Abstract:
:The intracellular activity of flurithromycin, erythromycin, roxithromycin and miocamycin against susceptible clinical isolates of Staphylococcus aureus, phagocytosed by human monocytes, was investigated. Intracellular bioactivity was studied in a 24-hour assay, using experimental conditions which allowed the intracellular growth of bacteria. A colony counting method was used to differentiate between intracellular bacteriostatic and bactericidal activity of antibiotics. Moreover, the effect of macrolides against extracellular staphylococci was assessed. All agents showed higher intracellular than extracellular activity against staphylococci. At low concentration (0.1 mg/l) they had intracellular bacteriostatic activity. At concentrations higher than the minimal inhibitory ones (1 and 5 mg/l), miocamycin only still produced a bacteriostatic effect while flurithromycin, erythromycin and roxithromycin also showed intracellular bactericidal activity.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Fietta A,Boeri P,Colombo ML,Merlini C,Gialdroni Grassi Gdoi
10.1159/000238973subject
Has Abstractpub_date
1993-01-01 00:00:00pages
48-54issue
1eissn
0009-3157issn
1421-9794journal_volume
39pub_type
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