Abstract:
:Combination antiretroviral (ARV) treatment is a potent and effective therapy for human immunodeficiency virus infection. Unfortunately, ARV drugs frequently interact among themselves, as well as with other anti-infectives. These interactions determine positive or negative consequences resulting in recommendations to avoid some combinations or to adjust the dosage of coadministered drugs. The effective clinical use of ARVs requires deep knowledge of interaction mechanisms and the consequent recommendations when coadministering interacting ARVs with other anti-infectives. A brief review of the present knowledge on interactions of ARVs with anti-infective drugs is presented.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Pontali Edoi
10.1159/000098247subject
Has Abstractpub_date
2007-01-01 00:00:00pages
26-9issue
1eissn
0009-3157issn
1421-9794pii
000098247journal_volume
53pub_type
杂志文章,评审相关文献
CHEMOTHERAPY文献大全abstract::During the 5-year period 1989-1993, the incidence of Candida krusei, and other non-albicans Candida spp., was analyzed in a 60-bed cancer department. The frequency of C. krusei, before fluconazole was introduced into therapeutic protocols in 1990, was 16.5%, and after introduction of fluconazole into prophylaxis in ac...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239322
更新日期:1995-01-01 00:00:00
abstract::Oxygen radical generation by blood cells before and after chemotherapy was investigated in 16 elderly (72.8 +/- 1.0 years) and 14 adult (45.0 +/- 2.4 years) patients with lung cancer, using a lucigenin-dependent chemiluminescence method. The oxygen radical generation by 100 microliters of blood before chemotherapy in ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239348
更新日期:1995-05-01 00:00:00
abstract::Cephalosporins do not reach active therapeutical concentrations in the prostatic tissue in patients suffering from chronic bacterial prostatitis. Cefoperazone is an exception. Its efficacy in the treatment of chronic bacterial prostatitis in 20 patients was studied and the concentrations, obtained after intramuscular ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238704
更新日期:1989-01-01 00:00:00
abstract::The antibacterial activity of tobramycin, gentamicin, erythromycin, cloxacillin, kanamycin, cephalexin, penicillin, carbenicillin and polymyxin were compared against 303 clinical bacterial isolates from a pediatric hospital patient population. Standard disk diffusion and agar-dilution methods were employed. Significan...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221851
更新日期:1975-01-01 00:00:00
abstract::The in vitro activities of the newer agents Deptomycin, Difloxacin, A-56620 and Ciprofloxacin were compared with those of vancomycin, rifampin and gentamicin against methicillin-susceptible and -resistant Staphylococcus aureus and coagulase-negative staphylococci. All isolates were susceptible to vancomycin, rifampin,...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238691
更新日期:1989-01-01 00:00:00
abstract::Five healthy informed male volunteers received oral doses of 820 mg sulfadiazine (SDZ) plus 180 mg trimethoprim (TMP) (co-trimazine) every 24 h. Concentrations in serum, peripheral lymph from the leg and urine were determined after the first dose, and on the 4th day to reflect approximate steady-state conditions. TMP ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238418
更新日期:1986-01-01 00:00:00
abstract::Minimal bactericidal concentrations of thienamycin revealed moderate intraphagolysosomal bactericidal activity against pseudo-(PSR) and genuinely serum-resistant (NSS) assay strains of Serratia marcescens. Combinations of inhibitory and subinhibitory concentrations of thienamycin with 55 vol% of defibrinated human blo...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238185
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Adherence to imatinib therapy has been significantly associated with disease progression and direct medical costs in gastrointestinal stromal tumor (GIST) patients. However, adherence to oral anticancer drugs is frequently hindered by the influence of various factors. The aim of this study was to evaluate th...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000505177
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:In a previous investigation of the genetic characterization of extended-spectrum beta-lactamases (ESBLs) in Klebsiella pneumoniae from Zagreb, Croatia, 20 strains were found to produce SHV-2 beta-lactamase. Those strains displayed varying degrees of beta-lactam resistance and a wide range of beta-lactamase a...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048581
更新日期:2002-03-01 00:00:00
abstract::This study was performed in female B6C3F1 mice to confirm previously observed effects of selected cephalosporin antibiotics on nonspecific immunity, and to determine possible effects on specific acquired immunity and host resistance. Mice were treated intravenously with DQ-2556, ceftizoxime or ceftezole at 800 mg/kg/d...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239137
更新日期:1993-07-01 00:00:00
abstract::Local chemotherapy is an option in bone metastasis treatment. On the other hand, evaluation of side effects on bone is a difficult issue in drug development and biomaterials research. Most animal models to date are inappropriate or not feasible. Rabbits are an alternative to other bigger mammals and have an appropriat...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000153315
更新日期:2008-01-01 00:00:00
abstract::A new semisynthetic ureidopenicillin (Bay K 4999) demonstrates favorably in vitro antibacterial efficacy against human-pathogenic gram-negative rods in comparison to mezlocillin and azlocillin. A comparative paramcokinetic study was done with 10 test subjects after 30 min intravenous infusion of 4.0 g of Bay K and mez...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237887
更新日期:1980-01-01 00:00:00
abstract::Therapeutic effectiveness of pretazettine (PTZ) has been demonstrated in the intraperitoneally (i.p.) implanted Lewis lung carcinoma (LLC) in both syngeneic and allogeneic mice. The i.p. implanted LLC has been found to be sensitive to most standard drugs tested such as cyclophosphamide (CY), actinomycin D, 5-fluoroura...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238212
更新日期:1983-01-01 00:00:00
abstract::Treatment of enterococcal infections is often difficult because of intrinsic and acquired resistance to a variety of antimicrobial agents. Between January 1993 and May 1997, enterococci were isolated from blood cultures of 117 patients at the Institute of Medical Microbiology and Immunology, University Hospital Eppend...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007263
更新日期:2000-03-01 00:00:00
abstract::A modified Rieckmann test was developed for assessing chloroquine sensitivity of Plasmodium vivax strains. This test envisages the evaluation of parasite growth with different concentrations of the drug and its comparison with controls, at the end of a 48-hour experimental period. Using this test, 16 strains were asse...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238664
更新日期:1989-01-01 00:00:00
abstract::Differences in the pharmacokinetic parameters of cephalosporins between children and adults may be predictable on the basis of the level of maturation of the physiologic processes involved in drug disposition. It appears that the most important of these factors (gastrointestinal, renal and hepatic function) are reason...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000239090
更新日期:1992-01-01 00:00:00
abstract::A total of 1,442 patients with symptoms of chronic prostatitis were examined over a 4-year period at the Outpatient Department for Urogenital Infections, University Hospital for Infectious Diseases Dr. Fran Mihaljević, Zagreb, Croatia. The inclusion criteria for chronic prostatitis caused by Ureaplasma urealyticum wer...
journal_title:Chemotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1159/000090234
更新日期:2006-01-01 00:00:00
abstract::Rifampicin and rifapentine were used in the treatment of Listeria monocytogenes infections in normal mice and congenitally athymic (nude) mice. Results were compared with untreated controls and with the results obtained from a previous study of ampicillin in which this model was used. Low doses of rifampicin or rifape...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238268
更新日期:1984-01-01 00:00:00
abstract::The microbiological properties of cephapirin, a new semisynthetis cephalosporin, have been studied. This antibiotic, if compared with ampicillin, shows a greater activity against gram positive bacteria, a lack of sensitivity to staphlococcal beta-lactamase, and a lower sensitivity to those produced by gram-negative ba...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221871
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:The application of liposome-encapsulated cytostatics results in higher concentrations in tumor tissue. This effect can be further increased by blood flow retardation with longer retention time in the tumor and by arterial administration realized in abdominal stop-flow therapy, a separate partial circulation ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000077805
更新日期:2004-06-01 00:00:00
abstract::Bacterial growth kinetic experiments have been performed to study the potentiating effect of trimethoprim (TMP) AND TMP derivatives on the antibacterial action of sulfonamides (SA). The TMP derivatives showed different inhibitory effects when used alone. Derivatives with decreased inhibitory activity excerted 'bacteri...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237928
更新日期:1980-01-01 00:00:00
abstract::Our previous studies demonstrated the efficacy of cationic liposome-encapsulated doxycycline (CaL-DOX) on the course of infection with Chlamydia trachomatis in vitro and in vivo. In this investigation, the pharmacokinetics of CaL-DOX are reported. Female mice inoculated intravaginally with 4.84 x 10(5) inclusion-formi...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000077279
更新日期:2004-04-01 00:00:00
abstract::Niridazole was shown to be an effective chemotherapeutic agent for mice infected intravenously with a niridazole-sensitive strain of Salmonella typhimurium. Death rates as well as bacterial counts per spleen were reduced, even in compromised animals. Histologic examination of spleens proved the reduction of inflammato...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238069
更新日期:1982-01-01 00:00:00
abstract:AIMS:This study aimed to evaluate the different abilities of various Phellinus igniarius strains inhibiting quorum sensing (QS), to search for novel QS inhibitors from them and to analyze their inhibitory activity, with a view to their possible use in controlling infections. METHODS:The bioactive metabolites produced ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000338383
更新日期:2012-01-01 00:00:00
abstract::A group of cis-ethylenediammine platinum (II) complexes were synthesized and their activity against Sarcoma-180 ascites tumour cells in mouse was tested. One of the compounds, Pt(HOCH2CH2NHCH2CH2NH2)Cl2, showed significant antitumour activity having little toxicity to the host. Like the parent compound, cis-DDP, it bi...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238314
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Patients with cancer are particularly susceptible to drug interactions (DIs), but the extent of the problem has received limited attention. We aimed to evaluate the frequency of interactions with anticancer agents in a group of cancer patients. METHODS:The study was performed in a Belgian teaching hospital....
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000351133
更新日期:2013-01-01 00:00:00
abstract::Eight thiadiazine 1,1-dioxide derivatives were evaluated for antitrichomonal and antitrypanosomal activities. In vivo tests were performed on a murine model for trichomoniasis standardized in our laboratory. The capacity of compounds to clear visceral lesions in experimentally infected animals as well as their effects...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239040
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:The purpose of this preliminary and descriptive study was to evaluate a biodegradable drug delivery system in combination with an innovative ceramic implant. METHODS:The delivery of gentamicin of standardized samples was measured in the laboratory using ultra-high-performance liquid chromatography. Biocompatib...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000354986
更新日期:2013-01-01 00:00:00
abstract::The in vitro bactericidal effects of therapeutic concentrations of levofloxacin (LVFX) on clinical isolates of Pseudomonas aeruginosa and Enterococcus faecalis were assessed. Starting from 10(7) CFU/ml, the bacterial count was determined serially during the exposure to LVFX present at concentrations automatically simu...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007133
更新日期:1998-09-01 00:00:00
abstract::CPC10997 was found to be effective in vitro as an antiandrogen without effects on either the estrogen or the progesterone receptors in carcinomas of the breast, ovary and prostate as well as in malignant melanomas. Using the clonogenic assay of Salmon et al. [Cancer Treat. Rep. 65: 1-12, 1981], CPC10997 was found to b...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238360
更新日期:1985-01-01 00:00:00