Abstract:
BACKGROUND/AIM:A phase 3 trial of S-1, leucovorin (LV), and oxaliplatin for treating gastric cancer is now underway. However, the antitumor efficacy of the combination has not yet been examined in an in vivo preclinical study. This study examined the antitumor efficacy of combination therapy consisting of S-1, LV, and oxaliplatin against 4 human gastric cancer xenografts: NUGC-4, St-40, SC-2, and SC-4. METHODS:The antitumor efficacy was evaluated using human gastric cancer xenograft-bearing nude mice. S-1 and LV were administered orally once daily on days 1-7 at doses of 6.9 and 10 mg/kg, respectively. Oxaliplatin was administered intravenously at a dose of 8.3 mg/kg on day 1. The tumor volume was measured on day 15, and the relative tumor volume (RTV) was calculated. RESULTS:In all 4 xenograft models, S-1 alone and oxaliplatin alone, but not LV alone, had significant antitumor activities (p < 0.001). Combination therapy consisting of S-1 and LV resulted in a significantly smaller RTV than S-1 alone (p < 0.001). Combination therapy consisting of S-1 and oxaliplatin also resulted in a significantly smaller RTV than either S-1 alone (p < 0.001) or oxaliplatin alone (p < 0.001). Furthermore, combination therapy consisting of S-1, LV, and oxaliplatin resulted in the highest antitumor activity in these models (p < 0.001 vs. S-1 + LV; p < 0.001 or p = 0.003 vs. S-1 + oxaliplatin). CONCLUSION:Combination therapy consisting of S-1, LV, and oxaliplatin administered according to a 1-week-on/1-week-off schedule may be useful for the treatment of patients with gastric cancer.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Nagase H,Nakagawa F,Uchida Jdoi
10.1159/000486029subject
Has Abstractpub_date
2018-01-01 00:00:00pages
46-52issue
1eissn
0009-3157issn
1421-9794pii
000486029journal_volume
63pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract:BACKGROUND:Ciprofloxacin is commonly used and considered to be relatively safe in patients with cirrhosis, especially in the treatment of enteric and urinary tract infections. Among the adverse effects of ciprofloxacin, neurologic complications are rare. METHODS/RESULTS:We report a case of hemiballism and altered ment...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000218098
更新日期:2009-01-01 00:00:00
abstract::BMY-28142 was compared in vitro with ceftazidime, cefotaxime and cefoperazone and was found to be more active against Pseudomonas aeruginosa and Staphylococcus aureus. Essentially no effect of increasing inoculum size 100-fold was seen-on MICs with BMY-28142 or ceftazidime; some effect was noted with cefotaxime and ce...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238470
更新日期:1987-01-01 00:00:00
abstract::Contrary to L-lysine, D-lysine showed no inhibitory effect on growth of Ehrlich ascites tumour cell in in vivo studies. The in vitro studies on the growth of cultured Ehrlich ascites tumour cells showed similar results, namely, the growth of tumour cells was inhibited when cultured in 0.02 or 0.03 M L-lysine; while 0....
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238657
更新日期:1989-01-01 00:00:00
abstract::Ofloxacin, like other 4-quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial DNA synthesis, rather than cell wall or protein synthesis. The 4-quinolones are also unusual because even for serious infections they can be given orally. Most unusually transferable...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000238899
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Gallbladder cancer is a common and lethal digestive malignancy which is nonsensitive to routine chemotherapy. Doxorubicin (DOX) is one of the major chemotherapeutic drugs for patients with gallbladder cancer. We tried to evaluate if combined use of somatostatin (SST) and DOX could have synergistic effect in ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000158662
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Helicobacter pylori is one of the most common infections of mankind, with persistent colonization causing significant morbidity and mortality. TREATMENT:First-line therapy, consisting of 7-day treatment with a proton pump inhibitor or ranitidine bismuth citrate, amoxicillin and clarithromycin, with second-l...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000087250
更新日期:2005-08-01 00:00:00
abstract::Enterococcus faecalis plays an important role as a pathogen in polymicrobial infections. We evaluated the efficacy of cefozopran (CZOP) using polymicrobial pyometra rats. Rats were infected with a mixed intrauterine inoculation of E. faecalis plus either Bacteroides fragilis or Prevotella bivia (minimal inhibitory con...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007100
更新日期:1998-03-01 00:00:00
abstract::Phase contrast microscopy, killing curves and turbidimetric growth curves were used in a comparative study of the antibacterial effects of imipenem and meropenem on Haemophilus influenzae. The minimal inhibitory concentrations (MICs) and their ranges of meropenem and imipenem using five beta-lactamase-producing strain...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238830
更新日期:1991-01-01 00:00:00
abstract::Concentrations of latamoxef, cefoperazone and piperacillin, administered intravenously, were measured in serum and sputum of cystic fibrosis patients with recurrent pulmonary infections, chronically colonized with Pseudomonas aeruginosa. Serum pharmacokinetic data were consistent with prior reports. Peak sputum to pea...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238344
更新日期:1985-01-01 00:00:00
abstract::Combination of 9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] and 6-azauridine (AzUrd) is highly active in the selective inhibition of vaccinia virus in chick embryo cell culture. Synergic effect of this combination of compounds was not encountered in HeLa cell culture. Of the 17 analogues related to DHPA studied in th...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237903
更新日期:1980-01-01 00:00:00
abstract::In this study, rational dosing guidelines for amphotericin B-deoxycholate (AmB) are proposed for children. AmB steady-state trough concentrations (C(ss,trough)) and plasma creatinine concentrations (C(creat)) were measured in 83 children (age: 10 months to 18 years) receiving prophylactic AmB therapy (1 mg/kg/day). Ma...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章
doi:10.1159/000100013
更新日期:2007-01-01 00:00:00
abstract::The influence of normal human serum on bactericidal activity of ceftizoxime sodium (CZX) was studied in vitro against Escherichia coli and Staphylococcus aureus. Subminimal inhibitory concentrations of CZX inhibited the growth of bacteria. Normal human serum as a source of complement and low doses of CZX, such as 1/20...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238399
更新日期:1986-01-01 00:00:00
abstract::Serial serum erythropoietin (EPO) levels were measured in 12 adult lung cancer patients during cancer chemotherapy. In major cases, EPO levels increased significantly after chemotherapy while the hemoglobin (Hb) remained at initial levels. EPO fell gradually or rapidly to initial levels after a peak, although the pati...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239014
更新日期:1992-01-01 00:00:00
abstract::The potency of fosfomycin (60 micrograms/ml) to induce bacterial L-forms and protoplasts was studied on two strains of Staphylococcus aureus. On osmotically appropriate agar, L-colonies could be grown and repeatedly transferred to fresh media. The L-forms were sensitive to tetracycline and resistant to penicillin. Pro...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238242
更新日期:1984-01-01 00:00:00
abstract::The effect of deficiency of vitamin A and its supplementation on growth of murine sarcoma 180 was evaluated. The efficacy of cyclophosphamide under depleted and supplemented condition of the vitamin was also scrutinized. Supplemental vitamin A helped to check progression of tumour growth and also increased the effecti...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238497
更新日期:1987-01-01 00:00:00
abstract::The antitumour properties of the drug N-137 were assessed in vivo in two murine T lymphoma models and two naturally metastatic hamster fibrosarcomas of Herpesvirus hominis aetiology. N-137 therapy caused a significant delay in the subcutaneous growth rate of both lymphomas (EL4 and TLX9) and in many cases completely p...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238091
更新日期:1982-01-01 00:00:00
abstract::17,244 pathogens isolated from clinical specimens of 24 hospitals in the Moers area (North-Rhine Westphalia, FRG) were tested in regard to their susceptibility to Augmentin (amoxicillin and clavulanic acid). For this purpose, minimal inhibitory concentrations were determined by use of microbroth dilution technique. 80...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238588
更新日期:1988-01-01 00:00:00
abstract::The influence of orally administered fosfomycin on intestinal disaccharidases in albino rats was studied. The enzymes were evaluated in a homogenate of the intestinal mucosa, using the method of SOLS and DE LA FUENTE which is based on the colored reaction of the glucose that is freed by the disaccharidases from disacc...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222052
更新日期:1977-01-01 00:00:00
abstract::The filamentous forms of a serum resistant Escherichia coli strain developed under in vitro exposure to subminimal inhibitory concentration of the compound LY 127935 showed a higher resistance against host defence than the nontreated control bacteria. Significantly diminished LD50 values and a longer lasting persisten...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238068
更新日期:1982-01-01 00:00:00
abstract::Biliary excretion of cefaclor, a new orally active cephalosporin, was studied in vitro using an isolated rabbit liver preparation perfused for 3 h (n = 5). Under these conditions, bile recovery amounted to 2.3% of the cefaclor dose added to the circulating blood (10 mg). In humans, after oral administration of a 1-gra...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238075
更新日期:1982-01-01 00:00:00
abstract::Five healthy informed male volunteers received oral doses of 820 mg sulfadiazine (SDZ) plus 180 mg trimethoprim (TMP) (co-trimazine) every 24 h. Concentrations in serum, peripheral lymph from the leg and urine were determined after the first dose, and on the 4th day to reflect approximate steady-state conditions. TMP ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238418
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Recurrent tumor growth of colorectal carcinoma at the peritoneal site remains an unsolved problem. The aim of this study was to investigate whether the substance taxol (paclitaxel) can alter intraperitoneal tumor spread using different modes of drug application. METHODS:Intraperitoneal tumor growth was indu...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000110005
更新日期:2007-01-01 00:00:00
abstract::Fifty-two children (mean age 23 months) with acute otitis media were treated randomly with either a single intramuscular dose of ceftriaxone (Rocephin) 50 mg/kg (27 patients) or 7 days of amoxicillin 12.5 mg/kg t.i.d. (25 patients). The rate of resolution of acute symptoms and incidence of recurrences and relapses dur...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000238646
更新日期:1988-01-01 00:00:00
abstract::The pharmacokinetics of flomoxef in serum and in the mucosal tissue of the middle ear and mastoid were studied in 9 patients undergoing tympanoplasties. All patients received 1 g of flomoxef intravenously. Flomoxef levels in serum and in mucosal tissue were determined by a bioassay method. The peak value of mean conce...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238766
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Bloodstream infections are a significant cause of neonatal morbidity and death. An increase in the incidence of early neonatal sepsis due to Escherichia coli has been reported. The objective was to evaluate the antimicrobial resistance of E. coli strains causing early-onset neonatal sepsis (EONS) and late-on...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000337062
更新日期:2012-01-01 00:00:00
abstract::The in vitro susceptibilities of 703 clinical isolates of Salmonella to ciprofloxacin (CIP) and pefloxacin (PEF) were compared with those to trimethoprim-sulfamethoxazole (TMP-SMZ), chloramphenicol (CO) and ampicillin (AP). All isolates were susceptible to CIP, while PEF inhibited 90.7% of the strains. In contrast, re...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238745
更新日期:1990-01-01 00:00:00
abstract::The two studies which are reviewed in this paper demonstrate the value of fluorescent microscopic observations in the studying of the distribution of antibiotics in lung tissue and in sinus secretions. In the lung tissue study, the standard microbiologic assay data on doxycycline concentrations in respiratory tissue t...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221889
更新日期:1975-01-01 00:00:00
abstract::Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is one of the most important chemotherapeutic agents; however, the mechanisms of resistance to this drug are still unknown. Recent reports have demonstrated that chemotherapy can induce apoptosis in some cancer cells, indicating that apoptosis may play a very importan...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007258
更新日期:2000-01-01 00:00:00
abstract::The effect of acyclovir (ACV) treatment on selected functions of human blood-derived macrophages was examined. ACV was not cytotoxic when applied in a wide range of concentrations. Only minor effects on macrophage functions were observed when cells were treated with therapeutic concentrations of ACV:phagocytosis and t...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239126
更新日期:1993-05-01 00:00:00
abstract::Fleroxacin, a new long-acting quinolone, induces rapid killing and bacterial filamentation as do other quinolones. Ten strains of Escherichia coli were exposed comparatively to fleroxacin and ampicillin in order to determine the effect of sub- and supra-inhibitory concentrations of each of these two compounds on turbi...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238706
更新日期:1989-01-01 00:00:00