Use of the collagen gel droplet embedded drug sensitivity test to determine drug sensitivity against ovarian mature cystic teratoma with malignant transformation to adenocarcinoma: a case report.

abstract：:Hydrocortisone (HC) has been observed to influence an in vitro Dexter culture system with maintenance of pluripotent hematopoietic stem cells (CFU-s) and progenitor cells (CFU-gm, BFU-e). In the present study, a two-phase murine Dexter culture system was established to study the mechanism of HC-mediated suppression of...

journal_title：Chemotherapy

authors： Horikoshi A,Murphy MJ Jr

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Adherence to imatinib therapy has been significantly associated with disease progression and direct medical costs in gastrointestinal stromal tumor (GIST) patients. However, adherence to oral anticancer drugs is frequently hindered by the influence of various factors. The aim of this study was to evaluate th...

journal_title：Chemotherapy

authors： Wang Y,Zhang P,Han Y,Nelson RS,McLeod HL,Tao K,Yuan Y,Zhang M,Xiang H,Zhou H

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:This study assessed the population pharmacokinetics and metabolic conversion of a novel histone deacetylase (HDAC) inhibitor, SD-2007, into its active metabolite, apicidin, in rats. METHODS:SD-2007 was given to rats by intravenous injection (4 mg/kg) and oral administration (40 mg/kg). Serum concentrations ...

journal_title：Chemotherapy

authors： Shin BS,Bulitta JB,Hong DK,Kim HY,Kim MK,Choi Y,Lee JB,Hwang SW,Lee MH,Yoo SD

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:In this study (part of the global TEST program), the in vitro activity of tigecycline, a member of a new class of antimicrobial agents, the glycylcyclines, against clinical isolates collected in Italy was evaluated. METHODS:A total of 200 clinical isolates were collected and identified in our institution du...

journal_title：Chemotherapy

authors： Roveta S,Marchese A,Debbia EA

更新日期：2008-01-01 00:00:00

abstract：:An in vitro infection model was created using a suspension of macrophages, polymorphonuclear leukocytes, lymphocytes, fibroblasts, and human serum to which pathogen and antibiotic were added. Separate intracellular and extracellular antibiotic concentrations and activity against Staphylococcus aureus and Legionella pn...

journal_title：Chemotherapy

authors： Scaglione F,Demartini G,Dugnani S,Fraschini F

更新日期：1993-11-01 00:00:00

abstract：:A rational choice of an antimicrobial agent must take into account not only the activity against the specific pathogen but also any possible negative or positive effects on the host defense system. Rokitamycin (RKM) is an orally active 16-membered-ring macrolide; there are no reports of specific investigations of thes...

journal_title：Chemotherapy

authors： Braga PC,Maci S,Dal Sasso M,Fonti E,Ghessi A

更新日期：1997-05-01 00:00:00

abstract：:Itraconazole has emerged as an important new oral agent in the treatment of systemic fungal infections. This paper summarizes the data available on its use in aspergillosis, cryptococcosis and histoplasmosis, compiled in the United States with particular attention to the immunocompromised host. Data have been accrued ...

journal_title：Chemotherapy

authors： Hostetler JS,Denning DW,Stevens DA

更新日期：1992-01-01 00:00:00

abstract：:Cefpirome and six other antimicrobial agents were tested against 884 blood culture isolates from cancer patients. Cefpirome was highly active against aerobic gram-negative bacilli including Acinetobacter spp., and the Enterobacteriaceae. Only imipenem was more active than cefpirome against Pseudomonas aeruginosa. Cefp...

journal_title：Chemotherapy

authors： Rolston K,Alvarez ME,Hoy JF,LeBlanc B,Ho DH,Bodey GP

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Recurrent tumor growth of colorectal carcinoma at the peritoneal site remains an unsolved problem. The aim of this study was to investigate whether the substance taxol (paclitaxel) can alter intraperitoneal tumor spread using different modes of drug application. METHODS:Intraperitoneal tumor growth was indu...

journal_title：Chemotherapy

authors： Hribaschek A,Meyer F,Schneider-Stock R,Pross M,Ridwelski K,Lippert H

更新日期：2007-01-01 00:00:00

abstract：:We conducted a survey of susceptibility among 758 gram-negative bacilli (GNB; collected from cancer patients over a 3-month period) to commonly used antibiotics. The overall resistance among GNB was least for piperacillin/tazobactam and meropenem (5 and 6%, respectively) followed by cefepime (8%), imipenem (9%), amika...

journal_title：Chemotherapy

authors： Jacobson K,Rolston K,Elting L,LeBlanc B,Whimbey E,Ho DH

更新日期：1999-09-01 00:00:00

abstract：:137 patients with febrile neutropenia after cytotoxic therapy not responding to ceftazidime plus or ceftriaxone plus netilmicin in received additionally to the previous combination either vancomycin alone or combined with another anti-gram-negative compound: imipenem in those treated prophylactically with ofloxacin an...

journal_title：Chemotherapy

authors： Lacka J,Oravcova E,Sevcikova L,Studena M,Bachanova V,Kukuckova E,Spanik S,Sufliarsky J,Helpianska L,Trupl J,Kunova A,Vochyanova I,Sycova Z,Grey E,Krcméry V Jr

更新日期：1996-03-01 00:00:00

abstract：:The binding of five structurally diverse beta-lactam antibiotics to penicillin-binding proteins (PBPs) of two clinical isolates of Streptococcus pneumoniae resistant to penicillin G was compared with that of a susceptible strain. A common feature of the PBP patterns of the resistant strains was the absence of PBP 1a d...

journal_title：Chemotherapy

authors： Ikeda F,Yokota Y,Ikemoto A,Teratani N,Shimomura K,Kanno H

更新日期：1995-05-01 00:00:00

abstract：:The effect of three nucleoside analogs, including 2-methyl-2'-deoxyadenosine (MDA), 5-amino-2'-deoxyuridine (ADU) and 2',3'-dideoxycytidine (DDC) on colony formation from unfractionated human bone marrow obtained from volunteers expressing parameters typical for normal cells (NBM) and from patients with the diagnosis ...

journal_title：Chemotherapy

authors： Cinatl J Jr,Cinatl J,Gussetis ES,Nemeth U,Mainke M,Kornhuber B,Brendel M,Doerr HW

更新日期：1991-01-01 00:00:00

abstract：:Serum (beta 1-->3)-D-glucan was elevated in 34 of 126 patients (27%) with hematologic malignancy who were clinically suspected of having a deep-seated mycosis. Although 11 patients (8.8%) were thought to have fungemia, fungi were isolated from blood culture in only 4. These results suggest that measurement of serum be...

journal_title：Chemotherapy

authors： Niitsu N,Umeda M

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Cisplatin resistance has been mainly associated with decreased cellular accumulation and increased intracellular glutathione (GSH) levels. ATP is known to increase the membrane permeability of cells and to decrease intracellular GSH levels. Our study aimed at using extracellular ATP to sensitize ovarian carc...

journal_title：Chemotherapy

authors： Rotte A,Garmann D,Buss I,Jaehde U

更新日期：2010-01-01 00:00:00

abstract：:We studied penicillin-binding protein (PBP) profiles of two Pseudomonas aeruginosa strains stably derepressed for constitutive, type Id beta-lactamase overproduction. Substantial levels of beta-lactamase were found to be strongly associated with isolated inner membranes of these two strains, as well as from a plasmid-...

journal_title：Chemotherapy

authors： Parr TR Jr,Chan L,Bayer AS

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Ginkgolic acids (GAs), extracted from the seed coat of Ginkgo biloba L. Our previous study has shown that GA monomer could inhibit the growth of Hep-2 significantly and induce the fragmentation of the chromosomal DNA. To further assess the antitumor potential and turn it into a candidate new antitumor drug, ...

journal_title：Chemotherapy

authors： Zhou C,Li X,Du W,Feng Y,Kong X,Li Y,Xiao L,Zhang P

更新日期：2010-01-01 00:00:00

abstract：:The in vitro activity of ceftazidime has been compared with those of cephalothin, cefuroxime, and netilmicin against a variety of gram-positive and gram-negative bacteria in order to register sensitivity patterns in the western part of Norway. An agar dilution method was used for minimal inhibitory concentration (MIC)...

journal_title：Chemotherapy

authors： Digranes A,Dibb WL,Benonisen E

更新日期：1984-01-01 00:00:00

abstract：:On the basis of a regression analysis of the correlation between minimal inhibitory concentration (MIC) and inhibitory zone diameter, interpretative criteria are established for the agar diffusion test with ceftriaxone disks (30 micrograms) in DST agar according to the DIN method. The correlation is good (r = -0.9242)...

journal_title：Chemotherapy

authors： Grimm H

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:This phase II study was conducted to evaluate the efficacy and safety of the chemotherapy combination of gemcitabine and vinorelbine in taxane-pretreated Japanese metastatic breast cancer patients. METHODS:In this multicenter, phase II, single-arm study, patients with recurrent or metastatic HER2-negative b...

journal_title：Chemotherapy

authors： Yamamura J,Masuda N,Yamamoto D,Tsuyuki S,Yamaguchi M,Tanaka S,Tsurutani J,Tokunaga S,Yoshidome K,Mizutani M,Aono T,Ooe A,Tanino H,Matsunami N,Yasojima H,Nakayama T,Nishida Y

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:In a previous investigation of the genetic characterization of extended-spectrum beta-lactamases (ESBLs) in Klebsiella pneumoniae from Zagreb, Croatia, 20 strains were found to produce SHV-2 beta-lactamase. Those strains displayed varying degrees of beta-lactam resistance and a wide range of beta-lactamase a...

journal_title：Chemotherapy

authors： Bedenić B

更新日期：2002-03-01 00:00:00

abstract：:Combination of 9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] and 6-azauridine (AzUrd) is highly active in the selective inhibition of vaccinia virus in chick embryo cell culture. Synergic effect of this combination of compounds was not encountered in HeLa cell culture. Of the 17 analogues related to DHPA studied in th...

journal_title：Chemotherapy

authors： Rada B,Holý A

更新日期：1980-01-01 00:00:00

abstract：:In this study, rational dosing guidelines for amphotericin B-deoxycholate (AmB) are proposed for children. AmB steady-state trough concentrations (C(ss,trough)) and plasma creatinine concentrations (C(creat)) were measured in 83 children (age: 10 months to 18 years) receiving prophylactic AmB therapy (1 mg/kg/day). Ma...

journal_title：Chemotherapy

authors： Nath CE,McLachlan AJ,Shaw PJ,Coakley JC,Earl JW

更新日期：2007-01-01 00:00:00

abstract：:Without treatment all mice died after receiving 10(3) Klebsiella pneumoniae by intraperitoneal injection. Nevertheless, it was possible to delay treatment for 12 h and still observe a therapeutic response from im gentamicin (5 mg/kg). This gave initial serum concentrations comparable to clinical levels, which fell rap...

journal_title：Chemotherapy

authors： Queiroz ML,Bathirunathan N,Mawer GE

更新日期：1987-01-01 00:00:00

abstract：:The affinity of meropenem for various known types of beta-lactamases and its stability to them were tested in comparison with other beta-lactams, including imipenem. Meropenem exhibited a marked stability to all beta-lactamases tested and was only hydrolyzed by Xanthomonas maltophilia beta-lactamase, as were other bet...

journal_title：Chemotherapy

authors： Nouda H,Harabe ET,Sumita Y,Okuda T,Fukasawa M

更新日期：1992-01-01 00:00:00

abstract：:Concentrations of latamoxef, cefoperazone and piperacillin, administered intravenously, were measured in serum and sputum of cystic fibrosis patients with recurrent pulmonary infections, chronically colonized with Pseudomonas aeruginosa. Serum pharmacokinetic data were consistent with prior reports. Peak sputum to pea...

journal_title：Chemotherapy

authors： Laferriere C,Stutman HR,Marks MI,Kramer J,Flux M

更新日期：1985-01-01 00:00:00

abstract：:The pharmacokinetics of miocamycin, a new macrolide antibiotic, was studied in 6 healthy controls and 6 patients with compensated liver cirrhosis. The results indicate that in chronic liver disease the kinetics of the drug is altered. Therefore, a dosage adjustment of miocamycin is recommended when dealing with these ...

journal_title：Chemotherapy

authors： Miglioli PA,Pivetta P,Orlando R,Palatini P,Varotto A,Okolicsanyi L

更新日期：1989-01-01 00:00:00

abstract：:Resistant variants of three clinical Pseudomonas aeruginosa isolates were obtained in the presence of aztreonam. The variants exhibited a four- to eightfold increase in the minimal inhibitory concentrations to beta-lactam antibiotics (except imipenem) to quinolones, such as norfloxacin and fleroxacin, chloramphenicol ...

journal_title：Chemotherapy

authors： Leying HJ,Büscher KH,Cullmann W,Then RL

更新日期：1992-01-01 00:00:00

abstract：:The study of resistance patterns of strains of bacteria to antibiotics in different regions of a country and, if possible, comparing them at international level appears to be a useful exercise. The patterns of resistance during 1968-71 revealed an increasing resistance for most antibiotics with an unexpected increase ...

journal_title：Chemotherapy

authors： Driessen JH

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND/AIMS:Species-level identification of nontuberculous mycobacteria (NTM) is important in making decisions about the necessity and choice of antimicrobial treatment. The reason is predictable clinical significance and the susceptibility profile of specific NTM species. Matrix-assisted laser desorption/ionizatio...

journal_title：Chemotherapy

authors： Mareković I,Bošnjak Z,Jakopović M,Boras Z,Janković M,Popović-Grle S

更新日期：2016-01-01 00:00:00