Abstract:
:A group of cis-ethylenediammine platinum (II) complexes were synthesized and their activity against Sarcoma-180 ascites tumour cells in mouse was tested. One of the compounds, Pt(HOCH2CH2NHCH2CH2NH2)Cl2, showed significant antitumour activity having little toxicity to the host. Like the parent compound, cis-DDP, it binds to DNA, but transcription is not the primary process inhibited by these compounds. The drug-DNA complex, though less toxic, was not more effective than the free drug.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Chakraborty BK,Biswas N,Choudhury K,Neogy RK,Das Sarma Bdoi
10.1159/000238314subject
Has Abstractpub_date
1985-01-01 00:00:00pages
55-9issue
1eissn
0009-3157issn
1421-9794journal_volume
31pub_type
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