Abstract:
:Therapy of listeriosis with ampicillin was examined in two murine models with compromised defense mechanisms. In mice treated with dextran sulfate paralysing the function of the macrophage system, ampicillin was less able to reduce death rates as well as bacterial counts in the spleens than after infection of normal mice. In nude mice with chronic listeriosis, treatment with ampicillin was started 8 days after infection. The numbers of viable listeria cells decreased under therapy, but a bacteriologic cure was not achieved in a 6-day schedule. Relapse followed cessation of therapy.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Hof H,Emmerling P,Seeliger HPdoi
10.1159/000237980subject
Has Abstractpub_date
1981-01-01 00:00:00pages
214-9issue
3eissn
0009-3157issn
1421-9794journal_volume
27pub_type
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