Comparison between 5-fluorocytosine, amphotericin B and the combined administration of these agents in the therapeutic effectiveness for cryptococcal meningitis.

abstract：BACKGROUND:The purpose of this study was to evaluate the feasibility and compliance of adjuvant chemotherapy of S-1 plus carboplatin for patients with completely resected non-small cell lung cancer (NSCLC) of pathological stage IB-IIIB. METHODS:S-1 was given orally at a dose of 80 mg/m²/day for 2 weeks, followed by a ...

journal_title：Chemotherapy

authors： Komazaki Y,Sakashita H,Furuiye M,Fujie T,Tamaoka M,Sumi Y,Miyazaki Y,Kojima K,Jin Y,Inase N

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The rise in the rates of antibiotic resistance among Pseudomonas aeruginosa strains from cystic fibrosis (CF) patients is concerning and underscores the need for the development of novel compounds. Among them CSA-13, a cationic steroid molecule, mimics the activity of naturally occurring antimicrobial peptid...

journal_title：Chemotherapy

authors： Bozkurt-Guzel C,Savage PB,Gerceker AA

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The aim of this clinical study was to evaluate the efficacy of combination chemotherapy of oxaliplatin, leucovorin and continuous-infusion 5-fluorouracil (5-FU) for advanced gastric cancer. METHODS:Patients with previously untreated gastric cancer with measurable disease received oxaliplatin (100 mg/m(2), d...

journal_title：Chemotherapy

authors： Lim JY,Cho JY,Oh KJ,Choi SH,Lee SI,Jeung HC

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Adherence to imatinib therapy has been significantly associated with disease progression and direct medical costs in gastrointestinal stromal tumor (GIST) patients. However, adherence to oral anticancer drugs is frequently hindered by the influence of various factors. The aim of this study was to evaluate th...

journal_title：Chemotherapy

authors： Wang Y,Zhang P,Han Y,Nelson RS,McLeod HL,Tao K,Yuan Y,Zhang M,Xiang H,Zhou H

更新日期：2019-01-01 00:00:00

abstract：:Two groups of patients suffering surgical infections were treated with fosfomycin. The first includes 21 suppurating dermic of soft underlying tissue lesions. The second group includes 29 surgical abdominal infections. The bacteriology of the first group was made up of gram-positive and gram-negative germs predominant...

journal_title：Chemotherapy

authors： Gallardo A,Sáez JM,Enriquez G,Cobacho AR,Torronteras R,Recordan C,Del Moral A,Arroyo A,Curiel AG

更新日期：1977-01-01 00:00:00

abstract：:The treatment of diffuse large B-cell lymphoma in the presence of cardiac comorbidities can be challenging considering that the standard treatment regimen used for this aggressive subtype of non-Hodgkin lymphoma (NHL) consists of a combination of rituximab, cyclophosphamide, doxorubicin hydrochloride, Oncovin (vincris...

journal_title：Chemotherapy

authors： Alrifai T,Grant Szymanski K,Venugopal P,Mahon B,Okwuosa T,Karmali R

更新日期：2017-01-01 00:00:00

abstract：:The two studies which are reviewed in this paper demonstrate the value of fluorescent microscopic observations in the studying of the distribution of antibiotics in lung tissue and in sinus secretions. In the lung tissue study, the standard microbiologic assay data on doxycycline concentrations in respiratory tissue t...

journal_title：Chemotherapy

authors： Liss RH,Norman JC

更新日期：1975-01-01 00:00:00

abstract：:The in vitro activity of cefetamet against Escherichia coli, Klebsiella pneumoniae and Serratia marcescens strains expressing an SHV-5-type beta-lactamase was evaluated. Most of the examined strains were susceptible to the antibiotic. Cefetamet was found to be considerably more active than ceftazidime and aztreonam. I...

journal_title：Chemotherapy

authors： Tzouvelekis LS,Prinarakis EE,Gazouli M,Miriagou V,Tzelepi E,Legakis NJ

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:The brain is a frequent site of metastases in small-cell lung cancer. Symptoms of cerebral involvement are headache, disorientation, nausea/vomiting and seizures. CASE:A man with small-cell lung cancer developed a human herpesvirus 6 (HHV-6) meningoencephalitis with neurological symptoms that simulated brai...

journal_title：Chemotherapy

authors： Mordenti P,Zaffignani E,Immovilli P,Nobili E,Cavanna L

更新日期：2013-01-01 00:00:00

abstract：:Combination antiretroviral (ARV) treatment is a potent and effective therapy for human immunodeficiency virus infection. Unfortunately, ARV drugs frequently interact among themselves, as well as with other anti-infectives. These interactions determine positive or negative consequences resulting in recommendations to a...

journal_title：Chemotherapy

authors： Pontali E

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Cisplatin resistance has been mainly associated with decreased cellular accumulation and increased intracellular glutathione (GSH) levels. ATP is known to increase the membrane permeability of cells and to decrease intracellular GSH levels. Our study aimed at using extracellular ATP to sensitize ovarian carc...

journal_title：Chemotherapy

authors： Rotte A,Garmann D,Buss I,Jaehde U

更新日期：2010-01-01 00:00:00

abstract：:Pharmacokinetic studies were conducted with norfloxacin administered by the oral and subcutaneous routes to mice and rats, and by the oral route to rhesus monkeys. The compound was moderately well absorbed following oral dosing in these animal species. Serum levels in monkeys ranged from 1.0 to 2.35 micrograms/ml afte...

journal_title：Chemotherapy

authors： Gilfillan EC,Pelak BA,Bland JA,Malatesta PF,Gadebusch HH

更新日期：1984-01-01 00:00:00

abstract：:Concentrations of latamoxef, cefoperazone and piperacillin, administered intravenously, were measured in serum and sputum of cystic fibrosis patients with recurrent pulmonary infections, chronically colonized with Pseudomonas aeruginosa. Serum pharmacokinetic data were consistent with prior reports. Peak sputum to pea...

journal_title：Chemotherapy

authors： Laferriere C,Stutman HR,Marks MI,Kramer J,Flux M

更新日期：1985-01-01 00:00:00

abstract：:Cardiovascular (CV) adverse events are considered common complications of ponatinib treatment. Recently, it has been demonstrated that ponatinib dose reductions in definite settings can obtain optimal responses and lower ponatinib-related CV events. In this study, we describe the management of 5 patients with chronic ...

journal_title：Chemotherapy

authors： Santoro M,Accurso V,Mancuso S,Contrino AD,Sardo M,Novo G,Di Piazza F,Perez A,Russo A,Siragusa S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Brucellosis is one of the important health problems for both humans and animals in Turkey since agriculture and stock raising appears to be the most important means of subsistence. Investigations on the pathogenesis of brucellosis reveal that the etiologic agent can survive in phagocytic cells, and cell-medi...

journal_title：Chemotherapy

authors： Dizer U,Hayat L,Beker CM,Görenek L,Ozgüven V,Pahsa A

更新日期：2005-03-01 00:00:00

abstract：:The intraphagocytic killing of Escherichia coli, Serratia marcescens, Pseudomonas aeruginosa, and Salmonella typhi by ciprofloxacin (0.1, 1 and 5 microg/ml) within human neutrophils with intact and impaired (by phenylbutazone treatment) O2-dependent killing mechanisms was studied and compared with the extracellular ki...

journal_title：Chemotherapy

authors： Cantón E,Peman J,Cabrera E,Velert M,Orero A,Pastor A,Gobernado M

更新日期：1999-07-01 00:00:00

abstract：:Treatment of enterococcal infections is often difficult because of intrinsic and acquired resistance to a variety of antimicrobial agents. Between January 1993 and May 1997, enterococci were isolated from blood cultures of 117 patients at the Institute of Medical Microbiology and Immunology, University Hospital Eppend...

journal_title：Chemotherapy

authors： Elsner HA,Sobottka I,Feucht HH,Claussen M,Kaulfers PM,Laufs R,Mack D

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Our objectives were to assess the pharmacokinetic interaction and body fluid penetration of ciprofloxacin and levofloxacin. METHODS:This study was a single-dose open randomized three-way crossover in 15 healthy volunteers receiving 500 mg oral levofloxacin, 500 mg oral ciprofloxacin, or 250 mg levofloxacin ...

journal_title：Chemotherapy

authors： Bulitta JB,Kinzig M,Naber CK,Wagenlehner FM,Sauber C,Landersdorfer CB,Sörgel F,Naber KG

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Development of novel strategies to kill cancer by sparing normal cells is of utmost importance. Apart from their known antimicrobial activity, only limited information has been recorded regarding the antitumor potential of biocompatible silver oxide nanoparticles (AgONPs). There is a need to evaluate the ant...

journal_title：Chemotherapy

authors： Banerjee K,Das S,Choudhury P,Ghosh S,Baral R,Choudhuri SK

更新日期：2017-01-01 00:00:00

abstract：:Cefepime is active against bacteria producing chromosomally and plasmid-mediated extended broad-spectrum β-lactamase enzymes. The aim of this study was to evaluate risk factors for acquisition of cefepime resistance in Escherichia coli strains among hospitalized patients in a university hospital in Sanandaj, Iran. The...

journal_title：Chemotherapy

authors： Mansouri M,Ramazanzadeh R,Norabadi P

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Chronic hepatitis B (CHB) affects 400 million people worldwide and is a major cause of morbidity and mortality. It is known that HBV DNA sequences were detected after the clearance of serum hepatitis B surface antigen (HBsAg) often in serum, liver and peripheral blood mononuclear cells. The objectives of our...

journal_title：Chemotherapy

authors： Akhan SC,Yulugkural Z,Vahaboglu H

更新日期：2007-01-01 00:00:00

abstract：:Itraconazole has emerged as an important new oral agent in the treatment of systemic fungal infections. This paper summarizes the data available on its use in aspergillosis, cryptococcosis and histoplasmosis, compiled in the United States with particular attention to the immunocompromised host. Data have been accrued ...

journal_title：Chemotherapy

authors： Hostetler JS,Denning DW,Stevens DA

更新日期：1992-01-01 00:00:00

abstract：:Resistant variants of three clinical Pseudomonas aeruginosa isolates were obtained in the presence of aztreonam. The variants exhibited a four- to eightfold increase in the minimal inhibitory concentrations to beta-lactam antibiotics (except imipenem) to quinolones, such as norfloxacin and fleroxacin, chloramphenicol ...

journal_title：Chemotherapy

authors： Leying HJ,Büscher KH,Cullmann W,Then RL

更新日期：1992-01-01 00:00:00

abstract：:Body lice (Pediculus humanus corporis L) and ticks (Ornithodoros moubata) that had been infected with Rickettsia prowazekii received varying doses of erythromycin. The anti-rickettsial activity of this drug was evaluated with regard to the determination of the numbers of surviving microorganism (LID100) and the in viv...

journal_title：Chemotherapy

authors： Becla E

更新日期：1976-01-01 00:00:00

abstract：:Mezlocillin was used alone and in combination with cloxacillin in the treatment of chronic experimental osteomyelitis due to Morganella morganii. This combination showed in vitro synergy as measured by the checkerboard technique. A marked inoculum affect was demonstrated in vitro with mezlocillin and the infecting str...

journal_title：Chemotherapy

authors： Norden CW,Shaffer M

更新日期：1984-01-01 00:00:00

abstract：:Combination of 9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] and 6-azauridine (AzUrd) is highly active in the selective inhibition of vaccinia virus in chick embryo cell culture. Synergic effect of this combination of compounds was not encountered in HeLa cell culture. Of the 17 analogues related to DHPA studied in th...

journal_title：Chemotherapy

authors： Rada B,Holý A

更新日期：1980-01-01 00:00:00

abstract：:In this study, rational dosing guidelines for amphotericin B-deoxycholate (AmB) are proposed for children. AmB steady-state trough concentrations (C(ss,trough)) and plasma creatinine concentrations (C(creat)) were measured in 83 children (age: 10 months to 18 years) receiving prophylactic AmB therapy (1 mg/kg/day). Ma...

journal_title：Chemotherapy

authors： Nath CE,McLachlan AJ,Shaw PJ,Coakley JC,Earl JW

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Ciprofloxacin is commonly used and considered to be relatively safe in patients with cirrhosis, especially in the treatment of enteric and urinary tract infections. Among the adverse effects of ciprofloxacin, neurologic complications are rare. METHODS/RESULTS:We report a case of hemiballism and altered ment...

journal_title：Chemotherapy

authors： Kim SH,Jeong SH,Kim JW,Lee SH,Kim JM

更新日期：2009-01-01 00:00:00

abstract：:We have treated 45 cases of urinary tract infection with cefazolin (i.m.) and cure was achieved in 35 (77.77%). 26 of the 28 patients (92.85%) with acute cystitis who received 250 mg every 12 h for 6-10 days were cured. 17 patients with pyelonephritis received 500 mg every 12 h during 10-14 days and therapeutical succ...

journal_title：Chemotherapy

authors： Lus RG,Calvo MC,Lopez LG,Cancer RC,Molina AM,Sanchez ED,Parilla AC,Mur LL

更新日期：1977-01-01 00:00:00

abstract：:A-56619 and A-56620 are two new quinolone compounds that are currently being studied. They were found to be active against multi-resistant and routine isolates of Staphylococcus aureus, enterobacteria, aminoglycoside-sensitive and resistant strains of Pseudomonas aeruginosa. Most of the enterobacteria were inhibited b...

journal_title：Chemotherapy

authors： Fernandes CJ,Wilson RD,Ackerman VP

更新日期：1988-01-01 00:00:00