Abstract:
:We conducted a survey of susceptibility among 758 gram-negative bacilli (GNB; collected from cancer patients over a 3-month period) to commonly used antibiotics. The overall resistance among GNB was least for piperacillin/tazobactam and meropenem (5 and 6%, respectively) followed by cefepime (8%), imipenem (9%), amikacin (12%), ofloxacin (13%), ciprofloxacin, ceftazidime and ticarcillin/clavulanate (14% each), aztreonam (18%) and tobramycin (24%). In comparison to data on antibiotic resistance to ceftazidime, imipenem, ciprofloxacin and aztreonam in similar studies in 1985 and 1994, resistance has significantly increased to all four antibiotic classes. Based on our current study, meropenem, cefepime, imipenem and piperacillin/tazobactam would be the most appropriate choices in our institution for empiric therapy of GNB infections in febrile neutropenic patients.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Jacobson K,Rolston K,Elting L,LeBlanc B,Whimbey E,Ho DHdoi
10.1159/000007223subject
Has Abstractpub_date
1999-09-01 00:00:00pages
325-34issue
5eissn
0009-3157issn
1421-9794pii
7223journal_volume
45pub_type
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