The pharmacokinetics of new oral cephalosporins in children.

abstract：:The therapeutic efficacy of oral treatment with levofloxacin, ciprofloxacin, and ampicillin on an experimental pneumonia caused by the penicillin-intermediate Streptococcus pneumoniae for which the minimum inhibitory concentrations (MICs) of the quinolones are similar was assessed in immunocompetent CBA/J mice. Levofl...

journal_title：Chemotherapy

authors： Ishida Y,Kurosaka Y,Murakami Y,Otani T,Yamaguchi K

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Very little is documented in the medical literature on the association between malaria parasitemia and febrile neutropenia in patients undergoing cancer chemotherapy. METHODS:This report will concentrate on the clinical presentation and outcome of 3 patients with haematological malignancies undergoing chemo...

journal_title：Chemotherapy

authors： Rapoport BL,Uys A

更新日期：2008-01-01 00:00:00

abstract：:Combination antiretroviral (ARV) treatment is a potent and effective therapy for human immunodeficiency virus infection. Unfortunately, ARV drugs frequently interact among themselves, as well as with other anti-infectives. These interactions determine positive or negative consequences resulting in recommendations to a...

journal_title：Chemotherapy

authors： Pontali E

更新日期：2007-01-01 00:00:00

abstract：:We have tested the effectiveness of several antibiotic regimens, using a rat model of Escherichia coli experimental pyelonephritis that mimics the conditions of severe renal infections in man because the infection is acquired by the ascending route. We found that ceftriaxone, when given for 5 days to rats with severe ...

journal_title：Chemotherapy

authors： Glauser MP,Bonard

更新日期：1982-01-01 00:00:00

abstract：:Reference is made to the results obtained in 24 children, from 11 months to 12 years, affected with acute pneumopathies and treated with fosfomycin with a dosage of 200 mg/kg/day. In all cases a clinical, radiological, biological and bacteriological study was carried out. At the same time, levels of fosfomycin in plas...

journal_title：Chemotherapy

authors： Llorens J,Ley G,Forés A,Olay T

更新日期：1977-01-01 00:00:00

abstract：:Studies are presented on the in vitro phagocytic activity of rat and human polymorphonuclear leukocytes exposed in vivo to therapeutic concentrations of doxycycline. A 32P-labelled strain of Escherichia coli served as test microbe. No significant reduction of ingestion was observed although untreated AB leukocytes tes...

journal_title：Chemotherapy

authors： Melby K,Midtvedt T

更新日期：1981-01-01 00:00:00

abstract：:The post-antibiotic effects (PAEs) of a new cephalosporin, cefdinir, were determined against a range of organisms using a viable counting technique. Cefdinir exerted considerable PAEs against Staphylococcus aureus and Streptococcus pyogenes, but no overall post-antibiotic inhibition of growth was detected against Esch...

journal_title：Chemotherapy

authors： Howard BM,Pinney RJ,Smith JT

更新日期：1994-07-01 00:00:00

abstract：:Postantibiotic effects were induced in three Pseudomonas aeruginosa strains after short-term treatment (30 min) with amikacin at suprainhibitory concentrations in the range of 0.6-1.2 h (2 x MIC) and of 3.0-4.4 h (4 x MIC). Significant suppression of P. aeruginosa elastase activity was found after treatment with amika...

journal_title：Chemotherapy

authors： Hostacká A,Karelová E

更新日期：1997-03-01 00:00:00

abstract：:We have previously reported that long-term treatment with clarithromycin (CAM) increased the median survival of patients with non-small cell lung cancer, and improved various clinical parameters in these patients. In the present study, CAM was administered to 33 patients with unresectable primary non-small cell lung c...

journal_title：Chemotherapy

authors： Sakamoto M,Mikasa K,Majima T,Hamada K,Konishi M,Maeda K,Kita E,Narita N

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:The rise in the rates of antibiotic resistance among Pseudomonas aeruginosa strains from cystic fibrosis (CF) patients is concerning and underscores the need for the development of novel compounds. Among them CSA-13, a cationic steroid molecule, mimics the activity of naturally occurring antimicrobial peptid...

journal_title：Chemotherapy

authors： Bozkurt-Guzel C,Savage PB,Gerceker AA

更新日期：2011-01-01 00:00:00

abstract：:Rifampicin and rifapentine were used in the treatment of Listeria monocytogenes infections in normal mice and congenitally athymic (nude) mice. Results were compared with untreated controls and with the results obtained from a previous study of ampicillin in which this model was used. Low doses of rifampicin or rifape...

journal_title：Chemotherapy

authors： Bakker-Woudenberg IA,de Bos P,Michel MF

更新日期：1984-01-01 00:00:00

abstract：:Niridazole was shown to be an effective chemotherapeutic agent for mice infected intravenously with a niridazole-sensitive strain of Salmonella typhimurium. Death rates as well as bacterial counts per spleen were reduced, even in compromised animals. Histologic examination of spleens proved the reduction of inflammato...

journal_title：Chemotherapy

authors： Hof H,Müller KM,Heine WD

更新日期：1982-01-01 00:00:00

abstract：:A new semisynthetic ureidopenicillin (Bay K 4999) demonstrates favorably in vitro antibacterial efficacy against human-pathogenic gram-negative rods in comparison to mezlocillin and azlocillin. A comparative paramcokinetic study was done with 10 test subjects after 30 min intravenous infusion of 4.0 g of Bay K and mez...

journal_title：Chemotherapy

authors： Lode H,Tomas W,Koeppe P,Wagner J

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Recently, multiple-line chemotherapy has become popular for non-small cell lung cancer (NSCLC). The survival time of patients is influenced by patient characteristics and subsequent treatments. METHODS:The usefulness of paclitaxel plus S1 (PTX+S1) was evaluated in 46 pretreated NSCLC patients. Time from the...

journal_title：Chemotherapy

authors： Aono N,Ito Y,Nishino K,Uchida J,Kumagai T,Akazawa Y,Okuyama T,Yoshinami T,Imamura F

更新日期：2012-01-01 00:00:00

abstract：:The 2,3-dihydroxy-6-bromo-pyrazino-[2,3-beta]-pyrazine is a substance selected during the antiviral screening of pyrazino-pyrazine derivatives. The compound shows antiviral activity in vitro against measles, NDV, some influenza viruses and against herpes simplex and zoster, infectious canine hepatitis and vaccinia vir...

journal_title：Chemotherapy

authors： Verini MA,Fioretti A,Casazza AM,Sanfilippo A,Palamidessi G,Ghione M

更新日期：1975-01-01 00:00:00

abstract：:The in vitro activity of fleroxacin was determined by broth microdilution against 2,079 recent bacterial isolates and compared to the activities of ciprofloxacin, ofloxacin, lomefloxacin, cefaclor, cefuroxime, cefixime, ceftriaxone, amoxicillin/clavulanate, trimethoprim/sulfamethoxazole (TMP-SMX), and, as appropriate,...

journal_title：Chemotherapy

authors： Markowitz SM,Williams DS,Hanna CB,Parker JL,Pierce MA,Steele JC Jr

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Urinary tract infections (UTIs) are a significant health problem and Escherichia coli has been exported to be the primary pathogen in approximately 80% of cases. E. coli express structures called adhesins, fimbriae or pili that help them bind to specific tissue receptors. One such adhesin is Dr, which binds ...

journal_title：Chemotherapy

authors： Kachroo BB

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND/AIMS:Species-level identification of nontuberculous mycobacteria (NTM) is important in making decisions about the necessity and choice of antimicrobial treatment. The reason is predictable clinical significance and the susceptibility profile of specific NTM species. Matrix-assisted laser desorption/ionizatio...

journal_title：Chemotherapy

authors： Mareković I,Bošnjak Z,Jakopović M,Boras Z,Janković M,Popović-Grle S

更新日期：2016-01-01 00:00:00

abstract：:Hydrocortisone (HC) has been observed to influence an in vitro Dexter culture system with maintenance of pluripotent hematopoietic stem cells (CFU-s) and progenitor cells (CFU-gm, BFU-e). In the present study, a two-phase murine Dexter culture system was established to study the mechanism of HC-mediated suppression of...

journal_title：Chemotherapy

authors： Horikoshi A,Murphy MJ Jr

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndrome (MDS) is an iron overload condition. Copper deficiency itself might induce dysplastic changes and iron overload. The relationship between the iron and copper metabolism is analyzed in MDS patients. METHODS:Copper, iron and ceruloplasmin levels were established, and transferrin satur...

journal_title：Chemotherapy

authors： Várkonyi J,Szabó T,Sebestyén P,Tordai A,Andrikovics H,Kollai G,Karádi I

更新日期：2006-01-01 00:00:00

abstract：:The effect of tinidazole on several ciliates (Stylonychia muscorum, Stylonychia mytilus, Tetrahymena pyriformis, Vorticella companula) has been studied. There is a very pronounced difference in sensitivity against this drug between the free-living ciliates here investigated and certain parasitic protozoa. A high resis...

journal_title：Chemotherapy

authors： Alonso P

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Kaposi's sarcoma (KS) is the most common neoplastic apoptosis manifestation of acquired immunodeficiency syndrome. Toremifene is known to upregulate transforming growth factor beta-1 (TGF-beta1), which is a growth-inhibitory factor for KS. We investigated the in vitro effect of toremifene on KS cells. METHO...

journal_title：Chemotherapy

authors： Hong A,Leigh BR

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Adjuvant platinum-based chemotherapy improves survival in women with early-stage epithelial ovarian cancer (EOC). Yet, there is a wide variety in clinical practice. METHODS:All patients diagnosed with FIGO I and IIa EOC (2006-2010) in the south of the Netherlands were analyzed. The percentage of patients th...

journal_title：Chemotherapy

authors： Frielink LM,Pijlman BM,Ezendam NP,Pijnenborg JM

更新日期：2016-01-01 00:00:00

abstract：:Chloramphenicol serum concentration is often monitored to assure efficacy and prevent toxicity. We studied the relationship between steady-state chloramphenicol serum concentration and hematologic adverse effects in 45 pediatric patients. The mean peak serum concentration of chloramphenicol in patients with and withou...

journal_title：Chemotherapy

authors： Nahata MC

更新日期：1987-01-01 00:00:00

abstract：:The pharmacokinetics and antibacterial efficacy of mezlocillin, cefotaxime, cefoperazone and the mezlocillin/cefalosporin combinations, respectively, were studied by adopting the granuloma pouch model in rats. Exudate concentrations of mezlocillin were higher after combined i.v. injection with a cefalosporin as determ...

journal_title：Chemotherapy

authors： Dalhoff A,Gehl AE,Gau W,Lode H

更新日期：1982-01-01 00:00:00

abstract：:Patients with a mycologically confirmed vaginal mycosis were treated either with one 100-mg vaginal ovule of clotrimazole each for 6 days, or with one 200-mg vaginal ovule of clotrimazole each for 3 days, or with one 500-mg vaginal ovule of clotrimazole for 1 day, the ovule having been supplied in a novel, acid formul...

journal_title：Chemotherapy

authors： Mendling W,Plempel M

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:We investigated the presence of Helicobacter pylori in laryngeal cancer specimens to reveal whether or not this is a risk factor in the development of squamous cell carcinoma of the larynx. METHODS:Sixty-nine total laryngectomy specimens with the pathologic diagnosis of squamous cell carcinoma and 30 larynge...

journal_title：Chemotherapy

authors： Kizilay A,Saydam L,Aydin A,Kalcioglu MT,Ozturan O,Aydin NE

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Development of novel strategies to kill cancer by sparing normal cells is of utmost importance. Apart from their known antimicrobial activity, only limited information has been recorded regarding the antitumor potential of biocompatible silver oxide nanoparticles (AgONPs). There is a need to evaluate the ant...

journal_title：Chemotherapy

authors： Banerjee K,Das S,Choudhury P,Ghosh S,Baral R,Choudhuri SK

更新日期：2017-01-01 00:00:00

abstract：:The in vitro bactericidal effects of therapeutic concentrations of levofloxacin (LVFX) on clinical isolates of Pseudomonas aeruginosa and Enterococcus faecalis were assessed. Starting from 10(7) CFU/ml, the bacterial count was determined serially during the exposure to LVFX present at concentrations automatically simu...

journal_title：Chemotherapy

authors： Takahashi S,Sano M,Nishimura M,Matsukawa M,Mikami M,Hirose T,Tsukamoto T

更新日期：1998-09-01 00:00:00

abstract：:Five aminoglycoside antibiotics (AGAs)--kanamycin (KM), bekamycin (AKM), dibekacin (DKB), ribostamycin (RSM) and paromomycin (PRM)--were studied for their effects on the nonenzymic reduction of cytochrome c by FeSO4 (Yamabe's system). Their inhibitory activity was in the order: DKB greater than AKM greater than KM gre...

journal_title：Chemotherapy

authors： Yamabe S

更新日期：1980-01-01 00:00:00