In vitro activity of cefetamet against enterobacteria expressing an SHV-5-type beta-lactamase.

abstract：:Itraconazole has emerged as an important new oral agent in the treatment of systemic fungal infections. This paper summarizes the data available on its use in aspergillosis, cryptococcosis and histoplasmosis, compiled in the United States with particular attention to the immunocompromised host. Data have been accrued ...

journal_title：Chemotherapy

authors： Hostetler JS,Denning DW,Stevens DA

更新日期：1992-01-01 00:00:00

abstract：:The pharmacokinetics of flomoxef in serum and in the mucosal tissue of the middle ear and mastoid were studied in 9 patients undergoing tympanoplasties. All patients received 1 g of flomoxef intravenously. Flomoxef levels in serum and in mucosal tissue were determined by a bioassay method. The peak value of mean conce...

journal_title：Chemotherapy

authors： Saito H,Kimura T,Takeda T,Kishimoto S,Oguma T,Shimamura K

更新日期：1990-01-01 00:00:00

abstract：:Current treatment modalities for bronchopulmonary aspergillosis are not very satisfying. We determined the in vitro activity of recently available azoles against Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger. Subsequently, these agents were evaluated in an animal model of bronchopulmonary aspergillos...

journal_title：Chemotherapy

authors： Schmitt HJ,Edwards F,Andrade J,Niki Y,Armstrong D

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Patients with cancer are particularly susceptible to drug interactions (DIs), but the extent of the problem has received limited attention. We aimed to evaluate the frequency of interactions with anticancer agents in a group of cancer patients. METHODS:The study was performed in a Belgian teaching hospital....

journal_title：Chemotherapy

authors： Mouzon A,Kerger J,D'Hondt L,Spinewine A

更新日期：2013-01-01 00:00:00

abstract：:The concentrations of clarithromycin after a single oral dose of 500 mg were determined in serum and saliva of ten healthy adult volunteers. After 2 h, the levels were 4.04 +/- 1.14 (SD) mg/l in serum and 2.72 +/- 0.87 mg/l in saliva. After 7 h these values were 1.98 +/- 0.65 and 1.21 +/- 0.34 mg/l, respectively, and ...

journal_title：Chemotherapy

authors： Wüst J,Hardegger U

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:The application of liposome-encapsulated cytostatics results in higher concentrations in tumor tissue. This effect can be further increased by blood flow retardation with longer retention time in the tumor and by arterial administration realized in abdominal stop-flow therapy, a separate partial circulation ...

journal_title：Chemotherapy

authors： Pohlen U,Binnenhei M,Reszka R,Buhr HJ,Berger G

更新日期：2004-06-01 00:00:00

abstract：:Eight thiadiazine 1,1-dioxide derivatives were evaluated for antitrichomonal and antitrypanosomal activities. In vivo tests were performed on a murine model for trichomoniasis standardized in our laboratory. The capacity of compounds to clear visceral lesions in experimentally infected animals as well as their effects...

journal_title：Chemotherapy

authors： Atienza J,Martínez Díaz RA,Gómez Barrio A,Escario JA,Herrero A,Ochoa C,Rodríguez J

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Chronic hepatitis B (CHB) affects 400 million people worldwide and is a major cause of morbidity and mortality. It is known that HBV DNA sequences were detected after the clearance of serum hepatitis B surface antigen (HBsAg) often in serum, liver and peripheral blood mononuclear cells. The objectives of our...

journal_title：Chemotherapy

authors： Akhan SC,Yulugkural Z,Vahaboglu H

更新日期：2007-01-01 00:00:00

abstract：:Combination antiretroviral (ARV) treatment is a potent and effective therapy for human immunodeficiency virus infection. Unfortunately, ARV drugs frequently interact among themselves, as well as with other anti-infectives. These interactions determine positive or negative consequences resulting in recommendations to a...

journal_title：Chemotherapy

authors： Pontali E

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Brucellosis is one of the important health problems for both humans and animals in Turkey since agriculture and stock raising appears to be the most important means of subsistence. Investigations on the pathogenesis of brucellosis reveal that the etiologic agent can survive in phagocytic cells, and cell-medi...

journal_title：Chemotherapy

authors： Dizer U,Hayat L,Beker CM,Görenek L,Ozgüven V,Pahsa A

更新日期：2005-03-01 00:00:00

abstract：:Two groups of patients suffering surgical infections were treated with fosfomycin. The first includes 21 suppurating dermic of soft underlying tissue lesions. The second group includes 29 surgical abdominal infections. The bacteriology of the first group was made up of gram-positive and gram-negative germs predominant...

journal_title：Chemotherapy

authors： Gallardo A,Sáez JM,Enriquez G,Cobacho AR,Torronteras R,Recordan C,Del Moral A,Arroyo A,Curiel AG

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Recently, multiple-line chemotherapy has become popular for non-small cell lung cancer (NSCLC). The survival time of patients is influenced by patient characteristics and subsequent treatments. METHODS:The usefulness of paclitaxel plus S1 (PTX+S1) was evaluated in 46 pretreated NSCLC patients. Time from the...

journal_title：Chemotherapy

authors： Aono N,Ito Y,Nishino K,Uchida J,Kumagai T,Akazawa Y,Okuyama T,Yoshinami T,Imamura F

更新日期：2012-01-01 00:00:00

abstract：:Prolonged intermittent renal replacement therapy (PIRRT) is an increasingly adopted method of renal replacement in critically ill patients. Like continuous renal replacement therapy, PIRRT can alter the pharmacokinetics (PK) of many drugs. In this setting, dosing data for antibiotics like benzylpenicillin are lacking....

journal_title：Chemotherapy

authors： Cheng V,Rawlins M,Chang T,Fox E,Dyer J,Allen C,Litton E,Page MM,Hoad K,Roberts JA

更新日期：2019-01-01 00:00:00

abstract：:The antibacterial activity of tobramycin, gentamicin, erythromycin, cloxacillin, kanamycin, cephalexin, penicillin, carbenicillin and polymyxin were compared against 303 clinical bacterial isolates from a pediatric hospital patient population. Standard disk diffusion and agar-dilution methods were employed. Significan...

journal_title：Chemotherapy

authors： Laxer RM,Mackay E,Marks MI

更新日期：1975-01-01 00:00:00

abstract：:Neutropenia induced by intensive chemotherapy and allogeneic bone marrow transplantation are increasingly commonly complicated by fungal infections; thus prophylaxis may be justified. The authors surveyed the literature and culled their experience - few randomized trials have been done and definitions have often been ...

journal_title：Chemotherapy

authors： Denning DW,Donnelly JP,Hellreigel KP,Ito J,Martino P,van't Wout JW

更新日期：1992-01-01 00:00:00

abstract：:Community-acquired pneumonia (CAP) is a common illness that creates significant burdens upon the healthcare system. Improving the quality of medical care for patients with this illness requires an evidence-based and cost-efficient treatment approach. The first step in this approach is to make an accurate diagnosis, wh...

journal_title：Chemotherapy

authors： Fine MJ

更新日期：2001-01-01 00:00:00

abstract：:Reference is made to the results obtained in 24 children, from 11 months to 12 years, affected with acute pneumopathies and treated with fosfomycin with a dosage of 200 mg/kg/day. In all cases a clinical, radiological, biological and bacteriological study was carried out. At the same time, levels of fosfomycin in plas...

journal_title：Chemotherapy

authors： Llorens J,Ley G,Forés A,Olay T

更新日期：1977-01-01 00:00:00

abstract：:Therapy of listeriosis with ampicillin was examined in two murine models with compromised defense mechanisms. In mice treated with dextran sulfate paralysing the function of the macrophage system, ampicillin was less able to reduce death rates as well as bacterial counts in the spleens than after infection of normal m...

journal_title：Chemotherapy

authors： Hof H,Emmerling P,Seeliger HP

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:Pneumolysin is an important virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities released during growth and autolysis. At concentrations above the minimal inhibitory concentration, the protein-synthesis-inhibiting antibiotics erythromycin, clindamycin and rifampicin inhib...

journal_title：Chemotherapy

authors： Spreer A,von Ruden C,Mitchell TJ,Eiffert H,Nau R

更新日期：2007-01-01 00:00:00

abstract：:The intraphagocytic killing of Escherichia coli, Serratia marcescens, Pseudomonas aeruginosa, and Salmonella typhi by ciprofloxacin (0.1, 1 and 5 microg/ml) within human neutrophils with intact and impaired (by phenylbutazone treatment) O2-dependent killing mechanisms was studied and compared with the extracellular ki...

journal_title：Chemotherapy

authors： Cantón E,Peman J,Cabrera E,Velert M,Orero A,Pastor A,Gobernado M

更新日期：1999-07-01 00:00:00

abstract：:The 2,3-dihydroxy-6-bromo-pyrazino-[2,3-beta]-pyrazine is a substance selected during the antiviral screening of pyrazino-pyrazine derivatives. The compound shows antiviral activity in vitro against measles, NDV, some influenza viruses and against herpes simplex and zoster, infectious canine hepatitis and vaccinia vir...

journal_title：Chemotherapy

authors： Verini MA,Fioretti A,Casazza AM,Sanfilippo A,Palamidessi G,Ghione M

更新日期：1975-01-01 00:00:00

abstract：:A total of 30 hospitalized patients with upper and lower urinary tract infections were treated with cefotaxime (HR-756) by intramuscular or intravenous route. All patients had a monomicrobial infection, and the major part of bacterial isolates were gram-negative bacilli (83%) while gram-positive cocci accounted only f...

journal_title：Chemotherapy

authors： Paradisi F,Cristiano P,Mirone V,D'Armiento V,Iovene MR

更新日期：1982-01-01 00:00:00

abstract：:An in vitro infection model was created using a suspension of macrophages, polymorphonuclear leukocytes, lymphocytes, fibroblasts, and human serum to which pathogen and antibiotic were added. Separate intracellular and extracellular antibiotic concentrations and activity against Staphylococcus aureus and Legionella pn...

journal_title：Chemotherapy

authors： Scaglione F,Demartini G,Dugnani S,Fraschini F

更新日期：1993-11-01 00:00:00

abstract：:The influence of orally administered fosfomycin on intestinal disaccharidases in albino rats was studied. The enzymes were evaluated in a homogenate of the intestinal mucosa, using the method of SOLS and DE LA FUENTE which is based on the colored reaction of the glucose that is freed by the disaccharidases from disacc...

journal_title：Chemotherapy

authors： Casanovas X,Torralba A

更新日期：1977-01-01 00:00:00

abstract：:The post-antibiotic effects (PAEs) of a new cephalosporin, cefdinir, were determined against a range of organisms using a viable counting technique. Cefdinir exerted considerable PAEs against Staphylococcus aureus and Streptococcus pyogenes, but no overall post-antibiotic inhibition of growth was detected against Esch...

journal_title：Chemotherapy

authors： Howard BM,Pinney RJ,Smith JT

更新日期：1994-07-01 00:00:00

abstract：:The pharmacokinetics and antibacterial efficacy of mezlocillin, cefotaxime, cefoperazone and the mezlocillin/cefalosporin combinations, respectively, were studied by adopting the granuloma pouch model in rats. Exudate concentrations of mezlocillin were higher after combined i.v. injection with a cefalosporin as determ...

journal_title：Chemotherapy

authors： Dalhoff A,Gehl AE,Gau W,Lode H

更新日期：1982-01-01 00:00:00

abstract：:Despite extensive research efforts, effective therapies for refractive cancers have not yet been established, and development of successful treatment strategies remains the most important task in the field of oncology. We recently showed that AVE8062 (formerly AC7700), a derivative of combretastatin A-4, achieved irre...

journal_title：Chemotherapy

authors： Hori K

更新日期：2005-10-01 00:00:00

abstract：:One hundred symptomatic women with clinical bacterial vaginosis (BV) were enrolled in this study. The bacteriological epidemiology of BV and efficacy of oral or vaginal administration of antimicrobial agents for treatment of BV were investigated. The epidemiology of BV was investigated before antimicrobial therapy. Fi...

journal_title：Chemotherapy

authors： Mikamo H,Kawazoe K,Izumi K,Ito K,Katoh N,Watanabe K,Ueno K,Tamaya T

更新日期：1996-01-01 00:00:00

abstract：:Ofloxacin, like other 4-quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial DNA synthesis, rather than cell wall or protein synthesis. The 4-quinolones are also unusual because even for serious infections they can be given orally. Most unusually transferable...

journal_title：Chemotherapy

authors： Smith JT

更新日期：1991-01-01 00:00:00

abstract：:The two studies which are reviewed in this paper demonstrate the value of fluorescent microscopic observations in the studying of the distribution of antibiotics in lung tissue and in sinus secretions. In the lung tissue study, the standard microbiologic assay data on doxycycline concentrations in respiratory tissue t...

journal_title：Chemotherapy

authors： Liss RH,Norman JC

更新日期：1975-01-01 00:00:00