A computer study of bacterial resistance patterns to antibiotics.

abstract：BACKGROUND:Development of novel strategies to kill cancer by sparing normal cells is of utmost importance. Apart from their known antimicrobial activity, only limited information has been recorded regarding the antitumor potential of biocompatible silver oxide nanoparticles (AgONPs). There is a need to evaluate the ant...

journal_title：Chemotherapy

authors： Banerjee K,Das S,Choudhury P,Ghosh S,Baral R,Choudhuri SK

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:An ethylacetate-soluble fraction (ET4) from the lichen Ramalina farinacea has previously been shown to inhibit the infectivity of lentiviral and adenoviral vectors, as well as wild-type HIV-1. We now determined the antiviral activity of ET4 against other wild-type viruses, including the herpes simplex virus ...

journal_title：Chemotherapy

authors： Esimone CO,Grunwald T,Nworu CS,Kuate S,Proksch P,Uberla K

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Bacterial endotoxin is known to act as a potent trigger of disseminated coagulation and septic shock. During clinical antibiotic treatment, endotoxin may be released from Gram-negative bacteria. It is known that antibiotic classes differ in their ability to induce endotoxin release. AIM:It was the aim of th...

journal_title：Chemotherapy

authors： Trautmann M,Scheibe C,Wellinghausen N,Holst O,Lepper PM

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:T790M is a major cause of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance, but the clinical significance of T790M disappearance is unknown. CASE REPORT:We report 3 cases of pulmonary adenocarcinoma which did not respond to EGFR-TKI retreatment even with T790M disappearance...

journal_title：Chemotherapy

authors： Kodama T,Watanabe K,Shinkai M,Kaneko T

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The effects of gemcitabine on postoperative adjuvant chemotherapy were evaluated in patients with stage IV pancreatic cancer. The results were compared with those of our historical control patients treated with surgery alone. PATIENTS AND METHODS:Nineteen patients with stage IV pancreatic cancer who had pan...

journal_title：Chemotherapy

authors： Kurosaki I,Hatakeyama K

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Gram-negative bacilli are the most common bacteria causing nosocomial bloodstream infections (NBSIs) in Latin American countries. METHODS:The antibiotic resistance profiles of Gram-negative bacilli isolated from blood cultures in pediatric patients with NBSIs over a 3-year period in a tertiary care pediatri...

journal_title：Chemotherapy

authors： Ares MÁ,Alcántar-Curiel MD,Jiménez-Galicia C,Rios-Sarabia N,Pacheco S,De la Cruz MÁ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells. We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ova...

journal_title：Chemotherapy

authors： Yamagami W,Banno K,Kawaguchi M,Yanokura M,Kuwabara Y,Hirao N,Susumu N,Tsukazaki K,Aoki D

更新日期：2007-01-01 00:00:00

abstract：:A group of cis-ethylenediammine platinum (II) complexes were synthesized and their activity against Sarcoma-180 ascites tumour cells in mouse was tested. One of the compounds, Pt(HOCH2CH2NHCH2CH2NH2)Cl2, showed significant antitumour activity having little toxicity to the host. Like the parent compound, cis-DDP, it bi...

journal_title：Chemotherapy

authors： Chakraborty BK,Biswas N,Choudhury K,Neogy RK,Das Sarma B

更新日期：1985-01-01 00:00:00

abstract：:The minimum inhibitory concentration (MIC) of the new penem ALP 201 was tested against 243 recent clinical isolates of which 95 were from the family Enterobacteriaceae, 50 were from the genus Streptococcus, 50 were Staphylococcus aureus and 48 were Staphylococcus epidermidis. An agar dilution technique was used to det...

journal_title：Chemotherapy

authors： Bergan T,da Fonseca J

更新日期：1991-01-01 00:00:00

abstract：:A technique for inducing pneumococcal meningitis in mice and a description of the histopathologic changes that accompany this experimentally produced disease are provided in the present report. This infection of mice was investigated to determine whether it could serve as a suitable model for detecting agents that hav...

journal_title：Chemotherapy

authors： Tsai YH,Williams EB,Hirth RS,Price KE

更新日期：1975-01-01 00:00:00

abstract：:Current treatment modalities for bronchopulmonary aspergillosis are not very satisfying. We determined the in vitro activity of recently available azoles against Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger. Subsequently, these agents were evaluated in an animal model of bronchopulmonary aspergillos...

journal_title：Chemotherapy

authors： Schmitt HJ,Edwards F,Andrade J,Niki Y,Armstrong D

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the therapeutic adult antibiotics prescribed by dental practitioners working in the Jordan University Hospital. METHODS:Adult dental prescriptions for therapeutic antibiotics issued between 1 January 2003 and 31 May 2004 by dental specialists working in the Jordan Unive...

journal_title：Chemotherapy

authors： Dar-Odeh NS,Abu-Hammad OA,Khraisat AS,El Maaytah MA,Shehabi A

更新日期：2008-01-01 00:00:00

abstract：:Therapy of listeriosis with ampicillin was examined in two murine models with compromised defense mechanisms. In mice treated with dextran sulfate paralysing the function of the macrophage system, ampicillin was less able to reduce death rates as well as bacterial counts in the spleens than after infection of normal m...

journal_title：Chemotherapy

authors： Hof H,Emmerling P,Seeliger HP

更新日期：1981-01-01 00:00:00

abstract：:Fosfomycin, an antibiotic discovered in Spain, has a unique chemical structure and pharmacologic features that are promising for clinical therapy. It is only partially absorbed orally, with relatively low blood levels. Intramuscularly, however, absorption is complete with peak blood levels 3-5 times as high as orally,...

journal_title：Chemotherapy

authors： Kirby WM

更新日期：1977-01-01 00:00:00

abstract：:The in vitro activities of quinupristin/dalfopristin (Synercid), ampicillin, erythromycin, clarithromycin, vancomycin, teicoplanin, ciprofloxacin and tetracycline were examined and compared against 526 gram-positive bacteria. The minimal inhibitory concentrations (MICs) for quinupristin/dalfopristin against Staphyloco...

journal_title：Chemotherapy

authors： Ling TK,Fung KS,Cheng AF

更新日期：2001-07-01 00:00:00

abstract：:Bacterial growth kinetic experiments have been performed to study the potentiating effect of trimethoprim (TMP) AND TMP derivatives on the antibacterial action of sulfonamides (SA). The TMP derivatives showed different inhibitory effects when used alone. Derivatives with decreased inhibitory activity excerted 'bacteri...

journal_title：Chemotherapy

authors： Seydel JK,Wempe E

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Transplant-related mortality (TRM) significantly decreases the long-term survival of patients with hematopoietic diseases who undergo hematopoietic stem cell transplantation (HSCT). METHODS:We retrospectively evaluated the risk factors for TRM of 58 consecutive patients with hematopoietic disease who underw...

journal_title：Chemotherapy

authors： Nakamae H,Yamane T,Aoyama Y,Yamamura R,Ohta K,Hino M

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Cisplatin resistance has been mainly associated with decreased cellular accumulation and increased intracellular glutathione (GSH) levels. ATP is known to increase the membrane permeability of cells and to decrease intracellular GSH levels. Our study aimed at using extracellular ATP to sensitize ovarian carc...

journal_title：Chemotherapy

authors： Rotte A,Garmann D,Buss I,Jaehde U

更新日期：2010-01-01 00:00:00

abstract：:Minimal bactericidal concentrations of thienamycin revealed moderate intraphagolysosomal bactericidal activity against pseudo-(PSR) and genuinely serum-resistant (NSS) assay strains of Serratia marcescens. Combinations of inhibitory and subinhibitory concentrations of thienamycin with 55 vol% of defibrinated human blo...

journal_title：Chemotherapy

authors： Traub WH

更新日期：1983-01-01 00:00:00

abstract：:Cefpirome and six other antimicrobial agents were tested against 884 blood culture isolates from cancer patients. Cefpirome was highly active against aerobic gram-negative bacilli including Acinetobacter spp., and the Enterobacteriaceae. Only imipenem was more active than cefpirome against Pseudomonas aeruginosa. Cefp...

journal_title：Chemotherapy

authors： Rolston K,Alvarez ME,Hoy JF,LeBlanc B,Ho DH,Bodey GP

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:The application of liposome-encapsulated cytostatics results in higher concentrations in tumor tissue. This effect can be further increased by blood flow retardation with longer retention time in the tumor and by arterial administration realized in abdominal stop-flow therapy, a separate partial circulation ...

journal_title：Chemotherapy

authors： Pohlen U,Binnenhei M,Reszka R,Buhr HJ,Berger G

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:This study assessed the population pharmacokinetics and metabolic conversion of a novel histone deacetylase (HDAC) inhibitor, SD-2007, into its active metabolite, apicidin, in rats. METHODS:SD-2007 was given to rats by intravenous injection (4 mg/kg) and oral administration (40 mg/kg). Serum concentrations ...

journal_title：Chemotherapy

authors： Shin BS,Bulitta JB,Hong DK,Kim HY,Kim MK,Choi Y,Lee JB,Hwang SW,Lee MH,Yoo SD

更新日期：2011-01-01 00:00:00

abstract：:Concentrations of cefotetan in the intestinal wall of patients with Crohn's disease were investigated with the method of tissue homogenates with the aim to evaluate the effects of inflammation on tissue distribution. Twenty-four patients who underwent surgery were treated with a 2-gram single dose of cefotetan intrave...

journal_title：Chemotherapy

authors： Mazzei T,Tonelli F,Anastasi A,Ficari F,Novelli A,Periti P

更新日期：1991-01-01 00:00:00

abstract：:The in vitro antimicrobial activities of AM-1155, a new fluoroquinolone, tosufloxacin and fleroxacin were tested against 55 clinical isolates of Neisseria gonorrhoeae using the agar dilution method. In our previous study, all the strains had been examined for mutations in the region corresponding to the quinolone-resi...

journal_title：Chemotherapy

authors： Deguchi T,Yasuda M,Nakano M,Ozeki S,Kanematsu E,Fukuda H,Maeda S,Saito I,Kawada Y

更新日期：1997-07-01 00:00:00

abstract：:Within recent years, novel serological and molecular methods have been developed to improve the early diagnosis of invasive fungal infections especially in patients with malignant hematological diseases being at highest risk of developing these life-threatening infections. Early diagnosis is essential for adequate the...

journal_title：Chemotherapy

authors： Buchheidt D,Skladny H,Baust C,Hehlmann R

更新日期：2000-05-01 00:00:00

abstract：:Aztreonam is the first monobactam antibiotic to be used clinically. It is highly resistant to beta-lactamases, and although its activity spectrum is similar to that of the aminoglycoside antibiotics, it has no effect on gram-positive bacteria. The current study was undertaken to determine the efficacy of aztreonam in ...

journal_title：Chemotherapy

authors： Schönwald S,Schoss-Vidensek Z,Car V,Krznar B

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the value of tumor markers in monitoring chemotherapy response and predicting prognosis in patients with advanced non-small cell lung cancer (NSCLC). METHODS:We studied carcinoembryonic antigen (CEA), CYFRA21-1 and neuron-specific enolase (NSE) of 111 untreated patients wi...

journal_title：Chemotherapy

authors： Jin B,Huang AM,Zhong RB,Han BH

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Patients with cancer are particularly susceptible to drug interactions (DIs), but the extent of the problem has received limited attention. We aimed to evaluate the frequency of interactions with anticancer agents in a group of cancer patients. METHODS:The study was performed in a Belgian teaching hospital....

journal_title：Chemotherapy

authors： Mouzon A,Kerger J,D'Hondt L,Spinewine A

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:To identify parameters/factors that may contribute to the differential sensitivity to etoposide in two clones isolated from the human ovarian carcinoma SKOV-3 cell line, which does not express p53 and is resistant to platinum-based regimens. METHODS:Differential sensitivity of the cells to etoposide was mon...

journal_title：Chemotherapy

authors： Balan KV,Sitaras NM,Dimas K,Han Z,Wyche JH,Pantazis P

更新日期：2006-01-01 00:00:00

abstract：:A modified Rieckmann test was developed for assessing chloroquine sensitivity of Plasmodium vivax strains. This test envisages the evaluation of parasite growth with different concentrations of the drug and its comparison with controls, at the end of a 48-hour experimental period. Using this test, 16 strains were asse...

journal_title：Chemotherapy

authors： Renapurkar DM,Pradhan VR,Sutar NK,Deshmukh RA,Pandit CH,Marathe SN

更新日期：1989-01-01 00:00:00