Serum concentrations and adverse effects of chloramphenicol in pediatric patients.

abstract：AIMS:This study aimed to evaluate the different abilities of various Phellinus igniarius strains inhibiting quorum sensing (QS), to search for novel QS inhibitors from them and to analyze their inhibitory activity, with a view to their possible use in controlling infections. METHODS:The bioactive metabolites produced ...

journal_title：Chemotherapy

authors： Zhu H,Liu W,Wang SX,Tian BZ,Zhang SS

更新日期：2012-01-01 00:00:00

abstract：:A review of the published literature has allowed the identification of a number of non-tubercular indications where rifampicin (trade mark Ciba-Geigy: Rimactane) has been successfully used in combination with other chemotherapeutic agents. The cases reviewed with regard to effectiveness sum 562. The most frequently co...

journal_title：Chemotherapy

authors： Kissling M,Bergamini N

更新日期：1981-01-01 00:00:00

abstract：:Current treatment modalities for bronchopulmonary aspergillosis are not very satisfying. We determined the in vitro activity of recently available azoles against Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger. Subsequently, these agents were evaluated in an animal model of bronchopulmonary aspergillos...

journal_title：Chemotherapy

authors： Schmitt HJ,Edwards F,Andrade J,Niki Y,Armstrong D

更新日期：1992-01-01 00:00:00

abstract：:The biliary excretion of tetroxoprim (TXP) was studied in 10 patients with T-tube drainage. A mean biliary peak of 32.56 +/- 7.69 micrograms/ml was observed 2-3 h after a single oral dose of 200 mg. The biliary elimination rate constant (kb) of TXP was found to be 0;056 (h-1), indicating a longer elimination from the ...

journal_title：Chemotherapy

authors： Vergin H,Luber P

更新日期：1982-01-01 00:00:00

abstract：:A semi-automated microdilution test was adapted for the in vitro testing of potential antitrichomonal agents. Washed cell suspensions of the pathogenic protozoan Trichomonas vaginalis were incubated in microtitration plates for 4 h at 37 degrees C in the presence radiolabelled adenine and serial dilutions of the test ...

journal_title：Chemotherapy

authors： Meingassner JG,Heyworth PG,Havelec L

更新日期：1985-01-01 00:00:00

abstract：:The effect of tinidazole on several ciliates (Stylonychia muscorum, Stylonychia mytilus, Tetrahymena pyriformis, Vorticella companula) has been studied. There is a very pronounced difference in sensitivity against this drug between the free-living ciliates here investigated and certain parasitic protozoa. A high resis...

journal_title：Chemotherapy

authors： Alonso P

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:The glomerular filtration rate (GFR) is essential for calculating the dose and the monitoring of carboplatin. Although GFR measurement (mGFR) by external markers is ideal, in most cases these are not employed; the most used method is GFR estimation (eGFR) by formulae, hence the need to identify the formula w...

journal_title：Chemotherapy

authors： Graciano Vera N,Pino Villarreal L,Ureña Vargas J

更新日期：2018-01-01 00:00:00

abstract：:Pyrazinamide (PZA) is an unconventional frontline tuberculosis drug characterized by high in vivo sterilizing activity, but poor in vitro activity. The study on the mechanism of action of PZA has attracted significant attention because of the peculiarity of PZA and its ability to shorten the tuberculosis chemotherapy....

journal_title：Chemotherapy

authors： Huang Q,Chen ZF,Li YY,Zhang Y,Ren Y,Fu Z,Xu SQ

更新日期：2007-01-01 00:00:00

abstract：:The in vitro activity of ceftazidime has been compared with those of cephalothin, cefuroxime, and netilmicin against a variety of gram-positive and gram-negative bacteria in order to register sensitivity patterns in the western part of Norway. An agar dilution method was used for minimal inhibitory concentration (MIC)...

journal_title：Chemotherapy

authors： Digranes A,Dibb WL,Benonisen E

更新日期：1984-01-01 00:00:00

abstract：:The study of resistance patterns of strains of bacteria to antibiotics in different regions of a country and, if possible, comparing them at international level appears to be a useful exercise. The patterns of resistance during 1968-71 revealed an increasing resistance for most antibiotics with an unexpected increase ...

journal_title：Chemotherapy

authors： Driessen JH

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate the impact of different temperatures (22, 35 and 37 degrees C) on the postantifungal effect (PAFE) and the effect of sub-MIC concentrations (1/4 x MIC) on Candida albicans and Candida glabrata in PAFE stage (PAFSE). METHODS:This stage was induced by a 1.5-hour ...

journal_title：Chemotherapy

authors： García MT,Llorente MT,Mínguez F,Prieto J

更新日期：2000-07-01 00:00:00

abstract：:Antimicrobial agents may interact with polymorphonuclear leukocytes and directly modify the leukocyte functions, or bacteria can be modified by the antimicrobial agents causing them to be treated differently by phagocytic cells. Brief exposure of bacteria to high levels of antimicrobials can affect their interaction w...

journal_title：Chemotherapy

authors： Pérez P,Herrera I,Martín M,Martínez P,Gómez-Lus ML

更新日期：1994-03-01 00:00:00

abstract：:Cephalosporins do not reach active therapeutical concentrations in the prostatic tissue in patients suffering from chronic bacterial prostatitis. Cefoperazone is an exception. Its efficacy in the treatment of chronic bacterial prostatitis in 20 patients was studied and the concentrations, obtained after intramuscular ...

journal_title：Chemotherapy

authors： Melloni D,Ammatuna P,Formica P,Falletta V,Gaglio F,Cacciatore M,Messina G

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Considering the potentials of gatifloxacin and moxifloxacin in the treatment of tuberculosis, the present study was aimed to define resistance to both these drugs. METHODS:Fifty Mycobacterium tuberculosis isolates, consisting of 30 ofloxacin-susceptible and 20 ofloxacin-resistant strains, were tested for th...

journal_title：Chemotherapy

authors： Somasundaram S,Paramasivan NC

更新日期：2006-01-01 00:00:00

abstract：:Using the biophotometer with ticarcillin no persistent bactericidal effect was found against Pseudomonas aeruginosa NCTC 10490. After addition of 1.2 microgram/ml gentamicin an increase of multiplication of bacteria was observed, but not after 1.2 microgram/ml tobramycin. With 6.2 microgram/ml tobramycin bactericidal ...

journal_title：Chemotherapy

authors： Ullmann U

更新日期：1977-01-01 00:00:00

abstract：:AM-1155 is a new 8-methoxyquinolonecarboxylic acid with a broad spectrum of antibacterial activity. It inhibited more than 90% of clinical isolates of Streptococcus agalactiae, Escherichia coli, Peptostreptococcus magnus, Bacteroides fragilis and Prevotella bivia at the concentration of 3.13 mg/l. The antibacterial ac...

journal_title：Chemotherapy

authors： Mikamo H,Kawazoe K,Sato Y,Hayasaki Y,Izumi K,Tamaya T

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:The effects of gemcitabine on postoperative adjuvant chemotherapy were evaluated in patients with stage IV pancreatic cancer. The results were compared with those of our historical control patients treated with surgery alone. PATIENTS AND METHODS:Nineteen patients with stage IV pancreatic cancer who had pan...

journal_title：Chemotherapy

authors： Kurosaki I,Hatakeyama K

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Dysfunction of the carnitine system in non-tumour tissue following anticancer therapy has been reported. In this setting, supplementation with carnitine derivatives might increase the general metabolic activity of normal cells so that they might better withstand the adverse effects of chemotherapy aimed at t...

journal_title：Chemotherapy

authors： Niang M,Soukup T,Zivný P,Tomšík P,Bukač J,Rezáčová M,Stoklasová A,Cerman J,Sišpera L

更新日期：2011-01-01 00:00:00

abstract：:The activities of amphotericin B, miconazole, fluconazole, and itraconazole against Trichosporon beigelii were assessed in a mouse model of disseminated infection. Cyclophosphamide plus prednisolone-immunosuppressed ICR mice, intravenously challenged with a lethal inoculum of (6 x 10(6) CFU/ mouse), were assigned to r...

journal_title：Chemotherapy

authors： Kamberi P,Atsuro H,Takayoshi T,Masaru N

更新日期：1998-01-01 00:00:00

abstract：:We have previously reported that long-term treatment with clarithromycin (CAM) increased the median survival of patients with non-small cell lung cancer, and improved various clinical parameters in these patients. In the present study, CAM was administered to 33 patients with unresectable primary non-small cell lung c...

journal_title：Chemotherapy

authors： Sakamoto M,Mikasa K,Majima T,Hamada K,Konishi M,Maeda K,Kita E,Narita N

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:An ethylacetate-soluble fraction (ET4) from the lichen Ramalina farinacea has previously been shown to inhibit the infectivity of lentiviral and adenoviral vectors, as well as wild-type HIV-1. We now determined the antiviral activity of ET4 against other wild-type viruses, including the herpes simplex virus ...

journal_title：Chemotherapy

authors： Esimone CO,Grunwald T,Nworu CS,Kuate S,Proksch P,Uberla K

更新日期：2009-01-01 00:00:00

abstract：:The antimicrobial resistance patterns of respiratory pathogens isolated during an 8-year period (1990-1997) in an Italian hospital from patients with bronchopulmonary infections were investigated. A global variation in the resistance of Staphylococcus aureus to all relevant antibiotics was observed during the years 19...

journal_title：Chemotherapy

authors： Dos Santos C,Capelo A,Cimbro M,Ferrara A

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:In a previous investigation of the genetic characterization of extended-spectrum beta-lactamases (ESBLs) in Klebsiella pneumoniae from Zagreb, Croatia, 20 strains were found to produce SHV-2 beta-lactamase. Those strains displayed varying degrees of beta-lactam resistance and a wide range of beta-lactamase a...

journal_title：Chemotherapy

authors： Bedenić B

更新日期：2002-03-01 00:00:00

abstract：:Serum (beta 1-->3)-D-glucan was elevated in 34 of 126 patients (27%) with hematologic malignancy who were clinically suspected of having a deep-seated mycosis. Although 11 patients (8.8%) were thought to have fungemia, fungi were isolated from blood culture in only 4. These results suggest that measurement of serum be...

journal_title：Chemotherapy

authors： Niitsu N,Umeda M

更新日期：1996-05-01 00:00:00

abstract：:We evaluated the efficacy of S-1 as a new oral antitumor agent in ovarian cancer-bearing nude rats. This drug consists of tegafur, 5-chloro-2,4-dihydroxypyridine, and oxonic acid in a molar ratio of 1:0.4:1.S-1 was given alone or in combination with cisplatin. When administered alone at a daily dose of 20 mg/ kg, S-1 ...

journal_title：Chemotherapy

authors： Suzuki M,Sekiguchi I,Sato I,Shirasaka T

更新日期：1996-11-01 00:00:00

abstract：:Contrary to L-lysine, D-lysine showed no inhibitory effect on growth of Ehrlich ascites tumour cell in in vivo studies. The in vitro studies on the growth of cultured Ehrlich ascites tumour cells showed similar results, namely, the growth of tumour cells was inhibited when cultured in 0.02 or 0.03 M L-lysine; while 0....

journal_title：Chemotherapy

authors： Choy YM,Fung KP

更新日期：1989-01-01 00:00:00

abstract：:Aztreonam is the first monobactam antibiotic to be used clinically. It is highly resistant to beta-lactamases, and although its activity spectrum is similar to that of the aminoglycoside antibiotics, it has no effect on gram-positive bacteria. The current study was undertaken to determine the efficacy of aztreonam in ...

journal_title：Chemotherapy

authors： Schönwald S,Schoss-Vidensek Z,Car V,Krznar B

更新日期：1989-01-01 00:00:00

abstract：:After metabolization, erdosteine (a mucoactive drug) produces an active metabolite (Met I) with an SH group that is capable of opening disulphide bonds, including those of pilin, a protein of bacterial fimbriae. This induces stereochemical conformational changes that interfere with the binding of bacterial adhesins (f...

journal_title：Chemotherapy

authors： Braga PC,Zuccotti T,Dal Sasso M

更新日期：2001-05-01 00:00:00

abstract：:Community-acquired pneumonia (CAP) is a common illness that creates significant burdens upon the healthcare system. Improving the quality of medical care for patients with this illness requires an evidence-based and cost-efficient treatment approach. The first step in this approach is to make an accurate diagnosis, wh...

journal_title：Chemotherapy

authors： Fine MJ

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Pneumolysin is an important virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities released during growth and autolysis. At concentrations above the minimal inhibitory concentration, the protein-synthesis-inhibiting antibiotics erythromycin, clindamycin and rifampicin inhib...

journal_title：Chemotherapy

authors： Spreer A,von Ruden C,Mitchell TJ,Eiffert H,Nau R

更新日期：2007-01-01 00:00:00