Abstract:
:Some acridine compounds referred to as 9-imino, 9-oxo and 9-thio derivatives were screened for activity against Trypanosoma cruzi in vitro. The results are discussed here with reference to the structure of the compounds tested. Attempts to elucidate the mode of action of active acridines are also included. The most active compounds that were tested were 9-thioacridanones and 9-thio-1,2,3,4-tetrahydroacridanones Added to this, the dialkylaminoalkylthio group seems to be the most convenient molecular moiety for trypanocidal activity in the 9-substituted acridine series.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Osuna A,Ruiz-Perez LM,Gamarro F,Rodriguez-Santiago JI,Castanys S,Sharples D,Galy AM,Giovannageli G,Galy JP,Soyfer JCdoi
10.1159/000238559subject
Has Abstract,Author List Incompletepub_date
1988-01-01 00:00:00pages
127-33issue
2eissn
0009-3157issn
1421-9794journal_volume
34pub_type
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