Abstract:
:While the majority of patients can be treated safely with fluoropyrimidine, some experience severe fluoropyrimidine-associated toxicity. The frequency and severity of these adverse events vary from patient to patient and are partially explained by genetic polymorphism into the dihydropyrimidine dehydrogenase (DPYD) gene. Carriers of the rare allelic variants DPYD*2A, DPYD*13, and DPYD D949V are more likely to experience severe adverse reactions during fluoropyrimidine-based therapy. However, these 3 genetic variants explain only a small percentage of the overall drug toxicity, and more frequent ones such as homozygous or compound heterozygous DPYD V732I can play a key role.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Falvella FS,Luoni M,Cheli S,Fava S,Cergnul Mdoi
10.1159/000477333subject
Has Abstractpub_date
2017-01-01 00:00:00pages
323-326issue
5eissn
0009-3157issn
1421-9794pii
000477333journal_volume
62pub_type
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