Antibiotic resistance of gram-negative bacilli isolated from pediatric patients with nosocomial bloodstream infections in a Mexican tertiary care hospital.

abstract：OBJECTIVE:We investigated the presence of Helicobacter pylori in laryngeal cancer specimens to reveal whether or not this is a risk factor in the development of squamous cell carcinoma of the larynx. METHODS:Sixty-nine total laryngectomy specimens with the pathologic diagnosis of squamous cell carcinoma and 30 larynge...

journal_title：Chemotherapy

authors： Kizilay A,Saydam L,Aydin A,Kalcioglu MT,Ozturan O,Aydin NE

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:This phase II study was conducted to evaluate the efficacy and safety of the chemotherapy combination of gemcitabine and vinorelbine in taxane-pretreated Japanese metastatic breast cancer patients. METHODS:In this multicenter, phase II, single-arm study, patients with recurrent or metastatic HER2-negative b...

journal_title：Chemotherapy

authors： Yamamura J,Masuda N,Yamamoto D,Tsuyuki S,Yamaguchi M,Tanaka S,Tsurutani J,Tokunaga S,Yoshidome K,Mizutani M,Aono T,Ooe A,Tanino H,Matsunami N,Yasojima H,Nakayama T,Nishida Y

更新日期：2017-01-01 00:00:00

abstract：:Before appendectomy 36 adult patients were given an intravenous infusion of 500 mg of tinidazole. In the operation tissue samples were taken (blood, base of appendix vermiformis, muscle, fat) either 10, 20, 30, 60, or 120 min after cessation of infusion. The tinidazole concentrations were determined by liquid chromato...

journal_title：Chemotherapy

authors： Viitanen J,Auvinen O,Tunturi T

更新日期：1983-01-01 00:00:00

abstract：:Ofloxacin, like other 4-quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial DNA synthesis, rather than cell wall or protein synthesis. The 4-quinolones are also unusual because even for serious infections they can be given orally. Most unusually transferable...

journal_title：Chemotherapy

authors： Smith JT

更新日期：1991-01-01 00:00:00

abstract：:The cellular/extracellular (C/E) concentration ratio of teicoplanin in polymorphonuclear leukocytes (PMNs) increased rapidly with time (C/E 60 +/- 13 at 20 min). The C/E ratio was time- and concentration-dependent. At 20 min and an initial concentration of 75 +/- 16 micrograms/ml the cellular drug concentration was 4,...

journal_title：Chemotherapy

authors： Maderazo EG,Breaux SP,Woronick CL,Quintiliani R,Nightingale CH

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Dysfunction of the carnitine system in non-tumour tissue following anticancer therapy has been reported. In this setting, supplementation with carnitine derivatives might increase the general metabolic activity of normal cells so that they might better withstand the adverse effects of chemotherapy aimed at t...

journal_title：Chemotherapy

authors： Niang M,Soukup T,Zivný P,Tomšík P,Bukač J,Rezáčová M,Stoklasová A,Cerman J,Sišpera L

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The glomerular filtration rate (GFR) is essential for calculating the dose and the monitoring of carboplatin. Although GFR measurement (mGFR) by external markers is ideal, in most cases these are not employed; the most used method is GFR estimation (eGFR) by formulae, hence the need to identify the formula w...

journal_title：Chemotherapy

authors： Graciano Vera N,Pino Villarreal L,Ureña Vargas J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndrome (MDS) is an iron overload condition. Copper deficiency itself might induce dysplastic changes and iron overload. The relationship between the iron and copper metabolism is analyzed in MDS patients. METHODS:Copper, iron and ceruloplasmin levels were established, and transferrin satur...

journal_title：Chemotherapy

authors： Várkonyi J,Szabó T,Sebestyén P,Tordai A,Andrikovics H,Kollai G,Karádi I

更新日期：2006-01-01 00:00:00

abstract：:In a randomized study 87 patients received perioperative antibiotic prophylaxis with 2 x 2 g ceftriaxone (Rocephin) at the beginning of the operation and in the following morning. Seventy-two patients received no antibiotic prophylaxis. In patients receiving the prophylaxis, a lower incidence of infections was observe...

journal_title：Chemotherapy

authors： Winkler D,Rehn H,Freckmann N,Nowak G,Herrmann HD

更新日期：1989-01-01 00:00:00

abstract：:Uptake of the bifunctional alkylating agent, PTT.119, p-F-Phe-m-bis-(2-chloroethyl)amino-L-Phe-Met-ethoxy-HCl, by the MJY-alpha mammary tumor and B16 melanoma cell lines occurred via two natural pathways for amino acid transport. The primary route of PTT.119 entry was the classical L System, whereas, the ASC System ca...

journal_title：Chemotherapy

authors： Yagi MJ,Scanlon KJ,Chin SE,Bekesi JG

更新日期：1988-01-01 00:00:00

abstract：:The in vitro activity of ceftazidime has been compared with those of cephalothin, cefuroxime, and netilmicin against a variety of gram-positive and gram-negative bacteria in order to register sensitivity patterns in the western part of Norway. An agar dilution method was used for minimal inhibitory concentration (MIC)...

journal_title：Chemotherapy

authors： Digranes A,Dibb WL,Benonisen E

更新日期：1984-01-01 00:00:00

abstract：:The elimination of para-aminosalicylic acid (PAS) after the intravenous injection of 20 mg PAS sodium/kg was estimated in patients with liver disease, in uremic patients and in volunteers without damage of the liver or kidneys. The drug was estimated with a colorimetric and fluorometric method. In the volunteers, the ...

journal_title：Chemotherapy

authors： Held H,Fried F

更新日期：1977-01-01 00:00:00

abstract：:Rifampicin (RMP) and two riminophenazine compounds (B663 and B1912) suppressed the growth of Mycobacterium marinum in vitro and in a mouse footpad infection. At appropriate concentrations and dietary dosage, all three drugs showed bactericidal activity in vitro and in vivo. On the basis of minimum inhibitory concentra...

journal_title：Chemotherapy

authors： Banerjee DK,Holmes IB

更新日期：1976-01-01 00:00:00

abstract：:In this study, rational dosing guidelines for amphotericin B-deoxycholate (AmB) are proposed for children. AmB steady-state trough concentrations (C(ss,trough)) and plasma creatinine concentrations (C(creat)) were measured in 83 children (age: 10 months to 18 years) receiving prophylactic AmB therapy (1 mg/kg/day). Ma...

journal_title：Chemotherapy

authors： Nath CE,McLachlan AJ,Shaw PJ,Coakley JC,Earl JW

更新日期：2007-01-01 00:00:00

abstract：:Two gonococcal strains with differing susceptibility to cefotiam and ceftizoxime, as expressed by the minimum inhibitory concentration (MIC), are exposed to continuously changing concentrations of these antibiotics as they are found in plasma and skin cantharidal blister fluid (CBF) after a single intramuscular applic...

journal_title：Chemotherapy

authors： Korting HC,Niederauer H,Ollert M

更新日期：1986-01-01 00:00:00

abstract：:The efficacy of ofloxacin for the treatment of lower respiratory tract infection was evaluated in aged patients with chronic lung disease. Results are the following: improvement of leukocytosis and arterial oxygen tension was observed; peripheral blood cell analysis showed a decrease in natural killer cell counts and ...

journal_title：Chemotherapy

authors： Yamaoka M,Fukuchi Y,Yokouchi M,Teramoto N,Nagase T,Ishida K,Ohtomo E,Orimo H

更新日期：1991-01-01 00:00:00

abstract：:Hydrocortisone (HC) has been observed to influence an in vitro Dexter culture system with maintenance of pluripotent hematopoietic stem cells (CFU-s) and progenitor cells (CFU-gm, BFU-e). In the present study, a two-phase murine Dexter culture system was established to study the mechanism of HC-mediated suppression of...

journal_title：Chemotherapy

authors： Horikoshi A,Murphy MJ Jr

更新日期：1985-01-01 00:00:00

abstract：:Our previous studies demonstrated the efficacy of cationic liposome-encapsulated doxycycline (CaL-DOX) on the course of infection with Chlamydia trachomatis in vitro and in vivo. In this investigation, the pharmacokinetics of CaL-DOX are reported. Female mice inoculated intravaginally with 4.84 x 10(5) inclusion-formi...

journal_title：Chemotherapy

authors： Selliah S,Ravaoarinoro M

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Recently, multiple-line chemotherapy has become popular for non-small cell lung cancer (NSCLC). The survival time of patients is influenced by patient characteristics and subsequent treatments. METHODS:The usefulness of paclitaxel plus S1 (PTX+S1) was evaluated in 46 pretreated NSCLC patients. Time from the...

journal_title：Chemotherapy

authors： Aono N,Ito Y,Nishino K,Uchida J,Kumagai T,Akazawa Y,Okuyama T,Yoshinami T,Imamura F

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Gallbladder cancer is a common and lethal digestive malignancy which is nonsensitive to routine chemotherapy. Doxorubicin (DOX) is one of the major chemotherapeutic drugs for patients with gallbladder cancer. We tried to evaluate if combined use of somatostatin (SST) and DOX could have synergistic effect in ...

journal_title：Chemotherapy

authors： Quan ZW,Yue JN,Li JY,Qin YY,Guo RS,Li SG

更新日期：2008-01-01 00:00:00

abstract：:Treatment of enterococcal infections is often difficult because of intrinsic and acquired resistance to a variety of antimicrobial agents. Between January 1993 and May 1997, enterococci were isolated from blood cultures of 117 patients at the Institute of Medical Microbiology and Immunology, University Hospital Eppend...

journal_title：Chemotherapy

authors： Elsner HA,Sobottka I,Feucht HH,Claussen M,Kaulfers PM,Laufs R,Mack D

更新日期：2000-03-01 00:00:00

abstract：:Oxygen radical generation by blood cells before and after chemotherapy was investigated in 16 elderly (72.8 +/- 1.0 years) and 14 adult (45.0 +/- 2.4 years) patients with lung cancer, using a lucigenin-dependent chemiluminescence method. The oxygen radical generation by 100 microliters of blood before chemotherapy in ...

journal_title：Chemotherapy

authors： Teramoto S,Fukuchi Y,Shu CY,Orimo H

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:T790M is a major cause of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance, but the clinical significance of T790M disappearance is unknown. CASE REPORT:We report 3 cases of pulmonary adenocarcinoma which did not respond to EGFR-TKI retreatment even with T790M disappearance...

journal_title：Chemotherapy

authors： Kodama T,Watanabe K,Shinkai M,Kaneko T

更新日期：2018-01-01 00:00:00

abstract：:The choice of antimicrobial therapy for the treatment of bacteremia is often empirical and based on the knowledge of susceptibility profiles of the most common bacteria. We analyzed blood culture isolates from a teaching hospital for 13 years prospectively. This study examined the susceptibility profiles of 6,616 gram...

journal_title：Chemotherapy

authors： Ling TK,Liu EY,Cheng AF

更新日期：2001-01-01 00:00:00

abstract：:The pharmacokinetics of ceftriaxone (CRO) after subcutaneous and intravenous administration was studied in 10 healthy volunteers (5 males, 5 females, age 22-43 years, body weight 64.3 +/- 9.5 kg). Each of them received 2.0 g CRO i.v., and then 0.5 g i.v. and 0.5 g CRO s.c. in a randomized cross-over design. Subcutaneo...

journal_title：Chemotherapy

authors： Borner K,Lode H,Hampel B,Pfeuffer M,Koeppe P

更新日期：1985-01-01 00:00:00

abstract：:There is evidence that a variety of anticancer drugs exert their cytotoxic activity by a free-radical-mediated mechanism. These drugs include anthracyclines such as adriamycin, daunorubicin, 4-epi-adriblastin as well as bleomycin, procarbazine, vincristin, cyclophosphamide, etoposide and mitomycin C. The aim of this s...

journal_title：Chemotherapy

authors： Look MP,Musch E

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND/AIMS:There is no standard consensus on a strategy in the second-line setting for gemcitabine-refractory advanced pancreatic cancer. This study evaluated the activity and tolerability of oxaliplatin, irinotecan, 5-fluorouracil and leucovorin (FOLFIRINOX) as a second-line therapy in advanced pancreatic adenoca...

journal_title：Chemotherapy

authors： Lee MG,Lee SH,Lee SJ,Lee YS,Hwang JH,Ryu JK,Kim YT,Kim DU,Woo SM

更新日期：2013-01-01 00:00:00

abstract：:The frustration and disappointment in managing advanced cancers of the nose and paranasal sinuses are well known. We report a case of a successful treatment of such a tumour in a 37-year-old soldier, using a combination of therapy including surgery, chemotherapy and radiation. Each mode of treatment is discussed. ...

journal_title：Chemotherapy

authors： Chandrasekaran S,Baba AA,Othman N,Jayakumar CR

更新日期：1994-09-01 00:00:00

abstract：:The effect of three nucleoside analogs, including 2-methyl-2'-deoxyadenosine (MDA), 5-amino-2'-deoxyuridine (ADU) and 2',3'-dideoxycytidine (DDC) on colony formation from unfractionated human bone marrow obtained from volunteers expressing parameters typical for normal cells (NBM) and from patients with the diagnosis ...

journal_title：Chemotherapy

authors： Cinatl J Jr,Cinatl J,Gussetis ES,Nemeth U,Mainke M,Kornhuber B,Brendel M,Doerr HW

更新日期：1991-01-01 00:00:00

abstract：:We report here the antibacterial activity of the new penem antibiotic Men 10700 against a total of 740 gram-positive and gram-negative clinical isolates, in comparison to imipenem, meropenem, cefotaxime, ceftriaxone, ciprofloxacin and gentamicin. Men 10700 has shown a wide spectrum of antibacterial activity, with a po...

journal_title：Chemotherapy

authors： Varotto F,Parravidini E,De Luca M,Casini A,Fraschini F

更新日期：1999-11-01 00:00:00