Abstract:
:The biliary excretion of tetroxoprim (TXP) was studied in 10 patients with T-tube drainage. A mean biliary peak of 32.56 +/- 7.69 micrograms/ml was observed 2-3 h after a single oral dose of 200 mg. The biliary elimination rate constant (kb) of TXP was found to be 0;056 (h-1), indicating a longer elimination from the bile than from the central blood compartment. Taking into account the TXP serum levels, following the same oral dose as reported in the literature, concentration factors of 6-8 can be calculated in the bile.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Vergin H,Luber Pdoi
10.1159/000238097subject
Has Abstractpub_date
1982-01-01 00:00:00pages
313-7issue
5eissn
0009-3157issn
1421-9794journal_volume
28pub_type
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