5-year period 1989-1993, the incidence of Candida krusei, and other non-albicans Candida spp., was analyzed in a 60-bed cancer department. The frequency of C. krusei, before fluconazole was introduced into therapeutic protocols in 1990, was 16.5%, and after introduction of fluconazole into prophylaxis in ac...

journal_title：Chemotherapy

authors： Kunová A,Trupl J,Spánik S,Drgona L,Sufliarsky J,Lacka J,Studená V,Hlavácová E,Studená M,Kukucková E

更新日期：1995-01-01 00:00:00

abstract：:20 patients with serious infections were treated with cefazolin and tobramycin for 9--64 days. Minimal inhibitory concentration (MIC) values and minimal bactericidal concentration (MBC) values were determined for each of the 112 clinical bacterial isolates. The median cefazolin MIC/MBC was 1.56/12.5 micrograms/ml, and...

journal_title：Chemotherapy

authors： Franson TR,Edwards LD,Collins RF,Root TE

更新日期：1980-01-01 00:00:00

abstract：:Cefepime is active against bacteria producing chromosomally and plasmid-mediated extended broad-spectrum β-lactamase enzymes. The aim of this study was to evaluate risk factors for acquisition of cefepime resistance in Escherichia coli strains among hospitalized patients in a university hospital in Sanandaj, Iran. The...

journal_title：Chemotherapy

authors： Mansouri M,Ramazanzadeh R,Norabadi P

更新日期：2011-01-01 00:00:00

abstract：:Thirteen quinolone antibacterial agents were investigated as to their ability to inhibit Micrococcus luteus DNA gyrase and cell growth, and compared to those of novobiocin and coumermycin. Among the quinolones tested, the most active were found to be CI-934 and ciprofloxacin, which inhibited gyrase full supercoiling a...

journal_title：Chemotherapy

authors： Fu KP,Grace ME,McCloud SJ,Gregory FJ,Hung PP

更新日期：1986-01-01 00:00:00

abstract：:The aim of this research was to collect precise data on the antibacterial activity of ceftriaxone and cefotaxime in the respiratory tract. The diffusion into pulmonary tissue and bronchial secretion and the antibacterial activity of the two antibiotics were evaluated in vivo by means of the inhibitory quotient. Ceftri...

journal_title：Chemotherapy

authors： Fraschini F,Scaglione F

更新日期：1989-01-01 00:00:00

abstract：:A modified Rieckmann test was developed for assessing chloroquine sensitivity of Plasmodium vivax strains. This test envisages the evaluation of parasite growth with different concentrations of the drug and its comparison with controls, at the end of a 48-hour experimental period. Using this test, 16 strains were asse...

journal_title：Chemotherapy

authors： Renapurkar DM,Pradhan VR,Sutar NK,Deshmukh RA,Pandit CH,Marathe SN

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:Pneumolysin is an important virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities released during growth and autolysis. At concentrations above the minimal inhibitory concentration, the protein-synthesis-inhibiting antibiotics erythromycin, clindamycin and rifampicin inhib...

journal_title：Chemotherapy

authors： Spreer A,von Ruden C,Mitchell TJ,Eiffert H,Nau R

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:To define the maximum tolerated dose (MTD) tolerability and efficacy of intra-arterial chemotherapy with irinotecan in patients with liver metastases of colorectal carcinoma (CRC). METHODS:Superselective intra-arterial irinotecan was applied on days 1, 14, 28 and 42. The initial dose was 140 mg/m² with esca...

journal_title：Chemotherapy

authors： Eichler K,Dufas T,Hammerstingl R,Gruber-Rouh T,Vogl TJ,Zangos S

更新日期：2013-01-01 00:00:00

abstract：:The filamentous forms of a serum resistant Escherichia coli strain developed under in vitro exposure to subminimal inhibitory concentration of the compound LY 127935 showed a higher resistance against host defence than the nontreated control bacteria. Significantly diminished LD50 values and a longer lasting persisten...

journal_title：Chemotherapy

authors： Pusztai-Markos Z,Pranada F,Leimbrock C

更新日期：1982-01-01 00:00:00

abstract：:We conducted a retrospective clinical evaluation to assess the efficacy of a 1-gram once-daily regimen of intravenously administered ceftriaxone in the treatment of a variety of bacterial infections. Of the 250 patients studied, 167 had infections of the lower respiratory tract, approximately 70% of which were diagnos...

journal_title：Chemotherapy

authors： Brown R

更新日期：1991-01-01 00:00:00

abstract：:Rifampicin and rifapentine were used in the treatment of Listeria monocytogenes infections in normal mice and congenitally athymic (nude) mice. Results were compared with untreated controls and with the results obtained from a previous study of ampicillin in which this model was used. Low doses of rifampicin or rifape...

journal_title：Chemotherapy

authors： Bakker-Woudenberg IA,de Bos P,Michel MF

更新日期：1984-01-01 00:00:00

abstract：:Viscum album (VA) preparations consist of aqueous extracts of V. album, the European mistletoe. VA extracts contain mistletoe lectins, which are members of the ribosome-inactivating protein type II family. VA preparations have cytotoxic and immunomodulatory properties. Cytotoxicity induced by VA extracts may differ gr...

journal_title：Chemotherapy

authors： Duong Van Huyen JP,Delignat S,Kazatchkine MD,Kaveri SV

更新日期：2003-12-01 00:00:00

abstract：:We studied penicillin-binding protein (PBP) profiles of two Pseudomonas aeruginosa strains stably derepressed for constitutive, type Id beta-lactamase overproduction. Substantial levels of beta-lactamase were found to be strongly associated with isolated inner membranes of these two strains, as well as from a plasmid-...

journal_title：Chemotherapy

authors： Parr TR Jr,Chan L,Bayer AS

更新日期：1988-01-01 00:00:00

abstract：:CPC10997 was found to be effective in vitro as an antiandrogen without effects on either the estrogen or the progesterone receptors in carcinomas of the breast, ovary and prostate as well as in malignant melanomas. Using the clonogenic assay of Salmon et al. [Cancer Treat. Rep. 65: 1-12, 1981], CPC10997 was found to b...

journal_title：Chemotherapy

authors： Ford LC,Kasha W,Chang NH,DeLange RJ

更新日期：1985-01-01 00:00:00

abstract：:Differences in the pharmacokinetic parameters of cephalosporins between children and adults may be predictable on the basis of the level of maturation of the physiologic processes involved in drug disposition. It appears that the most important of these factors (gastrointestinal, renal and hepatic function) are reason...

journal_title：Chemotherapy

authors： Edwards DJ,Stoeckel K

更新日期：1992-01-01 00:00:00

abstract：:The in vitro activity of the new semisynthetic ureidopenicillins azlocillin (AZ) and mezlocillin (MZ), and of the new cephalosporin cefsulodin (CEF) were determined against 50 carbenicillin-sensitive (CARs) and 50 carbenicillin-resistant (CARr) P. aeruginosa clinical isolates. In the CARs group the most active antibio...

journal_title：Chemotherapy

authors： Perea EJ,Palomares JC,García-Iglesias MC

更新日期：1980-01-01 00:00:00

abstract：:In this study, rational dosing guidelines for amphotericin B-deoxycholate (AmB) are proposed for children. AmB steady-state trough concentrations (C(ss,trough)) and plasma creatinine concentrations (C(creat)) were measured in 83 children (age: 10 months to 18 years) receiving prophylactic AmB therapy (1 mg/kg/day). Ma...

journal_title：Chemotherapy

authors： Nath CE,McLachlan AJ,Shaw PJ,Coakley JC,Earl JW

更新日期：2007-01-01 00:00:00

abstract：:28 patients suffering from a variety of bacterial infections have been treated with cefuroxime. 18 were cured and 6 improved during treatment. Side effects were minimal and intramuscular injection was well tolerated. Serum and urine levels well in excess of the MICs of sensitive organisms were obtained using dosages o...

journal_title：Chemotherapy

authors： Ball AP,Brookes GR,Farrell ID,Geddes AM,Gould I

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:The effects of gemcitabine on postoperative adjuvant chemotherapy were evaluated in patients with stage IV pancreatic cancer. The results were compared with those of our historical control patients treated with surgery alone. PATIENTS AND METHODS:Nineteen patients with stage IV pancreatic cancer who had pan...

journal_title：Chemotherapy

authors： Kurosaki I,Hatakeyama K

更新日期：2005-10-01 00:00:00

abstract：:The effect of linezolid on the phagocytic and bactericidal functions of human polymorphonuclear neutrophils (PMN) against gram-positive cocci was evaluated. Preincubation (30 min; 37 degrees C) of PMN with different concentrations of linezolid (2, 10 and 20 mg/l) did not significantly affect the phagocytosis of either...

journal_title：Chemotherapy

authors： Ballesta S,Pascual A,García I,Perea EJ

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Ginkgolic acids (GAs), extracted from the seed coat of Ginkgo biloba L. Our previous study has shown that GA monomer could inhibit the growth of Hep-2 significantly and induce the fragmentation of the chromosomal DNA. To further assess the antitumor potential and turn it into a candidate new antitumor drug, ...

journal_title：Chemotherapy

authors： Zhou C,Li X,Du W,Feng Y,Kong X,Li Y,Xiao L,Zhang P

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:We investigated the presence of Helicobacter pylori in laryngeal cancer specimens to reveal whether or not this is a risk factor in the development of squamous cell carcinoma of the larynx. METHODS:Sixty-nine total laryngectomy specimens with the pathologic diagnosis of squamous cell carcinoma and 30 larynge...

journal_title：Chemotherapy

authors： Kizilay A,Saydam L,Aydin A,Kalcioglu MT,Ozturan O,Aydin NE

更新日期：2006-01-01 00:00:00

abstract：:137 patients with febrile neutropenia after cytotoxic therapy not responding to ceftazidime plus or ceftriaxone plus netilmicin in received additionally to the previous combination either vancomycin alone or combined with another anti-gram-negative compound: imipenem in those treated prophylactically with ofloxacin an...

journal_title：Chemotherapy

authors： Lacka J,Oravcova E,Sevcikova L,Studena M,Bachanova V,Kukuckova E,Spanik S,Sufliarsky J,Helpianska L,Trupl J,Kunova A,Vochyanova I,Sycova Z,Grey E,Krcméry V Jr

更新日期：1996-03-01 00:00:00

abstract：:One hundred symptomatic women with clinical bacterial vaginosis (BV) were enrolled in this study. The bacteriological epidemiology of BV and efficacy of oral or vaginal administration of antimicrobial agents for treatment of BV were investigated. The epidemiology of BV was investigated before antimicrobial therapy. Fi...

journal_title：Chemotherapy

authors： Mikamo H,Kawazoe K,Izumi K,Ito K,Katoh N,Watanabe K,Ueno K,Tamaya T

更新日期：1996-01-01 00:00:00

abstract：:Several agar media (Mueller-Hinton agar, MHA; diagnostic sensitivity test agar, DSTA; Schaedler agar, SchA; Todd-Hewitt agar with added yeast extract, THYA; Wilkins-Chalgren agar, WCA) were compared using the Bauer-Kirby agar disk diffusion test against six nonfastidious quality control strains: Staphylococcus aureus ...

journal_title：Chemotherapy

authors： Traub WH,Leonhard B

更新日期：1994-01-01 00:00:00

abstract：:Twenty Pseudomonas maltophilia isolates were examined for susceptibility to beta-lactam antibiotics, including carbapenems, and for beta-lactamase production. All the isolates were resistant to imipenem (MICs 64-512 mg/l) and to a lesser extent, to meropenem (MICs 16-256 mg/l). None of the isolates produced significan...

journal_title：Chemotherapy

authors： Cullmann W,Dick W

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the value of tumor markers in monitoring chemotherapy response and predicting prognosis in patients with advanced non-small cell lung cancer (NSCLC). METHODS:We studied carcinoembryonic antigen (CEA), CYFRA21-1 and neuron-specific enolase (NSE) of 111 untreated patients wi...

journal_title：Chemotherapy

authors： Jin B,Huang AM,Zhong RB,Han BH

更新日期：2010-01-01 00:00:00

abstract：:We tested 42 strains of amikacin-resistant gram-negative bacilli with amikacin in combination with six beta-lactam antibiotics using the checkerboard and time-kill curve techniques. Synergism was demonstrated with time-killing curve in 43-68% of the strains tested. Ceftazidime plus amikacin was the most active combina...

journal_title：Chemotherapy

authors： Alvarez S,Jones M,Holtsclaw-Berk S,Berk SL

更新日期：1988-01-01 00:00:00

abstract：:Ocular penetration of grepafloxacin into several ocular tissues was determined in albino and pigmented rabbits following a single intravitreal administration. After administration, grepafloxacin was detected in all ocular tissues studied in both breeds of rabbits. The superior mean penetration ratios were found in the...

journal_title：Chemotherapy

authors： Solans C,Bregante MA,Garcia MA,Perez S

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori is one of the most common infections of mankind, with persistent colonization causing significant morbidity and mortality. TREATMENT:First-line therapy, consisting of 7-day treatment with a proton pump inhibitor or ranitidine bismuth citrate, amoxicillin and clarithromycin, with second-l...

journal_title：Chemotherapy

authors： McLoughlin R,O'Morain C

更新日期：2005-08-01 00:00:00