Abstract:
BACKGROUND:This study was designed to examine the efficacy and compliance of S-1 for the patients with peritoneal metastasis of gastric cancer. METHODS:Sixteen consecutive patients with peritoneal metastasis of gastric cancer were treated with S-1. Their survival was compared with that of the historical control group (25 patients). Thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase and orotate phosphoribosyl transferase mRNA expression in the tumor were evaluated. RESULTS:The median survival time of S-1-treated patients was 550 days, which was significantly longer than that of the historical control group (215 days). We elucidated some factors to prolong the survival of the patients treated with S-1 for peritoneal metastasis: peritoneal metastasis without other distant metastases, the combination of S-1 treatment and gastrectomy, and low expression of thymidine phosphorylase mRNA in primary tumors. CONCLUSIONS:S-1 showed a surprisingly long-term survival with minimum toxicity in patients with peritoneal metastasis of gastric cancer.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Ishizone S,Maruta F,Saito H,Koide N,Sugiyama A,Nakayama J,Miyagawa Sdoi
10.1159/000096002subject
Has Abstractpub_date
2006-01-01 00:00:00pages
301-7issue
6eissn
0009-3157issn
1421-9794pii
96002journal_volume
52pub_type
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