Abstract:
:Hydrocortisone (HC) has been observed to influence an in vitro Dexter culture system with maintenance of pluripotent hematopoietic stem cells (CFU-s) and progenitor cells (CFU-gm, BFU-e). In the present study, a two-phase murine Dexter culture system was established to study the mechanism of HC-mediated suppression of stem cells or progenitor cells. Furthermore, the effect of exposing 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) to an adherent cell layer for 1 h was investigated for maintenance of progenitor cells. Cultures supplemented with selenium and transferrin showed relatively good growth. The BFU-e number was significantly enhanced at 2 and 3 weeks of culture in the BCNU-treated group. This system is a good model for monitoring the influence of agents to a hematopoietic-inductive microenvironment.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Horikoshi A,Murphy MJ Jrdoi
10.1159/000238340subject
Has Abstractpub_date
1985-01-01 00:00:00pages
223-7issue
3eissn
0009-3157issn
1421-9794journal_volume
31pub_type
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