Susceptibility of Mycobacterium tuberculosis strains to gatifloxacin and moxifloxacin by different methods.


BACKGROUND:Considering the potentials of gatifloxacin and moxifloxacin in the treatment of tuberculosis, the present study was aimed to define resistance to both these drugs. METHODS:Fifty Mycobacterium tuberculosis isolates, consisting of 30 ofloxacin-susceptible and 20 ofloxacin-resistant strains, were tested for their susceptibility to gatifloxacin and moxifloxacin using different susceptibility testing methods, namely the absolute concentration method on Lowenstein-Jensen medium (LJ), the proportion susceptibility testing method (PST) on LJ and 7H11 agar media, and the BACTEC radiometric method. RESULT:The minimal inhibitory concentration (MIC) of gatifloxacin and moxifloxacin was 1 microg/ml by the absolute concentration method on LJ. In the PST method on LJ and 7H11, using a criterion of > or =1% growth as resistant, there was 100% agreement with the absolute concentration method at a concentration of 0.5 microg/ml for gatifloxacin, and 96% agreement with the BACTEC method at a concentration of 0.25 microg/ml. For moxifloxacin, results by the PST method showed 96% agreement with the absolute concentration method on LJ at a concentration of 1 microg/ml and 92% agreement at a concentration of 0.5 microg/ml for both the absolute concentration method on 7H11 and the BACTEC method. CONCLUSIONS:The MICs of gatifloxacin and moxifloxacin were much lower than the MICs of other quinolones like ofloxacin and ciprofloxacin. Additionally, these two drugs have shown a low mean MIC and low concentration as a definition of resistance, which might help in treating the patients with low levels of quinolone resistance.






Somasundaram S,Paramasivan NC




Has Abstract


2006-01-01 00:00:00














  • Post-antibiotic effect of levofloxacin and tobramycin alone or in combination with cefepime against Pseudomonas aeruginosa.

    abstract:BACKGROUND:Levofloxacin and tobramycin, alone and in combination with cefepime, were investigated for their in vitro activities and post-antibiotic effects (PAEs) on Pseudomonas aeruginosa. METHODS:The in vitro activities of tobramycin and levofloxacin in combination with cefepime were determined by microbroth chequer...


    pub_type: 杂志文章


    authors: Ozbek B,Otuk G

    更新日期:2009-01-01 00:00:00

  • Biophotometric comparison of cephalexin and cephradine against gram-positive bacteria.

    abstract::We have compared the antibacterial activities of cephalexin and cephradine against Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus saprophyticus (Micrococcus spp. type III), and group B streptococci (35 strains in total), using the Biophotometer. Analysis of growth curves obtained in the presence of ...


    pub_type: 杂志文章


    authors: Brumfitt W,Hamilton-Miller JM

    更新日期:1982-01-01 00:00:00

  • Biliary excretion of cefaclor. Experimental and clinical study.

    abstract::Biliary excretion of cefaclor, a new orally active cephalosporin, was studied in vitro using an isolated rabbit liver preparation perfused for 3 h (n = 5). Under these conditions, bile recovery amounted to 2.3% of the cefaclor dose added to the circulating blood (10 mg). In humans, after oral administration of a 1-gra...


    pub_type: 杂志文章


    authors: Brogard JM,Pinget M,Comte F,Adloff M,Lavillaureix J

    更新日期:1982-01-01 00:00:00

  • Antiproliferative properties of toremifene on AIDS-related Kaposi's sarcoma cells.

    abstract:BACKGROUND:Kaposi's sarcoma (KS) is the most common neoplastic apoptosis manifestation of acquired immunodeficiency syndrome. Toremifene is known to upregulate transforming growth factor beta-1 (TGF-beta1), which is a growth-inhibitory factor for KS. We investigated the in vitro effect of toremifene on KS cells. METHO...


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    authors: Hong A,Leigh BR

    更新日期:2002-12-01 00:00:00

  • Pharmacokinetics of cationic liposome-encapsulated doxycycline in mice challenged with genital infection by Chlamydia trachomatis.

    abstract::Our previous studies demonstrated the efficacy of cationic liposome-encapsulated doxycycline (CaL-DOX) on the course of infection with Chlamydia trachomatis in vitro and in vivo. In this investigation, the pharmacokinetics of CaL-DOX are reported. Female mice inoculated intravaginally with 4.84 x 10(5) inclusion-formi...


    pub_type: 杂志文章


    authors: Selliah S,Ravaoarinoro M

    更新日期:2004-04-01 00:00:00

  • Visualization of doxycycline in lung tissue and sinus secretions by fluorescent techniques.

    abstract::The two studies which are reviewed in this paper demonstrate the value of fluorescent microscopic observations in the studying of the distribution of antibiotics in lung tissue and in sinus secretions. In the lung tissue study, the standard microbiologic assay data on doxycycline concentrations in respiratory tissue t...


    pub_type: 杂志文章


    authors: Liss RH,Norman JC

    更新日期:1975-01-01 00:00:00

  • Sensitivity of clinical isolates from German hospitals to amoxicillin/clavulanic acid (Augmentin) compared with other antibiotics.

    abstract::17,244 pathogens isolated from clinical specimens of 24 hospitals in the Moers area (North-Rhine Westphalia, FRG) were tested in regard to their susceptibility to Augmentin (amoxicillin and clavulanic acid). For this purpose, minimal inhibitory concentrations were determined by use of microbroth dilution technique. 80...


    pub_type: 杂志文章


    authors: Focht J,Klietmann W,Nösner K,Rolinson GN,Johnsen J

    更新日期:1988-01-01 00:00:00

  • Intra-aortal therapy with 5-fluorouracil- polyethylene glycol stealth liposomes: does the metabolism of 5-fluorouracil into 5-fluoro-2'-deoxyuridine depend on ph value?. An animal study in VX-2 liver tumor-bearing rabbits.

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    authors: Pohlen U,Binnenhei M,Reszka R,Buhr HJ,Berger G

    更新日期:2004-06-01 00:00:00

  • Newer agents against methicillin and/or gentamicin-resistant and -susceptible staphylococci.

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    authors: Chandrasekar PH,Sluchak JA

    更新日期:1989-01-01 00:00:00

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    abstract::Prolonged intermittent renal replacement therapy (PIRRT) is an increasingly adopted method of renal replacement in critically ill patients. Like continuous renal replacement therapy, PIRRT can alter the pharmacokinetics (PK) of many drugs. In this setting, dosing data for antibiotics like benzylpenicillin are lacking....




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    authors: Bozkurt-Guzel C,Savage PB,Gerceker AA

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    pub_type: 杂志文章


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    abstract::In this paper the bactericidal activities of ofloxacin and its optically active derivative, DR-3355, against non-growing cells of Escherichia coli and Pseudomonas aeruginosa are described. E. coli and P. aeruginosa were killed rapidly by ofloxacin and DR-3355. After treatment with these quinolones, the resting cells o...


    pub_type: 杂志文章


    authors: Tanaka M,Otsuki M,Nishino T

    更新日期:1992-01-01 00:00:00

  • Biliary excretion of tetroxoprim in man.

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    pub_type: 杂志文章


    authors: Vergin H,Luber P

    更新日期:1982-01-01 00:00:00

  • The effect of erythromycin on the growth of Rickettsia prowazekii in the body louse (Pediculus humanus corporis L) and the tick (Ornithodoros moubata Murray).

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    pub_type: 杂志文章


    authors: Becla E

    更新日期:1976-01-01 00:00:00

  • Mutant prevention concentration of isoniazid, rifampicin and rifabutin against Mycobacterium tuberculosis.

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    authors: Elo H

    更新日期:1990-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Meingassner JG,Heyworth PG,Havelec L

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    authors: Kolonitsiou F,Mani V,Parikou H,Trakala M,Dimitracopoulos G,Spiliopoulou I

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    pub_type: 杂志文章


    authors: Seydel JK,Wempe E

    更新日期:1980-01-01 00:00:00

  • Analytical studies on beta-lactam antibiotics. II. Displacement effect of beta-lactam antibiotics on bilirubin bound to human serum albumin.

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    pub_type: 杂志文章


    authors: Matsuura A,Nagayama T,Kitagawa T

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    authors: Mese H,Sasaki A,Alcalde RE,Nakayama S,Matsumura T

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    pub_type: 杂志文章,多中心研究


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    pub_type: 杂志文章,随机对照试验


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    pub_type: 杂志文章


    authors: Parr TR Jr,Chan L,Bayer AS

    更新日期:1988-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Lus RG,Calvo MC,Lopez LG,Cancer RC,Molina AM,Sanchez ED,Parilla AC,Mur LL

    更新日期:1977-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Renapurkar DM,Pradhan VR,Sutar NK,Deshmukh RA,Pandit CH,Marathe SN

    更新日期:1989-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Banerjee K,Das S,Choudhury P,Ghosh S,Baral R,Choudhuri SK

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    pub_type: 杂志文章


    authors: Nagase H,Nakagawa F,Uchida J

    更新日期:2018-01-01 00:00:00