Effects of platinum antitumor agents on in vitro assays of human antitumor immunity. II. Effects of cis-[Pt(NH3)2Cl2] on spontaneous cell-mediated cytotoxicity.

abstract：BACKGROUND:The aim of this study was to evaluate the efficacy and tolerability of hepatic arterial infusion (HAI) of gemcitabine plus oxaliplatin as second-line treatment for unresectable locally advanced intrahepatic cholangiocarcinoma. PATIENTS AND METHODS:We retrospectively analyzed the outcome of 12 consecutive pa...

journal_title：Chemotherapy

authors： Ghiringhelli F,Lorgis V,Vincent J,Ladoire S,Guiu B

更新日期：2013-01-01 00:00:00

abstract：:We studied penicillin-binding protein (PBP) profiles of two Pseudomonas aeruginosa strains stably derepressed for constitutive, type Id beta-lactamase overproduction. Substantial levels of beta-lactamase were found to be strongly associated with isolated inner membranes of these two strains, as well as from a plasmid-...

journal_title：Chemotherapy

authors： Parr TR Jr,Chan L,Bayer AS

更新日期：1988-01-01 00:00:00

abstract：:The in vitro antimicrobial activities of AM-1155, a new fluoroquinolone, tosufloxacin and fleroxacin were tested against 55 clinical isolates of Neisseria gonorrhoeae using the agar dilution method. In our previous study, all the strains had been examined for mutations in the region corresponding to the quinolone-resi...

journal_title：Chemotherapy

authors： Deguchi T,Yasuda M,Nakano M,Ozeki S,Kanematsu E,Fukuda H,Maeda S,Saito I,Kawada Y

更新日期：1997-07-01 00:00:00

abstract：:100 febrile patients with chemotherapy-induced neutropenia (less than 0.5 x 10(9)/l) were empirically treated by ceftriaxone (2 g daily in adults, 50 mg/kg daily in children, as a once daily injection) and amikacin (15-20 mg/kg daily). The mean age was 41 years (range 8-72). 51 patients had acute leukemia, 29 non-Hodg...

journal_title：Chemotherapy

authors： Blanc C,Pollet JP,Bauters F

更新日期：1991-01-01 00:00:00

abstract：:Two gonococcal strains with differing susceptibility to cefotiam and ceftizoxime, as expressed by the minimum inhibitory concentration (MIC), are exposed to continuously changing concentrations of these antibiotics as they are found in plasma and skin cantharidal blister fluid (CBF) after a single intramuscular applic...

journal_title：Chemotherapy

authors： Korting HC,Niederauer H,Ollert M

更新日期：1986-01-01 00:00:00

abstract：:Antimicrobial agents may interact with polymorphonuclear leukocytes and directly modify the leukocyte functions, or bacteria can be modified by the antimicrobial agents causing them to be treated differently by phagocytic cells. Brief exposure of bacteria to high levels of antimicrobials can affect their interaction w...

journal_title：Chemotherapy

authors： Pérez P,Herrera I,Martín M,Martínez P,Gómez-Lus ML

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Cisplatin (CDDP) is known to cause inner ear damage while carboplatin (CBDCA) induces less ototoxicity than CDDP. We examined apoptotic changes in the cochlea of guinea pigs after injection of CDDP or CBDCA using immunohistochemical and electrophysiological techniques. METHODS:Three days after the injection...

journal_title：Chemotherapy

authors： Watanabe KC,Jinnouchi K,Hess A,Michel O,Baba S,Yagi T

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:There are only limited data on tissue kinetics of ertapenem in colorectal tissue more than 3 h after administration of the drug. The purpose of this study was to assess the pharmacokinetics (PK) of ertapenem in colorectal tissue via population PK modeling. PATIENTS AND METHODS:Patients ≥18 years requiring s...

journal_title：Chemotherapy

authors： Wittau M,Scheele J,Bulitta JB,Mayer B,Kaever V,Burhenne H,Henne-Bruns D,Isenmann R,Brockschmidt C

更新日期：2011-01-01 00:00:00

abstract：:A semi-automated microdilution test was adapted for the in vitro testing of potential antitrichomonal agents. Washed cell suspensions of the pathogenic protozoan Trichomonas vaginalis were incubated in microtitration plates for 4 h at 37 degrees C in the presence radiolabelled adenine and serial dilutions of the test ...

journal_title：Chemotherapy

authors： Meingassner JG,Heyworth PG,Havelec L

更新日期：1985-01-01 00:00:00

abstract：:The choice of antimicrobial therapy for the treatment of bacteremia is often empirical and based on the knowledge of susceptibility profiles of the most common bacteria. We analyzed blood culture isolates from a teaching hospital for 13 years prospectively. This study examined the susceptibility profiles of 6,616 gram...

journal_title：Chemotherapy

authors： Ling TK,Liu EY,Cheng AF

更新日期：2001-01-01 00:00:00

abstract：:Several agar media (Mueller-Hinton agar, MHA; diagnostic sensitivity test agar, DSTA; Schaedler agar, SchA; Todd-Hewitt agar with added yeast extract, THYA; Wilkins-Chalgren agar, WCA) were compared using the Bauer-Kirby agar disk diffusion test against six nonfastidious quality control strains: Staphylococcus aureus ...

journal_title：Chemotherapy

authors： Traub WH,Leonhard B

更新日期：1994-01-01 00:00:00

abstract：:Fleroxacin, a new long-acting quinolone, induces rapid killing and bacterial filamentation as do other quinolones. Ten strains of Escherichia coli were exposed comparatively to fleroxacin and ampicillin in order to determine the effect of sub- and supra-inhibitory concentrations of each of these two compounds on turbi...

journal_title：Chemotherapy

authors： Yourassowsky E,Van der Linden MP,Crokaert F

更新日期：1989-01-01 00:00:00

abstract：:Therapy of listeriosis with ampicillin was examined in two murine models with compromised defense mechanisms. In mice treated with dextran sulfate paralysing the function of the macrophage system, ampicillin was less able to reduce death rates as well as bacterial counts in the spleens than after infection of normal m...

journal_title：Chemotherapy

authors： Hof H,Emmerling P,Seeliger HP

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells. We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ova...

journal_title：Chemotherapy

authors： Yamagami W,Banno K,Kawaguchi M,Yanokura M,Kuwabara Y,Hirao N,Susumu N,Tsukazaki K,Aoki D

更新日期：2007-01-01 00:00:00

abstract：:While the majority of patients can be treated safely with fluoropyrimidine, some experience severe fluoropyrimidine-associated toxicity. The frequency and severity of these adverse events vary from patient to patient and are partially explained by genetic polymorphism into the dihydropyrimidine dehydrogenase (DPYD) ge...

journal_title：Chemotherapy

authors： Falvella FS,Luoni M,Cheli S,Fava S,Cergnul M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The rise in the rates of antibiotic resistance among Pseudomonas aeruginosa strains from cystic fibrosis (CF) patients is concerning and underscores the need for the development of novel compounds. Among them CSA-13, a cationic steroid molecule, mimics the activity of naturally occurring antimicrobial peptid...

journal_title：Chemotherapy

authors： Bozkurt-Guzel C,Savage PB,Gerceker AA

更新日期：2011-01-01 00:00:00

abstract：:This study was performed in female B6C3F1 mice to confirm previously observed effects of selected cephalosporin antibiotics on nonspecific immunity, and to determine possible effects on specific acquired immunity and host resistance. Mice were treated intravenously with DQ-2556, ceftizoxime or ceftezole at 800 mg/kg/d...

journal_title：Chemotherapy

authors： Furuhama K,Benson RW,Knowles BJ,Roberts DW

更新日期：1993-07-01 00:00:00

abstract：:After intravenous bolus injection of single doses of 25, 50, 75 and 100 mg of ofloxacin (HOE 280) to 34 healthy male volunteers, concentrations of unchanged drug were estimated at various times in serum and urine over 32 and 48 h. Ofloxacin concentrations were determined using high-pressure liquid chromatography (HPLC...

journal_title：Chemotherapy

authors： Verho M,Korn A,Badian M,Malerczyk V,Waldhäusl W

更新日期：1988-01-01 00:00:00

abstract：:Chloramphenicol serum concentration is often monitored to assure efficacy and prevent toxicity. We studied the relationship between steady-state chloramphenicol serum concentration and hematologic adverse effects in 45 pediatric patients. The mean peak serum concentration of chloramphenicol in patients with and withou...

journal_title：Chemotherapy

authors： Nahata MC

更新日期：1987-01-01 00:00:00

abstract：:Ofloxacin, like other 4-quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial DNA synthesis, rather than cell wall or protein synthesis. The 4-quinolones are also unusual because even for serious infections they can be given orally. Most unusually transferable...

journal_title：Chemotherapy

authors： Smith JT

更新日期：1991-01-01 00:00:00

abstract：:Contrary to L-lysine, D-lysine showed no inhibitory effect on growth of Ehrlich ascites tumour cell in in vivo studies. The in vitro studies on the growth of cultured Ehrlich ascites tumour cells showed similar results, namely, the growth of tumour cells was inhibited when cultured in 0.02 or 0.03 M L-lysine; while 0....

journal_title：Chemotherapy

authors： Choy YM,Fung KP

更新日期：1989-01-01 00:00:00

abstract：:BMY-28142 was compared in vitro with ceftazidime, cefotaxime and cefoperazone and was found to be more active against Pseudomonas aeruginosa and Staphylococcus aureus. Essentially no effect of increasing inoculum size 100-fold was seen-on MICs with BMY-28142 or ceftazidime; some effect was noted with cefotaxime and ce...

journal_title：Chemotherapy

authors： Norden CW,Neiderriter K

更新日期：1987-01-01 00:00:00

abstract：:Combination of 9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] and 6-azauridine (AzUrd) is highly active in the selective inhibition of vaccinia virus in chick embryo cell culture. Synergic effect of this combination of compounds was not encountered in HeLa cell culture. Of the 17 analogues related to DHPA studied in th...

journal_title：Chemotherapy

authors： Rada B,Holý A

更新日期：1980-01-01 00:00:00

abstract：:The activity of aztreonam (a beta-lactam antibiotic with specific activity against gram-negative bacteria) was evaluated and compared with that of tobramycin in hospitalized patients with severe intra-abdominal infections due to gram-negative pathogens, either alone or in association with other bacteria. Of a total st...

journal_title：Chemotherapy

authors： Birolini D,Moraes MF,de Souza OS

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:This phase II study was conducted to evaluate the efficacy and safety of the chemotherapy combination of gemcitabine and vinorelbine in taxane-pretreated Japanese metastatic breast cancer patients. METHODS:In this multicenter, phase II, single-arm study, patients with recurrent or metastatic HER2-negative b...

journal_title：Chemotherapy

authors： Yamamura J,Masuda N,Yamamoto D,Tsuyuki S,Yamaguchi M,Tanaka S,Tsurutani J,Tokunaga S,Yoshidome K,Mizutani M,Aono T,Ooe A,Tanino H,Matsunami N,Yasojima H,Nakayama T,Nishida Y

更新日期：2017-01-01 00:00:00

abstract：:The antibacterial activity of tobramycin, gentamicin, erythromycin, cloxacillin, kanamycin, cephalexin, penicillin, carbenicillin and polymyxin were compared against 303 clinical bacterial isolates from a pediatric hospital patient population. Standard disk diffusion and agar-dilution methods were employed. Significan...

journal_title：Chemotherapy

authors： Laxer RM,Mackay E,Marks MI

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:An ethylacetate-soluble fraction (ET4) from the lichen Ramalina farinacea has previously been shown to inhibit the infectivity of lentiviral and adenoviral vectors, as well as wild-type HIV-1. We now determined the antiviral activity of ET4 against other wild-type viruses, including the herpes simplex virus ...

journal_title：Chemotherapy

authors： Esimone CO,Grunwald T,Nworu CS,Kuate S,Proksch P,Uberla K

更新日期：2009-01-01 00:00:00

abstract：:Some acridine compounds referred to as 9-imino, 9-oxo and 9-thio derivatives were screened for activity against Trypanosoma cruzi in vitro. The results are discussed here with reference to the structure of the compounds tested. Attempts to elucidate the mode of action of active acridines are also included. The most ac...

journal_title：Chemotherapy

authors： Osuna A,Ruiz-Perez LM,Gamarro F,Rodriguez-Santiago JI,Castanys S,Sharples D,Galy AM,Giovannageli G,Galy JP,Soyfer JC

更新日期：1988-01-01 00:00:00

abstract：:The antitumour properties of the drug N-137 were assessed in vivo in two murine T lymphoma models and two naturally metastatic hamster fibrosarcomas of Herpesvirus hominis aetiology. N-137 therapy caused a significant delay in the subcutaneous growth rate of both lymphomas (EL4 and TLX9) and in many cases completely p...

journal_title：Chemotherapy

authors： Rees RC,Potter CW,Clegg A,Hall JM

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Adjuvant platinum-based chemotherapy improves survival in women with early-stage epithelial ovarian cancer (EOC). Yet, there is a wide variety in clinical practice. METHODS:All patients diagnosed with FIGO I and IIa EOC (2006-2010) in the south of the Netherlands were analyzed. The percentage of patients th...

journal_title：Chemotherapy

authors： Frielink LM,Pijlman BM,Ezendam NP,Pijnenborg JM

更新日期：2016-01-01 00:00:00