Vaginal secretion levels after 6 days, 3 days and 1 day of treatment with 100, 200 and 500 mg vaginal tablets of clotrimazole and their therapeutic efficacy.

abstract：:Antibacterial kinetics of modified-release clarithromycin (CLA) and azithromycin (AZI) against respiratory tract pathogens were compared in relation to their pharmacokinetic profile. The study was carried out in three strains of Streptococcus pneumoniae, group A beta-hemolytic Streptococcus pyogenes, Moraxella catarrh...

journal_title：Chemotherapy

authors： Scaglione F,Demartini G,Dugnani S,Fraschini F

更新日期：2000-09-01 00:00:00

abstract：:The introduction of highly active antiretroviral therapy (HAART) has significantly modified the course of human immunodeficiency virus (HIV) disease, with longer survival and improved quality of life of HIV-infected subjects. However, HAART regimens, especially those including protease inhibitors, have been shown to c...

journal_title：Chemotherapy

authors： Barbaro G,Barbarini G

更新日期：2006-01-01 00:00:00

abstract：:Several agar media (Mueller-Hinton agar, MHA; diagnostic sensitivity test agar, DSTA; Schaedler agar, SchA; Todd-Hewitt agar with added yeast extract, THYA; Wilkins-Chalgren agar, WCA) were compared using the Bauer-Kirby agar disk diffusion test against six nonfastidious quality control strains: Staphylococcus aureus ...

journal_title：Chemotherapy

authors： Traub WH,Leonhard B

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVES:To identify parameters/factors that may contribute to the differential sensitivity to etoposide in two clones isolated from the human ovarian carcinoma SKOV-3 cell line, which does not express p53 and is resistant to platinum-based regimens. METHODS:Differential sensitivity of the cells to etoposide was mon...

journal_title：Chemotherapy

authors： Balan KV,Sitaras NM,Dimas K,Han Z,Wyche JH,Pantazis P

更新日期：2006-01-01 00:00:00

abstract：:A modified Rieckmann test was developed for assessing chloroquine sensitivity of Plasmodium vivax strains. This test envisages the evaluation of parasite growth with different concentrations of the drug and its comparison with controls, at the end of a 48-hour experimental period. Using this test, 16 strains were asse...

journal_title：Chemotherapy

authors： Renapurkar DM,Pradhan VR,Sutar NK,Deshmukh RA,Pandit CH,Marathe SN

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:The prognosis of patients with advanced gastric cancer (AGC) remains poor, and no single chemotherapy regimen is recognized as a global standard. A phase II trial was conducted to determine the efficacy and tolerability of capecitabine and oxaliplatin (XELOX) given every 3 weeks in combination in patients wi...

journal_title：Chemotherapy

authors： Luo HY,Xu RH,Wang F,Qiu MZ,Li YH,Li FH,Zhou ZW,Chen XQ

更新日期：2010-01-01 00:00:00

abstract：BACKGROUNDS:The combination gemcitabine-oxaliplatin (GEMOX) is frequently used in patients with advanced biliary tract carcinoma (BTC). However, this is only based on phase II studies performed in selected patients.We assessed the efficacy and safety of the GEMOX regimen in non-selected patients with advanced BTC. MET...

journal_title：Chemotherapy

authors： Hollebecque A,Bouché O,Romano O,Scaglia E,Cattan S,Zerbib P,Heurgue A,Lagarde S,Mariette C,Triboulet JP,Pruvot FR,Hebbar M

更新日期：2010-01-01 00:00:00

abstract：:We have treated 45 cases of urinary tract infection with cefazolin (i.m.) and cure was achieved in 35 (77.77%). 26 of the 28 patients (92.85%) with acute cystitis who received 250 mg every 12 h for 6-10 days were cured. 17 patients with pyelonephritis received 500 mg every 12 h during 10-14 days and therapeutical succ...

journal_title：Chemotherapy

authors： Lus RG,Calvo MC,Lopez LG,Cancer RC,Molina AM,Sanchez ED,Parilla AC,Mur LL

更新日期：1977-01-01 00:00:00

abstract：:Ocular penetration of grepafloxacin into several ocular tissues was determined in albino and pigmented rabbits following a single intravitreal administration. After administration, grepafloxacin was detected in all ocular tissues studied in both breeds of rabbits. The superior mean penetration ratios were found in the...

journal_title：Chemotherapy

authors： Solans C,Bregante MA,Garcia MA,Perez S

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:To compare incidences of hypersensitivity reaction (HSR) between original and generic taxanes including paclitaxel and docetaxel. METHODS:We conducted a prospective study enrolling all patients receiving taxanes at King Chulalongkorn Memorial Hospital. Taxanes were infused accordingly to the step-wise rate esc...

journal_title：Chemotherapy

authors： Ratanajarusiri T,Sriuranpong V,Sitthideatphaiboon P,Poovoravan N,Vinayanuwat C,Parinyanitikul N,Angspatt P,Thawinwisan W,Tanasanvimon S

更新日期：2017-01-01 00:00:00

abstract：:We established a method for determining the KD value as a measure of the bilirubin-displacing effect for drugs by using bilirubin oxidase, which is produced by Myrothecium verrucaria MT-1. This method makes it possible to conduct measurements of many beta-lactam antibiotics, including those which could not be determin...

journal_title：Chemotherapy

authors： Matsuura A,Nagayama T,Kitagawa T

更新日期：1988-01-01 00:00:00

abstract：:Viscum album (VA) preparations consist of aqueous extracts of V. album, the European mistletoe. VA extracts contain mistletoe lectins, which are members of the ribosome-inactivating protein type II family. VA preparations have cytotoxic and immunomodulatory properties. Cytotoxicity induced by VA extracts may differ gr...

journal_title：Chemotherapy

authors： Duong Van Huyen JP,Delignat S,Kazatchkine MD,Kaveri SV

更新日期：2003-12-01 00:00:00

abstract：:The activity of aztreonam (a beta-lactam antibiotic with specific activity against gram-negative bacteria) was evaluated and compared with that of tobramycin in hospitalized patients with severe intra-abdominal infections due to gram-negative pathogens, either alone or in association with other bacteria. Of a total st...

journal_title：Chemotherapy

authors： Birolini D,Moraes MF,de Souza OS

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:T790M is a major cause of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance, but the clinical significance of T790M disappearance is unknown. CASE REPORT:We report 3 cases of pulmonary adenocarcinoma which did not respond to EGFR-TKI retreatment even with T790M disappearance...

journal_title：Chemotherapy

authors： Kodama T,Watanabe K,Shinkai M,Kaneko T

更新日期：2018-01-01 00:00:00

abstract：:Aztreonam is the first monobactam antibiotic to be used clinically. It is highly resistant to beta-lactamases, and although its activity spectrum is similar to that of the aminoglycoside antibiotics, it has no effect on gram-positive bacteria. The current study was undertaken to determine the efficacy of aztreonam in ...

journal_title：Chemotherapy

authors： Schönwald S,Schoss-Vidensek Z,Car V,Krznar B

更新日期：1989-01-01 00:00:00

abstract：:The minimum inhibitory concentration (MIC) of the new penem ALP 201 was tested against 243 recent clinical isolates of which 95 were from the family Enterobacteriaceae, 50 were from the genus Streptococcus, 50 were Staphylococcus aureus and 48 were Staphylococcus epidermidis. An agar dilution technique was used to det...

journal_title：Chemotherapy

authors： Bergan T,da Fonseca J

更新日期：1991-01-01 00:00:00

abstract：:The in vitro activities of quinupristin/dalfopristin (Synercid), ampicillin, erythromycin, clarithromycin, vancomycin, teicoplanin, ciprofloxacin and tetracycline were examined and compared against 526 gram-positive bacteria. The minimal inhibitory concentrations (MICs) for quinupristin/dalfopristin against Staphyloco...

journal_title：Chemotherapy

authors： Ling TK,Fung KS,Cheng AF

更新日期：2001-07-01 00:00:00

abstract：:The effects of cis-[Pt(NH3)2Cl2] on the spontaneous cell-mediated cytotoxicity of human lymphoblast cell lines mediated by normal human peripheral blood lymphocytes was investigated. Direct addition of cis-[Pt(NH3)2Cl2], but not its tumor inactive trans isomer, to the in vitro spontaneous cytotoxicity assay resulted i...

journal_title：Chemotherapy

authors： Mally MB,Taylor RC,Callewaert DM

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Dosage recommendations for antibiotics in patients receiving continuous veno-venous hemofiltration (CVVH) should be based on pharmacodynamic requirements. For meropenem, this would be achieving appropriate time above the minimum inhibitory concentration (T > MIC). We employed Monte Carlo simulation to calcul...

journal_title：Chemotherapy

authors： Kuti JL,Nicolau DP

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Cisplatin (CDDP) is known to cause inner ear damage while carboplatin (CBDCA) induces less ototoxicity than CDDP. We examined apoptotic changes in the cochlea of guinea pigs after injection of CDDP or CBDCA using immunohistochemical and electrophysiological techniques. METHODS:Three days after the injection...

journal_title：Chemotherapy

authors： Watanabe KC,Jinnouchi K,Hess A,Michel O,Baba S,Yagi T

更新日期：2002-05-01 00:00:00

abstract：:The elimination of para-aminosalicylic acid (PAS) after the intravenous injection of 20 mg PAS sodium/kg was estimated in patients with liver disease, in uremic patients and in volunteers without damage of the liver or kidneys. The drug was estimated with a colorimetric and fluorometric method. In the volunteers, the ...

journal_title：Chemotherapy

authors： Held H,Fried F

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndrome (MDS) is an iron overload condition. Copper deficiency itself might induce dysplastic changes and iron overload. The relationship between the iron and copper metabolism is analyzed in MDS patients. METHODS:Copper, iron and ceruloplasmin levels were established, and transferrin satur...

journal_title：Chemotherapy

authors： Várkonyi J,Szabó T,Sebestyén P,Tordai A,Andrikovics H,Kollai G,Karádi I

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:This study was designed to examine the efficacy and compliance of S-1 for the patients with peritoneal metastasis of gastric cancer. METHODS:Sixteen consecutive patients with peritoneal metastasis of gastric cancer were treated with S-1. Their survival was compared with that of the historical control group ...

journal_title：Chemotherapy

authors： Ishizone S,Maruta F,Saito H,Koide N,Sugiyama A,Nakayama J,Miyagawa S

更新日期：2006-01-01 00:00:00

abstract：AIMS:This study aimed to evaluate the different abilities of various Phellinus igniarius strains inhibiting quorum sensing (QS), to search for novel QS inhibitors from them and to analyze their inhibitory activity, with a view to their possible use in controlling infections. METHODS:The bioactive metabolites produced ...

journal_title：Chemotherapy

authors： Zhu H,Liu W,Wang SX,Tian BZ,Zhang SS

更新日期：2012-01-01 00:00:00

abstract：:Thirteen quinolone antibacterial agents were investigated as to their ability to inhibit Micrococcus luteus DNA gyrase and cell growth, and compared to those of novobiocin and coumermycin. Among the quinolones tested, the most active were found to be CI-934 and ciprofloxacin, which inhibited gyrase full supercoiling a...

journal_title：Chemotherapy

authors： Fu KP,Grace ME,McCloud SJ,Gregory FJ,Hung PP

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:A single-institution phase I trial to determine the feasibility of using filgrastim or pegfilgrastim to increase the dose intensity of biweekly docetaxel and gemcitabine. METHODS:Patients with metastatic solid tumors received gemcitabine 3,000 mg/m(2) and increasing doses of docetaxel (55 mg/m(2) in 10...

journal_title：Chemotherapy

authors： Dragnev KH,Hardin SB,Pipas JM,Davis TH,Rigas JR

更新日期：2010-01-01 00:00:00

abstract：:An agar dilution technique was used to determine the MIC of pristinamycin for 124 clinical isolates of methicillin-resistant Staphylococcus aureus. All were inhibited by less than or equal to 0.5 mg/1, quite similar to the sensitivity of a number of methicillin-sensitive strains. MICs obtained using a microdilution me...

journal_title：Chemotherapy

authors： Mutton KJ,Andrew JH

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Some new quinolones (NQs) modulate polymorphonuclear leukocyte (PMN) functions. We investigated these effects on PMN functions at concentrations <10 microg/ml. METHODS:Chemotactic activity and the production of reactive oxygen species (ROS) were measured using a 48-well chemotaxis chamber and by luminol-dep...

journal_title：Chemotherapy

authors： Koshio O,Ono Y

更新日期：2009-01-01 00:00:00

abstract：:Five aminoglycoside antibiotics (AGAs)--kanamycin (KM), bekamycin (AKM), dibekacin (DKB), ribostamycin (RSM) and paromomycin (PRM)--were studied for their effects on the nonenzymic reduction of cytochrome c by FeSO4 (Yamabe's system). Their inhibitory activity was in the order: DKB greater than AKM greater than KM gre...

journal_title：Chemotherapy

authors： Yamabe S

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells. We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ova...

journal_title：Chemotherapy

authors： Yamagami W,Banno K,Kawaguchi M,Yanokura M,Kuwabara Y,Hirao N,Susumu N,Tsukazaki K,Aoki D

更新日期：2007-01-01 00:00:00