Pharmacokinetics of oral co-trimazine and the penetration of its components sulfadiazine and trimethoprim into peripheral human lymph.

abstract：:Malignant tumors are known to exhibit high rates of glycolytic activity leading to high production of lactic acid. Hence, neoplastic cells have elevated activity of enzymes responsible for glycolysis. Echitamine chloride, an indole alkaloid extracted from the bark of Alstonia scholaris, has been reported to have a hig...

journal_title：Chemotherapy

authors： Saraswathi V,Ramamoorthy N,Subramaniam S,Mathuram V,Gunasekaran P,Govindasamy S

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:To define the maximum tolerated dose (MTD) tolerability and efficacy of intra-arterial chemotherapy with irinotecan in patients with liver metastases of colorectal carcinoma (CRC). METHODS:Superselective intra-arterial irinotecan was applied on days 1, 14, 28 and 42. The initial dose was 140 mg/m² with esca...

journal_title：Chemotherapy

authors： Eichler K,Dufas T,Hammerstingl R,Gruber-Rouh T,Vogl TJ,Zangos S

更新日期：2013-01-01 00:00:00

abstract：:Rifampicin (RMP) and two riminophenazine compounds (B663 and B1912) suppressed the growth of Mycobacterium marinum in vitro and in a mouse footpad infection. At appropriate concentrations and dietary dosage, all three drugs showed bactericidal activity in vitro and in vivo. On the basis of minimum inhibitory concentra...

journal_title：Chemotherapy

authors： Banerjee DK,Holmes IB

更新日期：1976-01-01 00:00:00

abstract：:Therapy of listeriosis with ampicillin was examined in two murine models with compromised defense mechanisms. In mice treated with dextran sulfate paralysing the function of the macrophage system, ampicillin was less able to reduce death rates as well as bacterial counts in the spleens than after infection of normal m...

journal_title：Chemotherapy

authors： Hof H,Emmerling P,Seeliger HP

更新日期：1981-01-01 00:00:00

abstract：:Two groups of patients suffering surgical infections were treated with fosfomycin. The first includes 21 suppurating dermic of soft underlying tissue lesions. The second group includes 29 surgical abdominal infections. The bacteriology of the first group was made up of gram-positive and gram-negative germs predominant...

journal_title：Chemotherapy

authors： Gallardo A,Sáez JM,Enriquez G,Cobacho AR,Torronteras R,Recordan C,Del Moral A,Arroyo A,Curiel AG

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Cisplatin resistance has been mainly associated with decreased cellular accumulation and increased intracellular glutathione (GSH) levels. ATP is known to increase the membrane permeability of cells and to decrease intracellular GSH levels. Our study aimed at using extracellular ATP to sensitize ovarian carc...

journal_title：Chemotherapy

authors： Rotte A,Garmann D,Buss I,Jaehde U

更新日期：2010-01-01 00:00:00

abstract：:A total of 1,442 patients with symptoms of chronic prostatitis were examined over a 4-year period at the Outpatient Department for Urogenital Infections, University Hospital for Infectious Diseases Dr. Fran Mihaljević, Zagreb, Croatia. The inclusion criteria for chronic prostatitis caused by Ureaplasma urealyticum wer...

journal_title：Chemotherapy

authors： Skerk V,Mareković I,Markovinović L,Begovac J,Skerk V,Barsić N,Majdak-Gluhinić V

更新日期：2006-01-01 00:00:00

abstract：:New fluoroquinolones, as exemplified by levofloxacin, possess broad spectrum activity against many common pathogens, including the majority responsible for respiratory tract infections (RTIs), atypical pathogens and those resistant to other therapeutic regimens. Following administration, levofloxacin attains high intr...

journal_title：Chemotherapy

authors： Graninger W,Zeitlinger M

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:5-Fluorouracil (5-FU) is a widely used drug in head and neck squamous cell carcinoma (HNSCC). Thymidylate synthase (TS), which is the target enzyme of 5-FU, has been demonstrated to be a key regulatory enzyme. In this study, we examined whether TS expression is correlated with chemosensitivity to 5-FU, cell ...

journal_title：Chemotherapy

authors： Yasumatsu R,Nakashima T,Uryu H,Ayada T,Wakasaki T,Kogo R,Masuda M,Fukushima M,Komune S

更新日期：2009-01-01 00:00:00

abstract：:The pharmacokinetics and antibacterial efficacy of mezlocillin, cefotaxime, cefoperazone and the mezlocillin/cefalosporin combinations, respectively, were studied by adopting the granuloma pouch model in rats. Exudate concentrations of mezlocillin were higher after combined i.v. injection with a cefalosporin as determ...

journal_title：Chemotherapy

authors： Dalhoff A,Gehl AE,Gau W,Lode H

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Gram-negative bacilli are the most common bacteria causing nosocomial bloodstream infections (NBSIs) in Latin American countries. METHODS:The antibiotic resistance profiles of Gram-negative bacilli isolated from blood cultures in pediatric patients with NBSIs over a 3-year period in a tertiary care pediatri...

journal_title：Chemotherapy

authors： Ares MÁ,Alcántar-Curiel MD,Jiménez-Galicia C,Rios-Sarabia N,Pacheco S,De la Cruz MÁ

更新日期：2013-01-01 00:00:00

abstract：:The susceptibility of 26 strains of Campylobacter pylori to 7 new quinolone antibiotics and nalidixic acid was determined. All strains were resistant to nalidixic acid. Difloxacin, A-56620, A-62254, and ciprofloxacin were equally effective against the test strains with MICs ranging from 0.06 to 2.0 micrograms/ml. Fler...

journal_title：Chemotherapy

authors： Hupertz V,Carr H,Czinn SJ

更新日期：1988-01-01 00:00:00

abstract：:We have tested the effectiveness of several antibiotic regimens, using a rat model of Escherichia coli experimental pyelonephritis that mimics the conditions of severe renal infections in man because the infection is acquired by the ascending route. We found that ceftriaxone, when given for 5 days to rats with severe ...

journal_title：Chemotherapy

authors： Glauser MP,Bonard

更新日期：1982-01-01 00:00:00

abstract：:The success of perioperative prophylaxis in gallbladder surgery was examined in two prospective randomized studies with a total of 326 patients. Postoperative wound-healing impairments did not occur in any of the patients receiving a single preoperative application of an antibiotic with a high biliary elimination rate...

journal_title：Chemotherapy

authors： Harnoss BM,Hirner A,Dibbelt H,Häring R,Rodloff R,Lode H

更新日期：1987-01-01 00:00:00

abstract：:Cephalosporins do not reach active therapeutical concentrations in the prostatic tissue in patients suffering from chronic bacterial prostatitis. Cefoperazone is an exception. Its efficacy in the treatment of chronic bacterial prostatitis in 20 patients was studied and the concentrations, obtained after intramuscular ...

journal_title：Chemotherapy

authors： Melloni D,Ammatuna P,Formica P,Falletta V,Gaglio F,Cacciatore M,Messina G

更新日期：1989-01-01 00:00:00

abstract：:Treatment of enterococcal infections is often difficult because of intrinsic and acquired resistance to a variety of antimicrobial agents. Between January 1993 and May 1997, enterococci were isolated from blood cultures of 117 patients at the Institute of Medical Microbiology and Immunology, University Hospital Eppend...

journal_title：Chemotherapy

authors： Elsner HA,Sobottka I,Feucht HH,Claussen M,Kaulfers PM,Laufs R,Mack D

更新日期：2000-03-01 00:00:00

abstract：:There is evidence that a variety of anticancer drugs exert their cytotoxic activity by a free-radical-mediated mechanism. These drugs include anthracyclines such as adriamycin, daunorubicin, 4-epi-adriblastin as well as bleomycin, procarbazine, vincristin, cyclophosphamide, etoposide and mitomycin C. The aim of this s...

journal_title：Chemotherapy

authors： Look MP,Musch E

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Mutant prevention concentration (MPC) is a new parameter that may be of aid in determining the risk of resistant mutants being selected. METHODS:The MPCs of 224 Mycobacterium tuberculosis clinical isolates were estimated by plating more than 10(10) cells on drug-containing agar and determining the concentra...

journal_title：Chemotherapy

authors： Rodríguez JC,Cebrián L,Ruiz M,López M,Royo G

更新日期：2005-05-01 00:00:00

abstract：:The antibacterial activity of imipenem combined with norfloxacin, ciprofloxacin, or ofloxacin against 43 gram-positive cocci and 53 aerobic gram-negative rods compared to results obtained with the combination of imipenem with amikacin. Synergistic antibacterial action (defined as FIC index less than or equal to 0.5) w...

journal_title：Chemotherapy

authors： Kern W,Gulden H,Vanek E,Kurrle E

更新日期：1988-01-01 00:00:00

abstract：:In this paper the bactericidal activities of ofloxacin and its optically active derivative, DR-3355, against non-growing cells of Escherichia coli and Pseudomonas aeruginosa are described. E. coli and P. aeruginosa were killed rapidly by ofloxacin and DR-3355. After treatment with these quinolones, the resting cells o...

journal_title：Chemotherapy

authors： Tanaka M,Otsuki M,Nishino T

更新日期：1992-01-01 00:00:00

abstract：:The study of resistance patterns of strains of bacteria to antibiotics in different regions of a country and, if possible, comparing them at international level appears to be a useful exercise. The patterns of resistance during 1968-71 revealed an increasing resistance for most antibiotics with an unexpected increase ...

journal_title：Chemotherapy

authors： Driessen JH

更新日期：1975-01-01 00:00:00

abstract：:Mezlocillin was used alone and in combination with cloxacillin in the treatment of chronic experimental osteomyelitis due to Morganella morganii. This combination showed in vitro synergy as measured by the checkerboard technique. A marked inoculum affect was demonstrated in vitro with mezlocillin and the infecting str...

journal_title：Chemotherapy

authors： Norden CW,Shaffer M

更新日期：1984-01-01 00:00:00

abstract：:A new semisynthetic ureidopenicillin (Bay K 4999) demonstrates favorably in vitro antibacterial efficacy against human-pathogenic gram-negative rods in comparison to mezlocillin and azlocillin. A comparative paramcokinetic study was done with 10 test subjects after 30 min intravenous infusion of 4.0 g of Bay K and mez...

journal_title：Chemotherapy

authors： Lode H,Tomas W,Koeppe P,Wagner J

更新日期：1980-01-01 00:00:00

abstract：:The pharmacokinetics of ceftriaxone (CRO) after subcutaneous and intravenous administration was studied in 10 healthy volunteers (5 males, 5 females, age 22-43 years, body weight 64.3 +/- 9.5 kg). Each of them received 2.0 g CRO i.v., and then 0.5 g i.v. and 0.5 g CRO s.c. in a randomized cross-over design. Subcutaneo...

journal_title：Chemotherapy

authors： Borner K,Lode H,Hampel B,Pfeuffer M,Koeppe P

更新日期：1985-01-01 00:00:00

abstract：:Cefpirome and six other antimicrobial agents were tested against 884 blood culture isolates from cancer patients. Cefpirome was highly active against aerobic gram-negative bacilli including Acinetobacter spp., and the Enterobacteriaceae. Only imipenem was more active than cefpirome against Pseudomonas aeruginosa. Cefp...

journal_title：Chemotherapy

authors： Rolston K,Alvarez ME,Hoy JF,LeBlanc B,Ho DH,Bodey GP

更新日期：1986-01-01 00:00:00

abstract：:We have treated 45 cases of urinary tract infection with cefazolin (i.m.) and cure was achieved in 35 (77.77%). 26 of the 28 patients (92.85%) with acute cystitis who received 250 mg every 12 h for 6-10 days were cured. 17 patients with pyelonephritis received 500 mg every 12 h during 10-14 days and therapeutical succ...

journal_title：Chemotherapy

authors： Lus RG,Calvo MC,Lopez LG,Cancer RC,Molina AM,Sanchez ED,Parilla AC,Mur LL

更新日期：1977-01-01 00:00:00

abstract：:The effect of acyclovir (ACV) treatment on selected functions of human blood-derived macrophages was examined. ACV was not cytotoxic when applied in a wide range of concentrations. Only minor effects on macrophage functions were observed when cells were treated with therapeutic concentrations of ACV:phagocytosis and t...

journal_title：Chemotherapy

authors： Stenseth AM,Rollag H,Degré M

更新日期：1993-05-01 00:00:00

abstract：:Combination antiretroviral (ARV) treatment is a potent and effective therapy for human immunodeficiency virus infection. Unfortunately, ARV drugs frequently interact among themselves, as well as with other anti-infectives. These interactions determine positive or negative consequences resulting in recommendations to a...

journal_title：Chemotherapy

authors： Pontali E

更新日期：2007-01-01 00:00:00

abstract：:Before appendectomy 36 adult patients were given an intravenous infusion of 500 mg of tinidazole. In the operation tissue samples were taken (blood, base of appendix vermiformis, muscle, fat) either 10, 20, 30, 60, or 120 min after cessation of infusion. The tinidazole concentrations were determined by liquid chromato...

journal_title：Chemotherapy

authors： Viitanen J,Auvinen O,Tunturi T

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Nevirapine (NVP) is a nonnucleoside reverse transcriptase inhibitor used in HIV patients and recently evaluated as a differentiating and antiproliferative agent in human malignancies. However, while NVP is a safe treatment in immunocompromised patients, NVP-containing regimens have been associated with sever...

journal_title：Chemotherapy

authors： Landriscina M,Fabiano A,Lombardi V,Santodirocco M,Piscazzi A,Fersini A,De Vis K,Barone C,Cignarelli M

更新日期：2008-01-01 00:00:00