Abstract:
BACKGROUND:Patients with cancer are particularly susceptible to drug interactions (DIs), but the extent of the problem has received limited attention. We aimed to evaluate the frequency of interactions with anticancer agents in a group of cancer patients. METHODS:The study was performed in a Belgian teaching hospital. One hundred and twenty-two patients with solid malignancies were included. A comprehensive drug history was performed by a clinical pharmacist. Three renowned DI compendia were used to identify DIs. RESULTS:Forty-one potential interactions involving an anticancer agent and considered to be clinically significant were identified among 25% of patients. The anticancer drugs mostly involved were cisplatin and methotrexate, and the most frequent co-medications involved were vitamin K antagonists, proton pump inhibitors and diuretics. In the majority of cases, the potential adverse consequence was increased toxicity of the anticancer agent and/or of the co-medication. Less than 10% of DIs were identified by the three compendia. CONCLUSIONS:Preventive measures should be taken to avoid increased toxicity or decreased efficacy of the drugs. Most of the time, this simply involves surveillance of biological or clinical parameters. Collaboration with a clinical pharmacist may be useful for the prescribing physician.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Mouzon A,Kerger J,D'Hondt L,Spinewine Adoi
10.1159/000351133subject
Has Abstractpub_date
2013-01-01 00:00:00pages
85-92issue
2eissn
0009-3157issn
1421-9794pii
000351133journal_volume
59pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract::Multiple hyperthermia was found to exert an additive antitumor effect when combined with the in vivo production of tumor necrosis factor alpha (TNF-alpha) in mice bearing Ehrlich ascites tumor (EAT). TNF-alpha was produced in EAT-bearing mice by priming the animals with zymosan and subsequently challenging with lipopo...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239370
更新日期:1995-09-01 00:00:00
abstract::The involvement of plasma testosterone in patients associated with scalp hair loss accelerated by anticancer drugs including aclarubicin and cisplatin was investigated. Scalp hair loss observed was minor in 12 and severe in 2 out of 31 patients. In patients without significant hair loss, the combination of aclarubicin...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238635
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Ginkgolic acids (GAs), extracted from the seed coat of Ginkgo biloba L. Our previous study has shown that GA monomer could inhibit the growth of Hep-2 significantly and induce the fragmentation of the chromosomal DNA. To further assess the antitumor potential and turn it into a candidate new antitumor drug, ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000317750
更新日期:2010-01-01 00:00:00
abstract::Two gonococcal strains with differing susceptibility to cefotiam and ceftizoxime, as expressed by the minimum inhibitory concentration (MIC), are exposed to continuously changing concentrations of these antibiotics as they are found in plasma and skin cantharidal blister fluid (CBF) after a single intramuscular applic...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238423
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:The glomerular filtration rate (GFR) is essential for calculating the dose and the monitoring of carboplatin. Although GFR measurement (mGFR) by external markers is ideal, in most cases these are not employed; the most used method is GFR estimation (eGFR) by formulae, hence the need to identify the formula w...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000488538
更新日期:2018-01-01 00:00:00
abstract::This study was performed in female B6C3F1 mice to confirm previously observed effects of selected cephalosporin antibiotics on nonspecific immunity, and to determine possible effects on specific acquired immunity and host resistance. Mice were treated intravenously with DQ-2556, ceftizoxime or ceftezole at 800 mg/kg/d...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239137
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND/AIM:A phase 3 trial of S-1, leucovorin (LV), and oxaliplatin for treating gastric cancer is now underway. However, the antitumor efficacy of the combination has not yet been examined in an in vivo preclinical study. This study examined the antitumor efficacy of combination therapy consisting of S-1, LV, and ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000486029
更新日期:2018-01-01 00:00:00
abstract::After intravenous bolus injection of single doses of 25, 50, 75 and 100 mg of ofloxacin (HOE 280) to 34 healthy male volunteers, concentrations of unchanged drug were estimated at various times in serum and urine over 32 and 48 h. Ofloxacin concentrations were determined using high-pressure liquid chromatography (HPLC...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238567
更新日期:1988-01-01 00:00:00
abstract::Using the biophotometer with ticarcillin no persistent bactericidal effect was found against Pseudomonas aeruginosa NCTC 10490. After addition of 1.2 microgram/ml gentamicin an increase of multiplication of bacteria was observed, but not after 1.2 microgram/ml tobramycin. With 6.2 microgram/ml tobramycin bactericidal ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222001
更新日期:1977-01-01 00:00:00
abstract::20 patients with serious infections were treated with cefazolin and tobramycin for 9--64 days. Minimal inhibitory concentration (MIC) values and minimal bactericidal concentration (MBC) values were determined for each of the 112 clinical bacterial isolates. The median cefazolin MIC/MBC was 1.56/12.5 micrograms/ml, and...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237931
更新日期:1980-01-01 00:00:00
abstract::A total of 1,442 patients with symptoms of chronic prostatitis were examined over a 4-year period at the Outpatient Department for Urogenital Infections, University Hospital for Infectious Diseases Dr. Fran Mihaljević, Zagreb, Croatia. The inclusion criteria for chronic prostatitis caused by Ureaplasma urealyticum wer...
journal_title:Chemotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1159/000090234
更新日期:2006-01-01 00:00:00
abstract::Lower respiratory tract infections are the major cause of death due to infectious disease in the developed and developing world. Despite substantial progress in defining pathogens and in therapeutic options, there continues to be major controversies in the clinical management of these infections. This report reviews t...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000048489
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Dosage recommendations for antibiotics in patients receiving continuous veno-venous hemofiltration (CVVH) should be based on pharmacodynamic requirements. For meropenem, this would be achieving appropriate time above the minimum inhibitory concentration (T > MIC). We employed Monte Carlo simulation to calcul...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000086598
更新日期:2005-07-01 00:00:00
abstract::A total of 5 healthy volunteers were enrolled in a crossover study on the dose dependency and the effect of probenecid on pharmacokinetics of DQ-2556. They were administered intravenously 0.5 and 1.0 g of DQ-2556, and 1.0 g of DQ-2556 with oral administration of probenecid. The linearity in pharmacokinetics of DQ-2556...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239029
更新日期:1992-01-01 00:00:00
abstract::Cefpirome and six other antimicrobial agents were tested against 884 blood culture isolates from cancer patients. Cefpirome was highly active against aerobic gram-negative bacilli including Acinetobacter spp., and the Enterobacteriaceae. Only imipenem was more active than cefpirome against Pseudomonas aeruginosa. Cefp...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238433
更新日期:1986-01-01 00:00:00
abstract::A-56619 and A-56620 are two new quinolone compounds that are currently being studied. They were found to be active against multi-resistant and routine isolates of Staphylococcus aureus, enterobacteria, aminoglycoside-sensitive and resistant strains of Pseudomonas aeruginosa. Most of the enterobacteria were inhibited b...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238573
更新日期:1988-01-01 00:00:00
abstract::AM-1155 is a new 8-methoxyquinolonecarboxylic acid with a broad spectrum of antibacterial activity. It inhibited more than 90% of clinical isolates of Streptococcus agalactiae, Escherichia coli, Peptostreptococcus magnus, Bacteroides fragilis and Prevotella bivia at the concentration of 3.13 mg/l. The antibacterial ac...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007120
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:An ethylacetate-soluble fraction (ET4) from the lichen Ramalina farinacea has previously been shown to inhibit the infectivity of lentiviral and adenoviral vectors, as well as wild-type HIV-1. We now determined the antiviral activity of ET4 against other wild-type viruses, including the herpes simplex virus ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000194974
更新日期:2009-01-01 00:00:00
abstract::100 febrile patients with chemotherapy-induced neutropenia (less than 0.5 x 10(9)/l) were empirically treated by ceftriaxone (2 g daily in adults, 50 mg/kg daily in children, as a once daily injection) and amikacin (15-20 mg/kg daily). The mean age was 41 years (range 8-72). 51 patients had acute leukemia, 29 non-Hodg...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238883
更新日期:1991-01-01 00:00:00
abstract::The in vitro activity of fleroxacin was determined by broth microdilution against 2,079 recent bacterial isolates and compared to the activities of ciprofloxacin, ofloxacin, lomefloxacin, cefaclor, cefuroxime, cefixime, ceftriaxone, amoxicillin/clavulanate, trimethoprim/sulfamethoxazole (TMP-SMX), and, as appropriate,...
journal_title:Chemotherapy
pub_type: 杂志文章,多中心研究
doi:10.1159/000239386
更新日期:1995-11-01 00:00:00
abstract::Gemifloxacin is a novel fluoroquinolone with a broad spectrum of activity. This double-blind, randomized, parallel-group study was designed to demonstrate the lack of effect of steady-state concentrations of gemifloxacin on the pharmacodynamic effects of warfarin. Healthy male subjects received loading doses of warfar...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000007243
更新日期:1999-11-01 00:00:00
abstract::The effect of linezolid on the phagocytic and bactericidal functions of human polymorphonuclear neutrophils (PMN) against gram-positive cocci was evaluated. Preincubation (30 min; 37 degrees C) of PMN with different concentrations of linezolid (2, 10 and 20 mg/l) did not significantly affect the phagocytosis of either...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000071139
更新日期:2003-07-01 00:00:00
abstract::Treatment of enterococcal infections is often difficult because of intrinsic and acquired resistance to a variety of antimicrobial agents. Between January 1993 and May 1997, enterococci were isolated from blood cultures of 117 patients at the Institute of Medical Microbiology and Immunology, University Hospital Eppend...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007263
更新日期:2000-03-01 00:00:00
abstract::108 white rats weighing 170-250 G were given trimethoprim, sulphamethoxazole and the combination trimethoprim 1/sulphamethoxazole orally and parenterally in order to test the preventive effect of these substances on experimental hematogenous pyelonephritis due to Staphylococcus aureus. Oral applications of 48 mg/kg/24...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221848
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:Levofloxacin and tobramycin, alone and in combination with cefepime, were investigated for their in vitro activities and post-antibiotic effects (PAEs) on Pseudomonas aeruginosa. METHODS:The in vitro activities of tobramycin and levofloxacin in combination with cefepime were determined by microbroth chequer...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000265128
更新日期:2009-01-01 00:00:00
abstract::The biliary excretion of tetroxoprim (TXP) was studied in 10 patients with T-tube drainage. A mean biliary peak of 32.56 +/- 7.69 micrograms/ml was observed 2-3 h after a single oral dose of 200 mg. The biliary elimination rate constant (kb) of TXP was found to be 0;056 (h-1), indicating a longer elimination from the ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238097
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:The combination of 5-fluorouracil (5-FU), cisplatin and interferon (IFN)-alpha was found to result in a high response rate in advanced esophageal squamous cell carcinoma (SCC). METHODS:Resectable cases of esophageal SCC were treated with 3 cycles of chemotherapy consisting of cisplatin 70 mg/m(2) i.v. on da...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000151353
更新日期:2008-01-01 00:00:00
abstract::A semi-automated microdilution test was adapted for the in vitro testing of potential antitrichomonal agents. Washed cell suspensions of the pathogenic protozoan Trichomonas vaginalis were incubated in microtitration plates for 4 h at 37 degrees C in the presence radiolabelled adenine and serial dilutions of the test ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238327
更新日期:1985-01-01 00:00:00
abstract::Thirteen quinolone antibacterial agents were investigated as to their ability to inhibit Micrococcus luteus DNA gyrase and cell growth, and compared to those of novobiocin and coumermycin. Among the quinolones tested, the most active were found to be CI-934 and ciprofloxacin, which inhibited gyrase full supercoiling a...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238458
更新日期:1986-01-01 00:00:00
abstract::The intracellular activity of flurithromycin, erythromycin, roxithromycin and miocamycin against susceptible clinical isolates of Staphylococcus aureus, phagocytosed by human monocytes, was investigated. Intracellular bioactivity was studied in a 24-hour assay, using experimental conditions which allowed the intracell...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238973
更新日期:1993-01-01 00:00:00