Abstract:
BACKGROUND:T790M is a major cause of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance, but the clinical significance of T790M disappearance is unknown. CASE REPORT:We report 3 cases of pulmonary adenocarcinoma which did not respond to EGFR-TKI retreatment even with T790M disappearance. T790M mutations were detected in the pleural effusions after the tumors had acquired EGFR-TKI resistance. T790M mutations disappeared from cancer cells in the pleural effusion after a break from the treatment drug and cytotoxic agent administration. However, no therapeutic effect was obtained despite EGFR-TKI reinitiation. CONCLUSIONS:Responsiveness to EGFR-TKI might not be restored in some cases, although the disappearance of T790M mutations is confirmed.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Kodama T,Watanabe K,Shinkai M,Kaneko Tdoi
10.1159/000491937subject
Has Abstractpub_date
2018-01-01 00:00:00pages
198-202issue
4eissn
0009-3157issn
1421-9794pii
000491937journal_volume
63pub_type
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