Abstract:
BACKGROUND:Recently, multiple-line chemotherapy has become popular for non-small cell lung cancer (NSCLC). The survival time of patients is influenced by patient characteristics and subsequent treatments. METHODS:The usefulness of paclitaxel plus S1 (PTX+S1) was evaluated in 46 pretreated NSCLC patients. Time from the start of individual regimens till the start of the next one (TNR) was calculated for regimens administered to the study population including PTX+S1 and analyzed by the shared frailty Cox model. RESULTS:The response rate and the median progression-free survival time of PTX+S1 were 32.6% and 253 days, respectively. Substantial difference in TNR was observed in epidermal growth factor receptor mutation status and in line and type of regimens, but not in stage, age, sex, performance status and histology, by univariate analysis. Multivariate analysis revealed that PTX+S1 was only one factor to prolong TNR. CONCLUSION:Because of long progression-free survival and long TNR, further evaluation of PTX+S1 is necessary.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Aono N,Ito Y,Nishino K,Uchida J,Kumagai T,Akazawa Y,Okuyama T,Yoshinami T,Imamura Fdoi
10.1159/000345624subject
Has Abstractpub_date
2012-01-01 00:00:00pages
454-60issue
6eissn
0009-3157issn
1421-9794pii
000345624journal_volume
58pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract::The influence of normal human serum on bactericidal activity of ceftizoxime sodium (CZX) was studied in vitro against Escherichia coli and Staphylococcus aureus. Subminimal inhibitory concentrations of CZX inhibited the growth of bacteria. Normal human serum as a source of complement and low doses of CZX, such as 1/20...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238399
更新日期:1986-01-01 00:00:00
abstract::Owing to the predominance of gram-positive pathogens in neutropenic cancer patients, newer generation quinolones with an expanded gram-positive spectrum and enhanced potency, may have a role to play for prophylaxis and/or empiric therapy in such patients. The in vitro activity of gatifloxacin was compared with that of...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000081708
更新日期:2004-11-01 00:00:00
abstract::Uptake of the bifunctional alkylating agent, PTT.119, p-F-Phe-m-bis-(2-chloroethyl)amino-L-Phe-Met-ethoxy-HCl, by the MJY-alpha mammary tumor and B16 melanoma cell lines occurred via two natural pathways for amino acid transport. The primary route of PTT.119 entry was the classical L System, whereas, the ASC System ca...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238549
更新日期:1988-01-01 00:00:00
abstract::The potency of fosfomycin (60 micrograms/ml) to induce bacterial L-forms and protoplasts was studied on two strains of Staphylococcus aureus. On osmotically appropriate agar, L-colonies could be grown and repeatedly transferred to fresh media. The L-forms were sensitive to tetracycline and resistant to penicillin. Pro...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238242
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Mitochondria have emerged as a major target for anticancer therapy because of their critical role in cancer cell survival. Our preliminary works have suggested that dihydroergotamine tartrate (DHE), an antimigraine agent, may have effects on mitochondria. METHODS:We examined the effect of DHE on the surviva...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000445044
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Nevirapine (NVP) is a nonnucleoside reverse transcriptase inhibitor used in HIV patients and recently evaluated as a differentiating and antiproliferative agent in human malignancies. However, while NVP is a safe treatment in immunocompromised patients, NVP-containing regimens have been associated with sever...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章
doi:10.1159/000159273
更新日期:2008-01-01 00:00:00
abstract::The antibacterial activity of imipenem combined with norfloxacin, ciprofloxacin, or ofloxacin against 43 gram-positive cocci and 53 aerobic gram-negative rods compared to results obtained with the combination of imipenem with amikacin. Synergistic antibacterial action (defined as FIC index less than or equal to 0.5) w...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238558
更新日期:1988-01-01 00:00:00
abstract::The efficacy of ofloxacin for the treatment of lower respiratory tract infection was evaluated in aged patients with chronic lung disease. Results are the following: improvement of leukocytosis and arterial oxygen tension was observed; peripheral blood cell analysis showed a decrease in natural killer cell counts and ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238901
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Mutant prevention concentration (MPC) is a new parameter that may be of aid in determining the risk of resistant mutants being selected. METHODS:The MPCs of 224 Mycobacterium tuberculosis clinical isolates were estimated by plating more than 10(10) cells on drug-containing agar and determining the concentra...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000085613
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Very little is documented in the medical literature on the association between malaria parasitemia and febrile neutropenia in patients undergoing cancer chemotherapy. METHODS:This report will concentrate on the clinical presentation and outcome of 3 patients with haematological malignancies undergoing chemo...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000118663
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Considering the potentials of gatifloxacin and moxifloxacin in the treatment of tuberculosis, the present study was aimed to define resistance to both these drugs. METHODS:Fifty Mycobacterium tuberculosis isolates, consisting of 30 ofloxacin-susceptible and 20 ofloxacin-resistant strains, were tested for th...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000093486
更新日期:2006-01-01 00:00:00
abstract::Eight thiadiazine 1,1-dioxide derivatives were evaluated for antitrichomonal and antitrypanosomal activities. In vivo tests were performed on a murine model for trichomoniasis standardized in our laboratory. The capacity of compounds to clear visceral lesions in experimentally infected animals as well as their effects...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239040
更新日期:1992-01-01 00:00:00
abstract::Five aminoglycoside antibiotics (AGAs)--kanamycin (KM), bekamycin (AKM), dibekacin (DKB), ribostamycin (RSM) and paromomycin (PRM)--were studied for their effects on the nonenzymic reduction of cytochrome c by FeSO4 (Yamabe's system). Their inhibitory activity was in the order: DKB greater than AKM greater than KM gre...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237880
更新日期:1980-01-01 00:00:00
abstract::17,244 pathogens isolated from clinical specimens of 24 hospitals in the Moers area (North-Rhine Westphalia, FRG) were tested in regard to their susceptibility to Augmentin (amoxicillin and clavulanic acid). For this purpose, minimal inhibitory concentrations were determined by use of microbroth dilution technique. 80...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238588
更新日期:1988-01-01 00:00:00
abstract::The 2,3-dihydroxy-6-bromo-pyrazino-[2,3-beta]-pyrazine is a substance selected during the antiviral screening of pyrazino-pyrazine derivatives. The compound shows antiviral activity in vitro against measles, NDV, some influenza viruses and against herpes simplex and zoster, infectious canine hepatitis and vaccinia vir...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221862
更新日期:1975-01-01 00:00:00
abstract::Rifampicin and rifapentine were used in the treatment of Listeria monocytogenes infections in normal mice and congenitally athymic (nude) mice. Results were compared with untreated controls and with the results obtained from a previous study of ampicillin in which this model was used. Low doses of rifampicin or rifape...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238268
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Myelodysplastic syndrome (MDS) is an iron overload condition. Copper deficiency itself might induce dysplastic changes and iron overload. The relationship between the iron and copper metabolism is analyzed in MDS patients. METHODS:Copper, iron and ceruloplasmin levels were established, and transferrin satur...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000091307
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:To define the maximum tolerated dose (MTD) tolerability and efficacy of intra-arterial chemotherapy with irinotecan in patients with liver metastases of colorectal carcinoma (CRC). METHODS:Superselective intra-arterial irinotecan was applied on days 1, 14, 28 and 42. The initial dose was 140 mg/m² with esca...
journal_title:Chemotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1159/000348579
更新日期:2013-01-01 00:00:00
abstract::Switch therapy, or step-down therapy, is the concept of switching from an intravenous antibiotic to an oral preparation after a few days, once the condition of the patient has improved and the pathogen and its susceptibility have been determined. The orally active third-generation cephalosporin cefixime is a primary c...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048460
更新日期:1998-09-01 00:00:00
abstract::The effect of tinidazole on several ciliates (Stylonychia muscorum, Stylonychia mytilus, Tetrahymena pyriformis, Vorticella companula) has been studied. There is a very pronounced difference in sensitivity against this drug between the free-living ciliates here investigated and certain parasitic protozoa. A high resis...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237820
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:The effects of gemcitabine on postoperative adjuvant chemotherapy were evaluated in patients with stage IV pancreatic cancer. The results were compared with those of our historical control patients treated with surgery alone. PATIENTS AND METHODS:Nineteen patients with stage IV pancreatic cancer who had pan...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000088952
更新日期:2005-10-01 00:00:00
abstract::The in vitro activities of quinupristin/dalfopristin (Synercid), ampicillin, erythromycin, clarithromycin, vancomycin, teicoplanin, ciprofloxacin and tetracycline were examined and compared against 526 gram-positive bacteria. The minimal inhibitory concentrations (MICs) for quinupristin/dalfopristin against Staphyloco...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048530
更新日期:2001-07-01 00:00:00
abstract::Prolonged intermittent renal replacement therapy (PIRRT) is an increasingly adopted method of renal replacement in critically ill patients. Like continuous renal replacement therapy, PIRRT can alter the pharmacokinetics (PK) of many drugs. In this setting, dosing data for antibiotics like benzylpenicillin are lacking....
journal_title:Chemotherapy
pub_type:
doi:10.1159/000499375
更新日期:2019-01-01 00:00:00
abstract::In a randomized study 87 patients received perioperative antibiotic prophylaxis with 2 x 2 g ceftriaxone (Rocephin) at the beginning of the operation and in the following morning. Seventy-two patients received no antibiotic prophylaxis. In patients receiving the prophylaxis, a lower incidence of infections was observe...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000238686
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:In an ongoing project to evaluate essential oils as modulators of antibiotic resistance, the essential oil from Origanum vulgare L. (OVEO), as well as its individual constituents carvacrol (CAR) and thymol (THY), were investigated using Staphylococcus aureus strains possessing efflux mechanisms of resistance...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000381175
更新日期:2014-01-01 00:00:00
abstract::The concentrations of clarithromycin after a single oral dose of 500 mg were determined in serum and saliva of ten healthy adult volunteers. After 2 h, the levels were 4.04 +/- 1.14 (SD) mg/l in serum and 2.72 +/- 0.87 mg/l in saliva. After 7 h these values were 1.98 +/- 0.65 and 1.21 +/- 0.34 mg/l, respectively, and ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239139
更新日期:1993-09-01 00:00:00
abstract::We established a method for determining the KD value as a measure of the bilirubin-displacing effect for drugs by using bilirubin oxidase, which is produced by Myrothecium verrucaria MT-1. This method makes it possible to conduct measurements of many beta-lactam antibiotics, including those which could not be determin...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238590
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:T790M is a major cause of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance, but the clinical significance of T790M disappearance is unknown. CASE REPORT:We report 3 cases of pulmonary adenocarcinoma which did not respond to EGFR-TKI retreatment even with T790M disappearance...
journal_title:Chemotherapy
pub_type:
doi:10.1159/000491937
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:In this study, the in vitro antimicrobial activity and spectrum of new dimeric compounds derived from the cyanobacterial alkaloid nostocarboline were investigated. The mechanism of action and selectivity to bacteria were studied and compared to the cationic antiseptic chlorhexidine. METHODS:Minimal inhibito...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000320033
更新日期:2010-01-01 00:00:00
abstract::Community-acquired pneumonia (CAP) is a common illness that creates significant burdens upon the healthcare system. Improving the quality of medical care for patients with this illness requires an evidence-based and cost-efficient treatment approach. The first step in this approach is to make an accurate diagnosis, wh...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000049174
更新日期:2001-01-01 00:00:00