Abstract:
BACKGROUND:Myelodysplastic syndrome (MDS) is an iron overload condition. Copper deficiency itself might induce dysplastic changes and iron overload. The relationship between the iron and copper metabolism is analyzed in MDS patients. METHODS:Copper, iron and ceruloplasmin levels were established, and transferrin saturation determination and HFE mutation analysis were performed in 32 MDS patients. RESULTS:Eleven of 32 MDS patients were copper deficient. A decreased copper level occurred together with a significantly elevated iron level and transferrin saturation and in 45% HFE gene mutation. In the normal copper group, twice as many patients had a decreased rather than an elevated iron content and carried the wild-type HFE gene rather than the mutant. CONCLUSIONS:Copper deficiency is a frequent finding in MDS. It is desirable to include copper level determination in the initial workup of MDS.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Várkonyi J,Szabó T,Sebestyén P,Tordai A,Andrikovics H,Kollai G,Karádi Idoi
10.1159/000091307subject
Has Abstractpub_date
2006-01-01 00:00:00pages
66-8issue
2eissn
0009-3157issn
1421-9794pii
91307journal_volume
52pub_type
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