Abstract：
BACKGROUND:There are only limited data on tissue kinetics of ertapenem in colorectal tissue more than 3 h after administration of the drug. The purpose of this study was to assess the pharmacokinetics (PK) of ertapenem in colorectal tissue via population PK modeling. PATIENTS AND METHODS:Patients ≥18 years requiring surgical intervention at the colon and/or rectum were eligible (ClinicalTrials.gov identifier: NCT 00535652). Tissue and blood samples were taken during surgery after a single dose of 1 g ertapenem. Ertapenem concentration was determined by high-performance liquid chromatography/mass spectrometry. Population PK modeling was performed in S-ADAPT. RESULTS:Twenty-three patients were enrolled. The highest tissue concentration was 6.4 ± 2.3 mg/kg, the highest total plasma concentration 51.34 ± 9.4 mg/l, the highest unbound plasma concentration 7.05 ± 1.1 mg/l, and the unbound fraction in plasma was 14-15% for total ertapenem concentrations below approximately 22 mg/l, 19% at 100 mg/l, and 25% at 250 mg/l. The estimated geometric mean terminal half-life was 2.5 h for plasma and tissue. In the Monte Carlo simulation, a single dose of 1,000 mg ertapenem achieved robust (≥90%) probabilities of target attainment up to a minimum inhibitory concentration (MIC) of approximately 2 mg/l for the bacteriostasis target (free time above MIC, fT(>)(MIC) = 20%) and up to 0.25-0.5 mg/l for the near-maximal killing target (40% fT(>)(MIC)). CONCLUSION:Our data indicate an adequate penetration of ertapenem into uninfected colorectal tissue up to 8.5 h (35% of the dosing interval) after administration of 1 g intravenously.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Wittau M,Scheele J,Bulitta JB,Mayer B,Kaever V,Burhenne H,Henne-Bruns D,Isenmann R,Brockschmidt Cdoi
10.1159/000333377subject
Has Abstractpub_date
2011-01-01 00:00:00pages
437-48issue
5eissn
0009-3157issn
1421-9794pii
000333377journal_volume
57pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract：:Concentrations of latamoxef, cefoperazone and piperacillin, administered intravenously, were measured in serum and sputum of cystic fibrosis patients with recurrent pulmonary infections, chronically colonized with Pseudomonas aeruginosa. Serum pharmacokinetic data were consistent with prior reports. Peak sputum to pea...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238344
更新日期：1985-01-01 00:00:00
abstract：:We established a method for determining the KD value as a measure of the bilirubin-displacing effect for drugs by using bilirubin oxidase, which is produced by Myrothecium verrucaria MT-1. This method makes it possible to conduct measurements of many beta-lactam antibiotics, including those which could not be determin...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238590
更新日期：1988-01-01 00:00:00
abstract：:17,244 pathogens isolated from clinical specimens of 24 hospitals in the Moers area (North-Rhine Westphalia, FRG) were tested in regard to their susceptibility to Augmentin (amoxicillin and clavulanic acid). For this purpose, minimal inhibitory concentrations were determined by use of microbroth dilution technique. 80...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238588
更新日期：1988-01-01 00:00:00
abstract：:Niridazole was shown to be an effective chemotherapeutic agent for mice infected intravenously with a niridazole-sensitive strain of Salmonella typhimurium. Death rates as well as bacterial counts per spleen were reduced, even in compromised animals. Histologic examination of spleens proved the reduction of inflammato...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238069
更新日期：1982-01-01 00:00:00
abstract：:A-56619 and A-56620 are two new quinolone compounds that are currently being studied. They were found to be active against multi-resistant and routine isolates of Staphylococcus aureus, enterobacteria, aminoglycoside-sensitive and resistant strains of Pseudomonas aeruginosa. Most of the enterobacteria were inhibited b...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238573
更新日期：1988-01-01 00:00:00
abstract：PURPOSE:To compare incidences of hypersensitivity reaction (HSR) between original and generic taxanes including paclitaxel and docetaxel. METHODS:We conducted a prospective study enrolling all patients receiving taxanes at King Chulalongkorn Memorial Hospital. Taxanes were infused accordingly to the step-wise rate esc...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000450748
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:This study was designed to examine the efficacy and compliance of S-1 for the patients with peritoneal metastasis of gastric cancer. METHODS:Sixteen consecutive patients with peritoneal metastasis of gastric cancer were treated with S-1. Their survival was compared with that of the historical control group ...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000096002
更新日期：2006-01-01 00:00:00
abstract：:Fleroxacin, a new long-acting quinolone, induces rapid killing and bacterial filamentation as do other quinolones. Ten strains of Escherichia coli were exposed comparatively to fleroxacin and ampicillin in order to determine the effect of sub- and supra-inhibitory concentrations of each of these two compounds on turbi...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238706
更新日期：1989-01-01 00:00:00
abstract：:A total of 5 healthy volunteers were enrolled in a crossover study on the dose dependency and the effect of probenecid on pharmacokinetics of DQ-2556. They were administered intravenously 0.5 and 1.0 g of DQ-2556, and 1.0 g of DQ-2556 with oral administration of probenecid. The linearity in pharmacokinetics of DQ-2556...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000239029
更新日期：1992-01-01 00:00:00
abstract：:Ten years of controlled clinical trials supported single-dose therapy efficacy and safety in uncomplicated lower urinary tract infections (UTI). Both local and systematic factors contribute to the high UTI prevalence seen in elderly people. A controlled open randomized study was undertaken to evaluate the clinical eff...
journal_title：Chemotherapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1159/000238817
更新日期：1990-01-01 00:00:00
abstract：:A modified Rieckmann test was developed for assessing chloroquine sensitivity of Plasmodium vivax strains. This test envisages the evaluation of parasite growth with different concentrations of the drug and its comparison with controls, at the end of a 48-hour experimental period. Using this test, 16 strains were asse...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238664
更新日期：1989-01-01 00:00:00
abstract：:BMY-28142 was compared in vitro with ceftazidime, cefotaxime and cefoperazone and was found to be more active against Pseudomonas aeruginosa and Staphylococcus aureus. Essentially no effect of increasing inoculum size 100-fold was seen-on MICs with BMY-28142 or ceftazidime; some effect was noted with cefotaxime and ce...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238470
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:Mutant prevention concentration (MPC) is a new parameter that may be of aid in determining the risk of resistant mutants being selected. METHODS:The MPCs of 224 Mycobacterium tuberculosis clinical isolates were estimated by plating more than 10(10) cells on drug-containing agar and determining the concentra...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000085613
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:It was the aim of this study to report clinical characteristics and treatment of thyroid tuberculosis (TT). METHODS:During 16 years, 2,426 patients have been operated on the thyroid in the surgical department 'A' in Ibn Sina Hospital, Rabat, Morocco. Anatomopathological results of the removed thyroid were an...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000090244
更新日期：2006-01-01 00:00:00
abstract：:The two studies which are reviewed in this paper demonstrate the value of fluorescent microscopic observations in the studying of the distribution of antibiotics in lung tissue and in sinus secretions. In the lung tissue study, the standard microbiologic assay data on doxycycline concentrations in respiratory tissue t...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000221889
更新日期：1975-01-01 00:00:00
abstract：:Reference is made to the results obtained in 24 children, from 11 months to 12 years, affected with acute pneumopathies and treated with fosfomycin with a dosage of 200 mg/kg/day. In all cases a clinical, radiological, biological and bacteriological study was carried out. At the same time, levels of fosfomycin in plas...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000222069
更新日期：1977-01-01 00:00:00
abstract：BACKGROUND:T790M is a major cause of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance, but the clinical significance of T790M disappearance is unknown. CASE REPORT:We report 3 cases of pulmonary adenocarcinoma which did not respond to EGFR-TKI retreatment even with T790M disappearance...
journal_title：Chemotherapy
pub_type：
doi：10.1159/000491937
更新日期：2018-01-01 00:00:00
abstract：:In children undergoing anticancer chemotherapy, a granulocytopenic febrile episode is a life-threatening condition. Prompt initiation of empirical broad-spectrum antibiotics is essential to limit morbidity and mortality. To evaluate the cost-effectiveness of combination antibiotics consisting of a third generation cep...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000239590
更新日期：1997-09-01 00:00:00
abstract：BACKGROUND:Dysfunction of the carnitine system in non-tumour tissue following anticancer therapy has been reported. In this setting, supplementation with carnitine derivatives might increase the general metabolic activity of normal cells so that they might better withstand the adverse effects of chemotherapy aimed at t...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000321296
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Taxanes cause hypersensitivity reactions, averted by premedication with H1 blockers and high glucocorticoid (GC) doses. Prolonged weekly taxane administration may lead to GC toxicity. PURPOSE:To determine whether patients not hypersensitive to initial paclitaxel (PTX) infusion after high-dose GC premedicati...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000085618
更新日期：2005-05-01 00:00:00
abstract：:Serial serum erythropoietin (EPO) levels were measured in 12 adult lung cancer patients during cancer chemotherapy. In major cases, EPO levels increased significantly after chemotherapy while the hemoglobin (Hb) remained at initial levels. EPO fell gradually or rapidly to initial levels after a peak, although the pati...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000239014
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Urinary tract infections (UTIs) are a significant health problem and Escherichia coli has been exported to be the primary pathogen in approximately 80% of cases. E. coli express structures called adhesins, fimbriae or pili that help them bind to specific tissue receptors. One such adhesin is Dr, which binds ...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000048507
更新日期：2001-03-01 00:00:00
abstract：:Uptake of the bifunctional alkylating agent, PTT.119, p-F-Phe-m-bis-(2-chloroethyl)amino-L-Phe-Met-ethoxy-HCl, by the MJY-alpha mammary tumor and B16 melanoma cell lines occurred via two natural pathways for amino acid transport. The primary route of PTT.119 entry was the classical L System, whereas, the ASC System ca...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238549
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:The prognosis of patients with advanced gastric cancer (AGC) remains poor, and no single chemotherapy regimen is recognized as a global standard. A phase II trial was conducted to determine the efficacy and tolerability of capecitabine and oxaliplatin (XELOX) given every 3 weeks in combination in patients wi...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000305256
更新日期：2010-01-01 00:00:00
abstract：:The minimum inhibitory concentration (MIC) of the new penem ALP 201 was tested against 243 recent clinical isolates of which 95 were from the family Enterobacteriaceae, 50 were from the genus Streptococcus, 50 were Staphylococcus aureus and 48 were Staphylococcus epidermidis. An agar dilution technique was used to det...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238888
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:This study assessed the population pharmacokinetics and metabolic conversion of a novel histone deacetylase (HDAC) inhibitor, SD-2007, into its active metabolite, apicidin, in rats. METHODS:SD-2007 was given to rats by intravenous injection (4 mg/kg) and oral administration (40 mg/kg). Serum concentrations ...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000328027
更新日期：2011-01-01 00:00:00
abstract：:We evaluated the efficacy of S-1 as a new oral antitumor agent in ovarian cancer-bearing nude rats. This drug consists of tegafur, 5-chloro-2,4-dihydroxypyridine, and oxonic acid in a molar ratio of 1:0.4:1.S-1 was given alone or in combination with cisplatin. When administered alone at a daily dose of 20 mg/ kg, S-1 ...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000239479
更新日期：1996-11-01 00:00:00
abstract：:Our previous study demonstrated that the effects of isoniazid (INH) on Mycobacterium tuberculosis at the cellular level varied according to the growth phases. In this study, the variations in the INH action on M. avium strain NCTC 8559 are reported. M. avium cells grown on Middlebrook 7H10 agar were harvested at diffe...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000104470
更新日期：2007-01-01 00:00:00
abstract：:28 patients suffering from a variety of bacterial infections have been treated with cefuroxime. 18 were cured and 6 improved during treatment. Side effects were minimal and intramuscular injection was well tolerated. Serum and urine levels well in excess of the MICs of sensitive organisms were obtained using dosages o...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000237842
更新日期：1979-01-01 00:00:00
abstract：BACKGROUND:An ethylacetate-soluble fraction (ET4) from the lichen Ramalina farinacea has previously been shown to inhibit the infectivity of lentiviral and adenoviral vectors, as well as wild-type HIV-1. We now determined the antiviral activity of ET4 against other wild-type viruses, including the herpes simplex virus ...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000194974
更新日期：2009-01-01 00:00:00
