Ceftazidime: in vitro comparison with cephalothin, cefuroxime, and netilmicin. A Norwegian study.

abstract：:A new semisynthetic ureidopenicillin (Bay K 4999) demonstrates favorably in vitro antibacterial efficacy against human-pathogenic gram-negative rods in comparison to mezlocillin and azlocillin. A comparative paramcokinetic study was done with 10 test subjects after 30 min intravenous infusion of 4.0 g of Bay K and mez...

journal_title：Chemotherapy

authors： Lode H,Tomas W,Koeppe P,Wagner J

更新日期：1980-01-01 00:00:00

abstract：:Concentrations of latamoxef, cefoperazone and piperacillin, administered intravenously, were measured in serum and sputum of cystic fibrosis patients with recurrent pulmonary infections, chronically colonized with Pseudomonas aeruginosa. Serum pharmacokinetic data were consistent with prior reports. Peak sputum to pea...

journal_title：Chemotherapy

authors： Laferriere C,Stutman HR,Marks MI,Kramer J,Flux M

更新日期：1985-01-01 00:00:00

abstract：:Antimicrobial agents may interact with polymorphonuclear leukocytes and directly modify the leukocyte functions, or bacteria can be modified by the antimicrobial agents causing them to be treated differently by phagocytic cells. Brief exposure of bacteria to high levels of antimicrobials can affect their interaction w...

journal_title：Chemotherapy

authors： Pérez P,Herrera I,Martín M,Martínez P,Gómez-Lus ML

更新日期：1994-03-01 00:00:00

abstract：:Minimal bactericidal concentrations of trimethoprim, nalidixic acid, and nitrofurantoin revealed effective intraphagolysosomal bactericidal activity against several assay strains of Serratia marcescens as determined with phenylbutazone-treated (2 mg/ml) fresh defibrinated human blood (55 vol%), following killing of ex...

journal_title：Chemotherapy

authors： Traub WH

更新日期：1982-01-01 00:00:00

abstract：:The effect of low concentrations of various antimicrobial agents on the adherence of mucoid Staphylococcus epidermidis to intraocular lenses was investigated. Adherent growth of S. epidermidis on to polymethylmethacrylate lenses was greatly diminished by ciprofloxacin and clindamycin (>75%), followed by ceftazidime ( ...

journal_title：Chemotherapy

authors： Kadry AA,Tawfik A,Abu El-Asrar AA,Shibl AM

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The combination of transarterial chemoembolization (TACE) and apatinib has been used in the treatment of intermediate or advanced hepatocellular carcinoma (HCC). However, its effectiveness and safety are also argued. METHODS:Eligible studies were collected from a computer search of literatures published fro...

journal_title：Chemotherapy

authors： Wei Y,Liu J,Yan M,Zhao S,Long Y,Zhang W

更新日期：2019-01-01 00:00:00

abstract：:We tested 42 strains of amikacin-resistant gram-negative bacilli with amikacin in combination with six beta-lactam antibiotics using the checkerboard and time-kill curve techniques. Synergism was demonstrated with time-killing curve in 43-68% of the strains tested. Ceftazidime plus amikacin was the most active combina...

journal_title：Chemotherapy

authors： Alvarez S,Jones M,Holtsclaw-Berk S,Berk SL

更新日期：1988-01-01 00:00:00

abstract：:The susceptibility of 26 strains of Campylobacter pylori to 7 new quinolone antibiotics and nalidixic acid was determined. All strains were resistant to nalidixic acid. Difloxacin, A-56620, A-62254, and ciprofloxacin were equally effective against the test strains with MICs ranging from 0.06 to 2.0 micrograms/ml. Fler...

journal_title：Chemotherapy

authors： Hupertz V,Carr H,Czinn SJ

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Transplant-related mortality (TRM) significantly decreases the long-term survival of patients with hematopoietic diseases who undergo hematopoietic stem cell transplantation (HSCT). METHODS:We retrospectively evaluated the risk factors for TRM of 58 consecutive patients with hematopoietic disease who underw...

journal_title：Chemotherapy

authors： Nakamae H,Yamane T,Aoyama Y,Yamamura R,Ohta K,Hino M

更新日期：2004-10-01 00:00:00

abstract：:20 patients with serious infections were treated with cefazolin and tobramycin for 9--64 days. Minimal inhibitory concentration (MIC) values and minimal bactericidal concentration (MBC) values were determined for each of the 112 clinical bacterial isolates. The median cefazolin MIC/MBC was 1.56/12.5 micrograms/ml, and...

journal_title：Chemotherapy

authors： Franson TR,Edwards LD,Collins RF,Root TE

更新日期：1980-01-01 00:00:00

abstract：:We conducted a retrospective clinical evaluation to assess the efficacy of a 1-gram once-daily regimen of intravenously administered ceftriaxone in the treatment of a variety of bacterial infections. Of the 250 patients studied, 167 had infections of the lower respiratory tract, approximately 70% of which were diagnos...

journal_title：Chemotherapy

authors： Brown R

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Recurrent tumor growth of colorectal carcinoma at the peritoneal site remains an unsolved problem. The aim of this study was to investigate whether the substance taxol (paclitaxel) can alter intraperitoneal tumor spread using different modes of drug application. METHODS:Intraperitoneal tumor growth was indu...

journal_title：Chemotherapy

authors： Hribaschek A,Meyer F,Schneider-Stock R,Pross M,Ridwelski K,Lippert H

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:There is no standard consensus on a strategy in the second-line setting for gemcitabine-refractory advanced pancreatic cancer. This study evaluated the activity and tolerability of oxaliplatin, irinotecan, 5-fluorouracil and leucovorin (FOLFIRINOX) as a second-line therapy in advanced pancreatic adenoca...

journal_title：Chemotherapy

authors： Lee MG,Lee SH,Lee SJ,Lee YS,Hwang JH,Ryu JK,Kim YT,Kim DU,Woo SM

更新日期：2013-01-01 00:00:00

abstract：:Using the biophotometer with ticarcillin no persistent bactericidal effect was found against Pseudomonas aeruginosa NCTC 10490. After addition of 1.2 microgram/ml gentamicin an increase of multiplication of bacteria was observed, but not after 1.2 microgram/ml tobramycin. With 6.2 microgram/ml tobramycin bactericidal ...

journal_title：Chemotherapy

authors： Ullmann U

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:To define the maximum tolerated dose (MTD) tolerability and efficacy of intra-arterial chemotherapy with irinotecan in patients with liver metastases of colorectal carcinoma (CRC). METHODS:Superselective intra-arterial irinotecan was applied on days 1, 14, 28 and 42. The initial dose was 140 mg/m² with esca...

journal_title：Chemotherapy

authors： Eichler K,Dufas T,Hammerstingl R,Gruber-Rouh T,Vogl TJ,Zangos S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndrome (MDS) is an iron overload condition. Copper deficiency itself might induce dysplastic changes and iron overload. The relationship between the iron and copper metabolism is analyzed in MDS patients. METHODS:Copper, iron and ceruloplasmin levels were established, and transferrin satur...

journal_title：Chemotherapy

authors： Várkonyi J,Szabó T,Sebestyén P,Tordai A,Andrikovics H,Kollai G,Karádi I

更新日期：2006-01-01 00:00:00

abstract：:Bacterial growth kinetic experiments have been performed to study the potentiating effect of trimethoprim (TMP) AND TMP derivatives on the antibacterial action of sulfonamides (SA). The TMP derivatives showed different inhibitory effects when used alone. Derivatives with decreased inhibitory activity excerted 'bacteri...

journal_title：Chemotherapy

authors： Seydel JK,Wempe E

更新日期：1980-01-01 00:00:00

abstract：:In children undergoing anticancer chemotherapy, a granulocytopenic febrile episode is a life-threatening condition. Prompt initiation of empirical broad-spectrum antibiotics is essential to limit morbidity and mortality. To evaluate the cost-effectiveness of combination antibiotics consisting of a third generation cep...

journal_title：Chemotherapy

authors： Pession A,Prete A,Paolucci G

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Kaposi's sarcoma (KS) is the most common neoplastic apoptosis manifestation of acquired immunodeficiency syndrome. Toremifene is known to upregulate transforming growth factor beta-1 (TGF-beta1), which is a growth-inhibitory factor for KS. We investigated the in vitro effect of toremifene on KS cells. METHO...

journal_title：Chemotherapy

authors： Hong A,Leigh BR

更新日期：2002-12-01 00:00:00

abstract：:Ninety-three representative, recent clinical isolates of Streptococcus pneumoniae were examined for susceptibility to 9 antimicrobial drugs utilizing Mueller-Hinton agar (MHA) enriched with sheep blood and a hypercapnic atmosphere of incubation. One isolate was resistant to penicillin G (minimum inhibitory concentrati...

journal_title：Chemotherapy

authors： Traub WH,Leonhard B

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:We investigated the presence of Helicobacter pylori in laryngeal cancer specimens to reveal whether or not this is a risk factor in the development of squamous cell carcinoma of the larynx. METHODS:Sixty-nine total laryngectomy specimens with the pathologic diagnosis of squamous cell carcinoma and 30 larynge...

journal_title：Chemotherapy

authors： Kizilay A,Saydam L,Aydin A,Kalcioglu MT,Ozturan O,Aydin NE

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Gram-negative bacilli are the most common bacteria causing nosocomial bloodstream infections (NBSIs) in Latin American countries. METHODS:The antibiotic resistance profiles of Gram-negative bacilli isolated from blood cultures in pediatric patients with NBSIs over a 3-year period in a tertiary care pediatri...

journal_title：Chemotherapy

authors： Ares MÁ,Alcántar-Curiel MD,Jiménez-Galicia C,Rios-Sarabia N,Pacheco S,De la Cruz MÁ

更新日期：2013-01-01 00:00:00

abstract：:The pharmacokinetics of ceftriaxone (CRO) after subcutaneous and intravenous administration was studied in 10 healthy volunteers (5 males, 5 females, age 22-43 years, body weight 64.3 +/- 9.5 kg). Each of them received 2.0 g CRO i.v., and then 0.5 g i.v. and 0.5 g CRO s.c. in a randomized cross-over design. Subcutaneo...

journal_title：Chemotherapy

authors： Borner K,Lode H,Hampel B,Pfeuffer M,Koeppe P

更新日期：1985-01-01 00:00:00

abstract：:Twenty Pseudomonas maltophilia isolates were examined for susceptibility to beta-lactam antibiotics, including carbapenems, and for beta-lactamase production. All the isolates were resistant to imipenem (MICs 64-512 mg/l) and to a lesser extent, to meropenem (MICs 16-256 mg/l). None of the isolates produced significan...

journal_title：Chemotherapy

authors： Cullmann W,Dick W

更新日期：1990-01-01 00:00:00

abstract：:A total of 1,442 patients with symptoms of chronic prostatitis were examined over a 4-year period at the Outpatient Department for Urogenital Infections, University Hospital for Infectious Diseases Dr. Fran Mihaljević, Zagreb, Croatia. The inclusion criteria for chronic prostatitis caused by Ureaplasma urealyticum wer...

journal_title：Chemotherapy

authors： Skerk V,Mareković I,Markovinović L,Begovac J,Skerk V,Barsić N,Majdak-Gluhinić V

更新日期：2006-01-01 00:00:00

abstract：:Combination of 9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] and 6-azauridine (AzUrd) is highly active in the selective inhibition of vaccinia virus in chick embryo cell culture. Synergic effect of this combination of compounds was not encountered in HeLa cell culture. Of the 17 analogues related to DHPA studied in th...

journal_title：Chemotherapy

authors： Rada B,Holý A

更新日期：1980-01-01 00:00:00

abstract：:The introduction of highly active antiretroviral therapy (HAART) has significantly modified the course of human immunodeficiency virus (HIV) disease, with longer survival and improved quality of life of HIV-infected subjects. However, HAART regimens, especially those including protease inhibitors, have been shown to c...

journal_title：Chemotherapy

authors： Barbaro G,Barbarini G

更新日期：2006-01-01 00:00:00

abstract：:Two gonococcal strains with differing susceptibility to cefotiam and ceftizoxime, as expressed by the minimum inhibitory concentration (MIC), are exposed to continuously changing concentrations of these antibiotics as they are found in plasma and skin cantharidal blister fluid (CBF) after a single intramuscular applic...

journal_title：Chemotherapy

authors： Korting HC,Niederauer H,Ollert M

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Nevirapine (NVP) is a nonnucleoside reverse transcriptase inhibitor used in HIV patients and recently evaluated as a differentiating and antiproliferative agent in human malignancies. However, while NVP is a safe treatment in immunocompromised patients, NVP-containing regimens have been associated with sever...

journal_title：Chemotherapy

authors： Landriscina M,Fabiano A,Lombardi V,Santodirocco M,Piscazzi A,Fersini A,De Vis K,Barone C,Cignarelli M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Fungal infections are common and life threatening among immunosupressive patients. Rare side effects may occur related to the use of voriconazole, which is the drug of choice in invasive aspergillosis. PATIENTS AND METHODS:Neuropathy was determined through clinical and electromyographic findings during the ...

journal_title：Chemotherapy

authors： Aksoy F,Akdogan E,Aydin K,Yilmaz M,Altunayoglu V,Sozen EE,Omay SB,Koksal I

更新日期：2008-01-01 00:00:00