Effects of grepafloxacin on the function of human polymorphonuclear leukocytes and the phosphorylation of p38 mitogen-activated protein kinase.

abstract：:Therapeutic effectiveness of pretazettine (PTZ) has been demonstrated in the intraperitoneally (i.p.) implanted Lewis lung carcinoma (LLC) in both syngeneic and allogeneic mice. The i.p. implanted LLC has been found to be sensitive to most standard drugs tested such as cyclophosphamide (CY), actinomycin D, 5-fluoroura...

journal_title：Chemotherapy

authors： Furusawa E,Furusawa E,Sokugawa L

更新日期：1983-01-01 00:00:00

abstract：:Cefepime is active against bacteria producing chromosomally and plasmid-mediated extended broad-spectrum β-lactamase enzymes. The aim of this study was to evaluate risk factors for acquisition of cefepime resistance in Escherichia coli strains among hospitalized patients in a university hospital in Sanandaj, Iran. The...

journal_title：Chemotherapy

authors： Mansouri M,Ramazanzadeh R,Norabadi P

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:In an ongoing project to evaluate essential oils as modulators of antibiotic resistance, the essential oil from Origanum vulgare L. (OVEO), as well as its individual constituents carvacrol (CAR) and thymol (THY), were investigated using Staphylococcus aureus strains possessing efflux mechanisms of resistance...

journal_title：Chemotherapy

authors： Cirino IC,Menezes-Silva SM,Silva HT,de Souza EL,Siqueira-Júnior JP

更新日期：2014-01-01 00:00:00

abstract：:Treatment of enterococcal infections is often difficult because of intrinsic and acquired resistance to a variety of antimicrobial agents. Between January 1993 and May 1997, enterococci were isolated from blood cultures of 117 patients at the Institute of Medical Microbiology and Immunology, University Hospital Eppend...

journal_title：Chemotherapy

authors： Elsner HA,Sobottka I,Feucht HH,Claussen M,Kaulfers PM,Laufs R,Mack D

更新日期：2000-03-01 00:00:00

abstract：:Ten years of controlled clinical trials supported single-dose therapy efficacy and safety in uncomplicated lower urinary tract infections (UTI). Both local and systematic factors contribute to the high UTI prevalence seen in elderly people. A controlled open randomized study was undertaken to evaluate the clinical eff...

journal_title：Chemotherapy

authors： Ferraro G,Ambrosi G,Bucci L,Palmieri R,Palmieri G

更新日期：1990-01-01 00:00:00

abstract：:The influence of orally administered fosfomycin on intestinal disaccharidases in albino rats was studied. The enzymes were evaluated in a homogenate of the intestinal mucosa, using the method of SOLS and DE LA FUENTE which is based on the colored reaction of the glucose that is freed by the disaccharidases from disacc...

journal_title：Chemotherapy

authors： Casanovas X,Torralba A

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndrome (MDS) is an iron overload condition. Copper deficiency itself might induce dysplastic changes and iron overload. The relationship between the iron and copper metabolism is analyzed in MDS patients. METHODS:Copper, iron and ceruloplasmin levels were established, and transferrin satur...

journal_title：Chemotherapy

authors： Várkonyi J,Szabó T,Sebestyén P,Tordai A,Andrikovics H,Kollai G,Karádi I

更新日期：2006-01-01 00:00:00

abstract：:Patients with a mycologically confirmed vaginal mycosis were treated either with one 100-mg vaginal ovule of clotrimazole each for 6 days, or with one 200-mg vaginal ovule of clotrimazole each for 3 days, or with one 500-mg vaginal ovule of clotrimazole for 1 day, the ovule having been supplied in a novel, acid formul...

journal_title：Chemotherapy

authors： Mendling W,Plempel M

更新日期：1982-01-01 00:00:00

abstract：:The effect of acyclovir (ACV) treatment on selected functions of human blood-derived macrophages was examined. ACV was not cytotoxic when applied in a wide range of concentrations. Only minor effects on macrophage functions were observed when cells were treated with therapeutic concentrations of ACV:phagocytosis and t...

journal_title：Chemotherapy

authors： Stenseth AM,Rollag H,Degré M

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Gram-negative bacilli are the most common bacteria causing nosocomial bloodstream infections (NBSIs) in Latin American countries. METHODS:The antibiotic resistance profiles of Gram-negative bacilli isolated from blood cultures in pediatric patients with NBSIs over a 3-year period in a tertiary care pediatri...

journal_title：Chemotherapy

authors： Ares MÁ,Alcántar-Curiel MD,Jiménez-Galicia C,Rios-Sarabia N,Pacheco S,De la Cruz MÁ

更新日期：2013-01-01 00:00:00

abstract：:137 patients with febrile neutropenia after cytotoxic therapy not responding to ceftazidime plus or ceftriaxone plus netilmicin in received additionally to the previous combination either vancomycin alone or combined with another anti-gram-negative compound: imipenem in those treated prophylactically with ofloxacin an...

journal_title：Chemotherapy

authors： Lacka J,Oravcova E,Sevcikova L,Studena M,Bachanova V,Kukuckova E,Spanik S,Sufliarsky J,Helpianska L,Trupl J,Kunova A,Vochyanova I,Sycova Z,Grey E,Krcméry V Jr

更新日期：1996-03-01 00:00:00

abstract：AIMS:This study aimed to evaluate the different abilities of various Phellinus igniarius strains inhibiting quorum sensing (QS), to search for novel QS inhibitors from them and to analyze their inhibitory activity, with a view to their possible use in controlling infections. METHODS:The bioactive metabolites produced ...

journal_title：Chemotherapy

authors： Zhu H,Liu W,Wang SX,Tian BZ,Zhang SS

更新日期：2012-01-01 00:00:00

abstract：:Therapeutic effectiveness of 5-fluorocytosine (5-FC), amphotericin B (Am B) and both in combined administration were retrospectively assessed and compared with one another in 28 patients with cryptococcal meningitis. Combined administration was significantly superior to Am B alone and to 5-FC alone, and these agents w...

journal_title：Chemotherapy

authors： Jimbow T,Tejima Y,Ikemoto H

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Recurrent tumor growth of colorectal carcinoma at the peritoneal site remains an unsolved problem. The aim of this study was to investigate whether the substance taxol (paclitaxel) can alter intraperitoneal tumor spread using different modes of drug application. METHODS:Intraperitoneal tumor growth was indu...

journal_title：Chemotherapy

authors： Hribaschek A,Meyer F,Schneider-Stock R,Pross M,Ridwelski K,Lippert H

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The combination of transarterial chemoembolization (TACE) and apatinib has been used in the treatment of intermediate or advanced hepatocellular carcinoma (HCC). However, its effectiveness and safety are also argued. METHODS:Eligible studies were collected from a computer search of literatures published fro...

journal_title：Chemotherapy

authors： Wei Y,Liu J,Yan M,Zhao S,Long Y,Zhang W

更新日期：2019-01-01 00:00:00

abstract：:The relative efficacy of 5-methoxymethyldeoxyuridine (MMUdR), adenine arabinoside (Ara-A), 5-iododeoxyuridine (IUdR) and the combination of MMUdR and Ara-A in the treatment of experimental herpes simplex keratitis was investigated in rabbits. Treatment was initiated either at 4 or 24 h post virus inoculation. The para...

journal_title：Chemotherapy

authors： Meldrum JB,Gupta VS,Babiuk LA

更新日期：1980-01-01 00:00:00

abstract：:On the basis of a regression analysis of the correlation between minimal inhibitory concentration (MIC) and inhibitory zone diameter, interpretative criteria are established for the agar diffusion test with ceftriaxone disks (30 micrograms) in DST agar according to the DIN method. The correlation is good (r = -0.9242)...

journal_title：Chemotherapy

authors： Grimm H

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Bacterial endotoxin is known to act as a potent trigger of disseminated coagulation and septic shock. During clinical antibiotic treatment, endotoxin may be released from Gram-negative bacteria. It is known that antibiotic classes differ in their ability to induce endotoxin release. AIM:It was the aim of th...

journal_title：Chemotherapy

authors： Trautmann M,Scheibe C,Wellinghausen N,Holst O,Lepper PM

更新日期：2010-01-01 00:00:00

abstract：:Hydrocortisone (HC) has been observed to influence an in vitro Dexter culture system with maintenance of pluripotent hematopoietic stem cells (CFU-s) and progenitor cells (CFU-gm, BFU-e). In the present study, a two-phase murine Dexter culture system was established to study the mechanism of HC-mediated suppression of...

journal_title：Chemotherapy

authors： Horikoshi A,Murphy MJ Jr

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Levofloxacin and tobramycin, alone and in combination with cefepime, were investigated for their in vitro activities and post-antibiotic effects (PAEs) on Pseudomonas aeruginosa. METHODS:The in vitro activities of tobramycin and levofloxacin in combination with cefepime were determined by microbroth chequer...

journal_title：Chemotherapy

authors： Ozbek B,Otuk G

更新日期：2009-01-01 00:00:00

abstract：:The frustration and disappointment in managing advanced cancers of the nose and paranasal sinuses are well known. We report a case of a successful treatment of such a tumour in a 37-year-old soldier, using a combination of therapy including surgery, chemotherapy and radiation. Each mode of treatment is discussed. ...

journal_title：Chemotherapy

authors： Chandrasekaran S,Baba AA,Othman N,Jayakumar CR

更新日期：1994-09-01 00:00:00

abstract：:Contrary to L-lysine, D-lysine showed no inhibitory effect on growth of Ehrlich ascites tumour cell in in vivo studies. The in vitro studies on the growth of cultured Ehrlich ascites tumour cells showed similar results, namely, the growth of tumour cells was inhibited when cultured in 0.02 or 0.03 M L-lysine; while 0....

journal_title：Chemotherapy

authors： Choy YM,Fung KP

更新日期：1989-01-01 00:00:00

abstract：:The sensitivity of 23 isolates of opportunistic fungi, Aspergillus fumigatus (5), A. flavus (5), A. niger (5), Pseudallescheria boydii (5), Alternaria alternata (2) and Xylohypha bantiana (1), was investigated against fluconazole and itraconazole, using Sabouraud's dextrose broth (SD) and a high-resolution (HR) medium...

journal_title：Chemotherapy

authors： Sekhon AS,Padhye AA,Garg AK,Hamir Z

更新日期：1992-01-01 00:00:00

abstract：:Without treatment all mice died after receiving 10(3) Klebsiella pneumoniae by intraperitoneal injection. Nevertheless, it was possible to delay treatment for 12 h and still observe a therapeutic response from im gentamicin (5 mg/kg). This gave initial serum concentrations comparable to clinical levels, which fell rap...

journal_title：Chemotherapy

authors： Queiroz ML,Bathirunathan N,Mawer GE

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Patients with cancer are particularly susceptible to drug interactions (DIs), but the extent of the problem has received limited attention. We aimed to evaluate the frequency of interactions with anticancer agents in a group of cancer patients. METHODS:The study was performed in a Belgian teaching hospital....

journal_title：Chemotherapy

authors： Mouzon A,Kerger J,D'Hondt L,Spinewine A

更新日期：2013-01-01 00:00:00

abstract：:The activities of amphotericin B, miconazole, fluconazole, and itraconazole against Trichosporon beigelii were assessed in a mouse model of disseminated infection. Cyclophosphamide plus prednisolone-immunosuppressed ICR mice, intravenously challenged with a lethal inoculum of (6 x 10(6) CFU/ mouse), were assigned to r...

journal_title：Chemotherapy

authors： Kamberi P,Atsuro H,Takayoshi T,Masaru N

更新日期：1998-01-01 00:00:00

abstract：:The aminoglycoside antibiotics are polycationic at physiological pH and hence do not enter most cells. Indeed, when intact mast cells were incubated with gentamicin or tobramycin, extremely low concentrations of the two drugs could be measured. In contrast, when a controlled, specific degranulation of mast cells was i...

journal_title：Chemotherapy

authors： Decorti G,Candussio L,Klugmann FB,Baldini L

更新日期：1997-01-01 00:00:00

abstract：:Mezlocillin was used alone and in combination with cloxacillin in the treatment of chronic experimental osteomyelitis due to Morganella morganii. This combination showed in vitro synergy as measured by the checkerboard technique. A marked inoculum affect was demonstrated in vitro with mezlocillin and the infecting str...

journal_title：Chemotherapy

authors： Norden CW,Shaffer M

更新日期：1984-01-01 00:00:00

abstract：:The activity of aztreonam (a beta-lactam antibiotic with specific activity against gram-negative bacteria) was evaluated and compared with that of tobramycin in hospitalized patients with severe intra-abdominal infections due to gram-negative pathogens, either alone or in association with other bacteria. Of a total st...

journal_title：Chemotherapy

authors： Birolini D,Moraes MF,de Souza OS

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:The glomerular filtration rate (GFR) is essential for calculating the dose and the monitoring of carboplatin. Although GFR measurement (mGFR) by external markers is ideal, in most cases these are not employed; the most used method is GFR estimation (eGFR) by formulae, hence the need to identify the formula w...

journal_title：Chemotherapy

authors： Graciano Vera N,Pino Villarreal L,Ureña Vargas J

更新日期：2018-01-01 00:00:00