Biliary excretion of tetroxoprim in man.

Abstract:

:The biliary excretion of tetroxoprim (TXP) was studied in 10 patients with T-tube drainage. A mean biliary peak of 32.56 +/- 7.69 micrograms/ml was observed 2-3 h after a single oral dose of 200 mg. The biliary elimination rate constant (kb) of TXP was found to be 0;056 (h-1), indicating a longer elimination from the bile than from the central blood compartment. Taking into account the TXP serum levels, following the same oral dose as reported in the literature, concentration factors of 6-8 can be calculated in the bile.

journal_name

Chemotherapy

journal_title

Chemotherapy

authors

Vergin H,Luber P

doi

10.1159/000238097

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

313-7

issue

5

eissn

0009-3157

issn

1421-9794

journal_volume

28

pub_type

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